GNL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GNL1
Entrez Gene ID	2794
Full Name	G protein nucleolar 1 (putative)
Synonyms	HSR1
General protein information	Preferred Names G protein nucleolar 1 (putative) Names guanine nucleotide-binding protein-like 1 GTP-binding protein HSR1 HSR1 GTP-binding protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.33
Summary	The GNL1 gene, identified in the human major histocompatibility complex class I region, shows a high degree of similarity with its mouse counterpart. The GNL1 gene is located less than 2 kb centromeric to HLA-E, in the same transcriptional orientation. GNL1 is telomeric to HLA-B and HLA-C. [provided by RefSeq, Jul 2008].
Disorder MIM:	143024

mRNA and Protein(s)

mRNA	Protein	Name
NM_005275.3	NP_005266.2	guanine nucleotide-binding protein-like 1
XM_005249015.3	XP_005249072.1	guanine nucleotide-binding protein-like 1 isoform X1
XM_005249015.4	XP_005249072.1	guanine nucleotide-binding protein-like 1 isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GNL1	NP_001096742.1
Mus musculus (house mouse)	Gnl1	NP_032162.2
Drosophila melanogaster (fruit fly)	ns4	NP_610055.1
Rattus norvegicus (Norway rat)	Gnl1	NP_997665.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008330	XP_317131.4
Xenopus tropicalis (tropical clawed frog)	gnl1	NP_001072441.1
Homo sapiens (human)	GNL1	NP_005266.2
Pan troglodytes (chimpanzee)	GNL1	NP_001065264.1
	GNL1	NP_001040604.1
Canis lupus familiaris (dog)	GNL1	XP_848324.1
Gallus gallus (chicken)	LOC101751100	XP_004950888.1
Danio rerio (zebrafish)	gnl1	NP_001070721.1

Gene Ontology
Bibliography

Related articles in PubMed

Single nucleotide polymorphisms at the PRR3, ABCF1, and GNL1 genes in the HLA class I region are associated with Graves' ophthalmopathy in a gender-dependent manner.
Liu YH, Chen YJ, Wu HH, Wang TY, Tsai FJ
Ophthalmology121(10)2033-9(2014 Oct)

Subcellular distribution of the human putative nucleolar GTPase GNL1 is regulated by a novel arginine/lysine-rich domain and a GTP binding domain in a cell cycle-dependent manner.
Boddapati N, Anbarasu K, Suryaraja R, Tendulkar AV, Mahalingam S
Journal of molecular biology416(3)346-66(2012 Feb)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia.
Paladini F, Belfiore F, Cocco E, Carcassi C, Cauli A, Vacca A, Fiorillo MT, Mathieu A, Cascino I, Sorrentino R
Arthritis research & therapy11(6)R171(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results suggested that SNPs at PRR3 and ABCF1 genes and the haplotype composed by SNPs at GNL1 and PRR3 between the HLA-A and HLA-C genes tended to predict Graves ophthalmology in a gender-dependent manner in patients with Graves Disease in Taiwan.
Title: Single nucleotide polymorphisms at the PRR3, ABCF1, and GNL1 genes in the HLA class I region are associated with Graves' ophthalmopathy in a gender-dependent manner.

The results demonstrated that multiple mechanisms are involved in the translocation of GNL1 to the nucleolus in a cell cycle-dependent manner to regulate cell growth and proliferation.
Title: Subcellular distribution of the human putative nucleolar GTPase GNL1 is regulated by a novel arginine/lysine-rich domain and a GTP binding domain in a cell cycle-dependent manner.

Observational study of gene-disease association. (HuGE Navigator)
Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.

Observational study of gene-disease association. (HuGE Navigator)
Title: HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia.

The following GNL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GNL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08529	NM_005275.3 Latest version!	Homo sapiens G protein nucleolar 1 (putative) (GNL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu08529	XM_005249015.4 Latest version!	Homo sapiens G protein nucleolar 1 (putative) (GNL1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
View Old Accession Versions >>
OHu08529	XM_005249015.3	Homo sapiens G protein nucleolar 1 (putative) (GNL1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GNL1 ( NM_005275.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005266.2 Homo sapiens G protein nucleolar 1 (putative) (GNL1), mRNA.

