DEFB108B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEFB108B
Entrez Gene ID	245911
Full Name	defensin beta 108B
Synonyms	DEFB-8,hBD-8
General protein information	Preferred Names defensin beta 108B Names beta-defensin 108B beta-defensin 8 defensin, beta 8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.4
Summary	Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. A pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Oct 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001002035.1	NP_001002035.1	beta-defensin 108B precursor
NM_001002035.2	NP_001002035.1	beta-defensin 108B precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DEFB108B	XP_001160287.1
	DEFB108B	XP_001085540.1
Homo sapiens (human)	DEFB108B	NP_001002035.1

Gene Ontology
Bibliography

Related articles in PubMed

Copy number variation of defensin genes and HIV infection in Brazilian children.
Milanese M, Segat L, Arraes LC, Garzino-Demo A, Crovella S
Journal of acquired immune deficiency syndromes (1999)50(3)331-3(2009 Mar)

ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes.
Kao CY, Chen Y, Zhao YH, Wu R
American journal of respiratory cell and molecular biology29(1)71-80(2003 Jul)

Duplication and selection in the evolution of primate beta-defensin genes.
Semple CA, Rolfe M, Dorin JR
Genome biology4(5)R31(2003)

Discovery of five conserved beta -defensin gene clusters using a computational search strategy.
Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr
Proceedings of the National Academy of Sciences of the United States of America99(4)2129-33(2002 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Copy number variation of defensin genes and HIV infection in Brazilian children.

The encoded protein is thought to have antimicrobial activity.
Title: ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes.

The following DEFB108B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFB108B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03388	NM_001002035.2 Latest version!	Homo sapiens defensin beta 108B (DEFB108B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu03388	NM_001002035.1	Homo sapiens defensin beta 108B (DEFB108B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEFB108B ( NM_001002035.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001002035.1 Homo sapiens defensin beta 108B (DEFB108B), mRNA.

Price & Availability↑

CloneID	OHu03388
Clone ID Related Accession (Same CDS sequence)	NM_001002035.1 , NM_001002035.2
Accession Version	NM_001002035.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 222bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	beta-defensin 108B precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF529416.1. ##Evidence-Data-START## Transcript exon combination :: AF529416.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12600824 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAGGATTG CTGTCCTCCT CTTCGCCATT TTCTTCTTTA TGAGCCAAGT TCTACCAGCC 
AGGGGCAAAT TCAAGGAGAT CTGTGAACGT CCAAATGGCT CCTGTCGGGA CTTTTGCCTT 
GAAACAGAAA TCCATGTTGG GAGATGTTTA AATAGCCAAC CCTGCTGCCT GCCTCTGGGG 
CATCAACCAA GAATTGAGAG CACTACACCC AAAAAGGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002035.1
CDS	1..222
Translation	MRIAVLLFAIFFFMSQVLPARGKFKEICERPNGSCRDFCLETEIHVGRCLNSQPCCLPLGHQPRIESTTPKKD

Target ORF information:

RefSeq Version	NM_001002035.1
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 108B (DEFB108B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002035.1

ORF Insert Sequence:

ATGAGGATTG CTGTCCTCCT CTTCGCCATT TTCTTCTTTA TGAGCCAAGT TCTACCAGCC 
AGGGGCAAAT TCAAGGAGAT CTGTGAACGT CCAAATGGCT CCTGTCGGGA CTTTTGCCTT 
GAAACAGAAA TCCATGTTGG GAGATGTTTA AATAGCCAAC CCTGCTGCCT GCCTCTGGGG 
CATCAACCAA GAATTGAGAG CACTACACCC AAAAAGGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEFB108B ( NM_001002035.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001002035.1 Homo sapiens defensin beta 108B (DEFB108B), mRNA.

Price & Availability↑

CloneID	OHu03388
Clone ID Related Accession (Same CDS sequence)	NM_001002035.1 , NM_001002035.2
Accession Version	NM_001002035.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 222bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	beta-defensin 108B precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AP002495.3. On Sep 2, 2019 this sequence version replaced NM_001002035.1. ##Evidence-Data-START## Transcript exon combination :: AF529416.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000328698.2/ ENSP00000333234.1 Protein has antimicrobial activity :: PMID: 12600824 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAGGATTG CTGTCCTCCT CTTCGCCATT TTCTTCTTTA TGAGCCAAGT TCTACCAGCC 
AGGGGCAAAT TCAAGGAGAT CTGTGAACGT CCAAATGGCT CCTGTCGGGA CTTTTGCCTT 
GAAACAGAAA TCCATGTTGG GAGATGTTTA AATAGCCAAC CCTGCTGCCT GCCTCTGGGG 
CATCAACCAA GAATTGAGAG CACTACACCC AAAAAGGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002035.1
CDS	1..222
Translation	MRIAVLLFAIFFFMSQVLPARGKFKEICERPNGSCRDFCLETEIHVGRCLNSQPCCLPLGHQPRIESTTPKKD

Target ORF information:

RefSeq Version	NM_001002035.2
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 108B (DEFB108B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002035.2

ORF Insert Sequence:

ATGAGGATTG CTGTCCTCCT CTTCGCCATT TTCTTCTTTA TGAGCCAAGT TCTACCAGCC 
AGGGGCAAAT TCAAGGAGAT CTGTGAACGT CCAAATGGCT CCTGTCGGGA CTTTTGCCTT 
GAAACAGAAA TCCATGTTGG GAGATGTTTA AATAGCCAAC CCTGCTGCCT GCCTCTGGGG 
CATCAACCAA GAATTGAGAG CACTACACCC AAAAAGGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Copy number variation of defensin genes and HIV infection in Brazilian children.
Journal of acquired immune deficiency syndromes (1999)50(3)331-3(2009 Mar)
Milanese M,Segat L,Arraes LC,Garzino-Demo A,Crovella S

ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes.
American journal of respiratory cell and molecular biology29(1)71-80(2003 Jul)
Kao CY,Chen Y,Zhao YH,Wu R

Duplication and selection in the evolution of primate beta-defensin genes.
Genome biology4(5)R31(2003)
Semple CA,Rolfe M,Dorin JR

Discovery of five conserved beta -defensin gene clusters using a computational search strategy.
Proceedings of the National Academy of Sciences of the United States of America99(4)2129-33(2002 Feb)
Schutte BC,Mitros JP,Bartlett JA,Walters JD,Jia HP,Welsh MJ,Casavant TL,McCray PB Jr

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DEFB108B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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