UTS2R cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UTS2R
Entrez Gene ID	2837
Full Name	urotensin 2 receptor
Synonyms	GPR14,UR-2-R,UTR,UTR2
General protein information	Preferred Names urotensin 2 receptor Names urotensin-2 receptor G-protein coupled receptor 14 UR-II-R urotensin II receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q25.3
Disorder MIM:	600896

mRNA and Protein(s)

mRNA	Protein	Name
NM_018949.2	NP_061822.1	urotensin-2 receptor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	UTS2R	NP_001035574.1
Xenopus tropicalis (tropical clawed frog)	LOC100485936	XP_004918483.1
Pan troglodytes (chimpanzee)	UTS2R	XP_001167994.1
	UTS2R	NP_001028066.1
Gallus gallus (chicken)	UTS2R	XP_004946151.1
Danio rerio (zebrafish)	LOC559133	XP_005156379.1
Homo sapiens (human)	UTS2R	NP_061822.1
Mus musculus (house mouse)	Uts2r	NP_663415.1
Canis lupus familiaris (dog)	UTS2R	XP_548799.3
Rattus norvegicus (Norway rat)	Uts2r	NP_065412.1

Gene Ontology
Bibliography

Related articles in PubMed

Urotensin-II Receptor: A Double Identity Receptor Involved in Vasoconstriction and in the Development of Digestive Tract Cancers and other Tumors.
Federico A, Zappavigna S, Dallio M, Misso G, Merlino F, Loguercio C, Novellino E, Grieco P, Caraglia M
Current cancer drug targets17(2)109-121(2017)

Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis.
Coly PM, Perzo N, Le Joncour V, Lecointre C, Schouft MT, Desrues L, Tonon MC, Wurtz O, Gandolfo P, Castel H, Morin F
Autophagy12(12)2344-2362(2016 Dec)

UII/GPR14 is involved in NF-?B-mediated colonic inflammation in vivo and in vitro.
Yang Y, Zhang J, Chen X, Wu T, Xu X, Cao G, Li H, Li Y
Oncology reports36(5)2800-2806(2016 Nov)

Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer.
De Cobelli O, Buonerba C, Terracciano D, Bottero D, Lucarelli G, Bove P, Altieri V, Coman I, Perdon? S, Facchini G, Berretta M, Di Lorenzo G, Grieco P, Novellino E, Franco R, Caraglia M, Manini C, Mirone V, De Placido S, Sonpavde G, Ferro M
Future oncology (London, England)11(22)3091-8(2015 Nov)

Up-regulation of urotensin II and its receptor contributes to human hepatocellular carcinoma growth via activation of the PKC, ERK1/2, and p38 MAPK signaling pathways.
Yu XT, Wang PY, Shi ZM, Dong K, Feng P, Wang HX, Wang XJ
Molecules (Basel, Switzerland)19(12)20768-79(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The role of Urotensin-II receptor in vasoconstriction and in the development of digestive tract cancers
Title: Urotensin-II Receptor: A Double Identity Receptor Involved in Vasoconstriction and in the Development of Digestive Tract Cancers and other Tumors.

ligand-induced activation of the chemokine receptor CXCR4 and the urotensin 2 receptor UTS2R, triggers a marked reduction in the biogenesis of autophagosomes.
Title: Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis.

UII/GPR14 signaling was involved in the DSS-induced colonic inflammation and its inhibition may serve as a potential therapeutic target, which may be associated with the NF-kappaB signaling pathway.
Title: UII/GPR14 is involved in NF-?B-mediated colonic inflammation in vivo and in vitro.

UTII-R expression on biopsy was associated with Gleason upgrading and pathology upstaging in prostate cancer patients.
Title: Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer.

Urotensin II can induce the proliferation of BEL-7402 cells via the urotensin receptor mediated PKC/ERK/p38 MAPK signaling pathways.
Title: Up-regulation of urotensin II and its receptor contributes to human hepatocellular carcinoma growth via activation of the PKC, ERK1/2, and p38 MAPK signaling pathways.

