GDF1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GDF1
Entrez Gene ID	2657
Full Name	growth differentiation factor 1
Synonyms	DORV,DTGA3,RAI
General protein information	Preferred Names growth differentiation factor 1 Names embryonic growth/differentiation factor 1 GDF-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.11
Summary	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. The encoded protein is translated from a bicistronic mRNA that also encodes ceramide synthase 1. Mutations in this gene are associated with several congenital cardiovascular malformations. [provided by RefSeq, Jul 2016].
Disorder MIM:	602880
Disorder Html:	Double-outlet right ventricle, 217095 (3); Tetralogy of Fallot, 187500 (3); Transposition of great arteries, dextro-looped 3, 613854 (3); Right atrial isomerism, 208530 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001492.6	NP_001483.3	embryonic growth/differentiation factor 1 precursor
NM_001492.5	NP_001483.3	embryonic growth/differentiation factor 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GDF1	NP_001483.3
Rattus norvegicus (Norway rat)	Gdf1	NP_001037705.1
	LOC720298	XP_001115596.2
Canis lupus familiaris (dog)	GDF1	XP_005633254.1
Mus musculus (house mouse)	Gdf1	NP_032133.2

Gene Ontology
Bibliography

Related articles in PubMed

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.
Jin SC, Homsy J, Zaidi S, Lu Q, Morton S, DePalma SR, Zeng X, Qi H, Chang W, Sierant MC, Hung WC, Haider S, Zhang J, Knight J, Bjornson RD, Castaldi C, Tikhonoa IR, Bilguvar K, Mane SM, Sanders SJ, Mital S, Russell MW, Gaynor JW, Deanfield J, Giardini A, Porter GA Jr, Srivastava D, Lo CW, Shen Y, Watkins WS, Yandell M, Yost HJ, Tristani-Firouzi M, Newburger JW, Roberts AE, Kim R, Zhao H, Kaltman JR, Goldmuntz E, Chung WK, Seidman JG, Gelb BD, Seidman CE, Lifton RP, Brueckner M
Nature genetics49(11)1593-1601(2017 Nov)

Association of GDF1 rs4808863 with fetal congenital heart defects: a case-control study.
Zhang J, Wu Q, Wang L, Li X, Ma Y, Yao L
BMJ open5(12)e009352(2015 Dec)

Nodal?Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation.
Fuerer C, Nostro MC, Constam DB
The Journal of biological chemistry289(25)17854-71(2014 Jun)

Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction.
Zhang Y, Zhang XF, Gao L, Liu Y, Jiang DS, Chen K, Yang Q, Fan GC, Zhang XD, Huang C
Biochimica et biophysica acta1842(2)232-44(2014 Feb)

Association of growth/differentiation factor 1 gene polymorphisms with the risk of congenital heart disease in the Chinese Han population.
Sun X, Meng Y, You T, Li P, Wu H, Yu M, Xie X
Molecular biology reports40(2)1291-9(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rare inherited and de novo variants in 2,871 congenital heart disease probands identified GDF1, MYH6, and FLT4 as causative genes.
Title: Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.

Our results suggest that the GDF1 rs4808863 polymorphism contributes to an increased risk of fetal CHDs, especially the subtypes of AVSD, LVOTO and left-right laterality defects.
Title: Association of GDF1 rs4808863 with fetal congenital heart defects: a case-control study.

This implies that Gdf1 potentiates Nodal activity by stabilizing a low molecular weight fraction that is susceptible to neutralization by soluble Acvr2.
Title: Nodal?Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation.

indicate that the expression of growth/differentiation factor 1 (GDF1) is up-regulated in human dilated cardiomyopathy (DCM)hearts and murine hypertrophic hearts.
Title: Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction.

GDF1 may be associated with congenital heart defects risk, and these variations contribute at least in part to the development of some subtypes of conotruncal defects in the Chinese Han population.
Title: Association of growth/differentiation factor 1 gene polymorphisms with the risk of congenital heart disease in the Chinese Han population.

