HTR4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HTR4
Entrez Gene ID	3360
Full Name	5-hydroxytryptamine receptor 4
Synonyms	5-HT4,5-HT4R
General protein information	Preferred Names 5-hydroxytryptamine receptor 4 Names 5-hydroxytryptamine receptor 4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5-hydroxytryptamine receptor 4 transcript variant b2 5-hydroxytryptamine receptor 4 transcript variant b3 cardiac 5-HT4 receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q32
Summary	This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010].
Disorder MIM:	602164

mRNA and Protein(s)

mRNA	Protein	Name
NM_001286410.1	NP_001273339.1	5-hydroxytryptamine receptor 4 isoform c
NM_001040172.2	NP_001035262.2	5-hydroxytryptamine receptor 4 isoform d
NM_001040173.2	NP_001035263.1	5-hydroxytryptamine receptor 4 isoform i
NM_199453.3	NP_955525.1	5-hydroxytryptamine receptor 4 isoform g
NM_000870.6	NP_000861.1	5-hydroxytryptamine receptor 4 isoform b
NM_001040169.2	NP_001035259.1	5-hydroxytryptamine receptor 4 isoform a
NM_000870.7	NP_000861.1	5-hydroxytryptamine receptor 4 isoform b

Pathways from BioSystems

Homologies

Homo sapiens (human)	HTR4	NP_001035263.1
Bos taurus (cattle)	HTR4	NP_001035575.1
Pan troglodytes (chimpanzee)	HTR4	XP_001162258.1
Gallus gallus (chicken)	HTR4	XP_414481.4
Drosophila melanogaster (fruit fly)	oa2	NP_001262843.1
	HTR4	XP_001105153.2
Canis lupus familiaris (dog)	HTR4	XP_005619377.1
Rattus norvegicus (Norway rat)	Htr4	NP_036985.1
Danio rerio (zebrafish)	LOC556843	XP_684857.5
Xenopus tropicalis (tropical clawed frog)	LOC100493952	XP_002939852.1
Mus musculus (house mouse)	Htr4	NP_032339.2

Gene Ontology
Bibliography

Related articles in PubMed

miR-16 and miR-103 impact 5-HT
Wohlfarth C, Schmitteckert S, H?rtle JD, Houghton LA, Dweep H, Fortea M, Assadi G, Braun A, Mederer T, P?hner S, Becker PP, Fischer C, Granzow M, M?nnikes H, Mayer EA, Sayuk G, Boeckxstaens G, Wouters MM, Simr?n M, Lindberg G, Ohlsson B, Schmidt PT, Dlugosz A, Agreus L, Andreasson A, D'Amato M, Burwinkel B, Bermejo JL, R?th R, Lasitschka F, Vicario M, Metzger M, Santos J, Rappold GA, Martinez C, Niesler B
Scientific reports7(1)14680(2017 Oct)

Functional studies of the 5'-untranslated region of human 5-HT4 receptor mRNA.
Maillet M, Gastineau M, Bochet P, Asselin-Labat ML, Morel E, Laverri?re JN, Lompr? AM, Fischmeister R, Lezoualc'h F
The Biochemical journal387(Pt 2)463-71(2005 Apr)

Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i).
Brattelid T, Kvingedal AM, Krobert KA, Andressen KW, Bach T, Hystad ME, Kaumann AJ, Levy FO
Naunyn-Schmiedeberg's archives of pharmacology369(6)616-28(2004 Jun)

Identification and characterization of the human serotonin-4 receptor gene promoter.
Hiroi T, Hayashi-Kobayashi N, Nagumo S, Ino M, Okawa Y, Aoba A, Matsui H
Biochemical and biophysical research communications289(2)337-44(2001 Nov)

Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.
Bender E, Pindon A, van Oers I, Zhang YB, Gommeren W, Verhasselt P, Jurzak M, Leysen J, Luyten W
Journal of neurochemistry74(2)478-89(2000 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings replicate our previous observation of a negative association between 5-HT 4R binding and memory performance in an independent cohort and provide novel evidence linking 5-HT 4R binding, as a biomarker for synaptic 5-HT levels, to the mnestic processing of positive and neutral word stimuli in healthy humans
Title: Brain serotonin 4 receptor binding is inversely associated with?verbal memory recall.

l-Lysine significantly reduced the surge of plasma aldosterone induced by metoclopramide indicating that l-Lysine is able to efficiently antagonize the adrenal 5-HT4 receptors in vivo.
Title: l-Lysine Acts as a Serotonin Type 4 Receptor Antagonist to Counteract In Vitro and In Vivo the Stimulatory Effect of Serotonergic Agents on Aldosterone Secretion in Man.

Results of this study indicated that HTR4 signaling upregulated ERbeta expression in hormone-naive prostate cancer and could impact on biological processes in hormone-naive prostate cancer.
Title: Serotonin receptor 4 (5-hydroxytryptamine receptor Type 4) regulates expression of estrogen receptor beta and cell migration in hormone-naive prostate cancer.

Acute administration of 5-hydroxytryptamine4 (5-HT4) receptor agonist, mosapride or esophageal infusion of the transient receptor potential vanilloid receptor-1 (TRPV1) agonist capsaicin promotes secondary peristalsis.Esophageal infusion with capsaicin-containing red pepper sauce suspension does create greater mechanosensitivity as measured by secondary peristalsis than 5-HT4 receptor agonist mosapride
Title: Differences in the Control of Secondary Peristalsis in the Human Esophagus: Influence of the 5-HT4 Receptor versus the TRPV1 Receptor.

This study demonistrated that 5-hydroxytryptamine (serotonin) receptor 4 regulate memory.
Title: Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.

The following HTR4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HTR4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11297	NM_001286410.1 Latest version!	Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant c, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu11361	NM_199453.3 Latest version!	Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant g, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu11550	NM_001040169.2 Latest version!	Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu11830	NM_001040173.2 Latest version!	Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant i, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$251.30 $359.00
OHu12288	NM_001040172.2 Latest version!	Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant d, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$202.30 $289.00
OHu20434	NM_000870.7 Latest version!	Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu20434	NM_000870.6	Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HTR4 ( NM_001286410.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001273339.1 Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant c, mRNA.