Price & Availability↑

CloneID	OHu08529
Clone ID Related Accession (Same CDS sequence)	NM_005275.3 , XM_005249015.3 , XM_005249015.4
Accession Version	NM_005275.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1824bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein-like 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BQ188153.1, DA044212.1, BC018366.1, AK302480.1, AL662800.4 and AI433804.1. On Jan 13, 2010 this sequence version replaced NM_005275.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.243033.1, SRR1660805.187647.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCGAGGA AGAAGCCATT CAGCGTGAAG CAGAAGAAGA AGCAGTTGCA GGACAAACGG 
GAGCGGAAGA GAGGGCTTCA AGATGGGCTG CGCTCCAGTT CCAACAGCCG CAGCGGGAGC 
CGGGAGCGGC GAGAGGAACA GACCGACACC TCGGACGGGG AGTCTGTGAC CCATCATATC 
CGCAGGCTTA ACCAGCAGCC TTCTCAGGGG CTGGGTCCAC GAGGCTACGA CCCAAATCGA 
TACCGACTGC ATTTTGAGAG AGACAGCAGG GAGGAGGTAG AGAGGAGAAA GAGAGCAGCC 
CGGGAGCAAG TTCTACAGCC GGTCAGTGCT GAGTTGTTGG AGCTGGACAT CCGGGAGGTG 
TATCAGCCTG GCTCAGTTCT GGACTTTCCT CGACGTCCTC CTTGGAGCTA TGAGATGTCC 
AAGGAGCAAC TAATGAGCCA AGAGGAACGG AGCTTCCAAG ACTATCTTGG GAAGATTCAT 
GGGGCTTACT CCTCTGAGAA ACTCAGCTAC TTTGAGCACA ATCTGGAGAC ATGGAGGCAG 
CTGTGGCGGG TGTTAGAGAT GTCTGACATC GTCCTGCTTA TCACTGATAT CCGACATCCA 
GTTGTGAATT TCCCGCCAGC ACTTTATGAG TATGTGACTG GAGAACTTGG ACTGGCCCTG 
GTGCTGGTTT TGAACAAGGT GGATCTGGCC CCGCCAGCTC TTGTGGTTGC CTGGAAGCAT 
TATTTCCATC AACACTATCC CCAGCTCCAC GTCGTCCTTT TCACCTCTTT TCCTCGGGAC 
CCCCGCACCC CACAGGACCC TAGTAGTGTC TTGAAGAAGA GTCGGAGGCG GGGGAGAGGA 
TGGACTCGGG CCCTGGGGCC AGAGCAGTTG CTGAGAGCCT GTGAAGCCAT CACTGTGGGG 
AAAGTGGACT TGAGCAGCTG GCGGGAGAAG ATTGCTCGGG ATGTGGCTGG GGCCACCTGG 
