ERVW-1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ERVW-1
Entrez Gene ID	30816
Full Name	endogenous retrovirus group W member 1, envelope
Synonyms	ENV,ENVW,ERVWE1,HERV-7q,HERV-W-ENV,HERV7Q,HERVW,HERVWENV
General protein information	Preferred Names endogenous retrovirus group W member 1, envelope Names syncytin-1 HERV-7q envelope protein HERV-W Env glycoprotein HERV-W envelope protein HERV-W_7q21.2 provirus ancestral Env polyprotein HERV-tryptophan envelope protein endogenous retroviral family W, env(C7), member 1 endogenous retrovirus group W member 1 envelope glycoprotein envelope polyprotein gPr73 enverin human endogenous retrovirus W envC7-1 envelope protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q21.2
Summary	Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010].
Disorder MIM:	604659

mRNA and Protein(s)

mRNA	Protein	Name
NM_001130925.2	NP_001124397.1	syncytin-1 precursor
NM_001130925.1	NP_001124397.1	syncytin-1 precursor
NM_014590.3	NP_055405.3	syncytin-1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	ERVW-1	NP_055405.3
Canis lupus familiaris (dog)	LOC102154491	XP_005642153.1

Gene Ontology
Bibliography

Related articles in PubMed

Osteoclast Fusion: Time-Lapse Reveals Involvement of CD47 and Syncytin-1 at Different Stages of Nuclearity.
M?ller AM, Delaiss? JM, S?e K
Journal of cellular physiology232(6)1396-1403(2017 Jun)

Human endogenous retrovirus W env increases nitric oxide production and enhances the migration ability of microglia by regulating the expression of inducible nitric oxide synthase.
Xiao R, Li S, Cao Q, Wang X, Yan Q, Tu X, Zhu Y, Zhu F
Virologica Sinica32(3)216-225(2017 Jun)

ERVW-1 gene polymorphisms related to preeclampsia.
Priscakova P, Konkolova J, Petrovic R, Lipov J, Minarik G, Bohmer D, Repiska V, Gbelcova H
Bratislavske lekarske listy117(6)340-4(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CD47 seems to mediate fusion mostly through broad contact surfaces between the partners' cell membrane while syncytin-1 mediate fusion through phagocytic-cup like structure.
Title: Osteoclast Fusion: Time-Lapse Reveals Involvement of CD47 and Syncytin-1 at Different Stages of Nuclearity.

HERV-W was expressed in demyelinated lesions from multiple sclerosis brains, which were all positive for this endogenous pathogenic protein. Pronounced HERV-W immunoreactivity in active multiple sclerosis lesions was intimately associated with areas of active demyelination throughout the successive stages of lesion evolution in multiple sclerosis brains.
Title: Human endogenous retrovirus W in brain lesions: Rationale for targeted therapy in multiple sclerosis.

ERVWE1, ERVFRDE1 and ERV3 transcription was down-regulated in hydatidiform moles and gestational trophoblastic neoplasia.
Title: Expression patterns of ERVWE1/Syncytin-1 and other placentally expressed human endogenous retroviruses along the malignant transformation process of hydatidiform moles.

Study found no associations between embroynal ERVW-1 polymorphisms and preeclampsia.
Title: ERVW-1 gene polymorphisms related to preeclampsia.

Identification of the two CpG dinucleotides around transcription start site as key epigenetic elements has provided valuable information for further studies on the epigenetic regulation of syncytin-1 in pancreatic cancer cells
Title: Promoter Hypermethylation and Decreased Expression of Syncytin-1 in Pancreatic Adenocarcinomas.