The following GDF1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GDF1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27937	NM_001492.6 Latest version!	Homo sapiens growth differentiation factor 1 (GDF1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu27937	NM_001492.5	Homo sapiens growth differentiation factor 1 (GDF1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GDF1 ( NM_001492.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_001483.3 Homo sapiens growth differentiation factor 1 (GDF1), mRNA.

Price & Availability↑

CloneID	OHu27937
Clone ID Related Accession (Same CDS sequence)	NM_001492.6 , NM_001492.5
Accession Version	NM_001492.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	embryonic growth/differentiation factor 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005197.1, M62302.1 and AC003972.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_001492.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: CX871104.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2157437 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## bicistronic transcript :: PMID: 2034669 MANE Ensembl match :: ENST00000247005.8/ ENSP00000247005.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCCACCGC CGCAGCAAGG TCCCTGCGGC CACCACCTCC TCCTCCTCCT GGCCCTGCTG 
CTGCCCTCGC TGCCCCTGAC CCGCGCCCCC GTGCCCCCAG GCCCAGCCGC CGCCCTGCTC 
CAGGCTCTAG GACTGCGCGA TGAGCCCCAG GGTGCCCCCA GGCTCCGGCC GGTTCCCCCG 
GTCATGTGGC GCCTGTTTCG ACGCCGGGAC CCCCAGGAGA CCAGGTCTGG CTCGCGGCGG 
ACGTCCCCAG GGGTCACCCT GCAACCGTGC CACGTGGAGG AGCTGGGGGT CGCCGGAAAC 
ATCGTGCGCC ACATCCCGGA CCGCGGTGCG CCCACCCGGG CCTCGGAGCC TGCCTCGGCC 
GCGGGGCATT GCCCTGAGTG GACAGTCGTC TTCGACCTGT CGGCTGTGGA ACCCGCTGAG 
CGCCCGAGCC GGGCCCGCCT GGAGCTGCGT TTCGCGGCGG CGGCGGCGGC AGCCCCGGAG 
GGCGGCTGGG AGCTGAGCGT GGCGCAAGCG GGCCAGGGCG CGGGCGCGGA CCCCGGGCCG 
GTGCTGCTCC GCCAGTTGGT GCCCGCCCTG GGGCCGCCAG TGCGCGCGGA GCTGCTGGGC 
GCCGCTTGGG CTCGCAACGC CTCATGGCCG CGCAGCCTCC GCCTGGCGCT GGCGCTACGC 
CCCCGGGCCC CTGCCGCCTG CGCGCGCCTG GCCGAGGCCT CGCTGCTGCT GGTGACCCTC 
GACCCGCGCC TGTGCCACCC CCTGGCCCGG CCGCGGCGCG ACGCCGAACC CGTGTTGGGC 
GGCGGCCCCG GGGGCGCTTG TCGCGCGCGG CGGCTGTACG TGAGCTTCCG CGAGGTGGGC 
TGGCACCGCT GGGTCATCGC GCCGCGCGGC TTCCTGGCCA ACTACTGCCA GGGTCAGTGC 
GCGCTGCCCG TCGCGCTGTC GGGGTCCGGG GGGCCGCCGG CGCTCAACCA CGCTGTGCTG 
CGCGCGCTCA TGCACGCGGC CGCCCCGGGA GCCGCCGACC TGCCCTGCTG CGTGCCCGCG 
CGCCTGTCGC CCATCTCCGT GCTCTTCTTT GACAACAGCG ACAACGTGGT GCTGCGGCAG 
TATGAGGACA TGGTGGTGGA CGAGTGCGGC TGCCGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001483.3
CDS	1409..2527
Translation	MPPPQQGPCGHHLLLLLALLLPSLPLTRAPVPPGPAAALLQALGLRDEPQGAPRLRPVPPVMWRLFRRRDPQETRSGSRRTSPGVTLQPCHVEELGVAGNIVRHIPDRGAPTRASEPASAAGHCPEWTVVFDLSAVEPAERPSRARLELRFAAAAAAAPEGGWELSVAQAGQGAGADPGPVLLRQLVPALGPPVRAELLGAAWARNASWPRSLRLALALRPRAPAACARLAEASLLLVTLDPRLCHPLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR

Target ORF information:

RefSeq Version	NM_001492.6
Organism	Homo sapiens(human)
Definition	Homo sapiens growth differentiation factor 1 (GDF1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001492.6

ORF Insert Sequence:

ATGCCACCGC CGCAGCAAGG TCCCTGCGGC CACCACCTCC TCCTCCTCCT GGCCCTGCTG 
CTGCCCTCGC TGCCCCTGAC CCGCGCCCCC GTGCCCCCAG GCCCAGCCGC CGCCCTGCTC 
CAGGCTCTAG GACTGCGCGA TGAGCCCCAG GGTGCCCCCA GGCTCCGGCC GGTTCCCCCG 
GTCATGTGGC GCCTGTTTCG ACGCCGGGAC CCCCAGGAGA CCAGGTCTGG CTCGCGGCGG 
ACGTCCCCAG GGGTCACCCT GCAACCGTGC CACGTGGAGG AGCTGGGGGT CGCCGGAAAC 
ATCGTGCGCC ACATCCCGGA CCGCGGTGCG CCCACCCGGG CCTCGGAGCC TGCCTCGGCC 
GCGGGGCATT GCCCTGAGTG GACAGTCGTC TTCGACCTGT CGGCTGTGGA ACCCGCTGAG 
CGCCCGAGCC GGGCCCGCCT GGAGCTGCGT TTCGCGGCGG CGGCGGCGGC AGCCCCGGAG 
GGCGGCTGGG AGCTGAGCGT GGCGCAAGCG GGCCAGGGCG CGGGCGCGGA CCCCGGGCCG 
GTGCTGCTCC GCCAGTTGGT GCCCGCCCTG GGGCCGCCAG TGCGCGCGGA GCTGCTGGGC 
GCCGCTTGGG CTCGCAACGC CTCATGGCCG CGCAGCCTCC GCCTGGCGCT GGCGCTACGC 
CCCCGGGCCC CTGCCGCCTG CGCGCGCCTG GCCGAGGCCT CGCTGCTGCT GGTGACCCTC 
GACCCGCGCC TGTGCCACCC CCTGGCCCGG CCGCGGCGCG ACGCCGAACC CGTGTTGGGC 
GGCGGCCCCG GGGGCGCTTG TCGCGCGCGG CGGCTGTACG TGAGCTTCCG CGAGGTGGGC 
TGGCACCGCT GGGTCATCGC GCCGCGCGGC TTCCTGGCCA ACTACTGCCA GGGTCAGTGC 
GCGCTGCCCG TCGCGCTGTC GGGGTCCGGG GGGCCGCCGG CGCTCAACCA CGCTGTGCTG 
CGCGCGCTCA TGCACGCGGC CGCCCCGGGA GCCGCCGACC TGCCCTGCTG CGTGCCCGCG 
CGCCTGTCGC CCATCTCCGT GCTCTTCTTT GACAACAGCG ACAACGTGGT GCTGCGGCAG 
TATGAGGACA TGGTGGTGGA CGAGTGCGGC TGCCGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GDF1 ( NM_001492.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001483.3 Homo sapiens growth differentiation factor 1 (GDF1), mRNA.

Price & Availability↑

CloneID	OHu27937
Clone ID Related Accession (Same CDS sequence)	NM_001492.6 , NM_001492.5
Accession Version	NM_001492.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	embryonic growth/differentiation factor 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005197.1, M62302.1 and AC003972.1. This sequence is a reference standard in the RefSeqGene project. On Mar 12, 2014 this sequence version replaced NM_001492.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M62302.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2157437 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## bicistronic transcript :: PMID: 2034669 ##RefSeq-Attributes-END##