Price & Availability↑

CloneID	OHu11297
Clone ID Related Accession (Same CDS sequence)	NM_001286410.1
Accession Version	NM_001286410.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 4 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008627.7, Y12506.1 and AM712912.1. Transcript Variant: This variant (c) has a shorter 5' UTR and uses an alternate exon in the 3' UTR and coding region. The encoded isoform (c) is shorter and has a distinct C-terminus compared to isoform b. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y12506.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2152474, SAMEA2152798 [ECO:0000348] ##Evidence-Data-END##

ATGGACAAAC TTGATGCTAA TGTGAGTTCT GAGGAGGGTT TCGGGTCAGT GGAGAAGGTG 
GTGCTGCTCA CGTTTCTCTC GACGGTTATC CTGATGGCCA TCTTGGGGAA CCTGCTGGTG 
ATGGTGGCTG TGTGCTGGGA CAGGCAGCTC AGGAAAATAA AAACAAATTA TTTCATTGTA 
TCTCTTGCTT TTGCGGATCT GCTGGTTTCG GTGCTGGTGA TGCCCTTTGG TGCCATTGAG 
CTGGTTCAAG ACATCTGGAT TTATGGGGAG GTGTTTTGTC TTGTTCGGAC ATCTCTGGAC 
GTCCTGCTCA CAACGGCATC GATTTTTCAC CTGTGCTGCA TTTCTCTGGA TAGGTATTAC 
GCCATCTGCT GCCAGCCTTT GGTCTATAGG AACAAGATGA CCCCTCTGCG CATCGCATTA 
ATGCTGGGAG GCTGCTGGGT CATCCCCACG TTTATTTCTT TTCTCCCTAT AATGCAAGGC 
TGGAATAACA TTGGCATAAT TGATTTGATA GAAAAGAGGA AGTTCAACCA GAACTCTAAC 
TCTACGTACT GTGTCTTCAT GGTCAACAAG CCCTACGCCA TCACCTGCTC TGTGGTGGCC 
TTCTACATCC CATTTCTCCT CATGGTGCTG GCCTATTACC GCATCTATGT CACAGCTAAG 
GAGCATGCCC ATCAGATCCA GATGTTACAA CGGGCAGGAG CCTCCTCCGA GAGCAGGCCT 
CAGTCGGCAG ACCAGCATAG CACTCATCGC ATGAGGACAG AGACCAAAGC AGCCAAGACC 
CTGTGCATCA TCATGGGTTG CTTCTGCCTC TGCTGGGCAC CATTCTTTGT CACCAATATT 
GTGGATCCTT TCATAGACTA CACTGTCCCT GGGCAGGTGT GGACTGCTTT CCTCTGGCTC 
GGCTATATCA ATTCCGGGTT GAACCCTTTT CTCTACGCCT TCTTGAATAA GTCTTTTAGA 
CGTGCCTTCC TCATCATCCT CTGCTGTGAT GATGAGCGCT ACCGAAGACC TTCCATTCTG 
GGCCAGACTG TCCCTTGTTC AACCACAACC ATTAATGGAT CCACACATGT ACTAAGTTCT 
GGAACTGAAA CCGACAGGAA GAAACTTTGG AATAAGGAAG AGAAGATTGA CCAAACCATC 
CAAATGCCAA AAAGAAAAAG AAAAAAAAAA GCCTCTCTGT CCTATGAAGA CTTAATTCTG 
TTGGGGAGAA AGTCATGTTT TAGGGAAGGA AAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001273339.1
CDS	48..1283
Translation	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLSSGTETDRKKLWNKEEKIDQTIQMPKRKRKKKASLSYEDLILLGRKSCFREGK

Target ORF information:

RefSeq Version	NM_001286410.1
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant c, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286410.1

ORF Insert Sequence:

ATGGACAAAC TTGATGCTAA TGTGAGTTCT GAGGAGGGTT TCGGGTCAGT GGAGAAGGTG 
GTGCTGCTCA CGTTTCTCTC GACGGTTATC CTGATGGCCA TCTTGGGGAA CCTGCTGGTG 
ATGGTGGCTG TGTGCTGGGA CAGGCAGCTC AGGAAAATAA AAACAAATTA TTTCATTGTA 
TCTCTTGCTT TTGCGGATCT GCTGGTTTCG GTGCTGGTGA TGCCCTTTGG TGCCATTGAG 
CTGGTTCAAG ACATCTGGAT TTATGGGGAG GTGTTTTGTC TTGTTCGGAC ATCTCTGGAC 
GTCCTGCTCA CAACGGCATC GATTTTTCAC CTGTGCTGCA TTTCTCTGGA TAGGTATTAC 
GCCATCTGCT GCCAGCCTTT GGTCTATAGG AACAAGATGA CCCCTCTGCG CATCGCATTA 
ATGCTGGGAG GCTGCTGGGT CATCCCCACG TTTATTTCTT TTCTCCCTAT AATGCAAGGC 
TGGAATAACA TTGGCATAAT TGATTTGATA GAAAAGAGGA AGTTCAACCA GAACTCTAAC 
TCTACGTACT GTGTCTTCAT GGTCAACAAG CCCTACGCCA TCACCTGCTC TGTGGTGGCC 
TTCTACATCC CATTTCTCCT CATGGTGCTG GCCTATTACC GCATCTATGT CACAGCTAAG 
GAGCATGCCC ATCAGATCCA GATGTTACAA CGGGCAGGAG CCTCCTCCGA GAGCAGGCCT 
CAGTCGGCAG ACCAGCATAG CACTCATCGC ATGAGGACAG AGACCAAAGC AGCCAAGACC 
CTGTGCATCA TCATGGGTTG CTTCTGCCTC TGCTGGGCAC CATTCTTTGT CACCAATATT 
GTGGATCCTT TCATAGACTA CACTGTCCCT GGGCAGGTGT GGACTGCTTT CCTCTGGCTC 
GGCTATATCA ATTCCGGGTT GAACCCTTTT CTCTACGCCT TCTTGAATAA GTCTTTTAGA 
CGTGCCTTCC TCATCATCCT CTGCTGTGAT GATGAGCGCT ACCGAAGACC TTCCATTCTG 
GGCCAGACTG TCCCTTGTTC AACCACAACC ATTAATGGAT CCACACATGT ACTAAGTTCT 
GGAACTGAAA CCGACAGGAA GAAACTTTGG AATAAGGAAG AGAAGATTGA CCAAACCATC 
CAAATGCCAA AAAGAAAAAG AAAAAAAAAA GCCTCTCTGT CCTATGAAGA CTTAATTCTG 
TTGGGGAGAA AGTCATGTTT TAGGGAAGGA AAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTR4 ( NM_199453.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_955525.1 Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant g, mRNA.

