GSC2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GSC2
Entrez Gene ID	2928
Full Name	goosecoid homeobox 2
Synonyms	GSCL
General protein information	Preferred Names goosecoid homeobox 2 Names homeobox protein goosecoid-2 GSC-2 GSC-L
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q11.21
Summary	Goosecoidlike (GSCL), a homeodomain-containing gene, resides in the critical region for VCFS/DGS on 22q11. Velocardiofacial syndrome (VCFS) is a developmental disorder characterized by conotruncal heart defects, craniofacial anomalies, and learning disabilities. VCFS is phenotypically related to DiGeorge syndrome (DGS) and both syndromes are associated with hemizygous 22q11 deletions. Because many of the tissues and structures affected in VCFS/DGS derive from the pharyngeal arches of the developing embryo, it is believed that haploinsufficiency of a gene involved in embryonic development may be responsible for its etiology. The gene is expressed in a limited number of adult tissues, as well as in early human development. [provided by RefSeq, Jul 2008].
Disorder MIM:	601845

mRNA and Protein(s)

mRNA	Protein	Name
NM_005315.1	NP_005306.1	homeobox protein goosecoid-2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Gsc2	NP_083745.1
Xenopus tropicalis (tropical clawed frog)	gsc2	XP_004911426.1
	LOC719051	XP_001112633.2
Rattus norvegicus (Norway rat)	Gsc2	NP_001102316.1
Danio rerio (zebrafish)	LOC101885810	XP_005171782.1
Homo sapiens (human)	GSC2	NP_005306.1
Gallus gallus (chicken)	GSC2	XP_004934385.1

Gene Ontology
Bibliography

Related articles in PubMed

DNA-binding specificities of human transcription factors.
Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J
Cell152(1-2)327-39(2013 Jan)

Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
Inouye M, Ripatti S, Kettunen J, Lyytik?inen LP, Oksala N, Laurila PP, Kangas AJ, Soininen P, Savolainen MJ, Viikari J, K?h?nen M, Perola M, Salomaa V, Raitakari O, Lehtim?ki T, Taskinen MR, J?rvelin MR, Ala-Korpela M, Palotie A, de Bakker PI
PLoS genetics8(8)e1002907(2012)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

Rnf4, a RING protein expressed in the developing nervous and reproductive systems, interacts with Gscl, a gene within the DiGeorge critical region.
Galili N, Nayak S, Epstein JA, Buck CA
Developmental dynamics : an official publication of the American Association of Anatomists218(1)102-11(2000 May)

Goosecoid-like, a gene deleted in DiGeorge and velocardiofacial syndromes, recognizes DNA with a bicoid-like specificity and is expressed in the developing mouse brain.
Gottlieb S, Hanes SD, Golden JA, Oakey RJ, Budarf ML
Human molecular genetics7(9)1497-505(1998 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GSC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GSC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu31306	NM_005315.1 Latest version!	Homo sapiens goosecoid homeobox 2 (GSC2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GSC2 ( NM_005315.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_005306.1 Homo sapiens goosecoid homeobox 2 (GSC2), mRNA.

Price & Availability↑

CloneID	OHu31306
Clone ID Related Accession (Same CDS sequence)	NM_005315.1
Accession Version	NM_005315.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-04
Organism	Homo sapiens(human)
Product	homeobox protein goosecoid-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U96402.1. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by experimental evidence. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2148093 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCGGCAG CGGCTGGGGG CGCGGCGAGC CGCCGGGGTG CCGGGCGGCC CTGCCCCTTC 
TCCATCGAGC ACATCCTCTC CAGCCTGCCC GAGCGGAGCC TCCCGGCCCG GGCCGCCTGC 
CCACCGCAGC CCGCCGGTCG CCAGAGCCCC GCGAAGCCAG AGGAGCCCGG GGCGCCCGAG 
GCTGCGCCCT GCGCCTGCTG CTGCTGCTGC GGCCCCCGCG CGGCGCCCTG CGGGCCCCCA 
GAGGCGGCCG CCGGGCTGGG CGCTCGTCTG GCGTGGCCGC TGAGGCTGGG ACCGGCGGTG 
CCCTTGTCTC TGGGTGCGCC AGCCGGAGGT TCCGGGGCGC TCCCGGGCGC GGTCGGCCCG 
GGTTCGCAGC GGCGCACGAG GCGCCACCGC ACCATCTTCA GCGAAGAGCA GCTGCAGGCG 
CTCGAGGCGC TTTTCGTGCA GAACCAGTAT CCTGACGTGA GTACGCGCGA GCGCCTGGCC 
GGCCGCATCC GCCTTCGCGA GGAGCGCGTG GAGGTCTGGT TCAAGAACCG CCGGGCCAAA 
TGGCGACACC AGAAGCGCGC GTCGGCTTCC GCGAGGCTCC TGCCCGGCGT CAAGAAGTCC 
CCGAAGGGGA GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005306.1
CDS	1..618
Translation	MAAAAGGAASRRGAGRPCPFSIEHILSSLPERSLPARAACPPQPAGRQSPAKPEEPGAPEAAPCACCCCCGPRAAPCGPPEAAAGLGARLAWPLRLGPAVPLSLGAPAGGSGALPGAVGPGSQRRTRRHRTIFSEEQLQALEALFVQNQYPDVSTRERLAGRIRLREERVEVWFKNRRAKWRHQKRASASARLLPGVKKSPKGSC