The following ERVW-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ERVW-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13527	NM_014590.3 Latest version!	Homo sapiens endogenous retrovirus group W member 1, envelope (ERVW-1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu13527	NM_001130925.2 Latest version!	Homo sapiens endogenous retrovirus group W member 1, envelope (ERVW-1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu13527	NM_001130925.1	Homo sapiens endogenous retrovirus group W member 1, envelope (ERVW-1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ERVW-1 ( NM_001130925.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001124397.1 Homo sapiens endogenous retrovirus group W member 1, envelope (ERVW-1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13527
Clone ID Related Accession (Same CDS sequence)	NM_001130925.2 , NM_001130925.1 , NM_014590.3
Accession Version	NM_001130925.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1617bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	syncytin-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007566.2, AF072506.2 and BC137381.1. On Nov 22, 2018 this sequence version replaced NM_001130925.1. Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## endogenous retrovirus :: PMID: 10693809 MANE Ensembl match :: ENST00000603053.2/ ENSP00000474984.1 RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCTCC CTTATCATAT TTTTCTCTTT ACTGTTCTTT TACCCTCTTT CACTCTCACT 
GCACCCCCTC CATGCCGCTG TATGACCAGT AGCTCCCCTT ACCAAGAGTT TCTATGGAGA 
ATGCAGCGTC CCGGAAATAT TGATGCCCCA TCGTATAGGA GTCTTTCTAA GGGAACCCCC 
ACCTTCACTG CCCACACCCA TATGCCCCGC AACTGCTATC ACTCTGCCAC TCTTTGCATG 
CATGCAAATA CTCATTATTG GACAGGAAAA ATGATTAATC CTAGTTGTCC TGGAGGACTT 
GGAGTCACTG TCTGTTGGAC TTACTTCACC CAAACTGGTA TGTCTGATGG GGGTGGAGTT 
CAAGATCAGG CAAGAGAAAA ACATGTAAAA GAAGTAATCT CCCAACTCAC CCGGGTACAT 
GGCACCTCTA GCCCCTACAA AGGACTAGAT CTCTCAAAAC TACATGAAAC CCTCCGTACC 
