IDS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IDS
Entrez Gene ID	3423
Full Name	iduronate 2-sulfatase
Synonyms	MPS2,SIDS
General protein information	Preferred Names iduronate 2-sulfatase Names iduronate 2-sulfatase alpha-L-iduronate sulfate sulfatase iduronate 2-sulfatase 14 kDa chain iduronate 2-sulfatase 42 kDa chain idursulfase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016].
Disorder MIM:	300823
Disorder Html:	Mucopolysaccharidosis II, 309900 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006123.4	NP_006114.1	iduronate 2-sulfatase isoform b precursor
NM_000202.8	NP_000193.1	iduronate 2-sulfatase isoform a preproprotein
NM_000202.6	NP_000193.1	iduronate 2-sulfatase isoform a preproprotein
NM_001166550.3	NP_001160022.1	iduronate 2-sulfatase isoform c
NM_001166550.4	NP_001160022.1	iduronate 2-sulfatase isoform c
NM_006123.5	NP_006114.1	iduronate 2-sulfatase isoform b precursor
NM_000202.7	NP_000193.1	iduronate 2-sulfatase isoform a preproprotein

Pathways from BioSystems

Homologies

	IDS	XP_001089323.1
Danio rerio (zebrafish)	ids	NP_001073537.1
Drosophila melanogaster (fruit fly)	CG12014	NP_647814.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005778	XP_315795.4
Mus musculus (house mouse)	Ids	NP_034628.2
Rattus norvegicus (Norway rat)	Ids	XP_006243311.1
Gallus gallus (chicken)	IDS	NP_001264589.1
Xenopus tropicalis (tropical clawed frog)	ids	NP_001184061.1
Homo sapiens (human)	IDS	NP_000193.1
Pan troglodytes (chimpanzee)	IDS	XP_521297.4
Canis lupus familiaris (dog)	IDS	NP_001041590.1
Bos taurus (cattle)	IDS	NP_001179780.1

Gene Ontology
Bibliography

Related articles in PubMed

Genotype-phenotype relationship in mucopolysaccharidosis II: predictive power of IDS variants for the neuronopathic phenotype.
Vollebregt AAM, Hoogeveen-Westerveld M, Kroos MA, Oussoren E, Plug I, Ruijter GJ, van der Ploeg AT, Pijnappel WWMP
Developmental medicine and child neurology59(10)1063-1070(2017 10)

Insights into Hunter syndrome from the structure of iduronate-2-sulfatase.
Demydchuk M, Hill CH, Zhou A, Bunk?czi G, Stein PE, Marchesan D, Deane JE, Read RJ
Nature communications815786(2017 Jun)

[Analysis of IDS gene mutation in a family affected with mucopolysaccharidosis type?].
Li Y, Mei S, Kong X, Zhao Z, Zhu X, Yang X, Qin Z, Wu H
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics34(1)58-60(2017 Feb)

Molecular diagnosis of 65 families with mucopolysaccharidosis type II (Hunter syndrome) characterized by 16 novel mutations in the IDS gene: Genetic, pathological, and structural studies on iduronate-2-sulfatase.
Kosuga M, Mashima R, Hirakiyama A, Fuji N, Kumagai T, Seo JH, Nikaido M, Saito S, Ohno K, Sakuraba H, Okuyama T
Molecular genetics and metabolism118(3)190-7(2016 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study analyzed the genotype-phenotype relationship for 17 patients with mucopolysaccharidosis II and performed expression studies for 12 variants, nine of which have not been reported previously; speculated that very low or cell-type-specific IDS residual activity is sufficient to prevent the neuronal phenotype.
Title: Genotype-phenotype relationship in mucopolysaccharidosis II: predictive power of IDS variants for the neuronopathic phenotype.

A splicing mutation, c.709-1G>A, was detected in the proband, for which his mother was heterozygous.
Title: [Analysis of IDS gene mutation in a family affected with mucopolysaccharidosis type?].

Functional characterization of all the novel sequence variants identified in the study would be helpful to confirm the clinical significance and to determine the effect of these variations on the function of respective proteins (IDUA and IDS)
Title: Identification and characterization of 20 novel pathogenic variants in 60 unrelated Indian patients with mucopolysaccharidoses type I and type II.

Study identified 16 novel mutations in the IDS gene and revealed that the severe type of mucopolysaccharidosis type II is strongly associated with large structural alteration of the gene.
Title: Molecular diagnosis of 65 families with mucopolysaccharidosis type II (Hunter syndrome) characterized by 16 novel mutations in the IDS gene: Genetic, pathological, and structural studies on iduronate-2-sulfatase.

Extensive iduronate 2-sulfatase (Hunter syndrome) (IDS) gene deletions were identified in four mucopolysaccharidosis type II (MPSII) patients.
Title: Wide allelic heterogeneity with predominance of large IDS gene complex rearrangements in a sample of Mexican patients with Hunter syndrome.

