TLX1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TLX1
Entrez Gene ID	3195
Full Name	T cell leukemia homeobox 1
Synonyms	HOX11,TCL3
General protein information	Preferred Names T cell leukemia homeobox 1 Names T-cell leukemia homeobox protein 1 T-cell leukemia/lymphoma protein 3 homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch) homeobox protein Hox-11 proto-oncogene TCL-3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q24.31
Summary	This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010].
Disorder MIM:	186770

mRNA and Protein(s)

mRNA	Protein	Name
NM_005521.3	NP_005512.1	T-cell leukemia homeobox protein 1 isoform 1
XM_011539745.3	XP_011538047.1	T-cell leukemia homeobox protein 1 isoform X2
XM_011539744.3	XP_011538046.1	T-cell leukemia homeobox protein 1 isoform X1
NM_001195517.2	NP_001182446.1	T-cell leukemia homeobox protein 1 isoform 2
XM_011539744.2	XP_011538046.1	T-cell leukemia homeobox protein 1 isoform X1
XM_011539745.2	XP_011538047.1	T-cell leukemia homeobox protein 1 isoform X2
NM_001195517.1	NP_001182446.1	T-cell leukemia homeobox protein 1 isoform 2
NM_005521.4	NP_005512.1	T-cell leukemia homeobox protein 1 isoform 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	TLX1	NP_990346.1
Danio rerio (zebrafish)	tlx1	NP_739571.1
Pan troglodytes (chimpanzee)	TLX1	XP_001169592.2
Canis lupus familiaris (dog)	TLX1	XP_850598.1
Bos taurus (cattle)	TLX1	NP_001178986.1
Mus musculus (house mouse)	Tlx1	NP_068701.1
Rattus norvegicus (Norway rat)	Tlx1	NP_001102636.1
Homo sapiens (human)	TLX1	NP_005512.1
	LOC711584	XP_001109904.1
Xenopus tropicalis (tropical clawed frog)	tlx1	XP_002936814.1

Gene Ontology
Bibliography

Related articles in PubMed

Increased methylation and decreased expression of homeobox genes TLX1, HOXA10 and DLX5 in human placenta are associated with trophoblast differentiation.
Novakovic B, Fournier T, Harris LK, James J, Roberts CT, Yong HEJ, Kalionis B, Evain-Brion D, Ebeling PR, Wallace EM, Saffery R, Murthi P
Scientific reports7(1)4523(2017 Jul)

Genome-wide methylation analysis identifies a core set of hypermethylated genes in CIMP-H colorectal cancer.
McInnes T, Zou D, Rao DS, Munro FM, Phillips VL, McCall JL, Black MA, Reeve AE, Guilford PJ
BMC cancer17(1)228(2017 03)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TLX1 hypermethylation is associated with colorectal cancer.
Title: Genome-wide methylation analysis identifies a core set of hypermethylated genes in CIMP-H colorectal cancer.

The occurrence of G-quadruplex structures at the HOX11 breakpoint region explain its fragility during the t(10;14) translocation.
Title: G-quadruplex structures formed at the HOX11 breakpoint region contribute to its fragility during t(10;14) translocation in T-cell leukemia.

The cortical thymic maturation arrest in T-lineage Acute lymphoblastic leukemias (ALLs) that overexpress TLX1 or TLX3 is due to binding of TLX1/TLX3 to ETS1.
Title: TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCR? gene expression.

these results place TLX1 and TLX3 at the top of an oncogenic transcriptional network controlling leukemia development, and identify RUNX1 as a tumor-suppressor gene in T-ALL
Title: Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.

Suppression of TLX1 expression slowed the growth of TLX1 tumor cell lines. Suppression of TLX1 in vivo also transiently delayed leukemia progression.
Title: Transient responses to NOTCH and TLX1/HOX11 inhibition in T-cell acute lymphoblastic leukemia/lymphoma.

The following TLX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TLX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22531	NM_001195517.2 Latest version!	Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
OHu26328	NM_005521.4 Latest version!	Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu58295	XM_011539744.3 Latest version!	Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu58296	XM_011539745.3 Latest version!	Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
View Old Accession Versions >>
OHu58295	XM_011539744.2	Homo sapiens T-cell leukemia homeobox 1 (TLX1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu58296	XM_011539745.2	Homo sapiens T-cell leukemia homeobox 1 (TLX1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu22531	NM_001195517.1	Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
OHu26328	NM_005521.3	Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TLX1 ( NM_001195517.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001182446.1 Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu22531
Clone ID Related Accession (Same CDS sequence)	NM_001195517.2 , NM_001195517.1
Accession Version	NM_001195517.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	T-cell leukemia homeobox protein 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL357395.13, BC130530.1 and BF514683.1. On May 31, 2019 this sequence version replaced NM_001195517.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which has a shorter C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC130530.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151887, SAMEA2153031 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCACC TGGGTCCGCA CCACCTCCAC CCGGGTCACG CAGAGCCCAT TAGCTTCGGC 
ATCGACCAGA TCCTCAACAG CCCGGACCAG GGTGGCTGCA TGGGACCCGC CTCGCGCCTC 
CAGGACGGAG AATACGGCCT TGGCTGCTTG GTCGGAGGCG CCTACACTTA CGGCGGCGGG 
GGCTCCGCGG CCGCGACGGG GGCTGGAGGA GCGGGGGCCT ATGGTACTGG AGGTCCCGGC 
GGCCCCGGAG GCCCGGCAGG CGGCGGCGGC GCCTGCAGCA TGGGTCCTCT GACCGGCTCC 
TACAACGTGA ACATGGCCTT GGCAGGCGGC CCCGGTCCTG GCGGCGGCGG CGGCAGCAGC 
GGCGGTGCCG GGGCACTCAG CGCTGCGGGG GTAATCCGGG TGCCGGCACA CAGGCCGCTC 
GCCGGAGCCG TGGCCCACCC CCAGCCCCTG GCCACCGGCT TGCCCACCGT GCCCTCTGTG 
CCTGCCATGC CGGGCGTCAA CAACCTCACT GGCCTCACCT TCCCCTGGAT GGAGAGTAAC 
CGCAGATACA CAAAGGACAG GTTCACAGGT CACCCCTATC AGAACCGGAC GCCCCCCAAG 
AAGAAGAAGC CGCGCACGTC CTTCACACGC CTGCAGATCT GCGAGCTGGA GAAGCGCTTC 
CACCGCCAGA AGTACCTGGC CTCGGCCGAG CGCGCCGCCC TGGCCAAGGC GCTCAAAATG 
ACCGATGCGC AGGTCAAAAC CTGGTTCCAG AACCGGCGGA CAAAGTGGAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182446.1
CDS	243..1016
Translation	MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGGGSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGGGSSGGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESNRRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWR

Target ORF information:

RefSeq Version	NM_001195517.2
Organism	Homo sapiens(human)
Definition	Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195517.2

ORF Insert Sequence:

ATGGAGCACC TGGGTCCGCA CCACCTCCAC CCGGGTCACG CAGAGCCCAT TAGCTTCGGC 
ATCGACCAGA TCCTCAACAG CCCGGACCAG GGTGGCTGCA TGGGACCCGC CTCGCGCCTC 
CAGGACGGAG AATACGGCCT TGGCTGCTTG GTCGGAGGCG CCTACACTTA CGGCGGCGGG 
GGCTCCGCGG CCGCGACGGG GGCTGGAGGA GCGGGGGCCT ATGGTACTGG AGGTCCCGGC 
GGCCCCGGAG GCCCGGCAGG CGGCGGCGGC GCCTGCAGCA TGGGTCCTCT GACCGGCTCC 
TACAACGTGA ACATGGCCTT GGCAGGCGGC CCCGGTCCTG GCGGCGGCGG CGGCAGCAGC 
GGCGGTGCCG GGGCACTCAG CGCTGCGGGG GTAATCCGGG TGCCGGCACA CAGGCCGCTC 
GCCGGAGCCG TGGCCCACCC CCAGCCCCTG GCCACCGGCT TGCCCACCGT GCCCTCTGTG 
CCTGCCATGC CGGGCGTCAA CAACCTCACT GGCCTCACCT TCCCCTGGAT GGAGAGTAAC 
CGCAGATACA CAAAGGACAG GTTCACAGGT CACCCCTATC AGAACCGGAC GCCCCCCAAG 
AAGAAGAAGC CGCGCACGTC CTTCACACGC CTGCAGATCT GCGAGCTGGA GAAGCGCTTC 
CACCGCCAGA AGTACCTGGC CTCGGCCGAG CGCGCCGCCC TGGCCAAGGC GCTCAAAATG 
ACCGATGCGC AGGTCAAAAC CTGGTTCCAG AACCGGCGGA CAAAGTGGAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TLX1 ( NM_001195517.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001182446.1 Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu22531
Clone ID Related Accession (Same CDS sequence)	NM_001195517.2 , NM_001195517.1
Accession Version	NM_001195517.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-11
Organism	Homo sapiens(human)
Product	T-cell leukemia homeobox protein 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC130530.1, AL357395.13 and BF514683.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which has a shorter C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC130530.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151887, SAMEA2153031 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCACC TGGGTCCGCA CCACCTCCAC CCGGGTCACG CAGAGCCCAT TAGCTTCGGC 
ATCGACCAGA TCCTCAACAG CCCGGACCAG GGTGGCTGCA TGGGACCCGC CTCGCGCCTC 
CAGGACGGAG AATACGGCCT TGGCTGCTTG GTCGGAGGCG CCTACACTTA CGGCGGCGGG 
GGCTCCGCGG CCGCGACGGG GGCTGGAGGA GCGGGGGCCT ATGGTACTGG AGGTCCCGGC 
GGCCCCGGAG GCCCGGCAGG CGGCGGCGGC GCCTGCAGCA TGGGTCCTCT GACCGGCTCC 
TACAACGTGA ACATGGCCTT GGCAGGCGGC CCCGGTCCTG GCGGCGGCGG CGGCAGCAGC 
GGCGGTGCCG GGGCACTCAG CGCTGCGGGG GTAATCCGGG TGCCGGCACA CAGGCCGCTC 
GCCGGAGCCG TGGCCCACCC CCAGCCCCTG GCCACCGGCT TGCCCACCGT GCCCTCTGTG 
CCTGCCATGC CGGGCGTCAA CAACCTCACT GGCCTCACCT TCCCCTGGAT GGAGAGTAAC 
CGCAGATACA CAAAGGACAG GTTCACAGGT CACCCCTATC AGAACCGGAC GCCCCCCAAG 
AAGAAGAAGC CGCGCACGTC CTTCACACGC CTGCAGATCT GCGAGCTGGA GAAGCGCTTC 
CACCGCCAGA AGTACCTGGC CTCGGCCGAG CGCGCCGCCC TGGCCAAGGC GCTCAAAATG 
ACCGATGCGC AGGTCAAAAC CTGGTTCCAG AACCGGCGGA CAAAGTGGAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182446.1
CDS	239..1012
Translation	MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGGGSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGGGSSGGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESNRRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWR

Target ORF information:

RefSeq Version	NM_001195517.1
Organism	Homo sapiens(human)
Definition	Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195517.1

ORF Insert Sequence:

ATGGAGCACC TGGGTCCGCA CCACCTCCAC CCGGGTCACG CAGAGCCCAT TAGCTTCGGC 
ATCGACCAGA TCCTCAACAG CCCGGACCAG GGTGGCTGCA TGGGACCCGC CTCGCGCCTC 
CAGGACGGAG AATACGGCCT TGGCTGCTTG GTCGGAGGCG CCTACACTTA CGGCGGCGGG 
GGCTCCGCGG CCGCGACGGG GGCTGGAGGA GCGGGGGCCT ATGGTACTGG AGGTCCCGGC 
GGCCCCGGAG GCCCGGCAGG CGGCGGCGGC GCCTGCAGCA TGGGTCCTCT GACCGGCTCC 
TACAACGTGA ACATGGCCTT GGCAGGCGGC CCCGGTCCTG GCGGCGGCGG CGGCAGCAGC 
GGCGGTGCCG GGGCACTCAG CGCTGCGGGG GTAATCCGGG TGCCGGCACA CAGGCCGCTC 
GCCGGAGCCG TGGCCCACCC CCAGCCCCTG GCCACCGGCT TGCCCACCGT GCCCTCTGTG 
CCTGCCATGC CGGGCGTCAA CAACCTCACT GGCCTCACCT TCCCCTGGAT GGAGAGTAAC 
CGCAGATACA CAAAGGACAG GTTCACAGGT CACCCCTATC AGAACCGGAC GCCCCCCAAG 
AAGAAGAAGC CGCGCACGTC CTTCACACGC CTGCAGATCT GCGAGCTGGA GAAGCGCTTC 
CACCGCCAGA AGTACCTGGC CTCGGCCGAG CGCGCCGCCC TGGCCAAGGC GCTCAAAATG 
ACCGATGCGC AGGTCAAAAC CTGGTTCCAG AACCGGCGGA CAAAGTGGAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TLX1 ( NM_005521.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005512.1 Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26328
Clone ID Related Accession (Same CDS sequence)	NM_005521.3 , NM_005521.4
Accession Version	NM_005521.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-12
Organism	Homo sapiens(human)
Product	T-cell leukemia homeobox protein 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC130530.1, M62626.1, S38742.1 and BF514683.1. This sequence is a reference standard in the RefSeqGene project. On Aug 26, 2008 this sequence version replaced NM_005521.2. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: S38742.1, M62626.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCACC TGGGTCCGCA CCACCTCCAC CCGGGTCACG CAGAGCCCAT TAGCTTCGGC 
ATCGACCAGA TCCTCAACAG CCCGGACCAG GGTGGCTGCA TGGGACCCGC CTCGCGCCTC 
CAGGACGGAG AATACGGCCT TGGCTGCTTG GTCGGAGGCG CCTACACTTA CGGCGGCGGG 
GGCTCCGCGG CCGCGACGGG GGCTGGAGGA GCGGGGGCCT ATGGTACTGG AGGTCCCGGC 
GGCCCCGGAG GCCCGGCAGG CGGCGGCGGC GCCTGCAGCA TGGGTCCTCT GACCGGCTCC 
TACAACGTGA ACATGGCCTT GGCAGGCGGC CCCGGTCCTG GCGGCGGCGG CGGCAGCAGC 
GGCGGTGCCG GGGCACTCAG CGCTGCGGGG GTAATCCGGG TGCCGGCACA CAGGCCGCTC 
GCCGGAGCCG TGGCCCACCC CCAGCCCCTG GCCACCGGCT TGCCCACCGT GCCCTCTGTG 
CCTGCCATGC CGGGCGTCAA CAACCTCACT GGCCTCACCT TCCCCTGGAT GGAGAGTAAC 
CGCAGATACA CAAAGGACAG GTTCACAGGT CACCCCTATC AGAACCGGAC GCCCCCCAAG 
AAGAAGAAGC CGCGCACGTC CTTCACACGC CTGCAGATCT GCGAGCTGGA GAAGCGCTTC 
CACCGCCAGA AGTACCTGGC CTCGGCCGAG CGCGCCGCCC TGGCCAAGGC GCTCAAAATG 
ACCGATGCGC AGGTCAAAAC CTGGTTCCAG AACCGGCGGA CAAAGTGGAG ACGGCAGACT 
GCGGAGGAAC GGGAGGCCGA GAGGCAGCAA GCGAACCGCA TCCTCCTGCA GTTGCAGCAG 
GAGGCCTTCC AGAAGAGCCT GGCACAGCCG CTGCCCGCTG ACCCTCTGTG CGTGCACAAC 
TCGTCGCTCT TCGCCCTGCA GAATCTGCAG CCGTGGTCTG ACGACTCGAC CAAAATCACT 
AGCGTCACGT CGGTGGCGTC GGCCTGCGAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005512.1
CDS	239..1231
Translation	MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGGGSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGGGSSGGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESNRRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQKSLAQPLPADPLCVHNSSLFALQNLQPWSDDSTKITSVTSVASACE

Target ORF information:

RefSeq Version	NM_005521.3
Organism	Homo sapiens(human)
Definition	Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005521.3

ORF Insert Sequence:

ATGGAGCACC TGGGTCCGCA CCACCTCCAC CCGGGTCACG CAGAGCCCAT TAGCTTCGGC 
ATCGACCAGA TCCTCAACAG CCCGGACCAG GGTGGCTGCA TGGGACCCGC CTCGCGCCTC 
CAGGACGGAG AATACGGCCT TGGCTGCTTG GTCGGAGGCG CCTACACTTA CGGCGGCGGG 
GGCTCCGCGG CCGCGACGGG GGCTGGAGGA GCGGGGGCCT ATGGTACTGG AGGTCCCGGC 
GGCCCCGGAG GCCCGGCAGG CGGCGGCGGC GCCTGCAGCA TGGGTCCTCT GACCGGCTCC 
TACAACGTGA ACATGGCCTT GGCAGGCGGC CCCGGTCCTG GCGGCGGCGG CGGCAGCAGC 
GGCGGTGCCG GGGCACTCAG CGCTGCGGGG GTAATCCGGG TGCCGGCACA CAGGCCGCTC 
GCCGGAGCCG TGGCCCACCC CCAGCCCCTG GCCACCGGCT TGCCCACCGT GCCCTCTGTG 
CCTGCCATGC CGGGCGTCAA CAACCTCACT GGCCTCACCT TCCCCTGGAT GGAGAGTAAC 
CGCAGATACA CAAAGGACAG GTTCACAGGT CACCCCTATC AGAACCGGAC GCCCCCCAAG 
AAGAAGAAGC CGCGCACGTC CTTCACACGC CTGCAGATCT GCGAGCTGGA GAAGCGCTTC 
CACCGCCAGA AGTACCTGGC CTCGGCCGAG CGCGCCGCCC TGGCCAAGGC GCTCAAAATG 
ACCGATGCGC AGGTCAAAAC CTGGTTCCAG AACCGGCGGA CAAAGTGGAG ACGGCAGACT 
GCGGAGGAAC GGGAGGCCGA GAGGCAGCAA GCGAACCGCA TCCTCCTGCA GTTGCAGCAG 
GAGGCCTTCC AGAAGAGCCT GGCACAGCCG CTGCCCGCTG ACCCTCTGTG CGTGCACAAC 
TCGTCGCTCT TCGCCCTGCA GAATCTGCAG CCGTGGTCTG ACGACTCGAC CAAAATCACT 
AGCGTCACGT CGGTGGCGTC GGCCTGCGAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TLX1 ( NM_005521.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005512.1 Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26328
Clone ID Related Accession (Same CDS sequence)	NM_005521.3 , NM_005521.4
Accession Version	NM_005521.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	T-cell leukemia homeobox protein 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL357395.13, BC130530.1, M62626.1, S38742.1 and BF514683.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_005521.3. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: S38742.1, M62626.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370196.11/ ENSP00000359215.6 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCACC TGGGTCCGCA CCACCTCCAC CCGGGTCACG CAGAGCCCAT TAGCTTCGGC 
ATCGACCAGA TCCTCAACAG CCCGGACCAG GGTGGCTGCA TGGGACCCGC CTCGCGCCTC 
CAGGACGGAG AATACGGCCT TGGCTGCTTG GTCGGAGGCG CCTACACTTA CGGCGGCGGG 
GGCTCCGCGG CCGCGACGGG GGCTGGAGGA GCGGGGGCCT ATGGTACTGG AGGTCCCGGC 
GGCCCCGGAG GCCCGGCAGG CGGCGGCGGC GCCTGCAGCA TGGGTCCTCT GACCGGCTCC 
TACAACGTGA ACATGGCCTT GGCAGGCGGC CCCGGTCCTG GCGGCGGCGG CGGCAGCAGC 
GGCGGTGCCG GGGCACTCAG CGCTGCGGGG GTAATCCGGG TGCCGGCACA CAGGCCGCTC 
GCCGGAGCCG TGGCCCACCC CCAGCCCCTG GCCACCGGCT TGCCCACCGT GCCCTCTGTG 
CCTGCCATGC CGGGCGTCAA CAACCTCACT GGCCTCACCT TCCCCTGGAT GGAGAGTAAC 
CGCAGATACA CAAAGGACAG GTTCACAGGT CACCCCTATC AGAACCGGAC GCCCCCCAAG 
AAGAAGAAGC CGCGCACGTC CTTCACACGC CTGCAGATCT GCGAGCTGGA GAAGCGCTTC 
CACCGCCAGA AGTACCTGGC CTCGGCCGAG CGCGCCGCCC TGGCCAAGGC GCTCAAAATG 
ACCGATGCGC AGGTCAAAAC CTGGTTCCAG AACCGGCGGA CAAAGTGGAG ACGGCAGACT 
GCGGAGGAAC GGGAGGCCGA GAGGCAGCAA GCGAACCGCA TCCTCCTGCA GTTGCAGCAG 
GAGGCCTTCC AGAAGAGCCT GGCACAGCCG CTGCCCGCTG ACCCTCTGTG CGTGCACAAC 
TCGTCGCTCT TCGCCCTGCA GAATCTGCAG CCGTGGTCTG ACGACTCGAC CAAAATCACT 
AGCGTCACGT CGGTGGCGTC GGCCTGCGAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005512.1
CDS	243..1235
Translation	MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGGGSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGGGSSGGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESNRRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQKSLAQPLPADPLCVHNSSLFALQNLQPWSDDSTKITSVTSVASACE

Target ORF information:

RefSeq Version	NM_005521.4
Organism	Homo sapiens(human)
Definition	Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005521.4

ORF Insert Sequence:

ATGGAGCACC TGGGTCCGCA CCACCTCCAC CCGGGTCACG CAGAGCCCAT TAGCTTCGGC 
ATCGACCAGA TCCTCAACAG CCCGGACCAG GGTGGCTGCA TGGGACCCGC CTCGCGCCTC 
CAGGACGGAG AATACGGCCT TGGCTGCTTG GTCGGAGGCG CCTACACTTA CGGCGGCGGG 
GGCTCCGCGG CCGCGACGGG GGCTGGAGGA GCGGGGGCCT ATGGTACTGG AGGTCCCGGC 
GGCCCCGGAG GCCCGGCAGG CGGCGGCGGC GCCTGCAGCA TGGGTCCTCT GACCGGCTCC 
TACAACGTGA ACATGGCCTT GGCAGGCGGC CCCGGTCCTG GCGGCGGCGG CGGCAGCAGC 
GGCGGTGCCG GGGCACTCAG CGCTGCGGGG GTAATCCGGG TGCCGGCACA CAGGCCGCTC 
GCCGGAGCCG TGGCCCACCC CCAGCCCCTG GCCACCGGCT TGCCCACCGT GCCCTCTGTG 
CCTGCCATGC CGGGCGTCAA CAACCTCACT GGCCTCACCT TCCCCTGGAT GGAGAGTAAC 
CGCAGATACA CAAAGGACAG GTTCACAGGT CACCCCTATC AGAACCGGAC GCCCCCCAAG 
AAGAAGAAGC CGCGCACGTC CTTCACACGC CTGCAGATCT GCGAGCTGGA GAAGCGCTTC 
CACCGCCAGA AGTACCTGGC CTCGGCCGAG CGCGCCGCCC TGGCCAAGGC GCTCAAAATG 
ACCGATGCGC AGGTCAAAAC CTGGTTCCAG AACCGGCGGA CAAAGTGGAG ACGGCAGACT 
GCGGAGGAAC GGGAGGCCGA GAGGCAGCAA GCGAACCGCA TCCTCCTGCA GTTGCAGCAG 
GAGGCCTTCC AGAAGAGCCT GGCACAGCCG CTGCCCGCTG ACCCTCTGTG CGTGCACAAC 
TCGTCGCTCT TCGCCCTGCA GAATCTGCAG CCGTGGTCTG ACGACTCGAC CAAAATCACT 
AGCGTCACGT CGGTGGCGTC GGCCTGCGAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TLX1 ( XM_011539744.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011538046.1 Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu58295
Clone ID Related Accession (Same CDS sequence)	XM_011539744.3 , XM_011539744.2
Accession Version	XM_011539744.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1029bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	T-cell leukemia homeobox protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011539744.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCACC TGGGTCCGCA CCACCTCCAC CCGGGTCACG CAGAGCCCAT TAGCTTCGGC 
ATCGACCAGA TCCTCAACAG CCCGGACCAG GGTGGCTGCA TGGGACCCGC CTCGCGCCTC 
CAGGACGGAG AATACGGCCT TGGCTGCTTG GTCGGAGGCG CCTACACTTA CGGCGGCGGG 
GGCTCCGCGG CCGCGACGGG GGCTGGAGGA GCGGGGGCCT ATGGTACTGG AGGTCCCGGC 
GGCCCCGGAG GCCCGGCAGG CGGCGGCGGC GCCTGCAGCA TGGGTCCTCT GACCGGCTCC 
TACAACGTGA ACATGGCCTT GGCAGGCGGC CCCGGTCCTG GCGGCGGCGG CGGCAGCAGC 
GGCGGTGCCG GGGCACTCAG CGCTGCGGGG GTAATCCGGG TGCCGGCACA CAGGCCGCTC 
GCCGGAGCCG TGGCCCACCC CCAGCCCCTG GCCACCGGCT TGCCCACCGT GCCCTCTGTG 
CCTGCCATGC CGGGCGTCAA CAACCTCACT GGCCTCACCT TCCCCTGGAT GGAGAGTAAC 
CGCAGATACA CAAAGGACAG GTTCACAGTG GCCCTCTCAC CCTTCACTGT AACACGCCGT 
ATAGGTCACC CCTATCAGAA CCGGACGCCC CCCAAGAAGA AGAAGCCGCG CACGTCCTTC 
ACACGCCTGC AGATCTGCGA GCTGGAGAAG CGCTTCCACC GCCAGAAGTA CCTGGCCTCG 
GCCGAGCGCG CCGCCCTGGC CAAGGCGCTC AAAATGACCG ATGCGCAGGT CAAAACCTGG 
TTCCAGAACC GGCGGACAAA GTGGAGACGG CAGACTGCGG AGGAACGGGA GGCCGAGAGG 
CAGCAAGCGA ACCGCATCCT CCTGCAGTTG CAGCAGGAGG CCTTCCAGAA GAGCCTGGCA 
CAGCCGCTGC CCGCTGACCC TCTGTGCGTG CACAACTCGT CGCTCTTCGC CCTGCAGAAT 
CTGCAGCCGT GGTCTGACGA CTCGACCAAA ATCACTAGCG TCACGTCGGT GGCGTCGGCC 
TGCGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011538046.1
CDS	754..1782
Translation	MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGGGSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGGGSSGGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESNRRYTKDRFTVALSPFTVTRRIGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQKSLAQPLPADPLCVHNSSLFALQNLQPWSDDSTKITSVTSVASACE

Target ORF information:

RefSeq Version	XM_011539744.3
Organism	Homo sapiens(human)
Definition	Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011539744.3

ORF Insert Sequence:

ATGGAGCACC TGGGTCCGCA CCACCTCCAC CCGGGTCACG CAGAGCCCAT TAGCTTCGGC 
ATCGACCAGA TCCTCAACAG CCCGGACCAG GGTGGCTGCA TGGGACCCGC CTCGCGCCTC 
CAGGACGGAG AATACGGCCT TGGCTGCTTG GTCGGAGGCG CCTACACTTA CGGCGGCGGG 
GGCTCCGCGG CCGCGACGGG GGCTGGAGGA GCGGGGGCCT ATGGTACTGG AGGTCCCGGC 
GGCCCCGGAG GCCCGGCAGG CGGCGGCGGC GCCTGCAGCA TGGGTCCTCT GACCGGCTCC 
TACAACGTGA ACATGGCCTT GGCAGGCGGC CCCGGTCCTG GCGGCGGCGG CGGCAGCAGC 
GGCGGTGCCG GGGCACTCAG CGCTGCGGGG GTAATCCGGG TGCCGGCACA CAGGCCGCTC 
GCCGGAGCCG TGGCCCACCC CCAGCCCCTG GCCACCGGCT TGCCCACCGT GCCCTCTGTG 
CCTGCCATGC CGGGCGTCAA CAACCTCACT GGCCTCACCT TCCCCTGGAT GGAGAGTAAC 
CGCAGATACA CAAAGGACAG GTTCACAGTG GCCCTCTCAC CCTTCACTGT AACACGCCGT 
ATAGGTCACC CCTATCAGAA CCGGACGCCC CCCAAGAAGA AGAAGCCGCG CACGTCCTTC 
ACACGCCTGC AGATCTGCGA GCTGGAGAAG CGCTTCCACC GCCAGAAGTA CCTGGCCTCG 
GCCGAGCGCG CCGCCCTGGC CAAGGCGCTC AAAATGACCG ATGCGCAGGT CAAAACCTGG 
TTCCAGAACC GGCGGACAAA GTGGAGACGG CAGACTGCGG AGGAACGGGA GGCCGAGAGG 
CAGCAAGCGA ACCGCATCCT CCTGCAGTTG CAGCAGGAGG CCTTCCAGAA GAGCCTGGCA 
CAGCCGCTGC CCGCTGACCC TCTGTGCGTG CACAACTCGT CGCTCTTCGC CCTGCAGAAT 
CTGCAGCCGT GGTCTGACGA CTCGACCAAA ATCACTAGCG TCACGTCGGT GGCGTCGGCC 
TGCGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TLX1 ( XM_011539744.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011538046.1 Homo sapiens T-cell leukemia homeobox 1 (TLX1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu58295
Clone ID Related Accession (Same CDS sequence)	XM_011539744.3 , XM_011539744.2
Accession Version	XM_011539744.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1029bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	T-cell leukemia homeobox protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011539744.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCACC TGGGTCCGCA CCACCTCCAC CCGGGTCACG CAGAGCCCAT TAGCTTCGGC 
ATCGACCAGA TCCTCAACAG CCCGGACCAG GGTGGCTGCA TGGGACCCGC CTCGCGCCTC 
CAGGACGGAG AATACGGCCT TGGCTGCTTG GTCGGAGGCG CCTACACTTA CGGCGGCGGG 
GGCTCCGCGG CCGCGACGGG GGCTGGAGGA GCGGGGGCCT ATGGTACTGG AGGTCCCGGC 
GGCCCCGGAG GCCCGGCAGG CGGCGGCGGC GCCTGCAGCA TGGGTCCTCT GACCGGCTCC 
TACAACGTGA ACATGGCCTT GGCAGGCGGC CCCGGTCCTG GCGGCGGCGG CGGCAGCAGC 
GGCGGTGCCG GGGCACTCAG CGCTGCGGGG GTAATCCGGG TGCCGGCACA CAGGCCGCTC 
GCCGGAGCCG TGGCCCACCC CCAGCCCCTG GCCACCGGCT TGCCCACCGT GCCCTCTGTG 
CCTGCCATGC CGGGCGTCAA CAACCTCACT GGCCTCACCT TCCCCTGGAT GGAGAGTAAC 
CGCAGATACA CAAAGGACAG GTTCACAGTG GCCCTCTCAC CCTTCACTGT AACACGCCGT 
ATAGGTCACC CCTATCAGAA CCGGACGCCC CCCAAGAAGA AGAAGCCGCG CACGTCCTTC 
ACACGCCTGC AGATCTGCGA GCTGGAGAAG CGCTTCCACC GCCAGAAGTA CCTGGCCTCG 
GCCGAGCGCG CCGCCCTGGC CAAGGCGCTC AAAATGACCG ATGCGCAGGT CAAAACCTGG 
TTCCAGAACC GGCGGACAAA GTGGAGACGG CAGACTGCGG AGGAACGGGA GGCCGAGAGG 
CAGCAAGCGA ACCGCATCCT CCTGCAGTTG CAGCAGGAGG CCTTCCAGAA GAGCCTGGCA 
CAGCCGCTGC CCGCTGACCC TCTGTGCGTG CACAACTCGT CGCTCTTCGC CCTGCAGAAT 
CTGCAGCCGT GGTCTGACGA CTCGACCAAA ATCACTAGCG TCACGTCGGT GGCGTCGGCC 
TGCGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011538046.1
CDS	755..1783
Translation	MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGGGSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGGGSSGGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESNRRYTKDRFTVALSPFTVTRRIGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQKSLAQPLPADPLCVHNSSLFALQNLQPWSDDSTKITSVTSVASACE

Target ORF information:

RefSeq Version	XM_011539744.2
Organism	Homo sapiens(human)
Definition	Homo sapiens T-cell leukemia homeobox 1 (TLX1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011539744.2

ORF Insert Sequence:

ATGGAGCACC TGGGTCCGCA CCACCTCCAC CCGGGTCACG CAGAGCCCAT TAGCTTCGGC 
ATCGACCAGA TCCTCAACAG CCCGGACCAG GGTGGCTGCA TGGGACCCGC CTCGCGCCTC 
CAGGACGGAG AATACGGCCT TGGCTGCTTG GTCGGAGGCG CCTACACTTA CGGCGGCGGG 
GGCTCCGCGG CCGCGACGGG GGCTGGAGGA GCGGGGGCCT ATGGTACTGG AGGTCCCGGC 
GGCCCCGGAG GCCCGGCAGG CGGCGGCGGC GCCTGCAGCA TGGGTCCTCT GACCGGCTCC 
TACAACGTGA ACATGGCCTT GGCAGGCGGC CCCGGTCCTG GCGGCGGCGG CGGCAGCAGC 
GGCGGTGCCG GGGCACTCAG CGCTGCGGGG GTAATCCGGG TGCCGGCACA CAGGCCGCTC 
GCCGGAGCCG TGGCCCACCC CCAGCCCCTG GCCACCGGCT TGCCCACCGT GCCCTCTGTG 
CCTGCCATGC CGGGCGTCAA CAACCTCACT GGCCTCACCT TCCCCTGGAT GGAGAGTAAC 
CGCAGATACA CAAAGGACAG GTTCACAGTG GCCCTCTCAC CCTTCACTGT AACACGCCGT 
ATAGGTCACC CCTATCAGAA CCGGACGCCC CCCAAGAAGA AGAAGCCGCG CACGTCCTTC 
ACACGCCTGC AGATCTGCGA GCTGGAGAAG CGCTTCCACC GCCAGAAGTA CCTGGCCTCG 
GCCGAGCGCG CCGCCCTGGC CAAGGCGCTC AAAATGACCG ATGCGCAGGT CAAAACCTGG 
TTCCAGAACC GGCGGACAAA GTGGAGACGG CAGACTGCGG AGGAACGGGA GGCCGAGAGG 
CAGCAAGCGA ACCGCATCCT CCTGCAGTTG CAGCAGGAGG CCTTCCAGAA GAGCCTGGCA 
CAGCCGCTGC CCGCTGACCC TCTGTGCGTG CACAACTCGT CGCTCTTCGC CCTGCAGAAT 
CTGCAGCCGT GGTCTGACGA CTCGACCAAA ATCACTAGCG TCACGTCGGT GGCGTCGGCC 
TGCGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TLX1 ( XM_011539745.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011538047.1 Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu58296
Clone ID Related Accession (Same CDS sequence)	XM_011539745.3 , XM_011539745.2
Accession Version	XM_011539745.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	T-cell leukemia homeobox protein 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011539745.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCACC TGGGTCCGCA CCACCTCCAC CCGGGTCACG CAGAGCCCAT TAGCTTCGGC 
ATCGACCAGA TCCTCAACAG CCCGGACCAG GGTGGCTGCA TGGGACCCGC CTCGCGCCTC 
CAGGACGGAG AATACGGCCT TGGCTGCTTG GTCGGAGGCG CCTACACTTA CGGCGGCGGG 
GGCTCCGCGG CCGCGACGGG GGCTGGAGGA GCGGGGGCCT ATGGTACTGG AGGTCCCGGC 
GGCCCCGGAG GCCCGGCAGG CGGCGGCGGC GCCTGCAGCA TGGGTCCTCT GACCGGCTCC 
TACAACGTGA ACATGGCCTT GGCAGGCGGC CCCGGTCCTG GCGGCGGCGG CGGCAGCAGC 
GGCGGTGCCG GGGCACTCAG CGCTGCGGGG GTAATCCGGG TGCCGGCACA CAGGCCGCTC 
GCCGGAGCCG TGGCCCACCC CCAGCCCCTG GCCACCGGCT TGCCCACCGT GCCCTCTGTG 
CCTGCCATGC CGGGCGTCAA CAACCTCACT GGCCTCACCT TCCCCTGGAT GGAGAGTAAC 
CGCAGATACA CAAAGGACAG GTTCACAGTG GCCCTCTCAC CCTTCACTGT AACACGCCGT 
ATAGGTCACC CCTATCAGAA CCGGACGCCC CCCAAGAAGA AGAAGCCGCG CACGTCCTTC 
ACACGCCTGC AGATCTGCGA GCTGGAGAAG CGCTTCCACC GCCAGAAGTA CCTGGCCTCG 
GCCGAGCGCG CCGCCCTGGC CAAGGCGCTC AAAATGACCG ATGCGCAGGT CAAAACCTGG 
TTCCAGAACC GGCGGACAAA GTGGAGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011538047.1
CDS	770..1579
Translation	MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGGGSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGGGSSGGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESNRRYTKDRFTVALSPFTVTRRIGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWR

Target ORF information:

RefSeq Version	XM_011539745.3
Organism	Homo sapiens(human)
Definition	Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011539745.3

ORF Insert Sequence:

ATGGAGCACC TGGGTCCGCA CCACCTCCAC CCGGGTCACG CAGAGCCCAT TAGCTTCGGC 
ATCGACCAGA TCCTCAACAG CCCGGACCAG GGTGGCTGCA TGGGACCCGC CTCGCGCCTC 
CAGGACGGAG AATACGGCCT TGGCTGCTTG GTCGGAGGCG CCTACACTTA CGGCGGCGGG 
GGCTCCGCGG CCGCGACGGG GGCTGGAGGA GCGGGGGCCT ATGGTACTGG AGGTCCCGGC 
GGCCCCGGAG GCCCGGCAGG CGGCGGCGGC GCCTGCAGCA TGGGTCCTCT GACCGGCTCC 
TACAACGTGA ACATGGCCTT GGCAGGCGGC CCCGGTCCTG GCGGCGGCGG CGGCAGCAGC 
GGCGGTGCCG GGGCACTCAG CGCTGCGGGG GTAATCCGGG TGCCGGCACA CAGGCCGCTC 
GCCGGAGCCG TGGCCCACCC CCAGCCCCTG GCCACCGGCT TGCCCACCGT GCCCTCTGTG 
CCTGCCATGC CGGGCGTCAA CAACCTCACT GGCCTCACCT TCCCCTGGAT GGAGAGTAAC 
CGCAGATACA CAAAGGACAG GTTCACAGTG GCCCTCTCAC CCTTCACTGT AACACGCCGT 
ATAGGTCACC CCTATCAGAA CCGGACGCCC CCCAAGAAGA AGAAGCCGCG CACGTCCTTC 
ACACGCCTGC AGATCTGCGA GCTGGAGAAG CGCTTCCACC GCCAGAAGTA CCTGGCCTCG 
GCCGAGCGCG CCGCCCTGGC CAAGGCGCTC AAAATGACCG ATGCGCAGGT CAAAACCTGG 
TTCCAGAACC GGCGGACAAA GTGGAGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TLX1 ( XM_011539745.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011538047.1 Homo sapiens T-cell leukemia homeobox 1 (TLX1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu58296
Clone ID Related Accession (Same CDS sequence)	XM_011539745.3 , XM_011539745.2
Accession Version	XM_011539745.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	T-cell leukemia homeobox protein 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011539745.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCACC TGGGTCCGCA CCACCTCCAC CCGGGTCACG CAGAGCCCAT TAGCTTCGGC 
ATCGACCAGA TCCTCAACAG CCCGGACCAG GGTGGCTGCA TGGGACCCGC CTCGCGCCTC 
CAGGACGGAG AATACGGCCT TGGCTGCTTG GTCGGAGGCG CCTACACTTA CGGCGGCGGG 
GGCTCCGCGG CCGCGACGGG GGCTGGAGGA GCGGGGGCCT ATGGTACTGG AGGTCCCGGC 
GGCCCCGGAG GCCCGGCAGG CGGCGGCGGC GCCTGCAGCA TGGGTCCTCT GACCGGCTCC 
TACAACGTGA ACATGGCCTT GGCAGGCGGC CCCGGTCCTG GCGGCGGCGG CGGCAGCAGC 
GGCGGTGCCG GGGCACTCAG CGCTGCGGGG GTAATCCGGG TGCCGGCACA CAGGCCGCTC 
GCCGGAGCCG TGGCCCACCC CCAGCCCCTG GCCACCGGCT TGCCCACCGT GCCCTCTGTG 
CCTGCCATGC CGGGCGTCAA CAACCTCACT GGCCTCACCT TCCCCTGGAT GGAGAGTAAC 
CGCAGATACA CAAAGGACAG GTTCACAGTG GCCCTCTCAC CCTTCACTGT AACACGCCGT 
ATAGGTCACC CCTATCAGAA CCGGACGCCC CCCAAGAAGA AGAAGCCGCG CACGTCCTTC 
ACACGCCTGC AGATCTGCGA GCTGGAGAAG CGCTTCCACC GCCAGAAGTA CCTGGCCTCG 
GCCGAGCGCG CCGCCCTGGC CAAGGCGCTC AAAATGACCG ATGCGCAGGT CAAAACCTGG 
TTCCAGAACC GGCGGACAAA GTGGAGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011538047.1
CDS	770..1579
Translation	MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGGGSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGGGSSGGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESNRRYTKDRFTVALSPFTVTRRIGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWR

Target ORF information:

RefSeq Version	XM_011539745.2
Organism	Homo sapiens(human)
Definition	Homo sapiens T-cell leukemia homeobox 1 (TLX1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011539745.2

ORF Insert Sequence:

ATGGAGCACC TGGGTCCGCA CCACCTCCAC CCGGGTCACG CAGAGCCCAT TAGCTTCGGC 
ATCGACCAGA TCCTCAACAG CCCGGACCAG GGTGGCTGCA TGGGACCCGC CTCGCGCCTC 
CAGGACGGAG AATACGGCCT TGGCTGCTTG GTCGGAGGCG CCTACACTTA CGGCGGCGGG 
GGCTCCGCGG CCGCGACGGG GGCTGGAGGA GCGGGGGCCT ATGGTACTGG AGGTCCCGGC 
GGCCCCGGAG GCCCGGCAGG CGGCGGCGGC GCCTGCAGCA TGGGTCCTCT GACCGGCTCC 
TACAACGTGA ACATGGCCTT GGCAGGCGGC CCCGGTCCTG GCGGCGGCGG CGGCAGCAGC 
GGCGGTGCCG GGGCACTCAG CGCTGCGGGG GTAATCCGGG TGCCGGCACA CAGGCCGCTC 
GCCGGAGCCG TGGCCCACCC CCAGCCCCTG GCCACCGGCT TGCCCACCGT GCCCTCTGTG 
CCTGCCATGC CGGGCGTCAA CAACCTCACT GGCCTCACCT TCCCCTGGAT GGAGAGTAAC 
CGCAGATACA CAAAGGACAG GTTCACAGTG GCCCTCTCAC CCTTCACTGT AACACGCCGT 
ATAGGTCACC CCTATCAGAA CCGGACGCCC CCCAAGAAGA AGAAGCCGCG CACGTCCTTC 
ACACGCCTGC AGATCTGCGA GCTGGAGAAG CGCTTCCACC GCCAGAAGTA CCTGGCCTCG 
GCCGAGCGCG CCGCCCTGGC CAAGGCGCTC AAAATGACCG ATGCGCAGGT CAAAACCTGG 
TTCCAGAACC GGCGGACAAA GTGGAGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased methylation and decreased expression of homeobox genes TLX1, HOXA10 and DLX5 in human placenta are associated with trophoblast differentiation.
Scientific reports7(1)4523(2017 Jul)
Novakovic B,Fournier T,Harris LK,James J,Roberts CT,Yong HEJ,Kalionis B,Evain-Brion D,Ebeling PR,Wallace EM,Saffery R,Murthi P

Genome-wide methylation analysis identifies a core set of hypermethylated genes in CIMP-H colorectal cancer.
BMC cancer17(1)228(2017 03)
McInnes T,Zou D,Rao DS,Munro FM,Phillips VL,McCall JL,Black MA,Reeve AE,Guilford PJ

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TLX1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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