GGTAATGGCT CTGGGGAGGA GGAGGAAGAG GAGGATGGCC CAGCAGTCCT GGTGGAGCAG 
CAGACTGATT CAGCAATGGA GCCAACTGGC CCAACCCAAG AGCGCTACAA GGATGGGGTG 
GTGACCATCG GCTGTGTGGG TTTCCCTAAT GTGGGAAAGT CCTCGCTGAT CAATGGGCTG 
GTGGGGCGGA AAGTCGTGAG TGTCTCCAGA ACCCCGGGCC ATACCCGATA CTTTCAGACC 
TACTTTCTTA CCCCCTCTGT GAAGCTCTGT GACTGCCCAG GCCTCATCTT CCCATCTCTT 
CTGCCTAGGC AGTTGCAGGT TCTGGCAGGG ATCTACCCTA TCGCCCAGAT CCAGGAGCCC 
TACACTGCTG TGGGCTACCT GGCCTCCCGA ATTCCCGTGC AGGCCCTGCT CCACCTGCGC 
CACCCAGAGG CTGAGGACCC CTCAGCGGAA CACCCCTGGT GTGCCTGGGA CATCTGTGAA 
GCCTGGGCAG AGAAACGTGG TTACAAGACA GCCAAGGCGG CTCGGAATGA TGTGTACAGA 
GCAGCCAACA GTCTCTTGCG GCTGGCAGTG GACGGCCGCC TCAGCCTGTG TTTTCATCCC 
CCAGGCTACA GTGAACAGAA AGGCACCTGG GAGTCCCATC CAGAGACCAC GGAGCTGGTG 
GTTTTGCAGG GCAGGGTGGG GCCAGCAGGT GACGAGGAGG AGGAGGAAGA GGAAGAGCTG 
AGCAGCTCCT GTGAGGAGGA GGGAGAGGAG GACCGGGATG CGGATGAGGA GGGAGAAGGG 
GATGAGGAGA CCCCAACCTC GGCTCCAGGG TCCAGCCTGG CTGGCCGAAA CCCTTATGCC 
CTGCTGGGTG AGGATGAGTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005266.2
CDS	1392..3215
Translation	MPRKKPFSVKQKKKQLQDKRERKRGLQDGLRSSSNSRSGSRERREEQTDTSDGESVTHHIRRLNQQPSQGLGPRGYDPNRYRLHFERDSREEVERRKRAAREQVLQPVSAELLELDIREVYQPGSVLDFPRRPPWSYEMSKEQLMSQEERSFQDYLGKIHGAYSSEKLSYFEHNLETWRQLWRVLEMSDIVLLITDIRHPVVNFPPALYEYVTGELGLALVLVLNKVDLAPPALVVAWKHYFHQHYPQLHVVLFTSFPRDPRTPQDPSSVLKKSRRRGRGWTRALGPEQLLRACEAITVGKVDLSSWREKIARDVAGATWGNGSGEEEEEEDGPAVLVEQQTDSAMEPTGPTQERYKDGVVTIGCVGFPNVGKSSLINGLVGRKVVSVSRTPGHTRYFQTYFLTPSVKLCDCPGLIFPSLLPRQLQVLAGIYPIAQIQEPYTAVGYLASRIPVQALLHLRHPEAEDPSAEHPWCAWDICEAWAEKRGYKTAKAARNDVYRAANSLLRLAVDGRLSLCFHPPGYSEQKGTWESHPETTELVVLQGRVGPAGDEEEEEEEELSSSCEEEGEEDRDADEEGEGDEETPTSAPGSSLAGRNPYALLGEDEC