The following UTS2R gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UTS2R cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu58023	NM_018949.2 Latest version!	Homo sapiens urotensin 2 receptor (UTS2R), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UTS2R ( NM_018949.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_061822.1 Homo sapiens urotensin 2 receptor (UTS2R), mRNA.

Price & Availability↑

CloneID	OHu58023
Clone ID Related Accession (Same CDS sequence)	NM_018949.2
Accession Version	NM_018949.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1170bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	urotensin-2 receptor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC136490.1. On Dec 11, 2014 this sequence version replaced NM_018949.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC136490.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCGCTGA CCCCCGAGTC CCCGAGCAGC TTCCCTGGGC TGGCCGCCAC TGGCAGCTCT 
GTGCCGGAGC CGCCTGGCGG CCCCAACGCA ACCCTCAACA GCTCCTGGGC CAGCCCGACC 
GAGCCCAGCT CCCTGGAGGA CCTGGTGGCC ACGGGCACCA TTGGGACTCT GCTGTCGGCC 
ATGGGCGTGG TGGGCGTGGT GGGCAACGCC TACACGCTGG TGGTCACCTG CCGCTCCCTG 
CGTGCGGTGG CCTCCATGTA CGTCTACGTG GTCAACCTGG CGCTGGCCGA CCTGCTGTAC 
CTGCTCAGCA TCCCCTTCAT CGTGGCCACC TACGTCACCA AGGAGTGGCA CTTCGGGGAC 
GTGGGCTGCC GCGTGCTCTT CGGCCTGGAC TTCCTGACCA TGCACGCCAG CATCTTCACG 
CTGACCGTCA TGAGCAGCGA GCGCTACGCT GCGGTGCTGC GGCCGCTGGA CACCGTGCAG 
CGCCCCAAGG GCTACCGCAA GCTGCTGGCG CTGGGCACCT GGCTGCTGGC GCTGCTGCTG 
ACGCTGCCCG TGATGCTGGC CATGCGGCTG GTGCGCCGGG GTCCCAAGAG CCTGTGCCTG 
CCCGCCTGGG GCCCGCGCGC CCACCGCGCC TACCTGACGC TGCTCTTCGC CACCAGCATC 
GCGGGGCCCG GGCTGCTCAT CGGGCTGCTC TACGCGCGCC TGGCCCGCGC CTACCGCCGC 
TCGCAGCGCG CCTCCTTCAA GCGGGCCCGG CGGCCGGGGG CGCGCGCGCT GCGCCTGGTG 
CTGGGCATCG TGCTGCTCTT CTGGGCCTGC TTCCTGCCCT TCTGGCTGTG GCAGCTGCTC 
GCCCAGTACC ACCAGGCCCC GCTGGCGCCG CGGACGGCGC GCATCGTCAA CTACCTGACC 
ACCTGCCTCA CCTACGGCAA CAGCTGCGCC AACCCCTTCC TCTACACGCT GCTCACCAGG 
AACTACCGCG ACCACCTGCG CGGCCGCGTG CGGGGCCCGG GCAGCGGGGG AGGCCGGGGG 
CCCGTTCCCT CCCTGCAGCC CCGCGCCCGC TTCCAGCGCT GTTCGGGCCG CTCCCTGTCT 
TCCTGCAGCC CACAGCCCAC TGACAGCCTC GTGCTGGCCC CAGCGGCCCC GGCCCGACCT 
GCGCCCGAGG GTCCCAGGGC CCCGGCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061822.1
CDS	49..1218
Translation	MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA

Target ORF information:

RefSeq Version	NM_018949.2
Organism	Homo sapiens(human)
Definition	Homo sapiens urotensin 2 receptor (UTS2R), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018949.2

ORF Insert Sequence:

ATGGCGCTGA CCCCCGAGTC CCCGAGCAGC TTCCCTGGGC TGGCCGCCAC TGGCAGCTCT 
GTGCCGGAGC CGCCTGGCGG CCCCAACGCA ACCCTCAACA GCTCCTGGGC CAGCCCGACC 
GAGCCCAGCT CCCTGGAGGA CCTGGTGGCC ACGGGCACCA TTGGGACTCT GCTGTCGGCC 
ATGGGCGTGG TGGGCGTGGT GGGCAACGCC TACACGCTGG TGGTCACCTG CCGCTCCCTG 
CGTGCGGTGG CCTCCATGTA CGTCTACGTG GTCAACCTGG CGCTGGCCGA CCTGCTGTAC 
CTGCTCAGCA TCCCCTTCAT CGTGGCCACC TACGTCACCA AGGAGTGGCA CTTCGGGGAC 
GTGGGCTGCC GCGTGCTCTT CGGCCTGGAC TTCCTGACCA TGCACGCCAG CATCTTCACG 
CTGACCGTCA TGAGCAGCGA GCGCTACGCT GCGGTGCTGC GGCCGCTGGA CACCGTGCAG 
CGCCCCAAGG GCTACCGCAA GCTGCTGGCG CTGGGCACCT GGCTGCTGGC GCTGCTGCTG 
ACGCTGCCCG TGATGCTGGC CATGCGGCTG GTGCGCCGGG GTCCCAAGAG CCTGTGCCTG 
CCCGCCTGGG GCCCGCGCGC CCACCGCGCC TACCTGACGC TGCTCTTCGC CACCAGCATC 
GCGGGGCCCG GGCTGCTCAT CGGGCTGCTC TACGCGCGCC TGGCCCGCGC CTACCGCCGC 
TCGCAGCGCG CCTCCTTCAA GCGGGCCCGG CGGCCGGGGG CGCGCGCGCT GCGCCTGGTG 
CTGGGCATCG TGCTGCTCTT CTGGGCCTGC TTCCTGCCCT TCTGGCTGTG GCAGCTGCTC 
GCCCAGTACC ACCAGGCCCC GCTGGCGCCG CGGACGGCGC GCATCGTCAA CTACCTGACC 
ACCTGCCTCA CCTACGGCAA CAGCTGCGCC AACCCCTTCC TCTACACGCT GCTCACCAGG 
AACTACCGCG ACCACCTGCG CGGCCGCGTG CGGGGCCCGG GCAGCGGGGG AGGCCGGGGG 
CCCGTTCCCT CCCTGCAGCC CCGCGCCCGC TTCCAGCGCT GTTCGGGCCG CTCCCTGTCT 
TCCTGCAGCC CACAGCCCAC TGACAGCCTC GTGCTGGCCC CAGCGGCCCC GGCCCGACCT 
GCGCCCGAGG GTCCCAGGGC CCCGGCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Urotensin-II Receptor: A Double Identity Receptor Involved in Vasoconstriction and in the Development of Digestive Tract Cancers and other Tumors.
Current cancer drug targets17(2)109-121(2017)
Federico A,Zappavigna S,Dallio M,Misso G,Merlino F,Loguercio C,Novellino E,Grieco P,Caraglia M

Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis.
Autophagy12(12)2344-2362(2016 Dec)
Coly PM,Perzo N,Le Joncour V,Lecointre C,Schouft MT,Desrues L,Tonon MC,Wurtz O,Gandolfo P,Castel H,Morin F

UII/GPR14 is involved in NF-?B-mediated colonic inflammation in vivo and in vitro.
Oncology reports36(5)2800-2806(2016 Nov)
Yang Y,Zhang J,Chen X,Wu T,Xu X,Cao G,Li H,Li Y

Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer.
Future oncology (London, England)11(22)3091-8(2015 Nov)
De Cobelli O,Buonerba C,Terracciano D,Bottero D,Lucarelli G,Bove P,Altieri V,Coman I,Perdon? S,Facchini G,Berretta M,Di Lorenzo G,Grieco P,Novellino E,Franco R,Caraglia M,Manini C,Mirone V,De Placido S,Sonpavde G,Ferro M

Up-regulation of urotensin II and its receptor contributes to human hepatocellular carcinoma growth via activation of the PKC, ERK1/2, and p38 MAPK signaling pathways.
Molecules (Basel, Switzerland)19(12)20768-79(2014 Dec)
Yu XT,Wang PY,Shi ZM,Dong K,Feng P,Wang HX,Wang XJ