CATACTCGCC TGGTAAGCCT ATTTAATACC ACCCTCACTG GGCTCCATGA GGTCTCGGCC 
CAAAACCCTA CTAACTGTTG GATATGCCTC CCCCTGAACT TCAGGCCATA TGTTTCAATC 
CCTGTACCTG AACAATGGAA CAACTTCAGC ACAGAAATAA ACACCACTTC CGTTTTAGTA 
GGACCTCTTG TTTCCAATCT GGAAATAACC CATACCTCAA ACCTCACCTG TGTAAAATTT 
AGCAATACTA CATACACAAC CAACTCCCAA TGCATCAGGT GGGTAACTCC TCCCACACAA 
ATAGTCTGCC TACCCTCAGG AATATTTTTT GTCTGTGGTA CCTCAGCCTA TCGTTGTTTG 
AATGGCTCTT CAGAATCTAT GTGCTTCCTC TCATTCTTAG TGCCCCCTAT GACCATCTAC 
ACTGAACAAG ATTTATACAG TTATGTCATA TCTAAGCCCC GCAACAAAAG AGTACCCATT 
CTTCCTTTTG TTATAGGAGC AGGAGTGCTA GGTGCACTAG GTACTGGCAT TGGCGGTATC 
ACAACCTCTA CTCAGTTCTA CTACAAACTA TCTCAAGAAC TAAATGGGGA CATGGAACGG 
GTCGCCGACT CCCTGGTCAC CTTGCAAGAT CAACTTAACT CCCTAGCAGC AGTAGTCCTT 
CAAAATCGAA GAGCTTTAGA CTTGCTAACC GCTGAAAGAG GGGGAACCTG TTTATTTTTA 
GGGGAAGAAT GCTGTTATTA TGTTAATCAA TCCGGAATCG TCACTGAGAA AGTTAAAGAA 
ATTCGAGATC GAATACAACG TAGAGCAGAG GAGCTTCGAA ACACTGGACC CTGGGGCCTC 
CTCAGCCAAT GGATGCCCTG GATTCTCCCC TTCTTAGGAC CTCTAGCAGC TATAATATTG 
CTACTCCTCT TTGGACCCTG TATCTTTAAC CTCCTTGTTA ACTTTGTCTC TTCCAGAATC 
GAAGCTGTAA AACTACAAAT GGAGCCCAAG ATGCAGTCCA AGACTAAGAT CTACCGCAGA 
CCCCTGGACC GGCCTGCTAG CCCACGATCT GATGTTAATG ACATCAAAGG CACCCCTCCT 
GAGGAAATCT CAGCTGCACA ACCTCTACTA CGCCCCAATT CAGCAGGAAG CAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001124397.1
CDS	793..2409
Translation	MALPYHIFLFTVLLPSFTLTAPPPCRCMTSSSPYQEFLWRMQRPGNIDAPSYRSLSKGTPTFTAHTHMPRNCYHSATLCMHANTHYWTGKMINPSCPGGLGVTVCWTYFTQTGMSDGGGVQDQAREKHVKEVISQLTRVHGTSSPYKGLDLSKLHETLRTHTRLVSLFNTTLTGLHEVSAQNPTNCWICLPLNFRPYVSIPVPEQWNNFSTEINTTSVLVGPLVSNLEITHTSNLTCVKFSNTTYTTNSQCIRWVTPPTQIVCLPSGIFFVCGTSAYRCLNGSSESMCFLSFLVPPMTIYTEQDLYSYVISKPRNKRVPILPFVIGAGVLGALGTGIGGITTSTQFYYKLSQELNGDMERVADSLVTLQDQLNSLAAVVLQNRRALDLLTAERGGTCLFLGEECCYYVNQSGIVTEKVKEIRDRIQRRAEELRNTGPWGLLSQWMPWILPFLGPLAAIILLLLFGPCIFNLLVNFVSSRIEAVKLQMEPKMQSKTKIYRRPLDRPASPRSDVNDIKGTPPEEISAAQPLLRPNSAGSS