Target ORF information:

RefSeq Version	NM_005275.3
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein nucleolar 1 (putative) (GNL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005275.3

ORF Insert Sequence:

ATGCCGAGGA AGAAGCCATT CAGCGTGAAG CAGAAGAAGA AGCAGTTGCA GGACAAACGG 
GAGCGGAAGA GAGGGCTTCA AGATGGGCTG CGCTCCAGTT CCAACAGCCG CAGCGGGAGC 
CGGGAGCGGC GAGAGGAACA GACCGACACC TCGGACGGGG AGTCTGTGAC CCATCATATC 
CGCAGGCTTA ACCAGCAGCC TTCTCAGGGG CTGGGTCCAC GAGGCTACGA CCCAAATCGA 
TACCGACTGC ATTTTGAGAG AGACAGCAGG GAGGAGGTAG AGAGGAGAAA GAGAGCAGCC 
CGGGAGCAAG TTCTACAGCC GGTCAGTGCT GAGTTGTTGG AGCTGGACAT CCGGGAGGTG 
TATCAGCCTG GCTCAGTTCT GGACTTTCCT CGACGTCCTC CTTGGAGCTA TGAGATGTCC 
AAGGAGCAAC TAATGAGCCA AGAGGAACGG AGCTTCCAAG ACTATCTTGG GAAGATTCAT 
GGGGCTTACT CCTCTGAGAA ACTCAGCTAC TTTGAGCACA ATCTGGAGAC ATGGAGGCAG 
CTGTGGCGGG TGTTAGAGAT GTCTGACATC GTCCTGCTTA TCACTGATAT CCGACATCCA 
GTTGTGAATT TCCCGCCAGC ACTTTATGAG TATGTGACTG GAGAACTTGG ACTGGCCCTG 
GTGCTGGTTT TGAACAAGGT GGATCTGGCC CCGCCAGCTC TTGTGGTTGC CTGGAAGCAT 
TATTTCCATC AACACTATCC CCAGCTCCAC GTCGTCCTTT TCACCTCTTT TCCTCGGGAC 
CCCCGCACCC CACAGGACCC TAGTAGTGTC TTGAAGAAGA GTCGGAGGCG GGGGAGAGGA 
TGGACTCGGG CCCTGGGGCC AGAGCAGTTG CTGAGAGCCT GTGAAGCCAT CACTGTGGGG 
AAAGTGGACT TGAGCAGCTG GCGGGAGAAG ATTGCTCGGG ATGTGGCTGG GGCCACCTGG 
GGTAATGGCT CTGGGGAGGA GGAGGAAGAG GAGGATGGCC CAGCAGTCCT GGTGGAGCAG 
CAGACTGATT CAGCAATGGA GCCAACTGGC CCAACCCAAG AGCGCTACAA GGATGGGGTG 
GTGACCATCG GCTGTGTGGG TTTCCCTAAT GTGGGAAAGT CCTCGCTGAT CAATGGGCTG 
GTGGGGCGGA AAGTCGTGAG TGTCTCCAGA ACCCCGGGCC ATACCCGATA CTTTCAGACC 
TACTTTCTTA CCCCCTCTGT GAAGCTCTGT GACTGCCCAG GCCTCATCTT CCCATCTCTT 
CTGCCTAGGC AGTTGCAGGT TCTGGCAGGG ATCTACCCTA TCGCCCAGAT CCAGGAGCCC 
TACACTGCTG TGGGCTACCT GGCCTCCCGA ATTCCCGTGC AGGCCCTGCT CCACCTGCGC 
CACCCAGAGG CTGAGGACCC CTCAGCGGAA CACCCCTGGT GTGCCTGGGA CATCTGTGAA 
GCCTGGGCAG AGAAACGTGG TTACAAGACA GCCAAGGCGG CTCGGAATGA TGTGTACAGA 
GCAGCCAACA GTCTCTTGCG GCTGGCAGTG GACGGCCGCC TCAGCCTGTG TTTTCATCCC 
CCAGGCTACA GTGAACAGAA AGGCACCTGG GAGTCCCATC CAGAGACCAC GGAGCTGGTG 
GTTTTGCAGG GCAGGGTGGG GCCAGCAGGT GACGAGGAGG AGGAGGAAGA GGAAGAGCTG 
AGCAGCTCCT GTGAGGAGGA GGGAGAGGAG GACCGGGATG CGGATGAGGA GGGAGAAGGG 
GATGAGGAGA CCCCAACCTC GGCTCCAGGG TCCAGCCTGG CTGGCCGAAA CCCTTATGCC 
CTGCTGGGTG AGGATGAGTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNL1 ( XM_005249015.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005249072.1 Homo sapiens G protein nucleolar 1 (putative) (GNL1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu08529
Clone ID Related Accession (Same CDS sequence)	NM_005275.3 , XM_005249015.3 , XM_005249015.4
Accession Version	XM_005249015.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1824bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein-like 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005249015.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGAGGA AGAAGCCATT CAGCGTGAAG CAGAAGAAGA AGCAGTTGCA GGACAAACGG 
