DEFB110 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEFB110
Entrez Gene ID	245913
Full Name	defensin beta 110
Synonyms	DEFB-10,DEFB-11,DEFB111
General protein information	Preferred Names defensin beta 110 Names beta-defensin 110 beta-defensin 10 beta-defensin 11 beta-defensin 111 defensin, beta 10 defensin, beta 110 locus
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p12.3
Summary	Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001037497.1	NP_001032586.1	beta-defensin 110 isoform a precursor
NM_001037728.2	NP_001032817.1	beta-defensin 110 isoform b precursor
NM_001037497.2	NP_001032586.1	beta-defensin 110 isoform a precursor

Pathways from BioSystems

Homologies

	DEFB110	XP_001105715.1
Canis lupus familiaris (dog)	DEFB110	XP_003431789.1
Homo sapiens (human)	DEFB110	NP_001032586.1
Pan troglodytes (chimpanzee)	DEFB110	NP_001123232.1
Bos taurus (cattle)	DEFB110	XP_002697354.1
Rattus norvegicus (Norway rat)	Defb17	NP_001032623.1

Gene Ontology
Bibliography

Related articles in PubMed

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Patil AA, Cai Y, Sang Y, Blecha F, Zhang G
Physiological genomics23(1)5-17(2005 Sep)

Discovery of five conserved beta -defensin gene clusters using a computational search strategy.
Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr
Proceedings of the National Academy of Sciences of the United States of America99(4)2129-33(2002 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The encoded protein is thought to have antimicrobial activity.
Title: Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.

The following DEFB110 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFB110 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30265	NM_001037497.2 Latest version!	Homo sapiens defensin beta 110 (DEFB110), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04675	NM_001037728.2 Latest version!	Homo sapiens defensin beta 110 (DEFB110), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu30265	NM_001037497.1	Homo sapiens defensin beta 110 (DEFB110), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEFB110 ( NM_001037497.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001032586.1 Homo sapiens defensin beta 110 (DEFB110), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30265
Clone ID Related Accession (Same CDS sequence)	NM_001037497.1 , NM_001037497.2
Accession Version	NM_001037497.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 204bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	beta-defensin 110 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ012015.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a, also known as DEFB111). ##Evidence-Data-START## Transcript exon combination :: DQ012015.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 16033865 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGATTC AACTTTTTTT CTTTATTCTG CACTTTTGGG TCACAATTTT ACCAGCCAAA 
AAGAAATATC CTGAGTATGG TAGCTTGGAC TTGAGGAGAG AGTGCAGAAT AGGTAATGGT 
CAATGTAAAA ATCAGTGTCA TGAAAATGAA ATTAGGATTG CTTACTGCAT AAGACCTGGA 
ACTCATTGCT GCTTGCAGCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032586.1
CDS	47..250
Translation	MKIQLFFFILHFWVTILPAKKKYPEYGSLDLRRECRIGNGQCKNQCHENEIRIAYCIRPGTHCCLQQ

Target ORF information:

RefSeq Version	NM_001037497.1
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 110 (DEFB110), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037497.1

ORF Insert Sequence:

ATGAAGATTC AACTTTTTTT CTTTATTCTG CACTTTTGGG TCACAATTTT ACCAGCCAAA 
AAGAAATATC CTGAGTATGG TAGCTTGGAC TTGAGGAGAG AGTGCAGAAT AGGTAATGGT 
CAATGTAAAA ATCAGTGTCA TGAAAATGAA ATTAGGATTG CTTACTGCAT AAGACCTGGA 
ACTCATTGCT GCTTGCAGCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEFB110 ( NM_001037497.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001032586.1 Homo sapiens defensin beta 110 (DEFB110), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30265
Clone ID Related Accession (Same CDS sequence)	NM_001037497.1 , NM_001037497.2
Accession Version	NM_001037497.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 204bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	beta-defensin 110 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL138879.10 and DQ012015.1. On May 17, 2019 this sequence version replaced NM_001037497.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a, also known as DEFB111). ##Evidence-Data-START## Transcript exon combination :: DQ012015.1, BX111343.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371148.3/ ENSP00000360190.2 Protein has antimicrobial activity :: PMID: 16033865 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGATTC AACTTTTTTT CTTTATTCTG CACTTTTGGG TCACAATTTT ACCAGCCAAA 
AAGAAATATC CTGAGTATGG TAGCTTGGAC TTGAGGAGAG AGTGCAGAAT AGGTAATGGT 
CAATGTAAAA ATCAGTGTCA TGAAAATGAA ATTAGGATTG CTTACTGCAT AAGACCTGGA 
ACTCATTGCT GCTTGCAGCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032586.1
CDS	60..263
Translation	MKIQLFFFILHFWVTILPAKKKYPEYGSLDLRRECRIGNGQCKNQCHENEIRIAYCIRPGTHCCLQQ

Target ORF information:

RefSeq Version	NM_001037497.2
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 110 (DEFB110), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037497.2

ORF Insert Sequence:

ATGAAGATTC AACTTTTTTT CTTTATTCTG CACTTTTGGG TCACAATTTT ACCAGCCAAA 
AAGAAATATC CTGAGTATGG TAGCTTGGAC TTGAGGAGAG AGTGCAGAAT AGGTAATGGT 
CAATGTAAAA ATCAGTGTCA TGAAAATGAA ATTAGGATTG CTTACTGCAT AAGACCTGGA 
ACTCATTGCT GCTTGCAGCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEFB110 ( NM_001037728.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001032817.1 Homo sapiens defensin beta 110 (DEFB110), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04675
Clone ID Related Accession (Same CDS sequence)	NM_001037728.2
Accession Version	NM_001037728.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 189bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	beta-defensin 110 isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ012015.1 and DQ012014.1. On Aug 13, 2009 this sequence version replaced NM_001037728.1. Transcript Variant: This variant (2) lacks a 3' UTR and differs in the 3' coding region, compared to variant 1, resulting in an isoform (b) that has a distinct C-terminus and is shorter than isoform a. ##Evidence-Data-START## Transcript exon combination :: DQ012014.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 16033865 ##RefSeq-Attributes-END##

ATGAAGATTC AACTTTTTTT CTTTATTCTG CACTTTTGGG TCACAATTTT ACCAGCCAGA 
AGCAATTTTG AACCAAAGTA TAGATTTGAA AGATGCGAAA AAGTGAGAGG AATATGTAAA 
ACGTTTTGTG ATGATGTTGA GTATGATTAT GGATACTGCA TTAAATGGAG AAGTCAGTGC 
TGCGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032817.1
CDS	47..235
Translation	MKIQLFFFILHFWVTILPARSNFEPKYRFERCEKVRGICKTFCDDVEYDYGYCIKWRSQCCV

Target ORF information:

RefSeq Version	NM_001037728.2
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 110 (DEFB110), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037728.2

ORF Insert Sequence:

ATGAAGATTC AACTTTTTTT CTTTATTCTG CACTTTTGGG TCACAATTTT ACCAGCCAGA 
AGCAATTTTG AACCAAAGTA TAGATTTGAA AGATGCGAAA AAGTGAGAGG AATATGTAAA 
ACGTTTTGTG ATGATGTTGA GTATGATTAT GGATACTGCA TTAAATGGAG AAGTCAGTGC 
TGCGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Physiological genomics23(1)5-17(2005 Sep)
Patil AA,Cai Y,Sang Y,Blecha F,Zhang G

Discovery of five conserved beta -defensin gene clusters using a computational search strategy.
Proceedings of the National Academy of Sciences of the United States of America99(4)2129-33(2002 Feb)
Schutte BC,Mitros JP,Bartlett JA,Walters JD,Jia HP,Welsh MJ,Casavant TL,McCray PB Jr

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DEFB110 cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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