HOXC4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOXC4
Entrez Gene ID	3221
Full Name	homeobox C4
Synonyms	HOX3,HOX3E,cp19
General protein information	Preferred Names homeobox C4 Names homeobox protein Hox-C4 homeo box 3E homeobox protein CP19 homeobox protein Hox-3E
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.13
Summary	This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons. [provided by RefSeq, Jul 2008].
Disorder MIM:	142974

mRNA and Protein(s)

mRNA	Protein	Name
NM_153633.2	NP_705897.1	homeobox protein Hox-C4
NM_014620.5	NP_055435.2	homeobox protein Hox-C4
NM_153633.3	NP_705897.1	homeobox protein Hox-C4
NM_014620.6	NP_055435.2	homeobox protein Hox-C4

Pathways from BioSystems

Homologies

	HOXC4	XP_002798656.1
Xenopus tropicalis (tropical clawed frog)	hoxc4	XP_002936684.1
Canis lupus familiaris (dog)	HOXC4	XP_005636811.1
Bos taurus (cattle)	HOXC4	NP_001095843.1
Pan troglodytes (chimpanzee)	HOXC4	XP_003313692.1
Danio rerio (zebrafish)	hoxc4a	NP_571197.1
Homo sapiens (human)	HOXC4	NP_055435.2
Rattus norvegicus (Norway rat)	Hoxc4	NP_001103354.1
Mus musculus (house mouse)	Hoxc4	NP_038581.2

Gene Ontology
Bibliography

Related articles in PubMed

A Y2H-seq approach defines the human protein methyltransferase interactome.
Weimann M, Grossmann A, Woodsmith J, ?zkan Z, Birth P, Meierhofer D, Benlasfer N, Valovka T, Timmermann B, Wanker EE, Sauer S, Stelzl U
Nature methods10(4)339-42(2013 Apr)

HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4.
Auvray C, Delahaye A, Pflumio F, Haddad R, Amsellem S, Miri-Nezhad A, Broix L, Yacia A, Bulle F, Fichelson S, Vigon I
Haematologica97(2)168-78(2012 Feb)

Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutation.
Mai T, Zan H, Zhang J, Hawkins JS, Xu Z, Casali P
The Journal of biological chemistry285(48)37797-810(2010 Nov)

HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation.
Park SR, Zan H, Pal Z, Zhang J, Al-Qahtani A, Pone EJ, Xu Z, Mai T, Casali P
Nature immunology10(5)540-50(2009 May)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HOXC4 homeoprotein expands human hematopoietic immature cells by 3 to 6 times ex vivo and significantly improves the level of in vivo engraftment.
Title: HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4.

Esr1 bind to and activate the HOXC4 promoter to potentiate HoxC4-mediated AID induction, immunoglobulin class switch and somatic hypermutation.
Title: Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutation.

HoxC4 directly activates the Aicda promoter
Title: HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation.

Human cytomegalovirus downregulates while all-trans retinoic acid upregulates expression of hoxc4 and hoxc6 in lymphocytic progenitor cells.
Title: [Effect of human cytomegalovirus infection on the expression of hoxc4 and hoxc6 genes in the proliferation of lymphocytic progenitor cells].

Observational study of gene-disease association. (HuGE Navigator)
Title: Analysis of single nucleotide polymorphisms and haplotypes in HOXC gene cluster within susceptible region 12q13 of simple congenital heart disease.