The following IDS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IDS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21016	NM_000202.8 Latest version!	Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$229.50-$321.30 $459.00
OHu16536	NM_006123.5 Latest version!	Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu16723	NM_001166550.4 Latest version!	Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$272.30 $389.00
View Old Accession Versions >>
OHu21016	NM_000202.6	Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$229.50-$321.30 $459.00
OHu16723	NM_001166550.3	Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$272.30 $389.00
OHu16536	NM_006123.4	Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu21016	NM_000202.7	Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$229.50-$321.30 $459.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IDS ( NM_000202.8 ) cDNA ORF clone, Homo sapiens(human) -> NP_000193.1 Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21016
Clone ID Related Accession (Same CDS sequence)	NM_000202.8 , NM_000202.6 , NM_000202.7
Accession Version	NM_000202.8 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1653bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	iduronate 2-sulfatase isoform a preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA325538.1, M58342.1, BY996633.1, AK055600.1, DA351886.1, CN303532.1, AK057191.1, AC233288.1, CK004173.1 and R46390.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_000202.7. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.154379.1, SRR1803612.252715.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000340855.11/ ENSP00000339801.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGCCAC CCCGGACCGG CCGAGGCCTT CTCTGGCTGG GTCTGGTTCT GAGCTCCGTC 
TGCGTCGCCC TCGGATCCGA AACGCAGGCC AACTCGACCA CAGATGCTCT GAACGTTCTT 
CTCATCATCG TGGATGACCT GCGCCCCTCC CTGGGCTGTT ATGGGGATAA GCTGGTGAGG 
TCCCCAAATA TTGACCAACT GGCATCCCAC AGCCTCCTCT TCCAGAATGC CTTTGCGCAG 
CAAGCAGTGT GCGCCCCGAG CCGCGTTTCT TTCCTCACTG GCAGGAGACC TGACACCACC 
CGCCTGTACG ACTTCAACTC CTACTGGAGG GTGCACGCTG GAAACTTCTC CACCATCCCC 
CAGTACTTCA AGGAGAATGG CTATGTGACC ATGTCGGTGG GAAAAGTCTT TCACCCTGGG 
ATATCTTCTA ACCATACCGA TGATTCTCCG TATAGCTGGT CTTTTCCACC TTATCATCCT 
TCCTCTGAGA AGTATGAAAA CACTAAGACA TGTCGAGGGC CAGATGGAGA ACTCCATGCC 
AACCTGCTTT GCCCTGTGGA TGTGCTGGAT GTTCCCGAGG GCACCTTGCC TGACAAACAG 
AGCACTGAGC AAGCCATACA GTTGTTGGAA AAGATGAAAA CGTCAGCCAG TCCTTTCTTC 
CTGGCCGTTG GGTATCATAA GCCACACATC CCCTTCAGAT ACCCCAAGGA ATTTCAGAAG 
TTGTATCCCT TGGAGAACAT CACCCTGGCC CCCGATCCCG AGGTCCCTGA TGGCCTACCC 
CCTGTGGCCT ACAACCCCTG GATGGACATC AGGCAACGGG AAGACGTCCA AGCCTTAAAC 
ATCAGTGTGC CGTATGGTCC AATTCCTGTG GACTTTCAGC GGAAAATCCG CCAGAGCTAC 
TTTGCCTCTG TGTCATATTT GGATACACAG GTCGGCCGCC TCTTGAGTGC TTTGGACGAT 
CTTCAGCTGG CCAACAGCAC CATCATTGCA TTTACCTCGG ATCATGGGTG GGCTCTAGGT 
GAACATGGAG AATGGGCCAA ATACAGCAAT TTTGATGTTG CTACCCATGT TCCCCTGATA 
TTCTATGTTC CTGGAAGGAC GGCTTCACTT CCGGAGGCAG GCGAGAAGCT TTTCCCTTAC 
CTCGACCCTT TTGATTCCGC CTCACAGTTG ATGGAGCCAG GCAGGCAATC CATGGACCTT 
GTGGAACTTG TGTCTCTTTT TCCCACGCTG GCTGGACTTG CAGGACTGCA GGTTCCACCT 
CGCTGCCCCG TTCCTTCATT TCACGTTGAG CTGTGCAGAG AAGGCAAGAA CCTTCTGAAG 
CATTTTCGAT TCCGTGACTT GGAAGAGGAT CCGTACCTCC CTGGTAATCC CCGTGAACTG 
ATTGCCTATA GCCAGTATCC CCGGCCTTCA GACATCCCTC AGTGGAATTC TGACAAGCCG 
AGTTTAAAAG ATATAAAGAT CATGGGCTAT TCCATACGCA CCATAGACTA TAGGTATACT 
GTGTGGGTTG GCTTCAATCC TGATGAATTT CTAGCTAACT TTTCTGACAT CCATGCAGGG 
GAACTGTATT TTGTGGATTC TGACCCATTG CAGGATCACA ATATGTATAA TGATTCCCAA 
GGTGGAGATC TTTTCCAGTT GTTGATGCCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000193.1
CDS	170..1822
Translation	MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP

Target ORF information:

RefSeq Version	NM_000202.8
Organism	Homo sapiens(human)
Definition	Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000202.8

ORF Insert Sequence:

ATGCCGCCAC CCCGGACCGG CCGAGGCCTT CTCTGGCTGG GTCTGGTTCT GAGCTCCGTC 
TGCGTCGCCC TCGGATCCGA AACGCAGGCC AACTCGACCA CAGATGCTCT GAACGTTCTT 
CTCATCATCG TGGATGACCT GCGCCCCTCC CTGGGCTGTT ATGGGGATAA GCTGGTGAGG 
TCCCCAAATA TTGACCAACT GGCATCCCAC AGCCTCCTCT TCCAGAATGC CTTTGCGCAG 
CAAGCAGTGT GCGCCCCGAG CCGCGTTTCT TTCCTCACTG GCAGGAGACC TGACACCACC 
CGCCTGTACG ACTTCAACTC CTACTGGAGG GTGCACGCTG GAAACTTCTC CACCATCCCC 
CAGTACTTCA AGGAGAATGG CTATGTGACC ATGTCGGTGG GAAAAGTCTT TCACCCTGGG 
ATATCTTCTA ACCATACCGA TGATTCTCCG TATAGCTGGT CTTTTCCACC TTATCATCCT 
TCCTCTGAGA AGTATGAAAA CACTAAGACA TGTCGAGGGC CAGATGGAGA ACTCCATGCC 
AACCTGCTTT GCCCTGTGGA TGTGCTGGAT GTTCCCGAGG GCACCTTGCC TGACAAACAG 
AGCACTGAGC AAGCCATACA GTTGTTGGAA AAGATGAAAA CGTCAGCCAG TCCTTTCTTC 
CTGGCCGTTG GGTATCATAA GCCACACATC CCCTTCAGAT ACCCCAAGGA ATTTCAGAAG 
TTGTATCCCT TGGAGAACAT CACCCTGGCC CCCGATCCCG AGGTCCCTGA TGGCCTACCC 
CCTGTGGCCT ACAACCCCTG GATGGACATC AGGCAACGGG AAGACGTCCA AGCCTTAAAC 
ATCAGTGTGC CGTATGGTCC AATTCCTGTG GACTTTCAGC GGAAAATCCG CCAGAGCTAC 
TTTGCCTCTG TGTCATATTT GGATACACAG GTCGGCCGCC TCTTGAGTGC TTTGGACGAT 
CTTCAGCTGG CCAACAGCAC CATCATTGCA TTTACCTCGG ATCATGGGTG GGCTCTAGGT 
GAACATGGAG AATGGGCCAA ATACAGCAAT TTTGATGTTG CTACCCATGT TCCCCTGATA 
TTCTATGTTC CTGGAAGGAC GGCTTCACTT CCGGAGGCAG GCGAGAAGCT TTTCCCTTAC 
CTCGACCCTT TTGATTCCGC CTCACAGTTG ATGGAGCCAG GCAGGCAATC CATGGACCTT 
GTGGAACTTG TGTCTCTTTT TCCCACGCTG GCTGGACTTG CAGGACTGCA GGTTCCACCT 
CGCTGCCCCG TTCCTTCATT TCACGTTGAG CTGTGCAGAG AAGGCAAGAA CCTTCTGAAG 
CATTTTCGAT TCCGTGACTT GGAAGAGGAT CCGTACCTCC CTGGTAATCC CCGTGAACTG 
ATTGCCTATA GCCAGTATCC CCGGCCTTCA GACATCCCTC AGTGGAATTC TGACAAGCCG 
AGTTTAAAAG ATATAAAGAT CATGGGCTAT TCCATACGCA CCATAGACTA TAGGTATACT 
GTGTGGGTTG GCTTCAATCC TGATGAATTT CTAGCTAACT TTTCTGACAT CCATGCAGGG 
GAACTGTATT TTGTGGATTC TGACCCATTG CAGGATCACA ATATGTATAA TGATTCCCAA 
GGTGGAGATC TTTTCCAGTT GTTGATGCCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IDS ( NM_000202.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_000193.1 Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21016
Clone ID Related Accession (Same CDS sequence)	NM_000202.8 , NM_000202.6 , NM_000202.7
Accession Version	NM_000202.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1653bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	iduronate 2-sulfatase isoform a preproprotein
Comment