GAGCGGAAGA GAGGGCTTCA AGATGGGCTG CGCTCCAGTT CCAACAGCCG CAGCGGGAGC 
CGGGAGCGGC GAGAGGAACA GACCGACACC TCGGACGGGG AGTCTGTGAC CCATCATATC 
CGCAGGCTTA ACCAGCAGCC TTCTCAGGGG CTGGGTCCAC GAGGCTACGA CCCAAATCGA 
TACCGACTGC ATTTTGAGAG AGACAGCAGG GAGGAGGTAG AGAGGAGAAA GAGAGCAGCC 
CGGGAGCAAG TTCTACAGCC GGTCAGTGCT GAGTTGTTGG AGCTGGACAT CCGGGAGGTG 
TATCAGCCTG GCTCAGTTCT GGACTTTCCT CGACGTCCTC CTTGGAGCTA TGAGATGTCC 
AAGGAGCAAC TAATGAGCCA AGAGGAACGG AGCTTCCAAG ACTATCTTGG GAAGATTCAT 
GGGGCTTACT CCTCTGAGAA ACTCAGCTAC TTTGAGCACA ATCTGGAGAC ATGGAGGCAG 
CTGTGGCGGG TGTTAGAGAT GTCTGACATC GTCCTGCTTA TCACTGATAT CCGACATCCA 
GTTGTGAATT TCCCGCCAGC ACTTTATGAG TATGTGACTG GAGAACTTGG ACTGGCCCTG 
GTGCTGGTTT TGAACAAGGT GGATCTGGCC CCGCCAGCTC TTGTGGTTGC CTGGAAGCAT 
TATTTCCATC AACACTATCC CCAGCTCCAC GTCGTCCTTT TCACCTCTTT TCCTCGGGAC 
CCCCGCACCC CACAGGACCC TAGTAGTGTC TTGAAGAAGA GTCGGAGGCG GGGGAGAGGA 
TGGACTCGGG CCCTGGGGCC AGAGCAGTTG CTGAGAGCCT GTGAAGCCAT CACTGTGGGG 
AAAGTGGACT TGAGCAGCTG GCGGGAGAAG ATTGCTCGGG ATGTGGCTGG GGCCACCTGG 
GGTAATGGCT CTGGGGAGGA GGAGGAAGAG GAGGATGGCC CAGCAGTCCT GGTGGAGCAG 
CAGACTGATT CAGCAATGGA GCCAACTGGC CCAACCCAAG AGCGCTACAA GGATGGGGTG 
GTGACCATCG GCTGTGTGGG TTTCCCTAAT GTGGGAAAGT CCTCGCTGAT CAATGGGCTG 
GTGGGGCGGA AAGTCGTGAG TGTCTCCAGA ACCCCGGGCC ATACCCGATA CTTTCAGACC 
TACTTTCTTA CCCCCTCTGT GAAGCTCTGT GACTGCCCAG GCCTCATCTT CCCATCTCTT 
CTGCCTAGGC AGTTGCAGGT TCTGGCAGGG ATCTACCCTA TCGCCCAGAT CCAGGAGCCC 
TACACTGCTG TGGGCTACCT GGCCTCCCGA ATTCCCGTGC AGGCCCTGCT CCACCTGCGC 
CACCCAGAGG CTGAGGACCC CTCAGCGGAA CACCCCTGGT GTGCCTGGGA CATCTGTGAA 
GCCTGGGCAG AGAAACGTGG TTACAAGACA GCCAAGGCGG CTCGGAATGA TGTGTACAGA 
GCAGCCAACA GTCTCTTGCG GCTGGCAGTG GACGGCCGCC TCAGCCTGTG TTTTCATCCC 
CCAGGCTACA GTGAACAGAA AGGCACCTGG GAGTCCCATC CAGAGACCAC GGAGCTGGTG 
GTTTTGCAGG GCAGGGTGGG GCCAGCAGGT GACGAGGAGG AGGAGGAAGA GGAAGAGCTG 
AGCAGCTCCT GTGAGGAGGA GGGAGAGGAG GACCGGGATG CGGATGAGGA GGGAGAAGGG 
GATGAGGAGA CCCCAACCTC GGCTCCAGGG TCCAGCCTGG CTGGCCGAAA CCCTTATGCC 
CTGCTGGGTG AGGATGAGTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005249072.1
CDS	855..2678
Translation	MPRKKPFSVKQKKKQLQDKRERKRGLQDGLRSSSNSRSGSRERREEQTDTSDGESVTHHIRRLNQQPSQGLGPRGYDPNRYRLHFERDSREEVERRKRAAREQVLQPVSAELLELDIREVYQPGSVLDFPRRPPWSYEMSKEQLMSQEERSFQDYLGKIHGAYSSEKLSYFEHNLETWRQLWRVLEMSDIVLLITDIRHPVVNFPPALYEYVTGELGLALVLVLNKVDLAPPALVVAWKHYFHQHYPQLHVVLFTSFPRDPRTPQDPSSVLKKSRRRGRGWTRALGPEQLLRACEAITVGKVDLSSWREKIARDVAGATWGNGSGEEEEEEDGPAVLVEQQTDSAMEPTGPTQERYKDGVVTIGCVGFPNVGKSSLINGLVGRKVVSVSRTPGHTRYFQTYFLTPSVKLCDCPGLIFPSLLPRQLQVLAGIYPIAQIQEPYTAVGYLASRIPVQALLHLRHPEAEDPSAEHPWCAWDICEAWAEKRGYKTAKAARNDVYRAANSLLRLAVDGRLSLCFHPPGYSEQKGTWESHPETTELVVLQGRVGPAGDEEEEEEEELSSSCEEEGEEDRDADEEGEGDEETPTSAPGSSLAGRNPYALLGEDEC