Price & Availability↑

CloneID	OHu11361
Clone ID Related Accession (Same CDS sequence)	NM_199453.3
Accession Version	NM_199453.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1137bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 4 isoform g
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ131724.1, AJ011371.1, AJ278981.1, Y08756.1 and AC114939.2. On May 29, 2010 this sequence version replaced NM_199453.2. Transcript Variant: This variant (g), also known as E or G1, differs in the 5' UTR, 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (isoform g) has a distinct C-terminus and is shorter than isoform b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ278981.1, AJ131725.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END##

ATGGACAAAC TTGATGCTAA TGTGAGTTCT GAGGAGGGTT TCGGGTCAGT GGAGAAGGTG 
GTGCTGCTCA CGTTTCTCTC GACGGTTATC CTGATGGCCA TCTTGGGGAA CCTGCTGGTG 
ATGGTGGCTG TGTGCTGGGA CAGGCAGCTC AGGAAAATAA AAACAAATTA TTTCATTGTA 
TCTCTTGCTT TTGCGGATCT GCTGGTTTCG GTGCTGGTGA TGCCCTTTGG TGCCATTGAG 
CTGGTTCAAG ACATCTGGAT TTATGGGGAG GTGTTTTGTC TTGTTCGGAC ATCTCTGGAC 
GTCCTGCTCA CAACGGCATC GATTTTTCAC CTGTGCTGCA TTTCTCTGGA TAGGTATTAC 
GCCATCTGCT GCCAGCCTTT GGTCTATAGG AACAAGATGA CCCCTCTGCG CATCGCATTA 
ATGCTGGGAG GCTGCTGGGT CATCCCCACG TTTATTTCTT TTCTCCCTAT AATGCAAGGC 
TGGAATAACA TTGGCATAAT TGATTTGATA GAAAAGAGGA AGTTCAACCA GAACTCTAAC 
TCTACGTACT GTGTCTTCAT GGTCAACAAG CCCTACGCCA TCACCTGCTC TGTGGTGGCC 
TTCTACATCC CATTTCTCCT CATGGTGCTG GCCTATTACC GCATCTATGT CACAGCTAAG 
GAGCATGCCC ATCAGATCCA GATGTTACAA CGGGCAGGAG CCTCCTCCGA GAGCAGGCCT 
CAGTCGGCAG ACCAGCATAG CACTCATCGC ATGAGGACAG AGACCAAAGC AGCCAAGACC 
CTGTGCATCA TCATGGGTTG CTTCTGCCTC TGCTGGGCAC CATTCTTTGT CACCAATATT 
GTGGATCCTT TCATAGACTA CACTGTCCCT GGGCAGGTGT GGACTGCTTT CCTCTGGCTC 
GGCTATATCA ATTCCGGGTT GAACCCTTTT CTCTACGCCT TCTTGAATAA GTCTTTTAGA 
CGTGCCTTCC TCATCATCCT CTGCTGTGAT GATGAGCGCT ACCGAAGACC TTCCATTCTG 
GGCCAGACTG TCCCTTGTTC AACCACAACC ATTAATGGAT CCACACATGT ACTAAGTGGC 
TGTTCCCCTG TCTCCAGCTT CCTCCTGCTC TTCTGCAATA GACCAGTTCC TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_955525.1
CDS	48..1184
Translation	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLSGCSPVSSFLLLFCNRPVPV

Target ORF information:

RefSeq Version	NM_199453.3
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant g, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199453.3

ORF Insert Sequence:

ATGGACAAAC TTGATGCTAA TGTGAGTTCT GAGGAGGGTT TCGGGTCAGT GGAGAAGGTG 
GTGCTGCTCA CGTTTCTCTC GACGGTTATC CTGATGGCCA TCTTGGGGAA CCTGCTGGTG 
ATGGTGGCTG TGTGCTGGGA CAGGCAGCTC AGGAAAATAA AAACAAATTA TTTCATTGTA 
TCTCTTGCTT TTGCGGATCT GCTGGTTTCG GTGCTGGTGA TGCCCTTTGG TGCCATTGAG 
CTGGTTCAAG ACATCTGGAT TTATGGGGAG GTGTTTTGTC TTGTTCGGAC ATCTCTGGAC 
GTCCTGCTCA CAACGGCATC GATTTTTCAC CTGTGCTGCA TTTCTCTGGA TAGGTATTAC 
GCCATCTGCT GCCAGCCTTT GGTCTATAGG AACAAGATGA CCCCTCTGCG CATCGCATTA 
ATGCTGGGAG GCTGCTGGGT CATCCCCACG TTTATTTCTT TTCTCCCTAT AATGCAAGGC 
TGGAATAACA TTGGCATAAT TGATTTGATA GAAAAGAGGA AGTTCAACCA GAACTCTAAC 
TCTACGTACT GTGTCTTCAT GGTCAACAAG CCCTACGCCA TCACCTGCTC TGTGGTGGCC 
TTCTACATCC CATTTCTCCT CATGGTGCTG GCCTATTACC GCATCTATGT CACAGCTAAG 
GAGCATGCCC ATCAGATCCA GATGTTACAA CGGGCAGGAG CCTCCTCCGA GAGCAGGCCT 
CAGTCGGCAG ACCAGCATAG CACTCATCGC ATGAGGACAG AGACCAAAGC AGCCAAGACC 
CTGTGCATCA TCATGGGTTG CTTCTGCCTC TGCTGGGCAC CATTCTTTGT CACCAATATT 
GTGGATCCTT TCATAGACTA CACTGTCCCT GGGCAGGTGT GGACTGCTTT CCTCTGGCTC 
GGCTATATCA ATTCCGGGTT GAACCCTTTT CTCTACGCCT TCTTGAATAA GTCTTTTAGA 
CGTGCCTTCC TCATCATCCT CTGCTGTGAT GATGAGCGCT ACCGAAGACC TTCCATTCTG 
GGCCAGACTG TCCCTTGTTC AACCACAACC ATTAATGGAT CCACACATGT ACTAAGTGGC 
TGTTCCCCTG TCTCCAGCTT CCTCCTGCTC TTCTGCAATA GACCAGTTCC TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTR4 ( NM_001040169.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035259.1 Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant a, mRNA.