ATGCCGCCAC CCCGGACCGG CCGAGGCCTT CTCTGGCTGG GTCTGGTTCT GAGCTCCGTC 
TGCGTCGCCC TCGGATCCGA AACGCAGGCC AACTCGACCA CAGATGCTCT GAACGTTCTT 
CTCATCATCG TGGATGACCT GCGCCCCTCC CTGGGCTGTT ATGGGGATAA GCTGGTGAGG 
TCCCCAAATA TTGACCAACT GGCATCCCAC AGCCTCCTCT TCCAGAATGC CTTTGCGCAG 
CAAGCAGTGT GCGCCCCGAG CCGCGTTTCT TTCCTCACTG GCAGGAGACC TGACACCACC 
CGCCTGTACG ACTTCAACTC CTACTGGAGG GTGCACGCTG GAAACTTCTC CACCATCCCC 
CAGTACTTCA AGGAGAATGG CTATGTGACC ATGTCGGTGG GAAAAGTCTT TCACCCTGGG 
ATATCTTCTA ACCATACCGA TGATTCTCCG TATAGCTGGT CTTTTCCACC TTATCATCCT 
TCCTCTGAGA AGTATGAAAA CACTAAGACA TGTCGAGGGC CAGATGGAGA ACTCCATGCC 
AACCTGCTTT GCCCTGTGGA TGTGCTGGAT GTTCCCGAGG GCACCTTGCC TGACAAACAG 
AGCACTGAGC AAGCCATACA GTTGTTGGAA AAGATGAAAA CGTCAGCCAG TCCTTTCTTC 
CTGGCCGTTG GGTATCATAA GCCACACATC CCCTTCAGAT ACCCCAAGGA ATTTCAGAAG 
TTGTATCCCT TGGAGAACAT CACCCTGGCC CCCGATCCCG AGGTCCCTGA TGGCCTACCC 
CCTGTGGCCT ACAACCCCTG GATGGACATC AGGCAACGGG AAGACGTCCA AGCCTTAAAC 
ATCAGTGTGC CGTATGGTCC AATTCCTGTG GACTTTCAGC GGAAAATCCG CCAGAGCTAC 
TTTGCCTCTG TGTCATATTT GGATACACAG GTCGGCCGCC TCTTGAGTGC TTTGGACGAT 
CTTCAGCTGG CCAACAGCAC CATCATTGCA TTTACCTCGG ATCATGGGTG GGCTCTAGGT 
GAACATGGAG AATGGGCCAA ATACAGCAAT TTTGATGTTG CTACCCATGT TCCCCTGATA 
TTCTATGTTC CTGGAAGGAC GGCTTCACTT CCGGAGGCAG GCGAGAAGCT TTTCCCTTAC 
CTCGACCCTT TTGATTCCGC CTCACAGTTG ATGGAGCCAG GCAGGCAATC CATGGACCTT 
GTGGAACTTG TGTCTCTTTT TCCCACGCTG GCTGGACTTG CAGGACTGCA GGTTCCACCT 
CGCTGCCCCG TTCCTTCATT TCACGTTGAG CTGTGCAGAG AAGGCAAGAA CCTTCTGAAG 
CATTTTCGAT TCCGTGACTT GGAAGAGGAT CCGTACCTCC CTGGTAATCC CCGTGAACTG 
ATTGCCTATA GCCAGTATCC CCGGCCTTCA GACATCCCTC AGTGGAATTC TGACAAGCCG 
AGTTTAAAAG ATATAAAGAT CATGGGCTAT TCCATACGCA CCATAGACTA TAGGTATACT 
GTGTGGGTTG GCTTCAATCC TGATGAATTT CTAGCTAACT TTTCTGACAT CCATGCAGGG 
GAACTGTATT TTGTGGATTC TGACCCATTG CAGGATCACA ATATGTATAA TGATTCCCAA 
GGTGGAGATC TTTTCCAGTT GTTGATGCCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_000193.1

Translation

MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP

Target ORF information:

RefSeq Version	NM_000202.6
Organism	Homo sapiens(Human)
Definition	Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000202.6

ORF Insert Sequence:

ATGCCGCCAC CCCGGACCGG CCGAGGCCTT CTCTGGCTGG GTCTGGTTCT GAGCTCCGTC 
TGCGTCGCCC TCGGATCCGA AACGCAGGCC AACTCGACCA CAGATGCTCT GAACGTTCTT 
CTCATCATCG TGGATGACCT GCGCCCCTCC CTGGGCTGTT ATGGGGATAA GCTGGTGAGG 
TCCCCAAATA TTGACCAACT GGCATCCCAC AGCCTCCTCT TCCAGAATGC CTTTGCGCAG 
CAAGCAGTGT GCGCCCCGAG CCGCGTTTCT TTCCTCACTG GCAGGAGACC TGACACCACC 
CGCCTGTACG ACTTCAACTC CTACTGGAGG GTGCACGCTG GAAACTTCTC CACCATCCCC 
CAGTACTTCA AGGAGAATGG CTATGTGACC ATGTCGGTGG GAAAAGTCTT TCACCCTGGG 
ATATCTTCTA ACCATACCGA TGATTCTCCG TATAGCTGGT CTTTTCCACC TTATCATCCT 
TCCTCTGAGA AGTATGAAAA CACTAAGACA TGTCGAGGGC CAGATGGAGA ACTCCATGCC 
AACCTGCTTT GCCCTGTGGA TGTGCTGGAT GTTCCCGAGG GCACCTTGCC TGACAAACAG 
AGCACTGAGC AAGCCATACA GTTGTTGGAA AAGATGAAAA CGTCAGCCAG TCCTTTCTTC 
CTGGCCGTTG GGTATCATAA GCCACACATC CCCTTCAGAT ACCCCAAGGA ATTTCAGAAG 
TTGTATCCCT TGGAGAACAT CACCCTGGCC CCCGATCCCG AGGTCCCTGA TGGCCTACCC 
CCTGTGGCCT ACAACCCCTG GATGGACATC AGGCAACGGG AAGACGTCCA AGCCTTAAAC 
ATCAGTGTGC CGTATGGTCC AATTCCTGTG GACTTTCAGC GGAAAATCCG CCAGAGCTAC 
TTTGCCTCTG TGTCATATTT GGATACACAG GTCGGCCGCC TCTTGAGTGC TTTGGACGAT 
CTTCAGCTGG CCAACAGCAC CATCATTGCA TTTACCTCGG ATCATGGGTG GGCTCTAGGT 
GAACATGGAG AATGGGCCAA ATACAGCAAT TTTGATGTTG CTACCCATGT TCCCCTGATA 
TTCTATGTTC CTGGAAGGAC GGCTTCACTT CCGGAGGCAG GCGAGAAGCT TTTCCCTTAC 
CTCGACCCTT TTGATTCCGC CTCACAGTTG ATGGAGCCAG GCAGGCAATC CATGGACCTT 
GTGGAACTTG TGTCTCTTTT TCCCACGCTG GCTGGACTTG CAGGACTGCA GGTTCCACCT 
CGCTGCCCCG TTCCTTCATT TCACGTTGAG CTGTGCAGAG AAGGCAAGAA CCTTCTGAAG 
CATTTTCGAT TCCGTGACTT GGAAGAGGAT CCGTACCTCC CTGGTAATCC CCGTGAACTG 
ATTGCCTATA GCCAGTATCC CCGGCCTTCA GACATCCCTC AGTGGAATTC TGACAAGCCG 
AGTTTAAAAG ATATAAAGAT CATGGGCTAT TCCATACGCA CCATAGACTA TAGGTATACT 
GTGTGGGTTG GCTTCAATCC TGATGAATTT CTAGCTAACT TTTCTGACAT CCATGCAGGG 
GAACTGTATT TTGTGGATTC TGACCCATTG CAGGATCACA ATATGTATAA TGATTCCCAA 
GGTGGAGATC TTTTCCAGTT GTTGATGCCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IDS ( NM_000202.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_000193.1 Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21016
Clone ID Related Accession (Same CDS sequence)	NM_000202.8 , NM_000202.6 , NM_000202.7
Accession Version	NM_000202.7	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1653bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	iduronate 2-sulfatase isoform a preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA325538.1, M58342.1, BY996633.1, AK055600.1, DA351886.1, CN303532.1, AK057191.1, AC233288.1, CK004173.1 and R46390.1. This sequence is a reference standard in the RefSeqGene project. On Jan 14, 2016 this sequence version replaced NM_000202.6. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.179443.1, SRR1660809.165074.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGCCAC CCCGGACCGG CCGAGGCCTT CTCTGGCTGG GTCTGGTTCT GAGCTCCGTC 
TGCGTCGCCC TCGGATCCGA AACGCAGGCC AACTCGACCA CAGATGCTCT GAACGTTCTT 
CTCATCATCG TGGATGACCT GCGCCCCTCC CTGGGCTGTT ATGGGGATAA GCTGGTGAGG 
TCCCCAAATA TTGACCAACT GGCATCCCAC AGCCTCCTCT TCCAGAATGC CTTTGCGCAG 
CAAGCAGTGT GCGCCCCGAG CCGCGTTTCT TTCCTCACTG GCAGGAGACC TGACACCACC 
CGCCTGTACG ACTTCAACTC CTACTGGAGG GTGCACGCTG GAAACTTCTC CACCATCCCC 
CAGTACTTCA AGGAGAATGG CTATGTGACC ATGTCGGTGG GAAAAGTCTT TCACCCTGGG 
ATATCTTCTA ACCATACCGA TGATTCTCCG TATAGCTGGT CTTTTCCACC TTATCATCCT 
TCCTCTGAGA AGTATGAAAA CACTAAGACA TGTCGAGGGC CAGATGGAGA ACTCCATGCC 
AACCTGCTTT GCCCTGTGGA TGTGCTGGAT GTTCCCGAGG GCACCTTGCC TGACAAACAG 
AGCACTGAGC AAGCCATACA GTTGTTGGAA AAGATGAAAA CGTCAGCCAG TCCTTTCTTC 
CTGGCCGTTG GGTATCATAA GCCACACATC CCCTTCAGAT ACCCCAAGGA ATTTCAGAAG 
TTGTATCCCT TGGAGAACAT CACCCTGGCC CCCGATCCCG AGGTCCCTGA TGGCCTACCC 
CCTGTGGCCT ACAACCCCTG GATGGACATC AGGCAACGGG AAGACGTCCA AGCCTTAAAC 
ATCAGTGTGC CGTATGGTCC AATTCCTGTG GACTTTCAGC GGAAAATCCG CCAGAGCTAC 
TTTGCCTCTG TGTCATATTT GGATACACAG GTCGGCCGCC TCTTGAGTGC TTTGGACGAT 
CTTCAGCTGG CCAACAGCAC CATCATTGCA TTTACCTCGG ATCATGGGTG GGCTCTAGGT 
GAACATGGAG AATGGGCCAA ATACAGCAAT TTTGATGTTG CTACCCATGT TCCCCTGATA 
TTCTATGTTC CTGGAAGGAC GGCTTCACTT CCGGAGGCAG GCGAGAAGCT TTTCCCTTAC 
CTCGACCCTT TTGATTCCGC CTCACAGTTG ATGGAGCCAG GCAGGCAATC CATGGACCTT 
GTGGAACTTG TGTCTCTTTT TCCCACGCTG GCTGGACTTG CAGGACTGCA GGTTCCACCT 
CGCTGCCCCG TTCCTTCATT TCACGTTGAG CTGTGCAGAG AAGGCAAGAA CCTTCTGAAG 
CATTTTCGAT TCCGTGACTT GGAAGAGGAT CCGTACCTCC CTGGTAATCC CCGTGAACTG 
ATTGCCTATA GCCAGTATCC CCGGCCTTCA GACATCCCTC AGTGGAATTC TGACAAGCCG 
AGTTTAAAAG ATATAAAGAT CATGGGCTAT TCCATACGCA CCATAGACTA TAGGTATACT 
GTGTGGGTTG GCTTCAATCC TGATGAATTT CTAGCTAACT TTTCTGACAT CCATGCAGGG 
GAACTGTATT TTGTGGATTC TGACCCATTG CAGGATCACA ATATGTATAA TGATTCCCAA 
GGTGGAGATC TTTTCCAGTT GTTGATGCCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000193.1
CDS	218..1870
Translation	MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP

Target ORF information:

RefSeq Version	NM_000202.7
Organism	Homo sapiens(human)
Definition	Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000202.7

ORF Insert Sequence:

ATGCCGCCAC CCCGGACCGG CCGAGGCCTT CTCTGGCTGG GTCTGGTTCT GAGCTCCGTC 
TGCGTCGCCC TCGGATCCGA AACGCAGGCC AACTCGACCA CAGATGCTCT GAACGTTCTT 
CTCATCATCG TGGATGACCT GCGCCCCTCC CTGGGCTGTT ATGGGGATAA GCTGGTGAGG 
TCCCCAAATA TTGACCAACT GGCATCCCAC AGCCTCCTCT TCCAGAATGC CTTTGCGCAG 
CAAGCAGTGT GCGCCCCGAG CCGCGTTTCT TTCCTCACTG GCAGGAGACC TGACACCACC 
CGCCTGTACG ACTTCAACTC CTACTGGAGG GTGCACGCTG GAAACTTCTC CACCATCCCC 
CAGTACTTCA AGGAGAATGG CTATGTGACC ATGTCGGTGG GAAAAGTCTT TCACCCTGGG 
ATATCTTCTA ACCATACCGA TGATTCTCCG TATAGCTGGT CTTTTCCACC TTATCATCCT 
TCCTCTGAGA AGTATGAAAA CACTAAGACA TGTCGAGGGC CAGATGGAGA ACTCCATGCC 
AACCTGCTTT GCCCTGTGGA TGTGCTGGAT GTTCCCGAGG GCACCTTGCC TGACAAACAG 
AGCACTGAGC AAGCCATACA GTTGTTGGAA AAGATGAAAA CGTCAGCCAG TCCTTTCTTC 
CTGGCCGTTG GGTATCATAA GCCACACATC CCCTTCAGAT ACCCCAAGGA ATTTCAGAAG 
TTGTATCCCT TGGAGAACAT CACCCTGGCC CCCGATCCCG AGGTCCCTGA TGGCCTACCC 
CCTGTGGCCT ACAACCCCTG GATGGACATC AGGCAACGGG AAGACGTCCA AGCCTTAAAC 
ATCAGTGTGC CGTATGGTCC AATTCCTGTG GACTTTCAGC GGAAAATCCG CCAGAGCTAC 
TTTGCCTCTG TGTCATATTT GGATACACAG GTCGGCCGCC TCTTGAGTGC TTTGGACGAT 
CTTCAGCTGG CCAACAGCAC CATCATTGCA TTTACCTCGG ATCATGGGTG GGCTCTAGGT 
GAACATGGAG AATGGGCCAA ATACAGCAAT TTTGATGTTG CTACCCATGT TCCCCTGATA 
TTCTATGTTC CTGGAAGGAC GGCTTCACTT CCGGAGGCAG GCGAGAAGCT TTTCCCTTAC 
CTCGACCCTT TTGATTCCGC CTCACAGTTG ATGGAGCCAG GCAGGCAATC CATGGACCTT 
GTGGAACTTG TGTCTCTTTT TCCCACGCTG GCTGGACTTG CAGGACTGCA GGTTCCACCT 
CGCTGCCCCG TTCCTTCATT TCACGTTGAG CTGTGCAGAG AAGGCAAGAA CCTTCTGAAG 
CATTTTCGAT TCCGTGACTT GGAAGAGGAT CCGTACCTCC CTGGTAATCC CCGTGAACTG 
ATTGCCTATA GCCAGTATCC CCGGCCTTCA GACATCCCTC AGTGGAATTC TGACAAGCCG 
AGTTTAAAAG ATATAAAGAT CATGGGCTAT TCCATACGCA CCATAGACTA TAGGTATACT 
GTGTGGGTTG GCTTCAATCC TGATGAATTT CTAGCTAACT TTTCTGACAT CCATGCAGGG 
GAACTGTATT TTGTGGATTC TGACCCATTG CAGGATCACA ATATGTATAA TGATTCCCAA 
GGTGGAGATC TTTTCCAGTT GTTGATGCCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IDS ( NM_006123.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006114.1 Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 2, mRNA.

