Gene Symbol | STING1 |
Entrez Gene ID | 340061 |
Full Name | transmembrane protein 173 |
Synonyms | ERIS,MITA,MPYS,NET23,SAVI,STING,hMITA,hSTING |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. |
Disorder MIM: | |
Disorder Html: | STING-associated vasculopathy, infantile-onset, 615934 (3) |