The following HOXC4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXC4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08135	NM_014620.6 Latest version!	Homo sapiens homeobox C4 (HOXC4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu08135	NM_153633.3 Latest version!	Homo sapiens homeobox C4 (HOXC4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu08135	NM_153633.2	Homo sapiens homeobox C4 (HOXC4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu08135	NM_014620.5	Homo sapiens homeobox C4 (HOXC4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOXC4 ( NM_153633.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_705897.1 Homo sapiens homeobox C4 (HOXC4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08135
Clone ID Related Accession (Same CDS sequence)	NM_153633.2 , NM_014620.5 , NM_153633.3 , NM_014620.6
Accession Version	NM_153633.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	homeobox protein Hox-C4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC050442.1 and AC023794.37. This sequence is a reference standard in the RefSeqGene project. On Apr 21, 2006 this sequence version replaced NM_153633.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050442.1, SRR1163658.59866.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCATGA GCTCGTATTT GATGGACTCT AACTACATCG ATCCGAAATT TCCTCCATGC 
GAAGAATATT CGCAAAATAG CTACATCCCT GAACACAGTC CGGAATATTA CGGCCGGACC 
AGGGAATCGG GATTCCAGCA TCACCACCAG GAGCTGTACC CACCACCGCC TCCGCGCCCT 
AGCTACCCTG AGCGCCAGTA TAGCTGCACC AGTCTCCAGG GGCCCGGCAA TTCGCGAGGC 
CACGGGCCGG CCCAGGCGGG CCACCACCAC CCCGAGAAAT CACAGTCGCT CTGCGAGCCG 
GCGCCTCTCT CAGGCGCCTC CGCCTCCCCG TCCCCAGCCC CGCCAGCCTG CAGCCAGCCA 
GCCCCCGACC ATCCCTCCAG CGCCGCCAGC AAGCAACCCA TAGTCTACCC ATGGATGAAA 
AAAATTCACG TTAGCACGGT GAACCCCAAT TATAACGGAG GGGAACCCAA GCGCTCGAGG 
ACAGCCTATA CCCGGCAGCA AGTCCTGGAA TTAGAGAAAG AGTTTCATTA CAACCGCTAC 
CTGACCCGAA GGAGAAGGAT CGAGATCGCC CACTCGCTGT GCCTCTCTGA GAGGCAGATC 
AAAATCTGGT TCCAAAACCG TCGCATGAAA TGGAAGAAGG ACCACCGACT CCCCAACACC 
AAAGTCAGGT CAGCACCCCC GGCCGGCGCT GCGCCCAGCA CCCTTTCGGC AGCTACCCCG 
GGTACTTCTG AAGACCACTC CCAGAGCGCC ACGCCGCCGG AGCAGCAACG GGCAGAGGAC 
ATTACCAGGT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_705897.1
CDS	47..841
Translation	MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPPPPRPSYPERQYSCTSLQGPGNSRGHGPAQAGHHHPEKSQSLCEPAPLSGASASPSPAPPACSQPAPDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQRAEDITRL

Target ORF information:

RefSeq Version	NM_153633.2
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox C4 (HOXC4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153633.2

ORF Insert Sequence:

ATGATCATGA GCTCGTATTT GATGGACTCT AACTACATCG ATCCGAAATT TCCTCCATGC 
GAAGAATATT CGCAAAATAG CTACATCCCT GAACACAGTC CGGAATATTA CGGCCGGACC 
AGGGAATCGG GATTCCAGCA TCACCACCAG GAGCTGTACC CACCACCGCC TCCGCGCCCT 
AGCTACCCTG AGCGCCAGTA TAGCTGCACC AGTCTCCAGG GGCCCGGCAA TTCGCGAGGC 
CACGGGCCGG CCCAGGCGGG CCACCACCAC CCCGAGAAAT CACAGTCGCT CTGCGAGCCG 
GCGCCTCTCT CAGGCGCCTC CGCCTCCCCG TCCCCAGCCC CGCCAGCCTG CAGCCAGCCA 
GCCCCCGACC ATCCCTCCAG CGCCGCCAGC AAGCAACCCA TAGTCTACCC ATGGATGAAA 
AAAATTCACG TTAGCACGGT GAACCCCAAT TATAACGGAG GGGAACCCAA GCGCTCGAGG 
ACAGCCTATA CCCGGCAGCA AGTCCTGGAA TTAGAGAAAG AGTTTCATTA CAACCGCTAC 
CTGACCCGAA GGAGAAGGAT CGAGATCGCC CACTCGCTGT GCCTCTCTGA GAGGCAGATC 
AAAATCTGGT TCCAAAACCG TCGCATGAAA TGGAAGAAGG ACCACCGACT CCCCAACACC 
AAAGTCAGGT CAGCACCCCC GGCCGGCGCT GCGCCCAGCA CCCTTTCGGC AGCTACCCCG 
GGTACTTCTG AAGACCACTC CCAGAGCGCC ACGCCGCCGG AGCAGCAACG GGCAGAGGAC 
ATTACCAGGT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXC4 ( NM_014620.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055435.2 Homo sapiens homeobox C4 (HOXC4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu08135
Clone ID Related Accession (Same CDS sequence)	NM_153633.2 , NM_014620.5 , NM_153633.3 , NM_014620.6
Accession Version	NM_014620.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	homeobox protein Hox-C4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC012531.11, DA905719.1, X07495.1, BC050442.1, AI200419.1, CA432146.1 and AA805317.1. This sequence is a reference standard in the RefSeqGene project. On Sep 27, 2013 this sequence version replaced NM_014620.4. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X07495.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCATGA GCTCGTATTT GATGGACTCT AACTACATCG ATCCGAAATT TCCTCCATGC 
GAAGAATATT CGCAAAATAG CTACATCCCT GAACACAGTC CGGAATATTA CGGCCGGACC 
AGGGAATCGG GATTCCAGCA TCACCACCAG GAGCTGTACC CACCACCGCC TCCGCGCCCT 
AGCTACCCTG AGCGCCAGTA TAGCTGCACC AGTCTCCAGG GGCCCGGCAA TTCGCGAGGC 
CACGGGCCGG CCCAGGCGGG CCACCACCAC CCCGAGAAAT CACAGTCGCT CTGCGAGCCG 
GCGCCTCTCT CAGGCGCCTC CGCCTCCCCG TCCCCAGCCC CGCCAGCCTG CAGCCAGCCA 
GCCCCCGACC ATCCCTCCAG CGCCGCCAGC AAGCAACCCA TAGTCTACCC ATGGATGAAA 
AAAATTCACG TTAGCACGGT GAACCCCAAT TATAACGGAG GGGAACCCAA GCGCTCGAGG 
ACAGCCTATA CCCGGCAGCA AGTCCTGGAA TTAGAGAAAG AGTTTCATTA CAACCGCTAC 
CTGACCCGAA GGAGAAGGAT CGAGATCGCC CACTCGCTGT GCCTCTCTGA GAGGCAGATC 
AAAATCTGGT TCCAAAACCG TCGCATGAAA TGGAAGAAGG ACCACCGACT CCCCAACACC 
AAAGTCAGGT CAGCACCCCC GGCCGGCGCT GCGCCCAGCA CCCTTTCGGC AGCTACCCCG 
GGTACTTCTG AAGACCACTC CCAGAGCGCC ACGCCGCCGG AGCAGCAACG GGCAGAGGAC 
ATTACCAGGT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055435.2
CDS	687..1481
Translation	MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPPPPRPSYPERQYSCTSLQGPGNSRGHGPAQAGHHHPEKSQSLCEPAPLSGASASPSPAPPACSQPAPDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQRAEDITRL

Target ORF information:

RefSeq Version	NM_014620.5
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox C4 (HOXC4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014620.5

ORF Insert Sequence:

ATGATCATGA GCTCGTATTT GATGGACTCT AACTACATCG ATCCGAAATT TCCTCCATGC 
GAAGAATATT CGCAAAATAG CTACATCCCT GAACACAGTC CGGAATATTA CGGCCGGACC 
AGGGAATCGG GATTCCAGCA TCACCACCAG GAGCTGTACC CACCACCGCC TCCGCGCCCT 
AGCTACCCTG AGCGCCAGTA TAGCTGCACC AGTCTCCAGG GGCCCGGCAA TTCGCGAGGC 
CACGGGCCGG CCCAGGCGGG CCACCACCAC CCCGAGAAAT CACAGTCGCT CTGCGAGCCG 
GCGCCTCTCT CAGGCGCCTC CGCCTCCCCG TCCCCAGCCC CGCCAGCCTG CAGCCAGCCA 
GCCCCCGACC ATCCCTCCAG CGCCGCCAGC AAGCAACCCA TAGTCTACCC ATGGATGAAA 
AAAATTCACG TTAGCACGGT GAACCCCAAT TATAACGGAG GGGAACCCAA GCGCTCGAGG 
ACAGCCTATA CCCGGCAGCA AGTCCTGGAA TTAGAGAAAG AGTTTCATTA CAACCGCTAC 
CTGACCCGAA GGAGAAGGAT CGAGATCGCC CACTCGCTGT GCCTCTCTGA GAGGCAGATC 
AAAATCTGGT TCCAAAACCG TCGCATGAAA TGGAAGAAGG ACCACCGACT CCCCAACACC 
AAAGTCAGGT CAGCACCCCC GGCCGGCGCT GCGCCCAGCA CCCTTTCGGC AGCTACCCCG 
GGTACTTCTG AAGACCACTC CCAGAGCGCC ACGCCGCCGG AGCAGCAACG GGCAGAGGAC 
ATTACCAGGT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXC4 ( NM_153633.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_705897.1 Homo sapiens homeobox C4 (HOXC4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08135
Clone ID Related Accession (Same CDS sequence)	NM_153633.2 , NM_014620.5 , NM_153633.3 , NM_014620.6
Accession Version	NM_153633.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	homeobox protein Hox-C4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC023794.37 and BC050442.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_153633.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050442.1, SRR1163658.59866.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000430889.3/ ENSP00000399808.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATCATGA GCTCGTATTT GATGGACTCT AACTACATCG ATCCGAAATT TCCTCCATGC 
GAAGAATATT CGCAAAATAG CTACATCCCT GAACACAGTC CGGAATATTA CGGCCGGACC 
AGGGAATCGG GATTCCAGCA TCACCACCAG GAGCTGTACC CACCACCGCC TCCGCGCCCT 
AGCTACCCTG AGCGCCAGTA TAGCTGCACC AGTCTCCAGG GGCCCGGCAA TTCGCGAGGC 
CACGGGCCGG CCCAGGCGGG CCACCACCAC CCCGAGAAAT CACAGTCGCT CTGCGAGCCG 
GCGCCTCTCT CAGGCGCCTC CGCCTCCCCG TCCCCAGCCC CGCCAGCCTG CAGCCAGCCA 
GCCCCCGACC ATCCCTCCAG CGCCGCCAGC AAGCAACCCA TAGTCTACCC ATGGATGAAA 
AAAATTCACG TTAGCACGGT GAACCCCAAT TATAACGGAG GGGAACCCAA GCGCTCGAGG 
ACAGCCTATA CCCGGCAGCA AGTCCTGGAA TTAGAGAAAG AGTTTCATTA CAACCGCTAC 
CTGACCCGAA GGAGAAGGAT CGAGATCGCC CACTCGCTGT GCCTCTCTGA GAGGCAGATC 
AAAATCTGGT TCCAAAACCG TCGCATGAAA TGGAAGAAGG ACCACCGACT CCCCAACACC 
AAAGTCAGGT CAGCACCCCC GGCCGGCGCT GCGCCCAGCA CCCTTTCGGC AGCTACCCCG 
GGTACTTCTG AAGACCACTC CCAGAGCGCC ACGCCGCCGG AGCAGCAACG GGCAGAGGAC 
ATTACCAGGT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_705897.1
CDS	89..883
Translation	MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPPPPRPSYPERQYSCTSLQGPGNSRGHGPAQAGHHHPEKSQSLCEPAPLSGASASPSPAPPACSQPAPDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQRAEDITRL

Target ORF information:

RefSeq Version	NM_153633.3
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox C4 (HOXC4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153633.3

ORF Insert Sequence:

ATGATCATGA GCTCGTATTT GATGGACTCT AACTACATCG ATCCGAAATT TCCTCCATGC 
GAAGAATATT CGCAAAATAG CTACATCCCT GAACACAGTC CGGAATATTA CGGCCGGACC 
AGGGAATCGG GATTCCAGCA TCACCACCAG GAGCTGTACC CACCACCGCC TCCGCGCCCT 
AGCTACCCTG AGCGCCAGTA TAGCTGCACC AGTCTCCAGG GGCCCGGCAA TTCGCGAGGC 
CACGGGCCGG CCCAGGCGGG CCACCACCAC CCCGAGAAAT CACAGTCGCT CTGCGAGCCG 
GCGCCTCTCT CAGGCGCCTC CGCCTCCCCG TCCCCAGCCC CGCCAGCCTG CAGCCAGCCA 
GCCCCCGACC ATCCCTCCAG CGCCGCCAGC AAGCAACCCA TAGTCTACCC ATGGATGAAA 
AAAATTCACG TTAGCACGGT GAACCCCAAT TATAACGGAG GGGAACCCAA GCGCTCGAGG 
ACAGCCTATA CCCGGCAGCA AGTCCTGGAA TTAGAGAAAG AGTTTCATTA CAACCGCTAC 
CTGACCCGAA GGAGAAGGAT CGAGATCGCC CACTCGCTGT GCCTCTCTGA GAGGCAGATC 
AAAATCTGGT TCCAAAACCG TCGCATGAAA TGGAAGAAGG ACCACCGACT CCCCAACACC 
AAAGTCAGGT CAGCACCCCC GGCCGGCGCT GCGCCCAGCA CCCTTTCGGC AGCTACCCCG 
GGTACTTCTG AAGACCACTC CCAGAGCGCC ACGCCGCCGG AGCAGCAACG GGCAGAGGAC 
ATTACCAGGT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOXC4 ( NM_014620.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_055435.2 Homo sapiens homeobox C4 (HOXC4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu08135
Clone ID Related Accession (Same CDS sequence)	NM_153633.2 , NM_014620.5 , NM_153633.3 , NM_014620.6
Accession Version	NM_014620.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	homeobox protein Hox-C4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA905719.1, X07495.1, BC050442.1, AI200419.1, CA432146.1 and AA805317.1. This sequence is a reference standard in the RefSeqGene project. On May 31, 2019 this sequence version replaced NM_014620.5. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X07495.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCATGA GCTCGTATTT GATGGACTCT AACTACATCG ATCCGAAATT TCCTCCATGC 
GAAGAATATT CGCAAAATAG CTACATCCCT GAACACAGTC CGGAATATTA CGGCCGGACC 
AGGGAATCGG GATTCCAGCA TCACCACCAG GAGCTGTACC CACCACCGCC TCCGCGCCCT 
AGCTACCCTG AGCGCCAGTA TAGCTGCACC AGTCTCCAGG GGCCCGGCAA TTCGCGAGGC 
CACGGGCCGG CCCAGGCGGG CCACCACCAC CCCGAGAAAT CACAGTCGCT CTGCGAGCCG 
GCGCCTCTCT CAGGCGCCTC CGCCTCCCCG TCCCCAGCCC CGCCAGCCTG CAGCCAGCCA 
GCCCCCGACC ATCCCTCCAG CGCCGCCAGC AAGCAACCCA TAGTCTACCC ATGGATGAAA 
AAAATTCACG TTAGCACGGT GAACCCCAAT TATAACGGAG GGGAACCCAA GCGCTCGAGG 
ACAGCCTATA CCCGGCAGCA AGTCCTGGAA TTAGAGAAAG AGTTTCATTA CAACCGCTAC 
CTGACCCGAA GGAGAAGGAT CGAGATCGCC CACTCGCTGT GCCTCTCTGA GAGGCAGATC 
AAAATCTGGT TCCAAAACCG TCGCATGAAA TGGAAGAAGG ACCACCGACT CCCCAACACC 
AAAGTCAGGT CAGCACCCCC GGCCGGCGCT GCGCCCAGCA CCCTTTCGGC AGCTACCCCG 
GGTACTTCTG AAGACCACTC CCAGAGCGCC ACGCCGCCGG AGCAGCAACG GGCAGAGGAC 
ATTACCAGGT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055435.2
CDS	651..1445
Translation	MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPPPPRPSYPERQYSCTSLQGPGNSRGHGPAQAGHHHPEKSQSLCEPAPLSGASASPSPAPPACSQPAPDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQRAEDITRL

Target ORF information:

RefSeq Version	NM_014620.6
Organism	Homo sapiens(human)
Definition	Homo sapiens homeobox C4 (HOXC4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014620.6

ORF Insert Sequence:

ATGATCATGA GCTCGTATTT GATGGACTCT AACTACATCG ATCCGAAATT TCCTCCATGC 
GAAGAATATT CGCAAAATAG CTACATCCCT GAACACAGTC CGGAATATTA CGGCCGGACC 
AGGGAATCGG GATTCCAGCA TCACCACCAG GAGCTGTACC CACCACCGCC TCCGCGCCCT 
AGCTACCCTG AGCGCCAGTA TAGCTGCACC AGTCTCCAGG GGCCCGGCAA TTCGCGAGGC 
CACGGGCCGG CCCAGGCGGG CCACCACCAC CCCGAGAAAT CACAGTCGCT CTGCGAGCCG 
GCGCCTCTCT CAGGCGCCTC CGCCTCCCCG TCCCCAGCCC CGCCAGCCTG CAGCCAGCCA 
GCCCCCGACC ATCCCTCCAG CGCCGCCAGC AAGCAACCCA TAGTCTACCC ATGGATGAAA 
AAAATTCACG TTAGCACGGT GAACCCCAAT TATAACGGAG GGGAACCCAA GCGCTCGAGG 
ACAGCCTATA CCCGGCAGCA AGTCCTGGAA TTAGAGAAAG AGTTTCATTA CAACCGCTAC 
CTGACCCGAA GGAGAAGGAT CGAGATCGCC CACTCGCTGT GCCTCTCTGA GAGGCAGATC 
AAAATCTGGT TCCAAAACCG TCGCATGAAA TGGAAGAAGG ACCACCGACT CCCCAACACC 
AAAGTCAGGT CAGCACCCCC GGCCGGCGCT GCGCCCAGCA CCCTTTCGGC AGCTACCCCG 
GGTACTTCTG AAGACCACTC CCAGAGCGCC ACGCCGCCGG AGCAGCAACG GGCAGAGGAC 
ATTACCAGGT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Y2H-seq approach defines the human protein methyltransferase interactome.
Nature methods10(4)339-42(2013 Apr)
Weimann M,Grossmann A,Woodsmith J,?zkan Z,Birth P,Meierhofer D,Benlasfer N,Valovka T,Timmermann B,Wanker EE,Sauer S,Stelzl U

HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4.
Haematologica97(2)168-78(2012 Feb)
Auvray C,Delahaye A,Pflumio F,Haddad R,Amsellem S,Miri-Nezhad A,Broix L,Yacia A,Bulle F,Fichelson S,Vigon I

Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutation.
The Journal of biological chemistry285(48)37797-810(2010 Nov)
Mai T,Zan H,Zhang J,Hawkins JS,Xu Z,Casali P

HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation.
Nature immunology10(5)540-50(2009 May)
Park SR,Zan H,Pal Z,Zhang J,Al-Qahtani A,Pone EJ,Xu Z,Mai T,Casali P

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

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HOXC4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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