ATGCCACCGC CGCAGCAAGG TCCCTGCGGC CACCACCTCC TCCTCCTCCT GGCCCTGCTG 
CTGCCCTCGC TGCCCCTGAC CCGCGCCCCC GTGCCCCCAG GCCCAGCCGC CGCCCTGCTC 
CAGGCTCTAG GACTGCGCGA TGAGCCCCAG GGTGCCCCCA GGCTCCGGCC GGTTCCCCCG 
GTCATGTGGC GCCTGTTTCG ACGCCGGGAC CCCCAGGAGA CCAGGTCTGG CTCGCGGCGG 
ACGTCCCCAG GGGTCACCCT GCAACCGTGC CACGTGGAGG AGCTGGGGGT CGCCGGAAAC 
ATCGTGCGCC ACATCCCGGA CCGCGGTGCG CCCACCCGGG CCTCGGAGCC TGCCTCGGCC 
GCGGGGCATT GCCCTGAGTG GACAGTCGTC TTCGACCTGT CGGCTGTGGA ACCCGCTGAG 
CGCCCGAGCC GGGCCCGCCT GGAGCTGCGT TTCGCGGCGG CGGCGGCGGC AGCCCCGGAG 
GGCGGCTGGG AGCTGAGCGT GGCGCAAGCG GGCCAGGGCG CGGGCGCGGA CCCCGGGCCG 
GTGCTGCTCC GCCAGTTGGT GCCCGCCCTG GGGCCGCCAG TGCGCGCGGA GCTGCTGGGC 
GCCGCTTGGG CTCGCAACGC CTCATGGCCG CGCAGCCTCC GCCTGGCGCT GGCGCTACGC 
CCCCGGGCCC CTGCCGCCTG CGCGCGCCTG GCCGAGGCCT CGCTGCTGCT GGTGACCCTC 
GACCCGCGCC TGTGCCACCC CCTGGCCCGG CCGCGGCGCG ACGCCGAACC CGTGTTGGGC 
GGCGGCCCCG GGGGCGCTTG TCGCGCGCGG CGGCTGTACG TGAGCTTCCG CGAGGTGGGC 
TGGCACCGCT GGGTCATCGC GCCGCGCGGC TTCCTGGCCA ACTACTGCCA GGGTCAGTGC 
GCGCTGCCCG TCGCGCTGTC GGGGTCCGGG GGGCCGCCGG CGCTCAACCA CGCTGTGCTG 
CGCGCGCTCA TGCACGCGGC CGCCCCGGGA GCCGCCGACC TGCCCTGCTG CGTGCCCGCG 
CGCCTGTCGC CCATCTCCGT GCTCTTCTTT GACAACAGCG ACAACGTGGT GCTGCGGCAG 
TATGAGGACA TGGTGGTGGA CGAGTGCGGC TGCCGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001483.3
CDS	1395..2513
Translation	MPPPQQGPCGHHLLLLLALLLPSLPLTRAPVPPGPAAALLQALGLRDEPQGAPRLRPVPPVMWRLFRRRDPQETRSGSRRTSPGVTLQPCHVEELGVAGNIVRHIPDRGAPTRASEPASAAGHCPEWTVVFDLSAVEPAERPSRARLELRFAAAAAAAPEGGWELSVAQAGQGAGADPGPVLLRQLVPALGPPVRAELLGAAWARNASWPRSLRLALALRPRAPAACARLAEASLLLVTLDPRLCHPLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR

Target ORF information:

RefSeq Version	NM_001492.5
Organism	Homo sapiens(human)
Definition	Homo sapiens growth differentiation factor 1 (GDF1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001492.5

ORF Insert Sequence:

ATGCCACCGC CGCAGCAAGG TCCCTGCGGC CACCACCTCC TCCTCCTCCT GGCCCTGCTG 
CTGCCCTCGC TGCCCCTGAC CCGCGCCCCC GTGCCCCCAG GCCCAGCCGC CGCCCTGCTC 
CAGGCTCTAG GACTGCGCGA TGAGCCCCAG GGTGCCCCCA GGCTCCGGCC GGTTCCCCCG 
GTCATGTGGC GCCTGTTTCG ACGCCGGGAC CCCCAGGAGA CCAGGTCTGG CTCGCGGCGG 
ACGTCCCCAG GGGTCACCCT GCAACCGTGC CACGTGGAGG AGCTGGGGGT CGCCGGAAAC 
ATCGTGCGCC ACATCCCGGA CCGCGGTGCG CCCACCCGGG CCTCGGAGCC TGCCTCGGCC 
GCGGGGCATT GCCCTGAGTG GACAGTCGTC TTCGACCTGT CGGCTGTGGA ACCCGCTGAG 
CGCCCGAGCC GGGCCCGCCT GGAGCTGCGT TTCGCGGCGG CGGCGGCGGC AGCCCCGGAG 
GGCGGCTGGG AGCTGAGCGT GGCGCAAGCG GGCCAGGGCG CGGGCGCGGA CCCCGGGCCG 
GTGCTGCTCC GCCAGTTGGT GCCCGCCCTG GGGCCGCCAG TGCGCGCGGA GCTGCTGGGC 
GCCGCTTGGG CTCGCAACGC CTCATGGCCG CGCAGCCTCC GCCTGGCGCT GGCGCTACGC 
CCCCGGGCCC CTGCCGCCTG CGCGCGCCTG GCCGAGGCCT CGCTGCTGCT GGTGACCCTC 
GACCCGCGCC TGTGCCACCC CCTGGCCCGG CCGCGGCGCG ACGCCGAACC CGTGTTGGGC 
GGCGGCCCCG GGGGCGCTTG TCGCGCGCGG CGGCTGTACG TGAGCTTCCG CGAGGTGGGC 
TGGCACCGCT GGGTCATCGC GCCGCGCGGC TTCCTGGCCA ACTACTGCCA GGGTCAGTGC 
GCGCTGCCCG TCGCGCTGTC GGGGTCCGGG GGGCCGCCGG CGCTCAACCA CGCTGTGCTG 
CGCGCGCTCA TGCACGCGGC CGCCCCGGGA GCCGCCGACC TGCCCTGCTG CGTGCCCGCG 
CGCCTGTCGC CCATCTCCGT GCTCTTCTTT GACAACAGCG ACAACGTGGT GCTGCGGCAG 
TATGAGGACA TGGTGGTGGA CGAGTGCGGC TGCCGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.
Nature genetics49(11)1593-1601(2017 Nov)
Jin SC,Homsy J,Zaidi S,Lu Q,Morton S,DePalma SR,Zeng X,Qi H,Chang W,Sierant MC,Hung WC,Haider S,Zhang J,Knight J,Bjornson RD,Castaldi C,Tikhonoa IR,Bilguvar K,Mane SM,Sanders SJ,Mital S,Russell MW,Gaynor JW,Deanfield J,Giardini A,Porter GA Jr,Srivastava D,Lo CW,Shen Y,Watkins WS,Yandell M,Yost HJ,Tristani-Firouzi M,Newburger JW,Roberts AE,Kim R,Zhao H,Kaltman JR,Goldmuntz E,Chung WK,Seidman JG,Gelb BD,Seidman CE,Lifton RP,Brueckner M

Association of GDF1 rs4808863 with fetal congenital heart defects: a case-control study.
BMJ open5(12)e009352(2015 Dec)
Zhang J,Wu Q,Wang L,Li X,Ma Y,Yao L

Nodal?Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation.
The Journal of biological chemistry289(25)17854-71(2014 Jun)
Fuerer C,Nostro MC,Constam DB

Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction.
Biochimica et biophysica acta1842(2)232-44(2014 Feb)
Zhang Y,Zhang XF,Gao L,Liu Y,Jiang DS,Chen K,Yang Q,Fan GC,Zhang XD,Huang C

Association of growth/differentiation factor 1 gene polymorphisms with the risk of congenital heart disease in the Chinese Han population.
Molecular biology reports40(2)1291-9(2013 Feb)
Sun X,Meng Y,You T,Li P,Wu H,Yu M,Xie X

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GDF1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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