Price & Availability↑

CloneID	OHu11550
Clone ID Related Accession (Same CDS sequence)	NM_001040169.2
Accession Version	NM_001040169.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1164bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 4 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ131724.1, AJ278979.1, Y08756.1 and AC114939.2. On May 29, 2010 this sequence version replaced NM_001040169.1. Transcript Variant: This variant (a) differs in the 5' UTR, 3' coding region and 3' UTR, compared to variant b. The resulting isoform (a) has a distinct C-terminus and is shorter than isoform b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y08756.1, AJ278979.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2152474, SAMEA2153733 [ECO:0000348] ##Evidence-Data-END##

ATGGACAAAC TTGATGCTAA TGTGAGTTCT GAGGAGGGTT TCGGGTCAGT GGAGAAGGTG 
GTGCTGCTCA CGTTTCTCTC GACGGTTATC CTGATGGCCA TCTTGGGGAA CCTGCTGGTG 
ATGGTGGCTG TGTGCTGGGA CAGGCAGCTC AGGAAAATAA AAACAAATTA TTTCATTGTA 
TCTCTTGCTT TTGCGGATCT GCTGGTTTCG GTGCTGGTGA TGCCCTTTGG TGCCATTGAG 
CTGGTTCAAG ACATCTGGAT TTATGGGGAG GTGTTTTGTC TTGTTCGGAC ATCTCTGGAC 
GTCCTGCTCA CAACGGCATC GATTTTTCAC CTGTGCTGCA TTTCTCTGGA TAGGTATTAC 
GCCATCTGCT GCCAGCCTTT GGTCTATAGG AACAAGATGA CCCCTCTGCG CATCGCATTA 
ATGCTGGGAG GCTGCTGGGT CATCCCCACG TTTATTTCTT TTCTCCCTAT AATGCAAGGC 
TGGAATAACA TTGGCATAAT TGATTTGATA GAAAAGAGGA AGTTCAACCA GAACTCTAAC 
TCTACGTACT GTGTCTTCAT GGTCAACAAG CCCTACGCCA TCACCTGCTC TGTGGTGGCC 
TTCTACATCC CATTTCTCCT CATGGTGCTG GCCTATTACC GCATCTATGT CACAGCTAAG 
GAGCATGCCC ATCAGATCCA GATGTTACAA CGGGCAGGAG CCTCCTCCGA GAGCAGGCCT 
CAGTCGGCAG ACCAGCATAG CACTCATCGC ATGAGGACAG AGACCAAAGC AGCCAAGACC 
CTGTGCATCA TCATGGGTTG CTTCTGCCTC TGCTGGGCAC CATTCTTTGT CACCAATATT 
GTGGATCCTT TCATAGACTA CACTGTCCCT GGGCAGGTGT GGACTGCTTT CCTCTGGCTC 
GGCTATATCA ATTCCGGGTT GAACCCTTTT CTCTACGCCT TCTTGAATAA GTCTTTTAGA 
CGTGCCTTCC TCATCATCCT CTGCTGTGAT GATGAGCGCT ACCGAAGACC TTCCATTCTG 
GGCCAGACTG TCCCTTGTTC AACCACAACC ATTAATGGAT CCACACATGT ACTAAGGTAC 
ACCGTTCTGC ACAGGGGACA TCATCAGGAA CTCGAGAAAC TGCCCATACA CAATGACCCA 
GAATCCCTGG AATCATGCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035259.1
CDS	48..1211
Translation	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRYTVLHRGHHQELEKLPIHNDPESLESCF

Target ORF information:

RefSeq Version	NM_001040169.2
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040169.2

ORF Insert Sequence:

ATGGACAAAC TTGATGCTAA TGTGAGTTCT GAGGAGGGTT TCGGGTCAGT GGAGAAGGTG 
GTGCTGCTCA CGTTTCTCTC GACGGTTATC CTGATGGCCA TCTTGGGGAA CCTGCTGGTG 
ATGGTGGCTG TGTGCTGGGA CAGGCAGCTC AGGAAAATAA AAACAAATTA TTTCATTGTA 
TCTCTTGCTT TTGCGGATCT GCTGGTTTCG GTGCTGGTGA TGCCCTTTGG TGCCATTGAG 
CTGGTTCAAG ACATCTGGAT TTATGGGGAG GTGTTTTGTC TTGTTCGGAC ATCTCTGGAC 
GTCCTGCTCA CAACGGCATC GATTTTTCAC CTGTGCTGCA TTTCTCTGGA TAGGTATTAC 
GCCATCTGCT GCCAGCCTTT GGTCTATAGG AACAAGATGA CCCCTCTGCG CATCGCATTA 
ATGCTGGGAG GCTGCTGGGT CATCCCCACG TTTATTTCTT TTCTCCCTAT AATGCAAGGC 
TGGAATAACA TTGGCATAAT TGATTTGATA GAAAAGAGGA AGTTCAACCA GAACTCTAAC 
TCTACGTACT GTGTCTTCAT GGTCAACAAG CCCTACGCCA TCACCTGCTC TGTGGTGGCC 
TTCTACATCC CATTTCTCCT CATGGTGCTG GCCTATTACC GCATCTATGT CACAGCTAAG 
GAGCATGCCC ATCAGATCCA GATGTTACAA CGGGCAGGAG CCTCCTCCGA GAGCAGGCCT 
CAGTCGGCAG ACCAGCATAG CACTCATCGC ATGAGGACAG AGACCAAAGC AGCCAAGACC 
CTGTGCATCA TCATGGGTTG CTTCTGCCTC TGCTGGGCAC CATTCTTTGT CACCAATATT 
GTGGATCCTT TCATAGACTA CACTGTCCCT GGGCAGGTGT GGACTGCTTT CCTCTGGCTC 
GGCTATATCA ATTCCGGGTT GAACCCTTTT CTCTACGCCT TCTTGAATAA GTCTTTTAGA 
CGTGCCTTCC TCATCATCCT CTGCTGTGAT GATGAGCGCT ACCGAAGACC TTCCATTCTG 
GGCCAGACTG TCCCTTGTTC AACCACAACC ATTAATGGAT CCACACATGT ACTAAGGTAC 
ACCGTTCTGC ACAGGGGACA TCATCAGGAA CTCGAGAAAC TGCCCATACA CAATGACCCA 
GAATCCCTGG AATCATGCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTR4 ( NM_001040173.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035263.1 Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant i, mRNA.

