CLDN17 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLDN17
Entrez Gene ID	26285
Full Name	claudin 17
General protein information	Preferred Names claudin 17 Names claudin-17 human CLDN17 gene for claudin-17
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q21.3
Summary	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11. [provided by RefSeq, Jun 2010].
Disorder MIM:	617005

mRNA and Protein(s)

mRNA	Protein	Name
NM_012131.2	NP_036263.1	claudin-17
NM_012131.3	NP_036263.1	claudin-17

Pathways from BioSystems

Homologies

	CLDN17	XP_001100305.1
Bos taurus (cattle)	CLDN17	XP_002684657.1
Pan troglodytes (chimpanzee)	CLDN17	XP_003949198.1
Canis lupus familiaris (dog)	CLDN17	XP_544844.1
Mus musculus (house mouse)	Cldn17	NP_852467.1
Gallus gallus (chicken)	CLDN17	XP_425543.2
Homo sapiens (human)	CLDN17	NP_036263.1
Rattus norvegicus (Norway rat)	Cldn17	NP_001100582.1
Danio rerio (zebrafish)	LOC570842	XP_005173846.1

Gene Ontology
Bibliography

Related articles in PubMed

Molecular basis of claudin-17 anion selectivity.
Conrad MP, Piontek J, G?nzel D, Fromm M, Krug SM
Cellular and molecular life sciences : CMLS73(1)185-200(2016 Jan)

The distinct expression patterns of claudin-10, -14, -17 and E-cadherin between adjacent non-neoplastic tissues and gastric cancer tissues.
Gao M, Li W, Wang H, Wang G
Diagnostic pathology8205(2013 Dec)

Claudin association with CD81 defines hepatitis C virus entry.
Harris HJ, Davis C, Mullins JG, Hu K, Goodall M, Farquhar MJ, Mee CJ, McCaffrey K, Young S, Drummer H, Balfe P, McKeating JA
The Journal of biological chemistry285(27)21092-102(2010 Jul)

Genome-wide association of lipid-lowering response to statins in combined study populations.
Barber MJ, Mangravite LM, Hyde CL, Chasman DI, Smith JD, McCarty CA, Li X, Wilke RA, Rieder MJ, Williams PT, Ridker PM, Chatterjee A, Rotter JI, Nickerson DA, Stephens M, Krauss RM
PloS one5(3)e9763(2010 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The structural features of Cldn17 contributing to anion channel formation are presented in this work.
Title: Molecular basis of claudin-17 anion selectivity.

Claudin 17 expression was down-regulated in gastric cancer.
Title: The distinct expression patterns of claudin-10, -14, -17 and E-cadherin between adjacent non-neoplastic tissues and gastric cancer tissues.

CLDN17, clustered with CLDN8 at human chromosome 21q22.11, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C.
Title: CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family.

The following CLDN17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLDN17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55716	NM_012131.3 Latest version!	Homo sapiens claudin 17 (CLDN17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu55716	NM_012131.2	Homo sapiens claudin 17 (CLDN17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLDN17 ( NM_012131.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036263.1 Homo sapiens claudin 17 (CLDN17), mRNA.

Price & Availability↑

CloneID	OHu55716
Clone ID Related Accession (Same CDS sequence)	NM_012131.2 , NM_012131.3
Accession Version	NM_012131.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-02
Organism	Homo sapiens(human)
Product	claudin-17
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC101503.1. On Jun 4, 2010 this sequence version replaced NM_012131.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC101503.1 [ECO:0000345] ##Evidence-Data-END##