Target ORF information:

RefSeq Version	NM_005315.1
Organism	Homo sapiens(human)
Definition	Homo sapiens goosecoid homeobox 2 (GSC2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005315.1

ORF Insert Sequence:

ATGGCGGCAG CGGCTGGGGG CGCGGCGAGC CGCCGGGGTG CCGGGCGGCC CTGCCCCTTC 
TCCATCGAGC ACATCCTCTC CAGCCTGCCC GAGCGGAGCC TCCCGGCCCG GGCCGCCTGC 
CCACCGCAGC CCGCCGGTCG CCAGAGCCCC GCGAAGCCAG AGGAGCCCGG GGCGCCCGAG 
GCTGCGCCCT GCGCCTGCTG CTGCTGCTGC GGCCCCCGCG CGGCGCCCTG CGGGCCCCCA 
GAGGCGGCCG CCGGGCTGGG CGCTCGTCTG GCGTGGCCGC TGAGGCTGGG ACCGGCGGTG 
CCCTTGTCTC TGGGTGCGCC AGCCGGAGGT TCCGGGGCGC TCCCGGGCGC GGTCGGCCCG 
GGTTCGCAGC GGCGCACGAG GCGCCACCGC ACCATCTTCA GCGAAGAGCA GCTGCAGGCG 
CTCGAGGCGC TTTTCGTGCA GAACCAGTAT CCTGACGTGA GTACGCGCGA GCGCCTGGCC 
GGCCGCATCC GCCTTCGCGA GGAGCGCGTG GAGGTCTGGT TCAAGAACCG CCGGGCCAAA 
TGGCGACACC AGAAGCGCGC GTCGGCTTCC GCGAGGCTCC TGCCCGGCGT CAAGAAGTCC 
CCGAAGGGGA GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DNA-binding specificities of human transcription factors.
Cell152(1-2)327-39(2013 Jan)
Jolma A,Yan J,Whitington T,Toivonen J,Nitta KR,Rastas P,Morgunova E,Enge M,Taipale M,Wei G,Palin K,Vaquerizas JM,Vincentelli R,Luscombe NM,Hughes TR,Lemaire P,Ukkonen E,Kivioja T,Taipale J

Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
PLoS genetics8(8)e1002907(2012)
Inouye M,Ripatti S,Kettunen J,Lyytik?inen LP,Oksala N,Laurila PP,Kangas AJ,Soininen P,Savolainen MJ,Viikari J,K?h?nen M,Perola M,Salomaa V,Raitakari O,Lehtim?ki T,Taskinen MR,J?rvelin MR,Ala-Korpela M,Palotie A,de Bakker PI

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

Rnf4, a RING protein expressed in the developing nervous and reproductive systems, interacts with Gscl, a gene within the DiGeorge critical region.
Developmental dynamics : an official publication of the American Association of Anatomists218(1)102-11(2000 May)
Galili N,Nayak S,Epstein JA,Buck CA

Goosecoid-like, a gene deleted in DiGeorge and velocardiofacial syndromes, recognizes DNA with a bicoid-like specificity and is expressed in the developing mouse brain.
Human molecular genetics7(9)1497-505(1998 Sep)
Gottlieb S,Hanes SD,Golden JA,Oakey RJ,Budarf ML

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GSC2 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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