Target ORF information:

RefSeq Version	NM_001130925.2
Organism	Homo sapiens(human)
Definition	Homo sapiens endogenous retrovirus group W member 1, envelope (ERVW-1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001130925.2

ORF Insert Sequence:

ATGGCCCTCC CTTATCATAT TTTTCTCTTT ACTGTTCTTT TACCCTCTTT CACTCTCACT 
GCACCCCCTC CATGCCGCTG TATGACCAGT AGCTCCCCTT ACCAAGAGTT TCTATGGAGA 
ATGCAGCGTC CCGGAAATAT TGATGCCCCA TCGTATAGGA GTCTTTCTAA GGGAACCCCC 
ACCTTCACTG CCCACACCCA TATGCCCCGC AACTGCTATC ACTCTGCCAC TCTTTGCATG 
CATGCAAATA CTCATTATTG GACAGGAAAA ATGATTAATC CTAGTTGTCC TGGAGGACTT 
GGAGTCACTG TCTGTTGGAC TTACTTCACC CAAACTGGTA TGTCTGATGG GGGTGGAGTT 
CAAGATCAGG CAAGAGAAAA ACATGTAAAA GAAGTAATCT CCCAACTCAC CCGGGTACAT 
GGCACCTCTA GCCCCTACAA AGGACTAGAT CTCTCAAAAC TACATGAAAC CCTCCGTACC 
CATACTCGCC TGGTAAGCCT ATTTAATACC ACCCTCACTG GGCTCCATGA GGTCTCGGCC 
CAAAACCCTA CTAACTGTTG GATATGCCTC CCCCTGAACT TCAGGCCATA TGTTTCAATC 
CCTGTACCTG AACAATGGAA CAACTTCAGC ACAGAAATAA ACACCACTTC CGTTTTAGTA 
GGACCTCTTG TTTCCAATCT GGAAATAACC CATACCTCAA ACCTCACCTG TGTAAAATTT 
AGCAATACTA CATACACAAC CAACTCCCAA TGCATCAGGT GGGTAACTCC TCCCACACAA 
ATAGTCTGCC TACCCTCAGG AATATTTTTT GTCTGTGGTA CCTCAGCCTA TCGTTGTTTG 
AATGGCTCTT CAGAATCTAT GTGCTTCCTC TCATTCTTAG TGCCCCCTAT GACCATCTAC 
ACTGAACAAG ATTTATACAG TTATGTCATA TCTAAGCCCC GCAACAAAAG AGTACCCATT 
CTTCCTTTTG TTATAGGAGC AGGAGTGCTA GGTGCACTAG GTACTGGCAT TGGCGGTATC 
ACAACCTCTA CTCAGTTCTA CTACAAACTA TCTCAAGAAC TAAATGGGGA CATGGAACGG 
GTCGCCGACT CCCTGGTCAC CTTGCAAGAT CAACTTAACT CCCTAGCAGC AGTAGTCCTT 
CAAAATCGAA GAGCTTTAGA CTTGCTAACC GCTGAAAGAG GGGGAACCTG TTTATTTTTA 
GGGGAAGAAT GCTGTTATTA TGTTAATCAA TCCGGAATCG TCACTGAGAA AGTTAAAGAA 
ATTCGAGATC GAATACAACG TAGAGCAGAG GAGCTTCGAA ACACTGGACC CTGGGGCCTC 
CTCAGCCAAT GGATGCCCTG GATTCTCCCC TTCTTAGGAC CTCTAGCAGC TATAATATTG 
CTACTCCTCT TTGGACCCTG TATCTTTAAC CTCCTTGTTA ACTTTGTCTC TTCCAGAATC 
GAAGCTGTAA AACTACAAAT GGAGCCCAAG ATGCAGTCCA AGACTAAGAT CTACCGCAGA 
CCCCTGGACC GGCCTGCTAG CCCACGATCT GATGTTAATG ACATCAAAGG CACCCCTCCT 
GAGGAAATCT CAGCTGCACA ACCTCTACTA CGCCCCAATT CAGCAGGAAG CAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ERVW-1 ( NM_001130925.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001124397.1 Homo sapiens endogenous retrovirus group W member 1, envelope (ERVW-1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13527
Clone ID Related Accession (Same CDS sequence)	NM_001130925.2 , NM_001130925.1 , NM_014590.3
Accession Version	NM_001130925.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1617bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-27
Organism	Homo sapiens(human)