ATGGCATTTT ATCCCTTGCA AATTGCTGGG CTGGTTCTTG GGTTCCTTGG CATGGTGGGG 
ACTCTTGCCA CAACCCTTCT GCCTCAGTGG AGAGTATCAG CTTTTGTTGG CAGCAACATT 
ATTGTCTTTG AGAGGCTCTG GGAAGGGCTC TGGATGAATT GCATCCGACA AGCCAGGGTC 
CGGTTGCAAT GCAAGTTCTA TAGCTCCTTG TTGGCTCTCC CGCCTGCCCT GGAAACAGCC 
CGGGCCCTCA TGTGTGTGGC TGTTGCTCTC TCCTTGATCG CCCTGCTTAT TGGCATCTGT 
GGCATGAAGC AGGTCCAGTG CACAGGCTCT AACGAGAGGG CCAAAGCATA CCTTCTGGGA 
ACTTCAGGAG TCCTCTTCAT CCTGACGGGC ATCTTCGTTC TGATTCCGGT GAGCTGGACA 
GCCAATATAA TCATCAGAGA TTTCTACAAC CCAGCCATCC ACATAGGTCA GAAACGAGAG 
CTGGGAGCAG CACTTTTCCT TGGCTGGGCA AGCGCTGCTG TCCTCTTCAT TGGAGGGGGT 
CTGCTTTGTG GATTTTGCTG CTGCAACAGA AAGAAGCAAG GGTACAGATA TCCAGTGCCT 
GGCTACCGTG TGCCACACAC AGATAAGCGA AGAAATACGA CAATGCTTAG TAAGACCTCC 
ACCAGTTATG TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036263.1
CDS	37..711
Translation	MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGGLLCGFCCCNRKKQGYRYPVPGYRVPHTDKRRNTTMLSKTSTSYV

Target ORF information:

RefSeq Version	NM_012131.2
Organism	Homo sapiens(human)
Definition	Homo sapiens claudin 17 (CLDN17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012131.2

ORF Insert Sequence:

ATGGCATTTT ATCCCTTGCA AATTGCTGGG CTGGTTCTTG GGTTCCTTGG CATGGTGGGG 
ACTCTTGCCA CAACCCTTCT GCCTCAGTGG AGAGTATCAG CTTTTGTTGG CAGCAACATT 
ATTGTCTTTG AGAGGCTCTG GGAAGGGCTC TGGATGAATT GCATCCGACA AGCCAGGGTC 
CGGTTGCAAT GCAAGTTCTA TAGCTCCTTG TTGGCTCTCC CGCCTGCCCT GGAAACAGCC 
CGGGCCCTCA TGTGTGTGGC TGTTGCTCTC TCCTTGATCG CCCTGCTTAT TGGCATCTGT 
GGCATGAAGC AGGTCCAGTG CACAGGCTCT AACGAGAGGG CCAAAGCATA CCTTCTGGGA 
ACTTCAGGAG TCCTCTTCAT CCTGACGGGC ATCTTCGTTC TGATTCCGGT GAGCTGGACA 
GCCAATATAA TCATCAGAGA TTTCTACAAC CCAGCCATCC ACATAGGTCA GAAACGAGAG 
CTGGGAGCAG CACTTTTCCT TGGCTGGGCA AGCGCTGCTG TCCTCTTCAT TGGAGGGGGT 
CTGCTTTGTG GATTTTGCTG CTGCAACAGA AAGAAGCAAG GGTACAGATA TCCAGTGCCT 
GGCTACCGTG TGCCACACAC AGATAAGCGA AGAAATACGA CAATGCTTAG TAAGACCTCC 
ACCAGTTATG TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLDN17 ( NM_012131.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036263.1 Homo sapiens claudin 17 (CLDN17), mRNA.