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CloneID	OHu16536
Clone ID Related Accession (Same CDS sequence)	NM_006123.4 , NM_006123.5
Accession Version	NM_006123.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	iduronate 2-sulfatase isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA325538.1, L40586.1 and BC006170.1. On Oct 28, 2009 this sequence version replaced NM_006123.3. Transcript Variant: This variant (2) contains an alternate 3' terminal exon compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.573465.1, SRR1803613.367323.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGCCAC CCCGGACCGG CCGAGGCCTT CTCTGGCTGG GTCTGGTTCT GAGCTCCGTC 
TGCGTCGCCC TCGGATCCGA AACGCAGGCC AACTCGACCA CAGATGCTCT GAACGTTCTT 
CTCATCATCG TGGATGACCT GCGCCCCTCC CTGGGCTGTT ATGGGGATAA GCTGGTGAGG 
TCCCCAAATA TTGACCAACT GGCATCCCAC AGCCTCCTCT TCCAGAATGC CTTTGCGCAG 
CAAGCAGTGT GCGCCCCGAG CCGCGTTTCT TTCCTCACTG GCAGGAGACC TGACACCACC 
CGCCTGTACG ACTTCAACTC CTACTGGAGG GTGCACGCTG GAAACTTCTC CACCATCCCC 
CAGTACTTCA AGGAGAATGG CTATGTGACC ATGTCGGTGG GAAAAGTCTT TCACCCTGGG 
ATATCTTCTA ACCATACCGA TGATTCTCCG TATAGCTGGT CTTTTCCACC TTATCATCCT 
TCCTCTGAGA AGTATGAAAA CACTAAGACA TGTCGAGGGC CAGATGGAGA ACTCCATGCC 
AACCTGCTTT GCCCTGTGGA TGTGCTGGAT GTTCCCGAGG GCACCTTGCC TGACAAACAG 
AGCACTGAGC AAGCCATACA GTTGTTGGAA AAGATGAAAA CGTCAGCCAG TCCTTTCTTC 
CTGGCCGTTG GGTATCATAA GCCACACATC CCCTTCAGAT ACCCCAAGGA ATTTCAGAAG 
TTGTATCCCT TGGAGAACAT CACCCTGGCC CCCGATCCCG AGGTCCCTGA TGGCCTACCC 
CCTGTGGCCT ACAACCCCTG GATGGACATC AGGCAACGGG AAGACGTCCA AGCCTTAAAC 
ATCAGTGTGC CGTATGGTCC AATTCCTGTG GACTTTCAGC GGAAAATCCG CCAGAGCTAC 
TTTGCCTCTG TGTCATATTT GGATACACAG GTCGGCCGCC TCTTGAGTGC TTTGGACGAT 
CTTCAGCTGG CCAACAGCAC CATCATTGCA TTTACCTCGG ATCATGGTTT CCTCATGAGG 
ACAAATACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006114.1
CDS	218..1249
Translation	MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGFLMRTNT

Target ORF information:

RefSeq Version	NM_006123.4
Organism	Homo sapiens(human)
Definition	Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006123.4

ORF Insert Sequence:

ATGCCGCCAC CCCGGACCGG CCGAGGCCTT CTCTGGCTGG GTCTGGTTCT GAGCTCCGTC 
TGCGTCGCCC TCGGATCCGA AACGCAGGCC AACTCGACCA CAGATGCTCT GAACGTTCTT 
CTCATCATCG TGGATGACCT GCGCCCCTCC CTGGGCTGTT ATGGGGATAA GCTGGTGAGG 
TCCCCAAATA TTGACCAACT GGCATCCCAC AGCCTCCTCT TCCAGAATGC CTTTGCGCAG 
CAAGCAGTGT GCGCCCCGAG CCGCGTTTCT TTCCTCACTG GCAGGAGACC TGACACCACC 
CGCCTGTACG ACTTCAACTC CTACTGGAGG GTGCACGCTG GAAACTTCTC CACCATCCCC 
CAGTACTTCA AGGAGAATGG CTATGTGACC ATGTCGGTGG GAAAAGTCTT TCACCCTGGG 
ATATCTTCTA ACCATACCGA TGATTCTCCG TATAGCTGGT CTTTTCCACC TTATCATCCT 
TCCTCTGAGA AGTATGAAAA CACTAAGACA TGTCGAGGGC CAGATGGAGA ACTCCATGCC 
AACCTGCTTT GCCCTGTGGA TGTGCTGGAT GTTCCCGAGG GCACCTTGCC TGACAAACAG 
AGCACTGAGC AAGCCATACA GTTGTTGGAA AAGATGAAAA CGTCAGCCAG TCCTTTCTTC 
CTGGCCGTTG GGTATCATAA GCCACACATC CCCTTCAGAT ACCCCAAGGA ATTTCAGAAG 
TTGTATCCCT TGGAGAACAT CACCCTGGCC CCCGATCCCG AGGTCCCTGA TGGCCTACCC 
CCTGTGGCCT ACAACCCCTG GATGGACATC AGGCAACGGG AAGACGTCCA AGCCTTAAAC 
ATCAGTGTGC CGTATGGTCC AATTCCTGTG GACTTTCAGC GGAAAATCCG CCAGAGCTAC 
TTTGCCTCTG TGTCATATTT GGATACACAG GTCGGCCGCC TCTTGAGTGC TTTGGACGAT 
CTTCAGCTGG CCAACAGCAC CATCATTGCA TTTACCTCGG ATCATGGTTT CCTCATGAGG 
ACAAATACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IDS ( NM_006123.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006114.1 Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16536
Clone ID Related Accession (Same CDS sequence)	NM_006123.4 , NM_006123.5
Accession Version	NM_006123.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	iduronate 2-sulfatase isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA325538.1, L40586.1 and BC006170.1. On May 31, 2019 this sequence version replaced NM_006123.4. Transcript Variant: This variant (2) contains an alternate 3' terminal exon compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.694213.1, SRR7410570.694217.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGCCAC CCCGGACCGG CCGAGGCCTT CTCTGGCTGG GTCTGGTTCT GAGCTCCGTC 
TGCGTCGCCC TCGGATCCGA AACGCAGGCC AACTCGACCA CAGATGCTCT GAACGTTCTT 
CTCATCATCG TGGATGACCT GCGCCCCTCC CTGGGCTGTT ATGGGGATAA GCTGGTGAGG 
TCCCCAAATA TTGACCAACT GGCATCCCAC AGCCTCCTCT TCCAGAATGC CTTTGCGCAG 
CAAGCAGTGT GCGCCCCGAG CCGCGTTTCT TTCCTCACTG GCAGGAGACC TGACACCACC 
CGCCTGTACG ACTTCAACTC CTACTGGAGG GTGCACGCTG GAAACTTCTC CACCATCCCC 
CAGTACTTCA AGGAGAATGG CTATGTGACC ATGTCGGTGG GAAAAGTCTT TCACCCTGGG 
ATATCTTCTA ACCATACCGA TGATTCTCCG TATAGCTGGT CTTTTCCACC TTATCATCCT 
TCCTCTGAGA AGTATGAAAA CACTAAGACA TGTCGAGGGC CAGATGGAGA ACTCCATGCC 
AACCTGCTTT GCCCTGTGGA TGTGCTGGAT GTTCCCGAGG GCACCTTGCC TGACAAACAG 
AGCACTGAGC AAGCCATACA GTTGTTGGAA AAGATGAAAA CGTCAGCCAG TCCTTTCTTC 
CTGGCCGTTG GGTATCATAA GCCACACATC CCCTTCAGAT ACCCCAAGGA ATTTCAGAAG 
TTGTATCCCT TGGAGAACAT CACCCTGGCC CCCGATCCCG AGGTCCCTGA TGGCCTACCC 
CCTGTGGCCT ACAACCCCTG GATGGACATC AGGCAACGGG AAGACGTCCA AGCCTTAAAC 
ATCAGTGTGC CGTATGGTCC AATTCCTGTG GACTTTCAGC GGAAAATCCG CCAGAGCTAC 
TTTGCCTCTG TGTCATATTT GGATACACAG GTCGGCCGCC TCTTGAGTGC TTTGGACGAT 
CTTCAGCTGG CCAACAGCAC CATCATTGCA TTTACCTCGG ATCATGGTTT CCTCATGAGG 
ACAAATACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006114.1
CDS	170..1201
Translation	MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGFLMRTNT

Target ORF information:

RefSeq Version	NM_006123.5
Organism	Homo sapiens(human)
Definition	Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006123.5

ORF Insert Sequence:

ATGCCGCCAC CCCGGACCGG CCGAGGCCTT CTCTGGCTGG GTCTGGTTCT GAGCTCCGTC 
TGCGTCGCCC TCGGATCCGA AACGCAGGCC AACTCGACCA CAGATGCTCT GAACGTTCTT 
CTCATCATCG TGGATGACCT GCGCCCCTCC CTGGGCTGTT ATGGGGATAA GCTGGTGAGG 
TCCCCAAATA TTGACCAACT GGCATCCCAC AGCCTCCTCT TCCAGAATGC CTTTGCGCAG 
CAAGCAGTGT GCGCCCCGAG CCGCGTTTCT TTCCTCACTG GCAGGAGACC TGACACCACC 
CGCCTGTACG ACTTCAACTC CTACTGGAGG GTGCACGCTG GAAACTTCTC CACCATCCCC 
CAGTACTTCA AGGAGAATGG CTATGTGACC ATGTCGGTGG GAAAAGTCTT TCACCCTGGG 
ATATCTTCTA ACCATACCGA TGATTCTCCG TATAGCTGGT CTTTTCCACC TTATCATCCT 
TCCTCTGAGA AGTATGAAAA CACTAAGACA TGTCGAGGGC CAGATGGAGA ACTCCATGCC 
AACCTGCTTT GCCCTGTGGA TGTGCTGGAT GTTCCCGAGG GCACCTTGCC TGACAAACAG 
AGCACTGAGC AAGCCATACA GTTGTTGGAA AAGATGAAAA CGTCAGCCAG TCCTTTCTTC 
CTGGCCGTTG GGTATCATAA GCCACACATC CCCTTCAGAT ACCCCAAGGA ATTTCAGAAG 
TTGTATCCCT TGGAGAACAT CACCCTGGCC CCCGATCCCG AGGTCCCTGA TGGCCTACCC 
CCTGTGGCCT ACAACCCCTG GATGGACATC AGGCAACGGG AAGACGTCCA AGCCTTAAAC 
ATCAGTGTGC CGTATGGTCC AATTCCTGTG GACTTTCAGC GGAAAATCCG CCAGAGCTAC 
TTTGCCTCTG TGTCATATTT GGATACACAG GTCGGCCGCC TCTTGAGTGC TTTGGACGAT 
CTTCAGCTGG CCAACAGCAC CATCATTGCA TTTACCTCGG ATCATGGTTT CCTCATGAGG 
ACAAATACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IDS ( NM_001166550.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001160022.1 Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu16723
Clone ID Related Accession (Same CDS sequence)	NM_001166550.3 , NM_001166550.4
Accession Version	NM_001166550.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1383bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	iduronate 2-sulfatase isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA325538.1, AK294541.1, M58342.1, BY996633.1, AK055600.1, DA351886.1, CN303532.1, AK057191.1, AC233288.1, CK004173.1 and R46390.1. On Jan 14, 2016 this sequence version replaced NM_001166550.2. Transcript Variant: This variant (3) uses an alternate acceptor splice site in the 5' coding region, which results in translation initiation from a downstream initiation codon compared to variant 1. The encoded isoform (c) has a shorter and distinct N-terminus, and lacks a predicted signal peptide compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.171406.1, SRR1660803.152132.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTTTGC GCAGGAGACC TGACACCACC CGCCTGTACG ACTTCAACTC CTACTGGAGG 
GTGCACGCTG GAAACTTCTC CACCATCCCC CAGTACTTCA AGGAGAATGG CTATGTGACC 
ATGTCGGTGG GAAAAGTCTT TCACCCTGGG ATATCTTCTA ACCATACCGA TGATTCTCCG 
TATAGCTGGT CTTTTCCACC TTATCATCCT TCCTCTGAGA AGTATGAAAA CACTAAGACA 
TGTCGAGGGC CAGATGGAGA ACTCCATGCC AACCTGCTTT GCCCTGTGGA TGTGCTGGAT 
GTTCCCGAGG GCACCTTGCC TGACAAACAG AGCACTGAGC AAGCCATACA GTTGTTGGAA 
AAGATGAAAA CGTCAGCCAG TCCTTTCTTC CTGGCCGTTG GGTATCATAA GCCACACATC 
CCCTTCAGAT ACCCCAAGGA ATTTCAGAAG TTGTATCCCT TGGAGAACAT CACCCTGGCC 
CCCGATCCCG AGGTCCCTGA TGGCCTACCC CCTGTGGCCT ACAACCCCTG GATGGACATC 
AGGCAACGGG AAGACGTCCA AGCCTTAAAC ATCAGTGTGC CGTATGGTCC AATTCCTGTG 
GACTTTCAGC GGAAAATCCG CCAGAGCTAC TTTGCCTCTG TGTCATATTT GGATACACAG 
GTCGGCCGCC TCTTGAGTGC TTTGGACGAT CTTCAGCTGG CCAACAGCAC CATCATTGCA 
TTTACCTCGG ATCATGGGTG GGCTCTAGGT GAACATGGAG AATGGGCCAA ATACAGCAAT 
TTTGATGTTG CTACCCATGT TCCCCTGATA TTCTATGTTC CTGGAAGGAC GGCTTCACTT 
CCGGAGGCAG GCGAGAAGCT TTTCCCTTAC CTCGACCCTT TTGATTCCGC CTCACAGTTG 
ATGGAGCCAG GCAGGCAATC CATGGACCTT GTGGAACTTG TGTCTCTTTT TCCCACGCTG 
GCTGGACTTG CAGGACTGCA GGTTCCACCT CGCTGCCCCG TTCCTTCATT TCACGTTGAG 
CTGTGCAGAG AAGGCAAGAA CCTTCTGAAG CATTTTCGAT TCCGTGACTT GGAAGAGGAT 
CCGTACCTCC CTGGTAATCC CCGTGAACTG ATTGCCTATA GCCAGTATCC CCGGCCTTCA 
GACATCCCTC AGTGGAATTC TGACAAGCCG AGTTTAAAAG ATATAAAGAT CATGGGCTAT 
TCCATACGCA CCATAGACTA TAGGTATACT GTGTGGGTTG GCTTCAATCC TGATGAATTT 
CTAGCTAACT TTTCTGACAT CCATGCAGGG GAACTGTATT TTGTGGATTC TGACCCATTG 
CAGGATCACA ATATGTATAA TGATTCCCAA GGTGGAGATC TTTTCCAGTT GTTGATGCCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001160022.1
CDS	444..1826
Translation	MPLRRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP

Target ORF information:

RefSeq Version	NM_001166550.3
Organism	Homo sapiens(human)
Definition	Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001166550.3

ORF Insert Sequence:

ATGCCTTTGC GCAGGAGACC TGACACCACC CGCCTGTACG ACTTCAACTC CTACTGGAGG 
GTGCACGCTG GAAACTTCTC CACCATCCCC CAGTACTTCA AGGAGAATGG CTATGTGACC 
ATGTCGGTGG GAAAAGTCTT TCACCCTGGG ATATCTTCTA ACCATACCGA TGATTCTCCG 
TATAGCTGGT CTTTTCCACC TTATCATCCT TCCTCTGAGA AGTATGAAAA CACTAAGACA 
TGTCGAGGGC CAGATGGAGA ACTCCATGCC AACCTGCTTT GCCCTGTGGA TGTGCTGGAT 
GTTCCCGAGG GCACCTTGCC TGACAAACAG AGCACTGAGC AAGCCATACA GTTGTTGGAA 
AAGATGAAAA CGTCAGCCAG TCCTTTCTTC CTGGCCGTTG GGTATCATAA GCCACACATC 
CCCTTCAGAT ACCCCAAGGA ATTTCAGAAG TTGTATCCCT TGGAGAACAT CACCCTGGCC 
CCCGATCCCG AGGTCCCTGA TGGCCTACCC CCTGTGGCCT ACAACCCCTG GATGGACATC 
AGGCAACGGG AAGACGTCCA AGCCTTAAAC ATCAGTGTGC CGTATGGTCC AATTCCTGTG 
GACTTTCAGC GGAAAATCCG CCAGAGCTAC TTTGCCTCTG TGTCATATTT GGATACACAG 
GTCGGCCGCC TCTTGAGTGC TTTGGACGAT CTTCAGCTGG CCAACAGCAC CATCATTGCA 
TTTACCTCGG ATCATGGGTG GGCTCTAGGT GAACATGGAG AATGGGCCAA ATACAGCAAT 
TTTGATGTTG CTACCCATGT TCCCCTGATA TTCTATGTTC CTGGAAGGAC GGCTTCACTT 
CCGGAGGCAG GCGAGAAGCT TTTCCCTTAC CTCGACCCTT TTGATTCCGC CTCACAGTTG 
ATGGAGCCAG GCAGGCAATC CATGGACCTT GTGGAACTTG TGTCTCTTTT TCCCACGCTG 
GCTGGACTTG CAGGACTGCA GGTTCCACCT CGCTGCCCCG TTCCTTCATT TCACGTTGAG 
CTGTGCAGAG AAGGCAAGAA CCTTCTGAAG CATTTTCGAT TCCGTGACTT GGAAGAGGAT 
CCGTACCTCC CTGGTAATCC CCGTGAACTG ATTGCCTATA GCCAGTATCC CCGGCCTTCA 
GACATCCCTC AGTGGAATTC TGACAAGCCG AGTTTAAAAG ATATAAAGAT CATGGGCTAT 
TCCATACGCA CCATAGACTA TAGGTATACT GTGTGGGTTG GCTTCAATCC TGATGAATTT 
CTAGCTAACT TTTCTGACAT CCATGCAGGG GAACTGTATT TTGTGGATTC TGACCCATTG 
CAGGATCACA ATATGTATAA TGATTCCCAA GGTGGAGATC TTTTCCAGTT GTTGATGCCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IDS ( NM_001166550.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001160022.1 Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 3, mRNA.