Product	syncytin-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF072506.2 and BC137381.1. Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## endogenous retrovirus :: PMID: 10693809 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCTCC CTTATCATAT TTTTCTCTTT ACTGTTCTTT TACCCTCTTT CACTCTCACT 
GCACCCCCTC CATGCCGCTG TATGACCAGT AGCTCCCCTT ACCAAGAGTT TCTATGGAGA 
ATGCAGCGTC CCGGAAATAT TGATGCCCCA TCGTATAGGA GTCTTTCTAA GGGAACCCCC 
ACCTTCACTG CCCACACCCA TATGCCCCGC AACTGCTATC ACTCTGCCAC TCTTTGCATG 
CATGCAAATA CTCATTATTG GACAGGAAAA ATGATTAATC CTAGTTGTCC TGGAGGACTT 
GGAGTCACTG TCTGTTGGAC TTACTTCACC CAAACTGGTA TGTCTGATGG GGGTGGAGTT 
CAAGATCAGG CAAGAGAAAA ACATGTAAAA GAAGTAATCT CCCAACTCAC CCGGGTACAT 
GGCACCTCTA GCCCCTACAA AGGACTAGAT CTCTCAAAAC TACATGAAAC CCTCCGTACC 
CATACTCGCC TGGTAAGCCT ATTTAATACC ACCCTCACTG GGCTCCATGA GGTCTCGGCC 
CAAAACCCTA CTAACTGTTG GATATGCCTC CCCCTGAACT TCAGGCCATA TGTTTCAATC 
CCTGTACCTG AACAATGGAA CAACTTCAGC ACAGAAATAA ACACCACTTC CGTTTTAGTA 
GGACCTCTTG TTTCCAATCT GGAAATAACC CATACCTCAA ACCTCACCTG TGTAAAATTT 
AGCAATACTA CATACACAAC CAACTCCCAA TGCATCAGGT GGGTAACTCC TCCCACACAA 
ATAGTCTGCC TACCCTCAGG AATATTTTTT GTCTGTGGTA CCTCAGCCTA TCGTTGTTTG 
AATGGCTCTT CAGAATCTAT GTGCTTCCTC TCATTCTTAG TGCCCCCTAT GACCATCTAC 
ACTGAACAAG ATTTATACAG TTATGTCATA TCTAAGCCCC GCAACAAAAG AGTACCCATT 
CTTCCTTTTG TTATAGGAGC AGGAGTGCTA GGTGCACTAG GTACTGGCAT TGGCGGTATC 
ACAACCTCTA CTCAGTTCTA CTACAAACTA TCTCAAGAAC TAAATGGGGA CATGGAACGG 
GTCGCCGACT CCCTGGTCAC CTTGCAAGAT CAACTTAACT CCCTAGCAGC AGTAGTCCTT 
CAAAATCGAA GAGCTTTAGA CTTGCTAACC GCTGAAAGAG GGGGAACCTG TTTATTTTTA 
GGGGAAGAAT GCTGTTATTA TGTTAATCAA TCCGGAATCG TCACTGAGAA AGTTAAAGAA 
ATTCGAGATC GAATACAACG TAGAGCAGAG GAGCTTCGAA ACACTGGACC CTGGGGCCTC 
CTCAGCCAAT GGATGCCCTG GATTCTCCCC TTCTTAGGAC CTCTAGCAGC TATAATATTG 
CTACTCCTCT TTGGACCCTG TATCTTTAAC CTCCTTGTTA ACTTTGTCTC TTCCAGAATC 
GAAGCTGTAA AACTACAAAT GGAGCCCAAG ATGCAGTCCA AGACTAAGAT CTACCGCAGA 
CCCCTGGACC GGCCTGCTAG CCCACGATCT GATGTTAATG ACATCAAAGG CACCCCTCCT 
GAGGAAATCT CAGCTGCACA ACCTCTACTA CGCCCCAATT CAGCAGGAAG CAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001124397.1
CDS	762..2378
Translation	MALPYHIFLFTVLLPSFTLTAPPPCRCMTSSSPYQEFLWRMQRPGNIDAPSYRSLSKGTPTFTAHTHMPRNCYHSATLCMHANTHYWTGKMINPSCPGGLGVTVCWTYFTQTGMSDGGGVQDQAREKHVKEVISQLTRVHGTSSPYKGLDLSKLHETLRTHTRLVSLFNTTLTGLHEVSAQNPTNCWICLPLNFRPYVSIPVPEQWNNFSTEINTTSVLVGPLVSNLEITHTSNLTCVKFSNTTYTTNSQCIRWVTPPTQIVCLPSGIFFVCGTSAYRCLNGSSESMCFLSFLVPPMTIYTEQDLYSYVISKPRNKRVPILPFVIGAGVLGALGTGIGGITTSTQFYYKLSQELNGDMERVADSLVTLQDQLNSLAAVVLQNRRALDLLTAERGGTCLFLGEECCYYVNQSGIVTEKVKEIRDRIQRRAEELRNTGPWGLLSQWMPWILPFLGPLAAIILLLLFGPCIFNLLVNFVSSRIEAVKLQMEPKMQSKTKIYRRPLDRPASPRSDVNDIKGTPPEEISAAQPLLRPNSAGSS