Target ORF information:

RefSeq Version	XM_005249015.3
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein nucleolar 1 (putative) (GNL1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005249015.3

ORF Insert Sequence:

ATGCCGAGGA AGAAGCCATT CAGCGTGAAG CAGAAGAAGA AGCAGTTGCA GGACAAACGG 
GAGCGGAAGA GAGGGCTTCA AGATGGGCTG CGCTCCAGTT CCAACAGCCG CAGCGGGAGC 
CGGGAGCGGC GAGAGGAACA GACCGACACC TCGGACGGGG AGTCTGTGAC CCATCATATC 
CGCAGGCTTA ACCAGCAGCC TTCTCAGGGG CTGGGTCCAC GAGGCTACGA CCCAAATCGA 
TACCGACTGC ATTTTGAGAG AGACAGCAGG GAGGAGGTAG AGAGGAGAAA GAGAGCAGCC 
CGGGAGCAAG TTCTACAGCC GGTCAGTGCT GAGTTGTTGG AGCTGGACAT CCGGGAGGTG 
TATCAGCCTG GCTCAGTTCT GGACTTTCCT CGACGTCCTC CTTGGAGCTA TGAGATGTCC 
AAGGAGCAAC TAATGAGCCA AGAGGAACGG AGCTTCCAAG ACTATCTTGG GAAGATTCAT 
GGGGCTTACT CCTCTGAGAA ACTCAGCTAC TTTGAGCACA ATCTGGAGAC ATGGAGGCAG 
CTGTGGCGGG TGTTAGAGAT GTCTGACATC GTCCTGCTTA TCACTGATAT CCGACATCCA 
GTTGTGAATT TCCCGCCAGC ACTTTATGAG TATGTGACTG GAGAACTTGG ACTGGCCCTG 
GTGCTGGTTT TGAACAAGGT GGATCTGGCC CCGCCAGCTC TTGTGGTTGC CTGGAAGCAT 
TATTTCCATC AACACTATCC CCAGCTCCAC GTCGTCCTTT TCACCTCTTT TCCTCGGGAC 
CCCCGCACCC CACAGGACCC TAGTAGTGTC TTGAAGAAGA GTCGGAGGCG GGGGAGAGGA 
TGGACTCGGG CCCTGGGGCC AGAGCAGTTG CTGAGAGCCT GTGAAGCCAT CACTGTGGGG 
AAAGTGGACT TGAGCAGCTG GCGGGAGAAG ATTGCTCGGG ATGTGGCTGG GGCCACCTGG 
GGTAATGGCT CTGGGGAGGA GGAGGAAGAG GAGGATGGCC CAGCAGTCCT GGTGGAGCAG 
CAGACTGATT CAGCAATGGA GCCAACTGGC CCAACCCAAG AGCGCTACAA GGATGGGGTG 
GTGACCATCG GCTGTGTGGG TTTCCCTAAT GTGGGAAAGT CCTCGCTGAT CAATGGGCTG 
GTGGGGCGGA AAGTCGTGAG TGTCTCCAGA ACCCCGGGCC ATACCCGATA CTTTCAGACC 
TACTTTCTTA CCCCCTCTGT GAAGCTCTGT GACTGCCCAG GCCTCATCTT CCCATCTCTT 
CTGCCTAGGC AGTTGCAGGT TCTGGCAGGG ATCTACCCTA TCGCCCAGAT CCAGGAGCCC 
TACACTGCTG TGGGCTACCT GGCCTCCCGA ATTCCCGTGC AGGCCCTGCT CCACCTGCGC 
CACCCAGAGG CTGAGGACCC CTCAGCGGAA CACCCCTGGT GTGCCTGGGA CATCTGTGAA 
GCCTGGGCAG AGAAACGTGG TTACAAGACA GCCAAGGCGG CTCGGAATGA TGTGTACAGA 
GCAGCCAACA GTCTCTTGCG GCTGGCAGTG GACGGCCGCC TCAGCCTGTG TTTTCATCCC 
CCAGGCTACA GTGAACAGAA AGGCACCTGG GAGTCCCATC CAGAGACCAC GGAGCTGGTG 
GTTTTGCAGG GCAGGGTGGG GCCAGCAGGT GACGAGGAGG AGGAGGAAGA GGAAGAGCTG 
AGCAGCTCCT GTGAGGAGGA GGGAGAGGAG GACCGGGATG CGGATGAGGA GGGAGAAGGG 
GATGAGGAGA CCCCAACCTC GGCTCCAGGG TCCAGCCTGG CTGGCCGAAA CCCTTATGCC 
CTGCTGGGTG AGGATGAGTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNL1 ( XM_005249015.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005249072.1 Homo sapiens G protein nucleolar 1 (putative) (GNL1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu08529
Clone ID Related Accession (Same CDS sequence)	NM_005275.3 , XM_005249015.3 , XM_005249015.4
Accession Version	XM_005249015.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1824bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein-like 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005249015.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGAGGA AGAAGCCATT CAGCGTGAAG CAGAAGAAGA AGCAGTTGCA GGACAAACGG 