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CloneID	OHu16723
Clone ID Related Accession (Same CDS sequence)	NM_001166550.3 , NM_001166550.4
Accession Version	NM_001166550.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1383bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	iduronate 2-sulfatase isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK294541.1, M58342.1, BY996633.1, AK055600.1, DA351886.1, CN303532.1, AK057191.1, AC233288.1, CK004173.1 and R46390.1. On May 31, 2019 this sequence version replaced NM_001166550.3. Transcript Variant: This variant (3) uses an alternate acceptor splice site in the 5' coding region, which results in translation initiation from a downstream initiation codon compared to variant 1. The encoded isoform (c) has a shorter and distinct N-terminus, and lacks a predicted signal peptide compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.77821.1, SRR1660807.171406.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTTTGC GCAGGAGACC TGACACCACC CGCCTGTACG ACTTCAACTC CTACTGGAGG 
GTGCACGCTG GAAACTTCTC CACCATCCCC CAGTACTTCA AGGAGAATGG CTATGTGACC 
ATGTCGGTGG GAAAAGTCTT TCACCCTGGG ATATCTTCTA ACCATACCGA TGATTCTCCG 
TATAGCTGGT CTTTTCCACC TTATCATCCT TCCTCTGAGA AGTATGAAAA CACTAAGACA 
TGTCGAGGGC CAGATGGAGA ACTCCATGCC AACCTGCTTT GCCCTGTGGA TGTGCTGGAT 
GTTCCCGAGG GCACCTTGCC TGACAAACAG AGCACTGAGC AAGCCATACA GTTGTTGGAA 
AAGATGAAAA CGTCAGCCAG TCCTTTCTTC CTGGCCGTTG GGTATCATAA GCCACACATC 
CCCTTCAGAT ACCCCAAGGA ATTTCAGAAG TTGTATCCCT TGGAGAACAT CACCCTGGCC 
CCCGATCCCG AGGTCCCTGA TGGCCTACCC CCTGTGGCCT ACAACCCCTG GATGGACATC 
AGGCAACGGG AAGACGTCCA AGCCTTAAAC ATCAGTGTGC CGTATGGTCC AATTCCTGTG 
GACTTTCAGC GGAAAATCCG CCAGAGCTAC TTTGCCTCTG TGTCATATTT GGATACACAG 
GTCGGCCGCC TCTTGAGTGC TTTGGACGAT CTTCAGCTGG CCAACAGCAC CATCATTGCA 
TTTACCTCGG ATCATGGGTG GGCTCTAGGT GAACATGGAG AATGGGCCAA ATACAGCAAT 
TTTGATGTTG CTACCCATGT TCCCCTGATA TTCTATGTTC CTGGAAGGAC GGCTTCACTT 
CCGGAGGCAG GCGAGAAGCT TTTCCCTTAC CTCGACCCTT TTGATTCCGC CTCACAGTTG 
ATGGAGCCAG GCAGGCAATC CATGGACCTT GTGGAACTTG TGTCTCTTTT TCCCACGCTG 
GCTGGACTTG CAGGACTGCA GGTTCCACCT CGCTGCCCCG TTCCTTCATT TCACGTTGAG 
CTGTGCAGAG AAGGCAAGAA CCTTCTGAAG CATTTTCGAT TCCGTGACTT GGAAGAGGAT 
CCGTACCTCC CTGGTAATCC CCGTGAACTG ATTGCCTATA GCCAGTATCC CCGGCCTTCA 
GACATCCCTC AGTGGAATTC TGACAAGCCG AGTTTAAAAG ATATAAAGAT CATGGGCTAT 
TCCATACGCA CCATAGACTA TAGGTATACT GTGTGGGTTG GCTTCAATCC TGATGAATTT 
CTAGCTAACT TTTCTGACAT CCATGCAGGG GAACTGTATT TTGTGGATTC TGACCCATTG 
CAGGATCACA ATATGTATAA TGATTCCCAA GGTGGAGATC TTTTCCAGTT GTTGATGCCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001160022.1
CDS	396..1778
Translation	MPLRRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP

Target ORF information:

RefSeq Version	NM_001166550.4
Organism	Homo sapiens(human)
Definition	Homo sapiens iduronate 2-sulfatase (IDS), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001166550.4

ORF Insert Sequence:

ATGCCTTTGC GCAGGAGACC TGACACCACC CGCCTGTACG ACTTCAACTC CTACTGGAGG 
GTGCACGCTG GAAACTTCTC CACCATCCCC CAGTACTTCA AGGAGAATGG CTATGTGACC 
ATGTCGGTGG GAAAAGTCTT TCACCCTGGG ATATCTTCTA ACCATACCGA TGATTCTCCG 
TATAGCTGGT CTTTTCCACC TTATCATCCT TCCTCTGAGA AGTATGAAAA CACTAAGACA 
TGTCGAGGGC CAGATGGAGA ACTCCATGCC AACCTGCTTT GCCCTGTGGA TGTGCTGGAT 
GTTCCCGAGG GCACCTTGCC TGACAAACAG AGCACTGAGC AAGCCATACA GTTGTTGGAA 
AAGATGAAAA CGTCAGCCAG TCCTTTCTTC CTGGCCGTTG GGTATCATAA GCCACACATC 
CCCTTCAGAT ACCCCAAGGA ATTTCAGAAG TTGTATCCCT TGGAGAACAT CACCCTGGCC 
CCCGATCCCG AGGTCCCTGA TGGCCTACCC CCTGTGGCCT ACAACCCCTG GATGGACATC 
AGGCAACGGG AAGACGTCCA AGCCTTAAAC ATCAGTGTGC CGTATGGTCC AATTCCTGTG 
GACTTTCAGC GGAAAATCCG CCAGAGCTAC TTTGCCTCTG TGTCATATTT GGATACACAG 
GTCGGCCGCC TCTTGAGTGC TTTGGACGAT CTTCAGCTGG CCAACAGCAC CATCATTGCA 
TTTACCTCGG ATCATGGGTG GGCTCTAGGT GAACATGGAG AATGGGCCAA ATACAGCAAT 
TTTGATGTTG CTACCCATGT TCCCCTGATA TTCTATGTTC CTGGAAGGAC GGCTTCACTT 
CCGGAGGCAG GCGAGAAGCT TTTCCCTTAC CTCGACCCTT TTGATTCCGC CTCACAGTTG 
ATGGAGCCAG GCAGGCAATC CATGGACCTT GTGGAACTTG TGTCTCTTTT TCCCACGCTG 
GCTGGACTTG CAGGACTGCA GGTTCCACCT CGCTGCCCCG TTCCTTCATT TCACGTTGAG 
CTGTGCAGAG AAGGCAAGAA CCTTCTGAAG CATTTTCGAT TCCGTGACTT GGAAGAGGAT 
CCGTACCTCC CTGGTAATCC CCGTGAACTG ATTGCCTATA GCCAGTATCC CCGGCCTTCA 
GACATCCCTC AGTGGAATTC TGACAAGCCG AGTTTAAAAG ATATAAAGAT CATGGGCTAT 
TCCATACGCA CCATAGACTA TAGGTATACT GTGTGGGTTG GCTTCAATCC TGATGAATTT 
CTAGCTAACT TTTCTGACAT CCATGCAGGG GAACTGTATT TTGTGGATTC TGACCCATTG 
CAGGATCACA ATATGTATAA TGATTCCCAA GGTGGAGATC TTTTCCAGTT GTTGATGCCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genotype-phenotype relationship in mucopolysaccharidosis II: predictive power of IDS variants for the neuronopathic phenotype.
Developmental medicine and child neurology59(10)1063-1070(2017 10)
Vollebregt AAM,Hoogeveen-Westerveld M,Kroos MA,Oussoren E,Plug I,Ruijter GJ,van der Ploeg AT,Pijnappel WWMP

Insights into Hunter syndrome from the structure of iduronate-2-sulfatase.
Nature communications815786(2017 Jun)
Demydchuk M,Hill CH,Zhou A,Bunk?czi G,Stein PE,Marchesan D,Deane JE,Read RJ

[Analysis of IDS gene mutation in a family affected with mucopolysaccharidosis type?].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics34(1)58-60(2017 Feb)
Li Y,Mei S,Kong X,Zhao Z,Zhu X,Yang X,Qin Z,Wu H

Molecular diagnosis of 65 families with mucopolysaccharidosis type II (Hunter syndrome) characterized by 16 novel mutations in the IDS gene: Genetic, pathological, and structural studies on iduronate-2-sulfatase.
Molecular genetics and metabolism118(3)190-7(2016 07)
Kosuga M,Mashima R,Hirakiyama A,Fuji N,Kumagai T,Seo JH,Nikaido M,Saito S,Ohno K,Sakuraba H,Okuyama T

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IDS cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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