Target ORF information:

RefSeq Version	NM_001130925.1
Organism	Homo sapiens(human)
Definition	Homo sapiens endogenous retrovirus group W member 1, envelope (ERVW-1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001130925.1

ORF Insert Sequence:

ATGGCCCTCC CTTATCATAT TTTTCTCTTT ACTGTTCTTT TACCCTCTTT CACTCTCACT 
GCACCCCCTC CATGCCGCTG TATGACCAGT AGCTCCCCTT ACCAAGAGTT TCTATGGAGA 
ATGCAGCGTC CCGGAAATAT TGATGCCCCA TCGTATAGGA GTCTTTCTAA GGGAACCCCC 
ACCTTCACTG CCCACACCCA TATGCCCCGC AACTGCTATC ACTCTGCCAC TCTTTGCATG 
CATGCAAATA CTCATTATTG GACAGGAAAA ATGATTAATC CTAGTTGTCC TGGAGGACTT 
GGAGTCACTG TCTGTTGGAC TTACTTCACC CAAACTGGTA TGTCTGATGG GGGTGGAGTT 
CAAGATCAGG CAAGAGAAAA ACATGTAAAA GAAGTAATCT CCCAACTCAC CCGGGTACAT 
GGCACCTCTA GCCCCTACAA AGGACTAGAT CTCTCAAAAC TACATGAAAC CCTCCGTACC 
CATACTCGCC TGGTAAGCCT ATTTAATACC ACCCTCACTG GGCTCCATGA GGTCTCGGCC 
CAAAACCCTA CTAACTGTTG GATATGCCTC CCCCTGAACT TCAGGCCATA TGTTTCAATC 
CCTGTACCTG AACAATGGAA CAACTTCAGC ACAGAAATAA ACACCACTTC CGTTTTAGTA 
GGACCTCTTG TTTCCAATCT GGAAATAACC CATACCTCAA ACCTCACCTG TGTAAAATTT 
AGCAATACTA CATACACAAC CAACTCCCAA TGCATCAGGT GGGTAACTCC TCCCACACAA 
ATAGTCTGCC TACCCTCAGG AATATTTTTT GTCTGTGGTA CCTCAGCCTA TCGTTGTTTG 
AATGGCTCTT CAGAATCTAT GTGCTTCCTC TCATTCTTAG TGCCCCCTAT GACCATCTAC 
ACTGAACAAG ATTTATACAG TTATGTCATA TCTAAGCCCC GCAACAAAAG AGTACCCATT 
CTTCCTTTTG TTATAGGAGC AGGAGTGCTA GGTGCACTAG GTACTGGCAT TGGCGGTATC 
ACAACCTCTA CTCAGTTCTA CTACAAACTA TCTCAAGAAC TAAATGGGGA CATGGAACGG 
GTCGCCGACT CCCTGGTCAC CTTGCAAGAT CAACTTAACT CCCTAGCAGC AGTAGTCCTT 
CAAAATCGAA GAGCTTTAGA CTTGCTAACC GCTGAAAGAG GGGGAACCTG TTTATTTTTA 
GGGGAAGAAT GCTGTTATTA TGTTAATCAA TCCGGAATCG TCACTGAGAA AGTTAAAGAA 
ATTCGAGATC GAATACAACG TAGAGCAGAG GAGCTTCGAA ACACTGGACC CTGGGGCCTC 
CTCAGCCAAT GGATGCCCTG GATTCTCCCC TTCTTAGGAC CTCTAGCAGC TATAATATTG 
CTACTCCTCT TTGGACCCTG TATCTTTAAC CTCCTTGTTA ACTTTGTCTC TTCCAGAATC 
GAAGCTGTAA AACTACAAAT GGAGCCCAAG ATGCAGTCCA AGACTAAGAT CTACCGCAGA 
CCCCTGGACC GGCCTGCTAG CCCACGATCT GATGTTAATG ACATCAAAGG CACCCCTCCT 
GAGGAAATCT CAGCTGCACA ACCTCTACTA CGCCCCAATT CAGCAGGAAG CAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ERVW-1 ( NM_014590.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055405.3 Homo sapiens endogenous retrovirus group W member 1, envelope (ERVW-1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13527
Clone ID Related Accession (Same CDS sequence)	NM_001130925.2 , NM_001130925.1 , NM_014590.3