GAGCGGAAGA GAGGGCTTCA AGATGGGCTG CGCTCCAGTT CCAACAGCCG CAGCGGGAGC 
CGGGAGCGGC GAGAGGAACA GACCGACACC TCGGACGGGG AGTCTGTGAC CCATCATATC 
CGCAGGCTTA ACCAGCAGCC TTCTCAGGGG CTGGGTCCAC GAGGCTACGA CCCAAATCGA 
TACCGACTGC ATTTTGAGAG AGACAGCAGG GAGGAGGTAG AGAGGAGAAA GAGAGCAGCC 
CGGGAGCAAG TTCTACAGCC GGTCAGTGCT GAGTTGTTGG AGCTGGACAT CCGGGAGGTG 
TATCAGCCTG GCTCAGTTCT GGACTTTCCT CGACGTCCTC CTTGGAGCTA TGAGATGTCC 
AAGGAGCAAC TAATGAGCCA AGAGGAACGG AGCTTCCAAG ACTATCTTGG GAAGATTCAT 
GGGGCTTACT CCTCTGAGAA ACTCAGCTAC TTTGAGCACA ATCTGGAGAC ATGGAGGCAG 
CTGTGGCGGG TGTTAGAGAT GTCTGACATC GTCCTGCTTA TCACTGATAT CCGACATCCA 
GTTGTGAATT TCCCGCCAGC ACTTTATGAG TATGTGACTG GAGAACTTGG ACTGGCCCTG 
GTGCTGGTTT TGAACAAGGT GGATCTGGCC CCGCCAGCTC TTGTGGTTGC CTGGAAGCAT 
TATTTCCATC AACACTATCC CCAGCTCCAC GTCGTCCTTT TCACCTCTTT TCCTCGGGAC 
CCCCGCACCC CACAGGACCC TAGTAGTGTC TTGAAGAAGA GTCGGAGGCG GGGGAGAGGA 
TGGACTCGGG CCCTGGGGCC AGAGCAGTTG CTGAGAGCCT GTGAAGCCAT CACTGTGGGG 
AAAGTGGACT TGAGCAGCTG GCGGGAGAAG ATTGCTCGGG ATGTGGCTGG GGCCACCTGG 
GGTAATGGCT CTGGGGAGGA GGAGGAAGAG GAGGATGGCC CAGCAGTCCT GGTGGAGCAG 
CAGACTGATT CAGCAATGGA GCCAACTGGC CCAACCCAAG AGCGCTACAA GGATGGGGTG 
GTGACCATCG GCTGTGTGGG TTTCCCTAAT GTGGGAAAGT CCTCGCTGAT CAATGGGCTG 
GTGGGGCGGA AAGTCGTGAG TGTCTCCAGA ACCCCGGGCC ATACCCGATA CTTTCAGACC 
TACTTTCTTA CCCCCTCTGT GAAGCTCTGT GACTGCCCAG GCCTCATCTT CCCATCTCTT 
CTGCCTAGGC AGTTGCAGGT TCTGGCAGGG ATCTACCCTA TCGCCCAGAT CCAGGAGCCC 
TACACTGCTG TGGGCTACCT GGCCTCCCGA ATTCCCGTGC AGGCCCTGCT CCACCTGCGC 
CACCCAGAGG CTGAGGACCC CTCAGCGGAA CACCCCTGGT GTGCCTGGGA CATCTGTGAA 
GCCTGGGCAG AGAAACGTGG TTACAAGACA GCCAAGGCGG CTCGGAATGA TGTGTACAGA 
GCAGCCAACA GTCTCTTGCG GCTGGCAGTG GACGGCCGCC TCAGCCTGTG TTTTCATCCC 
CCAGGCTACA GTGAACAGAA AGGCACCTGG GAGTCCCATC CAGAGACCAC GGAGCTGGTG 
GTTTTGCAGG GCAGGGTGGG GCCAGCAGGT GACGAGGAGG AGGAGGAAGA GGAAGAGCTG 
AGCAGCTCCT GTGAGGAGGA GGGAGAGGAG GACCGGGATG CGGATGAGGA GGGAGAAGGG 
GATGAGGAGA CCCCAACCTC GGCTCCAGGG TCCAGCCTGG CTGGCCGAAA CCCTTATGCC 
CTGCTGGGTG AGGATGAGTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005249072.1
CDS	848..2671
Translation	MPRKKPFSVKQKKKQLQDKRERKRGLQDGLRSSSNSRSGSRERREEQTDTSDGESVTHHIRRLNQQPSQGLGPRGYDPNRYRLHFERDSREEVERRKRAAREQVLQPVSAELLELDIREVYQPGSVLDFPRRPPWSYEMSKEQLMSQEERSFQDYLGKIHGAYSSEKLSYFEHNLETWRQLWRVLEMSDIVLLITDIRHPVVNFPPALYEYVTGELGLALVLVLNKVDLAPPALVVAWKHYFHQHYPQLHVVLFTSFPRDPRTPQDPSSVLKKSRRRGRGWTRALGPEQLLRACEAITVGKVDLSSWREKIARDVAGATWGNGSGEEEEEEDGPAVLVEQQTDSAMEPTGPTQERYKDGVVTIGCVGFPNVGKSSLINGLVGRKVVSVSRTPGHTRYFQTYFLTPSVKLCDCPGLIFPSLLPRQLQVLAGIYPIAQIQEPYTAVGYLASRIPVQALLHLRHPEAEDPSAEHPWCAWDICEAWAEKRGYKTAKAARNDVYRAANSLLRLAVDGRLSLCFHPPGYSEQKGTWESHPETTELVVLQGRVGPAGDEEEEEEEELSSSCEEEGEEDRDADEEGEGDEETPTSAPGSSLAGRNPYALLGEDEC