Price & Availability↑

CloneID	OHu55716
Clone ID Related Accession (Same CDS sequence)	NM_012131.2 , NM_012131.3
Accession Version	NM_012131.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Homo sapiens(human)
Product	claudin-17
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000884.1 and BC101503.1. On May 17, 2019 this sequence version replaced NM_012131.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR1803617.500281.1, AY358094.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000286808.5/ ENSP00000286808.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCATTTT ATCCCTTGCA AATTGCTGGG CTGGTTCTTG GGTTCCTTGG CATGGTGGGG 
ACTCTTGCCA CAACCCTTCT GCCTCAGTGG AGAGTATCAG CTTTTGTTGG CAGCAACATT 
ATTGTCTTTG AGAGGCTCTG GGAAGGGCTC TGGATGAATT GCATCCGACA AGCCAGGGTC 
CGGTTGCAAT GCAAGTTCTA TAGCTCCTTG TTGGCTCTCC CGCCTGCCCT GGAAACAGCC 
CGGGCCCTCA TGTGTGTGGC TGTTGCTCTC TCCTTGATCG CCCTGCTTAT TGGCATCTGT 
GGCATGAAGC AGGTCCAGTG CACAGGCTCT AACGAGAGGG CCAAAGCATA CCTTCTGGGA 
ACTTCAGGAG TCCTCTTCAT CCTGACGGGC ATCTTCGTTC TGATTCCGGT GAGCTGGACA 
GCCAATATAA TCATCAGAGA TTTCTACAAC CCAGCCATCC ACATAGGTCA GAAACGAGAG 
CTGGGAGCAG CACTTTTCCT TGGCTGGGCA AGCGCTGCTG TCCTCTTCAT TGGAGGGGGT 
CTGCTTTGTG GATTTTGCTG CTGCAACAGA AAGAAGCAAG GGTACAGATA TCCAGTGCCT 
GGCTACCGTG TGCCACACAC AGATAAGCGA AGAAATACGA CAATGCTTAG TAAGACCTCC 
ACCAGTTATG TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036263.1
CDS	189..863
Translation	MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGGLLCGFCCCNRKKQGYRYPVPGYRVPHTDKRRNTTMLSKTSTSYV

Target ORF information:

RefSeq Version	NM_012131.3
Organism	Homo sapiens(human)
Definition	Homo sapiens claudin 17 (CLDN17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012131.3

ORF Insert Sequence:

ATGGCATTTT ATCCCTTGCA AATTGCTGGG CTGGTTCTTG GGTTCCTTGG CATGGTGGGG 
ACTCTTGCCA CAACCCTTCT GCCTCAGTGG AGAGTATCAG CTTTTGTTGG CAGCAACATT 
ATTGTCTTTG AGAGGCTCTG GGAAGGGCTC TGGATGAATT GCATCCGACA AGCCAGGGTC 
CGGTTGCAAT GCAAGTTCTA TAGCTCCTTG TTGGCTCTCC CGCCTGCCCT GGAAACAGCC 
CGGGCCCTCA TGTGTGTGGC TGTTGCTCTC TCCTTGATCG CCCTGCTTAT TGGCATCTGT 
GGCATGAAGC AGGTCCAGTG CACAGGCTCT AACGAGAGGG CCAAAGCATA CCTTCTGGGA 
ACTTCAGGAG TCCTCTTCAT CCTGACGGGC ATCTTCGTTC TGATTCCGGT GAGCTGGACA 
GCCAATATAA TCATCAGAGA TTTCTACAAC CCAGCCATCC ACATAGGTCA GAAACGAGAG 
CTGGGAGCAG CACTTTTCCT TGGCTGGGCA AGCGCTGCTG TCCTCTTCAT TGGAGGGGGT 
CTGCTTTGTG GATTTTGCTG CTGCAACAGA AAGAAGCAAG GGTACAGATA TCCAGTGCCT 
GGCTACCGTG TGCCACACAC AGATAAGCGA AGAAATACGA CAATGCTTAG TAAGACCTCC 
ACCAGTTATG TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecular basis of claudin-17 anion selectivity.
Cellular and molecular life sciences : CMLS73(1)185-200(2016 Jan)
Conrad MP,Piontek J,G?nzel D,Fromm M,Krug SM

The distinct expression patterns of claudin-10, -14, -17 and E-cadherin between adjacent non-neoplastic tissues and gastric cancer tissues.
Diagnostic pathology8205(2013 Dec)
Gao M,Li W,Wang H,Wang G

Claudin association with CD81 defines hepatitis C virus entry.
The Journal of biological chemistry285(27)21092-102(2010 Jul)
Harris HJ,Davis C,Mullins JG,Hu K,Goodall M,Farquhar MJ,Mee CJ,McCaffrey K,Young S,Drummer H,Balfe P,McKeating JA

Genome-wide association of lipid-lowering response to statins in combined study populations.
PloS one5(3)e9763(2010 Mar)
Barber MJ,Mangravite LM,Hyde CL,Chasman DI,Smith JD,McCarty CA,Li X,Wilke RA,Rieder MJ,Williams PT,Ridker PM,Chatterjee A,Rotter JI,Nickerson DA,Stephens M,Krauss RM

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CLDN17 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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