HIST1H1C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HIST1H1C
Entrez Gene ID	3006
Full Name	histone cluster 1 H1 family member c
Synonyms	H1.2,H1C,H1F2,H1s-1
General protein information	Preferred Names histone cluster 1 H1 family member c Names histone H1.2 H1 histone family, member 2 histone 1, H1c histone H1c histone H1d histone H1s-1 histone cluster 1, H1c
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.2
Summary	Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015].
Disorder MIM:	142710

mRNA and Protein(s)

mRNA	Protein	Name
NM_005319.4	NP_005310.1	histone H1.2
NM_005319.3	NP_005310.1	histone H1.2

Pathways from BioSystems

Homologies

	LOC696005	XP_001084417.1
Mus musculus (house mouse)	Hist1h1c	NP_056601.1
Pan troglodytes (chimpanzee)	HIST1H1C	XP_001172525.1
Homo sapiens (human)	HIST1H1C	NP_005310.1

Gene Ontology
Bibliography

Related articles in PubMed

The linker histone H1.2 is a novel component of the nucleolar organizer regions.
Chen J, Teo BHD, Cai Y, Wee SYK, Lu J
The Journal of biological chemistry(2018 Jan)

Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function.
Munro S, Hookway ES, Floderer M, Carr SM, Konietzny R, Kessler BM, Oppermann U, La Thangue NB
Cell reports19(11)2193-2201(2017 Jun)

Histone HIST1H1C/H1.2 regulates autophagy in the development of diabetic retinopathy.
Wang W, Wang Q, Wan D, Sun Y, Wang L, Chen H, Liu C, Petersen RB, Li J, Xue W, Zheng L, Huang K
Autophagy13(5)941-954(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

BRG1 participates in gene repression by interacting with H1.2, facilitating its deposition and stabilizing nucleosome positioning around the transcription start site.
Title: Hormone-induced repression of genes requires BRG1-mediated H1.2 deposition at target promoters.

Results show that histones H1.2 and H1.4 were observed in MDA-MB-231 metastatic breast cancer cells. The phosphorylation at S173 of histone H1.2 and S172, S187, T18, T146, and T154 of H1.4 significantly increases during M phase suggesting that these events are cell cycle-dependent. Also, the study reports the observation of the H1.2 SNP variant A18V in MCF-10A cells.
Title: Quantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical Dependence.

Histone H1.2-T165 post translational modifications are dispensable for chromatin binding and cell proliferation while the H1.4-K26 modifications are essential for proper cell cycle progression.
Title: Dynamics and dispensability of variant-specific histone H1 Lys-26/Ser-27 and Thr-165 post-translational modifications.

H1.2 is less abundant than other histone H1 variants at the transcription start sites of inactive genes, and promoters enriched in H1.2 are different from those enriched in other histone H1 variants and tend to be repressed.
Title: Mapping of six somatic linker histone H1 variants in human breast cancer cells uncovers specific features of H1.2.

Integration with apoptotic intermediates (via C-terminal tail interactions) may constitute a more generalized function of linker histone isoforms in apoptotic cascades.
Title: The C-terminal domain (CTD) in linker histones antagonizes anti-apoptotic proteins to modulate apoptotic outcomes at the mitochondrion.

The following HIST1H1C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HIST1H1C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23934	NM_005319.4 Latest version!	Homo sapiens H1.2 linker histone, cluster member (H1-2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu23934	NM_005319.3	Homo sapiens histone cluster 1 H1 family member c (HIST1H1C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HIST1H1C ( NM_005319.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005310.1 Homo sapiens H1.2 linker histone, cluster member (H1-2), mRNA.