Target ORF information:

RefSeq Version	XM_005249015.4
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein nucleolar 1 (putative) (GNL1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005249015.4

ORF Insert Sequence:

ATGCCGAGGA AGAAGCCATT CAGCGTGAAG CAGAAGAAGA AGCAGTTGCA GGACAAACGG 
GAGCGGAAGA GAGGGCTTCA AGATGGGCTG CGCTCCAGTT CCAACAGCCG CAGCGGGAGC 
CGGGAGCGGC GAGAGGAACA GACCGACACC TCGGACGGGG AGTCTGTGAC CCATCATATC 
CGCAGGCTTA ACCAGCAGCC TTCTCAGGGG CTGGGTCCAC GAGGCTACGA CCCAAATCGA 
TACCGACTGC ATTTTGAGAG AGACAGCAGG GAGGAGGTAG AGAGGAGAAA GAGAGCAGCC 
CGGGAGCAAG TTCTACAGCC GGTCAGTGCT GAGTTGTTGG AGCTGGACAT CCGGGAGGTG 
TATCAGCCTG GCTCAGTTCT GGACTTTCCT CGACGTCCTC CTTGGAGCTA TGAGATGTCC 
AAGGAGCAAC TAATGAGCCA AGAGGAACGG AGCTTCCAAG ACTATCTTGG GAAGATTCAT 
GGGGCTTACT CCTCTGAGAA ACTCAGCTAC TTTGAGCACA ATCTGGAGAC ATGGAGGCAG 
CTGTGGCGGG TGTTAGAGAT GTCTGACATC GTCCTGCTTA TCACTGATAT CCGACATCCA 
GTTGTGAATT TCCCGCCAGC ACTTTATGAG TATGTGACTG GAGAACTTGG ACTGGCCCTG 
GTGCTGGTTT TGAACAAGGT GGATCTGGCC CCGCCAGCTC TTGTGGTTGC CTGGAAGCAT 
TATTTCCATC AACACTATCC CCAGCTCCAC GTCGTCCTTT TCACCTCTTT TCCTCGGGAC 
CCCCGCACCC CACAGGACCC TAGTAGTGTC TTGAAGAAGA GTCGGAGGCG GGGGAGAGGA 
TGGACTCGGG CCCTGGGGCC AGAGCAGTTG CTGAGAGCCT GTGAAGCCAT CACTGTGGGG 
AAAGTGGACT TGAGCAGCTG GCGGGAGAAG ATTGCTCGGG ATGTGGCTGG GGCCACCTGG 
GGTAATGGCT CTGGGGAGGA GGAGGAAGAG GAGGATGGCC CAGCAGTCCT GGTGGAGCAG 
CAGACTGATT CAGCAATGGA GCCAACTGGC CCAACCCAAG AGCGCTACAA GGATGGGGTG 
GTGACCATCG GCTGTGTGGG TTTCCCTAAT GTGGGAAAGT CCTCGCTGAT CAATGGGCTG 
GTGGGGCGGA AAGTCGTGAG TGTCTCCAGA ACCCCGGGCC ATACCCGATA CTTTCAGACC 
TACTTTCTTA CCCCCTCTGT GAAGCTCTGT GACTGCCCAG GCCTCATCTT CCCATCTCTT 
CTGCCTAGGC AGTTGCAGGT TCTGGCAGGG ATCTACCCTA TCGCCCAGAT CCAGGAGCCC 
TACACTGCTG TGGGCTACCT GGCCTCCCGA ATTCCCGTGC AGGCCCTGCT CCACCTGCGC 
CACCCAGAGG CTGAGGACCC CTCAGCGGAA CACCCCTGGT GTGCCTGGGA CATCTGTGAA 
GCCTGGGCAG AGAAACGTGG TTACAAGACA GCCAAGGCGG CTCGGAATGA TGTGTACAGA 
GCAGCCAACA GTCTCTTGCG GCTGGCAGTG GACGGCCGCC TCAGCCTGTG TTTTCATCCC 
CCAGGCTACA GTGAACAGAA AGGCACCTGG GAGTCCCATC CAGAGACCAC GGAGCTGGTG 
GTTTTGCAGG GCAGGGTGGG GCCAGCAGGT GACGAGGAGG AGGAGGAAGA GGAAGAGCTG 
AGCAGCTCCT GTGAGGAGGA GGGAGAGGAG GACCGGGATG CGGATGAGGA GGGAGAAGGG 
GATGAGGAGA CCCCAACCTC GGCTCCAGGG TCCAGCCTGG CTGGCCGAAA CCCTTATGCC 
CTGCTGGGTG AGGATGAGTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Single nucleotide polymorphisms at the PRR3, ABCF1, and GNL1 genes in the HLA class I region are associated with Graves' ophthalmopathy in a gender-dependent manner.
Ophthalmology121(10)2033-9(2014 Oct)
Liu YH,Chen YJ,Wu HH,Wang TY,Tsai FJ

Subcellular distribution of the human putative nucleolar GTPase GNL1 is regulated by a novel arginine/lysine-rich domain and a GTP binding domain in a cell cycle-dependent manner.
Journal of molecular biology416(3)346-66(2012 Feb)
Boddapati N,Anbarasu K,Suryaraja R,Tendulkar AV,Mahalingam S

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia.
Arthritis research & therapy11(6)R171(2009)
Paladini F,Belfiore F,Cocco E,Carcassi C,Cauli A,Vacca A,Fiorillo MT,Mathieu A,Cascino I,Sorrentino R

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GNL1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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