Price & Availability↑

CloneID	OHu11830
Clone ID Related Accession (Same CDS sequence)	NM_001040173.2
Accession Version	NM_001040173.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 4 isoform i
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ131724.1, AJ131726.1 and AC091971.4. On May 29, 2010 this sequence version replaced NM_001040173.1. Transcript Variant: This variant (i) differs in the 5' UTR and includes an alternate in-frame exon, compared to variant b. This results in a longer protein (isoform i), compared to isoform b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ131726.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA2142348 [ECO:0000350] ##Evidence-Data-END##

ATGGACAAAC TTGATGCTAA TGTGAGTTCT GAGGAGGGTT TCGGGTCAGT GGAGAAGGTG 
GTGCTGCTCA CGTTTCTCTC GACGGTTATC CTGATGGCCA TCTTGGGGAA CCTGCTGGTG 
ATGGTGGCTG TGTGCTGGGA CAGGCAGCTC AGGAAAATAA AAACAAATTA TTTCATTGTA 
TCTCTTGCTT TTGCGGATCT GCTGGTTTCG GTGCTGGTGA TGCCCTTTGG TGCCATTGAG 
CTGGTTCAAG ACATCTGGAT TTATGGGGAG GTGTTTTGTC TTGTTCGGAC ATCTCTGGAC 
GTCCTGCTCA CAACGGCATC GATTTTTCAC CTGTGCTGCA TTTCTCTGGA TAGGTATTAC 
GCCATCTGCT GCCAGCCTTT GGTCTATAGG AACAAGATGA CCCCTCTGCG CATCGCATTA 
ATGCTGGGAG GCTGCTGGGT CATCCCCACG TTTATTTCTT TTCTCCCTAT AATGCAAGGC 
TGGAATAACA TTGGCATAAT TGATTTGATA GAAAAGAGGA AGTTCAACCA GAACTCTAAC 
TCTACGTACT GTGTCTTCAT GGTCAACAAG CCCTACGCCA TCACCTGCTC TGTGGTGGCC 
TTCTACATCC CATTTCTCCT CATGGTGCTG GCCTATTACC GCATCTATGT CACAGCTAAG 
GAGCATGCCC ATCAGATCCA GATGTTACAA CGGGCAGGAG CCTCCTCCGA GAGCAGGCCT 
CAGTCGGCAG ACCAGCATAG CACTCATCGC ATGAGGACAG AGACCAAAGC AGCCAAGACC 
CTGTGCATCA TCATGGGTTG CTTCTGCCTC TGCTGGGCAC CATTCTTTGT CACCAATATT 
GTGGATCCTT TCATAGACTA CACTGTCCCT GGGCAGGTGT GGACTGCTTT CCTCTGGCTC 
GGCTATATCA ATTCCGGGTT GAACCCTTTT CTCTACGCCT TCTTGAATAA GTCTTTTAGA 
CGTGCCTTCC TCATCATCCT CTGCTGTGAT GATGAGCGCT ACCGAAGACC TTCCATTCTG 
GGCCAGACTG TCCCTTGTTC AACCACAACC ATTAATGGAT CCACACATGT ACTAAGGACA 
GATTTTCTGT TTGACAGAGA CATTTTAGCA AGGTATTGGA CAAAGCCTGC CAGAGCGGGT 
CCATTCTCAG GCACATTGAG CATTAGATGT TTGACTGCAA GGAAGCCTGT CTTGGGGGAT 
GCAGTGGAGT GTGGTGGCCA GTGGGAGAGT CAGTGTCACC CGCCAGCAAC TTCTCCTTTG 
GTGGCTGCTC AGCCCAGTGA CACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035263.1
CDS	48..1334
Translation	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRTDFLFDRDILARYWTKPARAGPFSGTLSIRCLTARKPVLGDAVECGGQWESQCHPPATSPLVAAQPSDT

Target ORF information:

RefSeq Version	NM_001040173.2
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant i, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040173.2

ORF Insert Sequence:

ATGGACAAAC TTGATGCTAA TGTGAGTTCT GAGGAGGGTT TCGGGTCAGT GGAGAAGGTG 
GTGCTGCTCA CGTTTCTCTC GACGGTTATC CTGATGGCCA TCTTGGGGAA CCTGCTGGTG 
ATGGTGGCTG TGTGCTGGGA CAGGCAGCTC AGGAAAATAA AAACAAATTA TTTCATTGTA 
TCTCTTGCTT TTGCGGATCT GCTGGTTTCG GTGCTGGTGA TGCCCTTTGG TGCCATTGAG 
CTGGTTCAAG ACATCTGGAT TTATGGGGAG GTGTTTTGTC TTGTTCGGAC ATCTCTGGAC 
GTCCTGCTCA CAACGGCATC GATTTTTCAC CTGTGCTGCA TTTCTCTGGA TAGGTATTAC 
GCCATCTGCT GCCAGCCTTT GGTCTATAGG AACAAGATGA CCCCTCTGCG CATCGCATTA 
ATGCTGGGAG GCTGCTGGGT CATCCCCACG TTTATTTCTT TTCTCCCTAT AATGCAAGGC 
TGGAATAACA TTGGCATAAT TGATTTGATA GAAAAGAGGA AGTTCAACCA GAACTCTAAC 
TCTACGTACT GTGTCTTCAT GGTCAACAAG CCCTACGCCA TCACCTGCTC TGTGGTGGCC 
TTCTACATCC CATTTCTCCT CATGGTGCTG GCCTATTACC GCATCTATGT CACAGCTAAG 
GAGCATGCCC ATCAGATCCA GATGTTACAA CGGGCAGGAG CCTCCTCCGA GAGCAGGCCT 
CAGTCGGCAG ACCAGCATAG CACTCATCGC ATGAGGACAG AGACCAAAGC AGCCAAGACC 
CTGTGCATCA TCATGGGTTG CTTCTGCCTC TGCTGGGCAC CATTCTTTGT CACCAATATT 
GTGGATCCTT TCATAGACTA CACTGTCCCT GGGCAGGTGT GGACTGCTTT CCTCTGGCTC 
GGCTATATCA ATTCCGGGTT GAACCCTTTT CTCTACGCCT TCTTGAATAA GTCTTTTAGA 
CGTGCCTTCC TCATCATCCT CTGCTGTGAT GATGAGCGCT ACCGAAGACC TTCCATTCTG 
GGCCAGACTG TCCCTTGTTC AACCACAACC ATTAATGGAT CCACACATGT ACTAAGGACA 
GATTTTCTGT TTGACAGAGA CATTTTAGCA AGGTATTGGA CAAAGCCTGC CAGAGCGGGT 
CCATTCTCAG GCACATTGAG CATTAGATGT TTGACTGCAA GGAAGCCTGT CTTGGGGGAT 
GCAGTGGAGT GTGGTGGCCA GTGGGAGAGT CAGTGTCACC CGCCAGCAAC TTCTCCTTTG 
GTGGCTGCTC AGCCCAGTGA CACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTR4 ( NM_001040172.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035262.2 Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant d, mRNA.