Accession Version	NM_014590.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1617bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	syncytin-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG012022.1, AF208161.1, BX391741.1 and BX365066.2. On Jun 18, 2004 this sequence version replaced NM_014590.2. Transcript Variant: This variant (1) represents the longer, unspliced transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## endogenous retrovirus :: PMID: 10693809 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCTCC CTTATCATAT TTTTCTCTTT ACTGTTCTTT TACCCTCTTT CACTCTCACT 
GCACCCCCTC CATGCCGCTG TATGACCAGT AGCTCCCCTT ACCAAGAGTT TCTATGGAGA 
ATGCAGCGTC CCGGAAATAT TGATGCCCCA TCGTATAGGA GTCTTTCTAA GGGAACCCCC 
ACCTTCACTG CCCACACCCA TATGCCCCGC AACTGCTATC ACTCTGCCAC TCTTTGCATG 
CATGCAAATA CTCATTATTG GACAGGAAAA ATGATTAATC CTAGTTGTCC TGGAGGACTT 
GGAGTCACTG TCTGTTGGAC TTACTTCACC CAAACTGGTA TGTCTGATGG GGGTGGAGTT 
CAAGATCAGG CAAGAGAAAA ACATGTAAAA GAAGTAATCT CCCAACTCAC CCGGGTACAT 
GGCACCTCTA GCCCCTACAA AGGACTAGAT CTCTCAAAAC TACATGAAAC CCTCCGTACC 
CATACTCGCC TGGTAAGCCT ATTTAATACC ACCCTCACTG GGCTCCATGA GGTCTCGGCC 
CAAAACCCTA CTAACTGTTG GATATGCCTC CCCCTGAACT TCAGGCCATA TGTTTCAATC 
CCTGTACCTG AACAATGGAA CAACTTCAGC ACAGAAATAA ACACCACTTC CGTTTTAGTA 
GGACCTCTTG TTTCCAATCT GGAAATAACC CATACCTCAA ACCTCACCTG TGTAAAATTT 
AGCAATACTA CATACACAAC CAACTCCCAA TGCATCAGGT GGGTAACTCC TCCCACACAA 
ATAGTCTGCC TACCCTCAGG AATATTTTTT GTCTGTGGTA CCTCAGCCTA TCGTTGTTTG 
AATGGCTCTT CAGAATCTAT GTGCTTCCTC TCATTCTTAG TGCCCCCTAT GACCATCTAC 
ACTGAACAAG ATTTATACAG TTATGTCATA TCTAAGCCCC GCAACAAAAG AGTACCCATT 
CTTCCTTTTG TTATAGGAGC AGGAGTGCTA GGTGCACTAG GTACTGGCAT TGGCGGTATC 
ACAACCTCTA CTCAGTTCTA CTACAAACTA TCTCAAGAAC TAAATGGGGA CATGGAACGG 
GTCGCCGACT CCCTGGTCAC CTTGCAAGAT CAACTTAACT CCCTAGCAGC AGTAGTCCTT 
CAAAATCGAA GAGCTTTAGA CTTGCTAACC GCTGAAAGAG GGGGAACCTG TTTATTTTTA 
GGGGAAGAAT GCTGTTATTA TGTTAATCAA TCCGGAATCG TCACTGAGAA AGTTAAAGAA 
ATTCGAGATC GAATACAACG TAGAGCAGAG GAGCTTCGAA ACACTGGACC CTGGGGCCTC 
CTCAGCCAAT GGATGCCCTG GATTCTCCCC TTCTTAGGAC CTCTAGCAGC TATAATATTG 
CTACTCCTCT TTGGACCCTG TATCTTTAAC CTCCTTGTTA ACTTTGTCTC TTCCAGAATC 
GAAGCTGTAA AACTACAAAT GGAGCCCAAG ATGCAGTCCA AGACTAAGAT CTACCGCAGA 
CCCCTGGACC GGCCTGCTAG CCCACGATCT GATGTTAATG ACATCAAAGG CACCCCTCCT 
GAGGAAATCT CAGCTGCACA ACCTCTACTA CGCCCCAATT CAGCAGGAAG CAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055405.3
CDS	1044..2660
Translation	MALPYHIFLFTVLLPSFTLTAPPPCRCMTSSSPYQEFLWRMQRPGNIDAPSYRSLSKGTPTFTAHTHMPRNCYHSATLCMHANTHYWTGKMINPSCPGGLGVTVCWTYFTQTGMSDGGGVQDQAREKHVKEVISQLTRVHGTSSPYKGLDLSKLHETLRTHTRLVSLFNTTLTGLHEVSAQNPTNCWICLPLNFRPYVSIPVPEQWNNFSTEINTTSVLVGPLVSNLEITHTSNLTCVKFSNTTYTTNSQCIRWVTPPTQIVCLPSGIFFVCGTSAYRCLNGSSESMCFLSFLVPPMTIYTEQDLYSYVISKPRNKRVPILPFVIGAGVLGALGTGIGGITTSTQFYYKLSQELNGDMERVADSLVTLQDQLNSLAAVVLQNRRALDLLTAERGGTCLFLGEECCYYVNQSGIVTEKVKEIRDRIQRRAEELRNTGPWGLLSQWMPWILPFLGPLAAIILLLLFGPCIFNLLVNFVSSRIEAVKLQMEPKMQSKTKIYRRPLDRPASPRSDVNDIKGTPPEEISAAQPLLRPNSAGSS