Price & Availability↑

CloneID	OHu23934
Clone ID Related Accession (Same CDS sequence)	NM_005319.4 , NM_005319.3
Accession Version	NM_005319.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	histone H1.2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U91328.1. On Dec 3, 2019 this sequence version replaced NM_005319.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK290947.1, CK126083.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCGAGA CTGCTCCTGC CGCTCCCGCT GCCGCGCCTC CTGCGGAGAA GGCCCCTGTA 
AAGAAGAAGG CGGCCAAAAA GGCTGGGGGT ACGCCTCGTA AGGCGTCTGG TCCCCCGGTG 
TCAGAGCTCA TCACCAAGGC TGTGGCCGCC TCTAAAGAGC GTAGCGGAGT TTCTCTGGCT 
GCTCTGAAAA AAGCGTTGGC TGCCGCCGGC TATGATGTGG AGAAAAACAA CAGCCGTATC 
AAACTTGGTC TCAAGAGCCT GGTGAGCAAG GGCACTCTGG TGCAAACGAA AGGCACCGGT 
GCTTCTGGCT CCTTTAAACT CAACAAGAAG GCAGCCTCCG GGGAAGCCAA GCCCAAGGTT 
AAAAAGGCGG GCGGAACCAA ACCTAAGAAG CCAGTTGGGG CAGCCAAGAA GCCCAAGAAG 
GCGGCTGGCG GCGCAACTCC GAAGAAGAGC GCTAAGAAAA CACCGAAGAA AGCGAAGAAG 
CCGGCCGCGG CCACTGTAAC CAAGAAAGTG GCTAAGAGCC CAAAGAAGGC CAAGGTTGCG 
AAGCCCAAGA AAGCTGCCAA AAGTGCTGCT AAGGCTGTGA AGCCCAAGGC CGCTAAGCCC 
AAGGTTGTCA AGCCTAAGAA GGCGGCGCCC AAGAAGAAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005310.1
CDS	43..684
Translation	MSETAPAAPAAAPPAEKAPVKKKAAKKAGGTPRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKVKKAGGTKPKKPVGAAKKPKKAAGGATPKKSAKKTPKKAKKPAAATVTKKVAKSPKKAKVAKPKKAAKSAAKAVKPKAAKPKVVKPKKAAPKKK

Target ORF information:

RefSeq Version	NM_005319.4
Organism	Homo sapiens(human)
Definition	Homo sapiens H1.2 linker histone, cluster member (H1-2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005319.4

ORF Insert Sequence:

ATGTCCGAGA CTGCTCCTGC CGCTCCCGCT GCCGCGCCTC CTGCGGAGAA GGCCCCTGTA 
AAGAAGAAGG CGGCCAAAAA GGCTGGGGGT ACGCCTCGTA AGGCGTCTGG TCCCCCGGTG 
TCAGAGCTCA TCACCAAGGC TGTGGCCGCC TCTAAAGAGC GTAGCGGAGT TTCTCTGGCT 
GCTCTGAAAA AAGCGTTGGC TGCCGCCGGC TATGATGTGG AGAAAAACAA CAGCCGTATC 
AAACTTGGTC TCAAGAGCCT GGTGAGCAAG GGCACTCTGG TGCAAACGAA AGGCACCGGT 
GCTTCTGGCT CCTTTAAACT CAACAAGAAG GCAGCCTCCG GGGAAGCCAA GCCCAAGGTT 
AAAAAGGCGG GCGGAACCAA ACCTAAGAAG CCAGTTGGGG CAGCCAAGAA GCCCAAGAAG 
GCGGCTGGCG GCGCAACTCC GAAGAAGAGC GCTAAGAAAA CACCGAAGAA AGCGAAGAAG 
CCGGCCGCGG CCACTGTAAC CAAGAAAGTG GCTAAGAGCC CAAAGAAGGC CAAGGTTGCG 
AAGCCCAAGA AAGCTGCCAA AAGTGCTGCT AAGGCTGTGA AGCCCAAGGC CGCTAAGCCC 
AAGGTTGTCA AGCCTAAGAA GGCGGCGCCC AAGAAGAAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HIST1H1C ( NM_005319.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005310.1 Homo sapiens histone cluster 1 H1 family member c (HIST1H1C), mRNA.