Price & Availability↑

CloneID	OHu12288
Clone ID Related Accession (Same CDS sequence)	NM_001040172.2
Accession Version	NM_001040172.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 4 isoform d
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ131724.1, Y12507.1 and AC091971.4. On or before May 29, 2010 this sequence version replaced NM_001040171.1, NM_001040172.1. Transcript Variant: This variant (d) differs in the 5' UTR and uses an alternate 3' terminal exon compared to variant b. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y12507.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACAAAC TTGATGCTAA TGTGAGTTCT GAGGAGGGTT TCGGGTCAGT GGAGAAGGTG 
GTGCTGCTCA CGTTTCTCTC GACGGTTATC CTGATGGCCA TCTTGGGGAA CCTGCTGGTG 
ATGGTGGCTG TGTGCTGGGA CAGGCAGCTC AGGAAAATAA AAACAAATTA TTTCATTGTA 
TCTCTTGCTT TTGCGGATCT GCTGGTTTCG GTGCTGGTGA TGCCCTTTGG TGCCATTGAG 
CTGGTTCAAG ACATCTGGAT TTATGGGGAG GTGTTTTGTC TTGTTCGGAC ATCTCTGGAC 
GTCCTGCTCA CAACGGCATC GATTTTTCAC CTGTGCTGCA TTTCTCTGGA TAGGTATTAC 
GCCATCTGCT GCCAGCCTTT GGTCTATAGG AACAAGATGA CCCCTCTGCG CATCGCATTA 
ATGCTGGGAG GCTGCTGGGT CATCCCCACG TTTATTTCTT TTCTCCCTAT AATGCAAGGC 
TGGAATAACA TTGGCATAAT TGATTTGATA GAAAAGAGGA AGTTCAACCA GAACTCTAAC 
TCTACGTACT GTGTCTTCAT GGTCAACAAG CCCTACGCCA TCACCTGCTC TGTGGTGGCC 
TTCTACATCC CATTTCTCCT CATGGTGCTG GCCTATTACC GCATCTATGT CACAGCTAAG 
GAGCATGCCC ATCAGATCCA GATGTTACAA CGGGCAGGAG CCTCCTCCGA GAGCAGGCCT 
CAGTCGGCAG ACCAGCATAG CACTCATCGC ATGAGGACAG AGACCAAAGC AGCCAAGACC 
CTGTGCATCA TCATGGGTTG CTTCTGCCTC TGCTGGGCAC CATTCTTTGT CACCAATATT 
GTGGATCCTT TCATAGACTA CACTGTCCCT GGGCAGGTGT GGACTGCTTT CCTCTGGCTC 
GGCTATATCA ATTCCGGGTT GAACCCTTTT CTCTACGCCT TCTTGAATAA GTCTTTTAGA 
CGTGCCTTCC TCATCATCCT CTGCTGTGAT GATGAGCGCT ACCGAAGACC TTCCATTCTG 
GGCCAGACTG TCCCTTGTTC AACCACAACC ATTAATGGAT CCACACATGT ACTAAGATTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035262.2
CDS	48..1130
Translation	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRF

Target ORF information:

RefSeq Version	NM_001040172.2
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant d, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040172.2

ORF Insert Sequence:

ATGGACAAAC TTGATGCTAA TGTGAGTTCT GAGGAGGGTT TCGGGTCAGT GGAGAAGGTG 
GTGCTGCTCA CGTTTCTCTC GACGGTTATC CTGATGGCCA TCTTGGGGAA CCTGCTGGTG 
ATGGTGGCTG TGTGCTGGGA CAGGCAGCTC AGGAAAATAA AAACAAATTA TTTCATTGTA 
TCTCTTGCTT TTGCGGATCT GCTGGTTTCG GTGCTGGTGA TGCCCTTTGG TGCCATTGAG 
CTGGTTCAAG ACATCTGGAT TTATGGGGAG GTGTTTTGTC TTGTTCGGAC ATCTCTGGAC 
GTCCTGCTCA CAACGGCATC GATTTTTCAC CTGTGCTGCA TTTCTCTGGA TAGGTATTAC 
GCCATCTGCT GCCAGCCTTT GGTCTATAGG AACAAGATGA CCCCTCTGCG CATCGCATTA 
ATGCTGGGAG GCTGCTGGGT CATCCCCACG TTTATTTCTT TTCTCCCTAT AATGCAAGGC 
TGGAATAACA TTGGCATAAT TGATTTGATA GAAAAGAGGA AGTTCAACCA GAACTCTAAC 
TCTACGTACT GTGTCTTCAT GGTCAACAAG CCCTACGCCA TCACCTGCTC TGTGGTGGCC 
TTCTACATCC CATTTCTCCT CATGGTGCTG GCCTATTACC GCATCTATGT CACAGCTAAG 
GAGCATGCCC ATCAGATCCA GATGTTACAA CGGGCAGGAG CCTCCTCCGA GAGCAGGCCT 
CAGTCGGCAG ACCAGCATAG CACTCATCGC ATGAGGACAG AGACCAAAGC AGCCAAGACC 
CTGTGCATCA TCATGGGTTG CTTCTGCCTC TGCTGGGCAC CATTCTTTGT CACCAATATT 
GTGGATCCTT TCATAGACTA CACTGTCCCT GGGCAGGTGT GGACTGCTTT CCTCTGGCTC 
GGCTATATCA ATTCCGGGTT GAACCCTTTT CTCTACGCCT TCTTGAATAA GTCTTTTAGA 
CGTGCCTTCC TCATCATCCT CTGCTGTGAT GATGAGCGCT ACCGAAGACC TTCCATTCTG 
GGCCAGACTG TCCCTTGTTC AACCACAACC ATTAATGGAT CCACACATGT ACTAAGATTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTR4 ( NM_000870.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_000861.1 Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant b, mRNA.

Price & Availability↑

CloneID	OHu20434
Clone ID Related Accession (Same CDS sequence)	NM_000870.6 , NM_000870.7
Accession Version	NM_000870.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1167bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 4 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008627.7, DR000612.1, AJ131724.1 and AC091971.4. This sequence is a reference standard in the RefSeqGene project. On Nov 5, 2013 this sequence version replaced NM_000870.5. Transcript Variant: This variant (b) encodes the longest isoform (b). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ131724.1, SRR1803611.185812.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2152568 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##