Target ORF information:

RefSeq Version	NM_014590.3
Organism	Homo sapiens(human)
Definition	Homo sapiens endogenous retrovirus group W member 1, envelope (ERVW-1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014590.3

ORF Insert Sequence:

ATGGCCCTCC CTTATCATAT TTTTCTCTTT ACTGTTCTTT TACCCTCTTT CACTCTCACT 
GCACCCCCTC CATGCCGCTG TATGACCAGT AGCTCCCCTT ACCAAGAGTT TCTATGGAGA 
ATGCAGCGTC CCGGAAATAT TGATGCCCCA TCGTATAGGA GTCTTTCTAA GGGAACCCCC 
ACCTTCACTG CCCACACCCA TATGCCCCGC AACTGCTATC ACTCTGCCAC TCTTTGCATG 
CATGCAAATA CTCATTATTG GACAGGAAAA ATGATTAATC CTAGTTGTCC TGGAGGACTT 
GGAGTCACTG TCTGTTGGAC TTACTTCACC CAAACTGGTA TGTCTGATGG GGGTGGAGTT 
CAAGATCAGG CAAGAGAAAA ACATGTAAAA GAAGTAATCT CCCAACTCAC CCGGGTACAT 
GGCACCTCTA GCCCCTACAA AGGACTAGAT CTCTCAAAAC TACATGAAAC CCTCCGTACC 
CATACTCGCC TGGTAAGCCT ATTTAATACC ACCCTCACTG GGCTCCATGA GGTCTCGGCC 
CAAAACCCTA CTAACTGTTG GATATGCCTC CCCCTGAACT TCAGGCCATA TGTTTCAATC 
CCTGTACCTG AACAATGGAA CAACTTCAGC ACAGAAATAA ACACCACTTC CGTTTTAGTA 
GGACCTCTTG TTTCCAATCT GGAAATAACC CATACCTCAA ACCTCACCTG TGTAAAATTT 
AGCAATACTA CATACACAAC CAACTCCCAA TGCATCAGGT GGGTAACTCC TCCCACACAA 
ATAGTCTGCC TACCCTCAGG AATATTTTTT GTCTGTGGTA CCTCAGCCTA TCGTTGTTTG 
AATGGCTCTT CAGAATCTAT GTGCTTCCTC TCATTCTTAG TGCCCCCTAT GACCATCTAC 
ACTGAACAAG ATTTATACAG TTATGTCATA TCTAAGCCCC GCAACAAAAG AGTACCCATT 
CTTCCTTTTG TTATAGGAGC AGGAGTGCTA GGTGCACTAG GTACTGGCAT TGGCGGTATC 
ACAACCTCTA CTCAGTTCTA CTACAAACTA TCTCAAGAAC TAAATGGGGA CATGGAACGG 
GTCGCCGACT CCCTGGTCAC CTTGCAAGAT CAACTTAACT CCCTAGCAGC AGTAGTCCTT 
CAAAATCGAA GAGCTTTAGA CTTGCTAACC GCTGAAAGAG GGGGAACCTG TTTATTTTTA 
GGGGAAGAAT GCTGTTATTA TGTTAATCAA TCCGGAATCG TCACTGAGAA AGTTAAAGAA 
ATTCGAGATC GAATACAACG TAGAGCAGAG GAGCTTCGAA ACACTGGACC CTGGGGCCTC 
CTCAGCCAAT GGATGCCCTG GATTCTCCCC TTCTTAGGAC CTCTAGCAGC TATAATATTG 
CTACTCCTCT TTGGACCCTG TATCTTTAAC CTCCTTGTTA ACTTTGTCTC TTCCAGAATC 
GAAGCTGTAA AACTACAAAT GGAGCCCAAG ATGCAGTCCA AGACTAAGAT CTACCGCAGA 
CCCCTGGACC GGCCTGCTAG CCCACGATCT GATGTTAATG ACATCAAAGG CACCCCTCCT 
GAGGAAATCT CAGCTGCACA ACCTCTACTA CGCCCCAATT CAGCAGGAAG CAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Osteoclast Fusion: Time-Lapse Reveals Involvement of CD47 and Syncytin-1 at Different Stages of Nuclearity.
Journal of cellular physiology232(6)1396-1403(2017 Jun)
M?ller AM,Delaiss? JM,S?e K

Human endogenous retrovirus W env increases nitric oxide production and enhances the migration ability of microglia by regulating the expression of inducible nitric oxide synthase.
Virologica Sinica32(3)216-225(2017 Jun)
Xiao R,Li S,Cao Q,Wang X,Yan Q,Tu X,Zhu Y,Zhu F

ERVW-1 gene polymorphisms related to preeclampsia.
Bratislavske lekarske listy117(6)340-4(2016)
Priscakova P,Konkolova J,Petrovic R,Lipov J,Minarik G,Bohmer D,Repiska V,Gbelcova H

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

ERVW-1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報