Price & Availability↑

CloneID	OHu23934
Clone ID Related Accession (Same CDS sequence)	NM_005319.4 , NM_005319.3
Accession Version	NM_005319.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Homo sapiens(human)
Product	histone H1.2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U91328.1. On May 22, 2002 this sequence version replaced NM_005319.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BU953725.1, CK126083.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCGAGA CTGCTCCTGC CGCTCCCGCT GCCGCGCCTC CTGCGGAGAA GGCCCCTGTA 
AAGAAGAAGG CGGCCAAAAA GGCTGGGGGT ACGCCTCGTA AGGCGTCTGG TCCCCCGGTG 
TCAGAGCTCA TCACCAAGGC TGTGGCCGCC TCTAAAGAGC GTAGCGGAGT TTCTCTGGCT 
GCTCTGAAAA AAGCGTTGGC TGCCGCCGGC TATGATGTGG AGAAAAACAA CAGCCGTATC 
AAACTTGGTC TCAAGAGCCT GGTGAGCAAG GGCACTCTGG TGCAAACGAA AGGCACCGGT 
GCTTCTGGCT CCTTTAAACT CAACAAGAAG GCAGCCTCCG GGGAAGCCAA GCCCAAGGTT 
AAAAAGGCGG GCGGAACCAA ACCTAAGAAG CCAGTTGGGG CAGCCAAGAA GCCCAAGAAG 
GCGGCTGGCG GCGCAACTCC GAAGAAGAGC GCTAAGAAAA CACCGAAGAA AGCGAAGAAG 
CCGGCCGCGG CCACTGTAAC CAAGAAAGTG GCTAAGAGCC CAAAGAAGGC CAAGGTTGCG 
AAGCCCAAGA AAGCTGCCAA AAGTGCTGCT AAGGCTGTGA AGCCCAAGGC CGCTAAGCCC 
AAGGTTGTCA AGCCTAAGAA GGCGGCGCCC AAGAAGAAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005310.1
CDS	44..685
Translation	MSETAPAAPAAAPPAEKAPVKKKAAKKAGGTPRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKVKKAGGTKPKKPVGAAKKPKKAAGGATPKKSAKKTPKKAKKPAAATVTKKVAKSPKKAKVAKPKKAAKSAAKAVKPKAAKPKVVKPKKAAPKKK

Target ORF information:

RefSeq Version	NM_005319.3
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 1 H1 family member c (HIST1H1C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005319.3

ORF Insert Sequence:

ATGTCCGAGA CTGCTCCTGC CGCTCCCGCT GCCGCGCCTC CTGCGGAGAA GGCCCCTGTA 
AAGAAGAAGG CGGCCAAAAA GGCTGGGGGT ACGCCTCGTA AGGCGTCTGG TCCCCCGGTG 
TCAGAGCTCA TCACCAAGGC TGTGGCCGCC TCTAAAGAGC GTAGCGGAGT TTCTCTGGCT 
GCTCTGAAAA AAGCGTTGGC TGCCGCCGGC TATGATGTGG AGAAAAACAA CAGCCGTATC 
AAACTTGGTC TCAAGAGCCT GGTGAGCAAG GGCACTCTGG TGCAAACGAA AGGCACCGGT 
GCTTCTGGCT CCTTTAAACT CAACAAGAAG GCAGCCTCCG GGGAAGCCAA GCCCAAGGTT 
AAAAAGGCGG GCGGAACCAA ACCTAAGAAG CCAGTTGGGG CAGCCAAGAA GCCCAAGAAG 
GCGGCTGGCG GCGCAACTCC GAAGAAGAGC GCTAAGAAAA CACCGAAGAA AGCGAAGAAG 
CCGGCCGCGG CCACTGTAAC CAAGAAAGTG GCTAAGAGCC CAAAGAAGGC CAAGGTTGCG 
AAGCCCAAGA AAGCTGCCAA AAGTGCTGCT AAGGCTGTGA AGCCCAAGGC CGCTAAGCCC 
AAGGTTGTCA AGCCTAAGAA GGCGGCGCCC AAGAAGAAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The linker histone H1.2 is a novel component of the nucleolar organizer regions.
The Journal of biological chemistry(2018 Jan)
Chen J,Teo BHD,Cai Y,Wee SYK,Lu J

Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function.
Cell reports19(11)2193-2201(2017 Jun)
Munro S,Hookway ES,Floderer M,Carr SM,Konietzny R,Kessler BM,Oppermann U,La Thangue NB

Histone HIST1H1C/H1.2 regulates autophagy in the development of diabetic retinopathy.
Autophagy13(5)941-954(2017 May)
Wang W,Wang Q,Wan D,Sun Y,Wang L,Chen H,Liu C,Petersen RB,Li J,Xue W,Zheng L,Huang K

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

HIST1H1C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報