ATGGACAAAC TTGATGCTAA TGTGAGTTCT GAGGAGGGTT TCGGGTCAGT GGAGAAGGTG 
GTGCTGCTCA CGTTTCTCTC GACGGTTATC CTGATGGCCA TCTTGGGGAA CCTGCTGGTG 
ATGGTGGCTG TGTGCTGGGA CAGGCAGCTC AGGAAAATAA AAACAAATTA TTTCATTGTA 
TCTCTTGCTT TTGCGGATCT GCTGGTTTCG GTGCTGGTGA TGCCCTTTGG TGCCATTGAG 
CTGGTTCAAG ACATCTGGAT TTATGGGGAG GTGTTTTGTC TTGTTCGGAC ATCTCTGGAC 
GTCCTGCTCA CAACGGCATC GATTTTTCAC CTGTGCTGCA TTTCTCTGGA TAGGTATTAC 
GCCATCTGCT GCCAGCCTTT GGTCTATAGG AACAAGATGA CCCCTCTGCG CATCGCATTA 
ATGCTGGGAG GCTGCTGGGT CATCCCCACG TTTATTTCTT TTCTCCCTAT AATGCAAGGC 
TGGAATAACA TTGGCATAAT TGATTTGATA GAAAAGAGGA AGTTCAACCA GAACTCTAAC 
TCTACGTACT GTGTCTTCAT GGTCAACAAG CCCTACGCCA TCACCTGCTC TGTGGTGGCC 
TTCTACATCC CATTTCTCCT CATGGTGCTG GCCTATTACC GCATCTATGT CACAGCTAAG 
GAGCATGCCC ATCAGATCCA GATGTTACAA CGGGCAGGAG CCTCCTCCGA GAGCAGGCCT 
CAGTCGGCAG ACCAGCATAG CACTCATCGC ATGAGGACAG AGACCAAAGC AGCCAAGACC 
CTGTGCATCA TCATGGGTTG CTTCTGCCTC TGCTGGGCAC CATTCTTTGT CACCAATATT 
GTGGATCCTT TCATAGACTA CACTGTCCCT GGGCAGGTGT GGACTGCTTT CCTCTGGCTC 
GGCTATATCA ATTCCGGGTT GAACCCTTTT CTCTACGCCT TCTTGAATAA GTCTTTTAGA 
CGTGCCTTCC TCATCATCCT CTGCTGTGAT GATGAGCGCT ACCGAAGACC TTCCATTCTG 
GGCCAGACTG TCCCTTGTTC AACCACAACC ATTAATGGAT CCACACATGT ACTAAGGGAT 
GCAGTGGAGT GTGGTGGCCA GTGGGAGAGT CAGTGTCACC CGCCAGCAAC TTCTCCTTTG 
GTGGCTGCTC AGCCCAGTGA CACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000861.1
CDS	514..1680
Translation	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT

Target ORF information:

RefSeq Version	NM_000870.6
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000870.6

ORF Insert Sequence:

ATGGACAAAC TTGATGCTAA TGTGAGTTCT GAGGAGGGTT TCGGGTCAGT GGAGAAGGTG 
GTGCTGCTCA CGTTTCTCTC GACGGTTATC CTGATGGCCA TCTTGGGGAA CCTGCTGGTG 
ATGGTGGCTG TGTGCTGGGA CAGGCAGCTC AGGAAAATAA AAACAAATTA TTTCATTGTA 
TCTCTTGCTT TTGCGGATCT GCTGGTTTCG GTGCTGGTGA TGCCCTTTGG TGCCATTGAG 
CTGGTTCAAG ACATCTGGAT TTATGGGGAG GTGTTTTGTC TTGTTCGGAC ATCTCTGGAC 
GTCCTGCTCA CAACGGCATC GATTTTTCAC CTGTGCTGCA TTTCTCTGGA TAGGTATTAC 
GCCATCTGCT GCCAGCCTTT GGTCTATAGG AACAAGATGA CCCCTCTGCG CATCGCATTA 
ATGCTGGGAG GCTGCTGGGT CATCCCCACG TTTATTTCTT TTCTCCCTAT AATGCAAGGC 
TGGAATAACA TTGGCATAAT TGATTTGATA GAAAAGAGGA AGTTCAACCA GAACTCTAAC 
TCTACGTACT GTGTCTTCAT GGTCAACAAG CCCTACGCCA TCACCTGCTC TGTGGTGGCC 
TTCTACATCC CATTTCTCCT CATGGTGCTG GCCTATTACC GCATCTATGT CACAGCTAAG 
GAGCATGCCC ATCAGATCCA GATGTTACAA CGGGCAGGAG CCTCCTCCGA GAGCAGGCCT 
CAGTCGGCAG ACCAGCATAG CACTCATCGC ATGAGGACAG AGACCAAAGC AGCCAAGACC 
CTGTGCATCA TCATGGGTTG CTTCTGCCTC TGCTGGGCAC CATTCTTTGT CACCAATATT 
GTGGATCCTT TCATAGACTA CACTGTCCCT GGGCAGGTGT GGACTGCTTT CCTCTGGCTC 
GGCTATATCA ATTCCGGGTT GAACCCTTTT CTCTACGCCT TCTTGAATAA GTCTTTTAGA 
CGTGCCTTCC TCATCATCCT CTGCTGTGAT GATGAGCGCT ACCGAAGACC TTCCATTCTG 
GGCCAGACTG TCCCTTGTTC AACCACAACC ATTAATGGAT CCACACATGT ACTAAGGGAT 
GCAGTGGAGT GTGGTGGCCA GTGGGAGAGT CAGTGTCACC CGCCAGCAAC TTCTCCTTTG 
GTGGCTGCTC AGCCCAGTGA CACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTR4 ( NM_000870.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_000861.1 Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant b, mRNA.

Price & Availability↑

CloneID	OHu20434
Clone ID Related Accession (Same CDS sequence)	NM_000870.6 , NM_000870.7
Accession Version	NM_000870.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1167bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-29
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 4 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008627.7, DR000612.1, AJ131724.1 and AC091971.4. On Nov 30, 2019 this sequence version replaced NM_000870.6. Transcript Variant: This variant (b) encodes the longest isoform (b). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ131724.1, SRR1803614.139874.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##

ATGGACAAAC TTGATGCTAA TGTGAGTTCT GAGGAGGGTT TCGGGTCAGT GGAGAAGGTG 
GTGCTGCTCA CGTTTCTCTC GACGGTTATC CTGATGGCCA TCTTGGGGAA CCTGCTGGTG 
ATGGTGGCTG TGTGCTGGGA CAGGCAGCTC AGGAAAATAA AAACAAATTA TTTCATTGTA 
TCTCTTGCTT TTGCGGATCT GCTGGTTTCG GTGCTGGTGA TGCCCTTTGG TGCCATTGAG 
CTGGTTCAAG ACATCTGGAT TTATGGGGAG GTGTTTTGTC TTGTTCGGAC ATCTCTGGAC 
GTCCTGCTCA CAACGGCATC GATTTTTCAC CTGTGCTGCA TTTCTCTGGA TAGGTATTAC 
GCCATCTGCT GCCAGCCTTT GGTCTATAGG AACAAGATGA CCCCTCTGCG CATCGCATTA 
ATGCTGGGAG GCTGCTGGGT CATCCCCACG TTTATTTCTT TTCTCCCTAT AATGCAAGGC 
TGGAATAACA TTGGCATAAT TGATTTGATA GAAAAGAGGA AGTTCAACCA GAACTCTAAC 
TCTACGTACT GTGTCTTCAT GGTCAACAAG CCCTACGCCA TCACCTGCTC TGTGGTGGCC 
TTCTACATCC CATTTCTCCT CATGGTGCTG GCCTATTACC GCATCTATGT CACAGCTAAG 
GAGCATGCCC ATCAGATCCA GATGTTACAA CGGGCAGGAG CCTCCTCCGA GAGCAGGCCT 
CAGTCGGCAG ACCAGCATAG CACTCATCGC ATGAGGACAG AGACCAAAGC AGCCAAGACC 
CTGTGCATCA TCATGGGTTG CTTCTGCCTC TGCTGGGCAC CATTCTTTGT CACCAATATT 
GTGGATCCTT TCATAGACTA CACTGTCCCT GGGCAGGTGT GGACTGCTTT CCTCTGGCTC 
GGCTATATCA ATTCCGGGTT GAACCCTTTT CTCTACGCCT TCTTGAATAA GTCTTTTAGA 
CGTGCCTTCC TCATCATCCT CTGCTGTGAT GATGAGCGCT ACCGAAGACC TTCCATTCTG 
GGCCAGACTG TCCCTTGTTC AACCACAACC ATTAATGGAT CCACACATGT ACTAAGGGAT 
GCAGTGGAGT GTGGTGGCCA GTGGGAGAGT CAGTGTCACC CGCCAGCAAC TTCTCCTTTG 
GTGGCTGCTC AGCCCAGTGA CACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000861.1
CDS	514..1680
Translation	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT

Target ORF information:

RefSeq Version	NM_000870.7
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 4 (HTR4), transcript variant b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000870.7

ORF Insert Sequence:

ATGGACAAAC TTGATGCTAA TGTGAGTTCT GAGGAGGGTT TCGGGTCAGT GGAGAAGGTG 
GTGCTGCTCA CGTTTCTCTC GACGGTTATC CTGATGGCCA TCTTGGGGAA CCTGCTGGTG 
ATGGTGGCTG TGTGCTGGGA CAGGCAGCTC AGGAAAATAA AAACAAATTA TTTCATTGTA 
TCTCTTGCTT TTGCGGATCT GCTGGTTTCG GTGCTGGTGA TGCCCTTTGG TGCCATTGAG 
CTGGTTCAAG ACATCTGGAT TTATGGGGAG GTGTTTTGTC TTGTTCGGAC ATCTCTGGAC 
GTCCTGCTCA CAACGGCATC GATTTTTCAC CTGTGCTGCA TTTCTCTGGA TAGGTATTAC 
GCCATCTGCT GCCAGCCTTT GGTCTATAGG AACAAGATGA CCCCTCTGCG CATCGCATTA 
ATGCTGGGAG GCTGCTGGGT CATCCCCACG TTTATTTCTT TTCTCCCTAT AATGCAAGGC 
TGGAATAACA TTGGCATAAT TGATTTGATA GAAAAGAGGA AGTTCAACCA GAACTCTAAC 
TCTACGTACT GTGTCTTCAT GGTCAACAAG CCCTACGCCA TCACCTGCTC TGTGGTGGCC 
TTCTACATCC CATTTCTCCT CATGGTGCTG GCCTATTACC GCATCTATGT CACAGCTAAG 
GAGCATGCCC ATCAGATCCA GATGTTACAA CGGGCAGGAG CCTCCTCCGA GAGCAGGCCT 
CAGTCGGCAG ACCAGCATAG CACTCATCGC ATGAGGACAG AGACCAAAGC AGCCAAGACC 
CTGTGCATCA TCATGGGTTG CTTCTGCCTC TGCTGGGCAC CATTCTTTGT CACCAATATT 
GTGGATCCTT TCATAGACTA CACTGTCCCT GGGCAGGTGT GGACTGCTTT CCTCTGGCTC 
GGCTATATCA ATTCCGGGTT GAACCCTTTT CTCTACGCCT TCTTGAATAA GTCTTTTAGA 
CGTGCCTTCC TCATCATCCT CTGCTGTGAT GATGAGCGCT ACCGAAGACC TTCCATTCTG 
GGCCAGACTG TCCCTTGTTC AACCACAACC ATTAATGGAT CCACACATGT ACTAAGGGAT 
GCAGTGGAGT GTGGTGGCCA GTGGGAGAGT CAGTGTCACC CGCCAGCAAC TTCTCCTTTG 
GTGGCTGCTC AGCCCAGTGA CACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-16 and miR-103 impact 5-HT
Scientific reports7(1)14680(2017 Oct)
Wohlfarth C,Schmitteckert S,H?rtle JD,Houghton LA,Dweep H,Fortea M,Assadi G,Braun A,Mederer T,P?hner S,Becker PP,Fischer C,Granzow M,M?nnikes H,Mayer EA,Sayuk G,Boeckxstaens G,Wouters MM,Simr?n M,Lindberg G,Ohlsson B,Schmidt PT,Dlugosz A,Agreus L,Andreasson A,D'Amato M,Burwinkel B,Bermejo JL,R?th R,Lasitschka F,Vicario M,Metzger M,Santos J,Rappold GA,Martinez C,Niesler B

Functional studies of the 5'-untranslated region of human 5-HT4 receptor mRNA.
The Biochemical journal387(Pt 2)463-71(2005 Apr)
Maillet M,Gastineau M,Bochet P,Asselin-Labat ML,Morel E,Laverri?re JN,Lompr? AM,Fischmeister R,Lezoualc'h F

Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i).
Naunyn-Schmiedeberg's archives of pharmacology369(6)616-28(2004 Jun)
Brattelid T,Kvingedal AM,Krobert KA,Andressen KW,Bach T,Hystad ME,Kaumann AJ,Levy FO

Identification and characterization of the human serotonin-4 receptor gene promoter.
Biochemical and biophysical research communications289(2)337-44(2001 Nov)
Hiroi T,Hayashi-Kobayashi N,Nagumo S,Ino M,Okawa Y,Aoba A,Matsui H

Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.
Journal of neurochemistry74(2)478-89(2000 Feb)
Bender E,Pindon A,van Oers I,Zhang YB,Gommeren W,Verhasselt P,Jurzak M,Leysen J,Luyten W

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HTR4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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