SNAPIN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SNAPIN
Entrez Gene ID	23557
Full Name	SNAP associated protein
Synonyms	BLOC1S7,BLOS7,BORCS3,SNAPAP
General protein information	Preferred Names SNAP associated protein Names SNARE-associated protein Snapin BLOC-1 subunit 7 SNAP-25-binding protein SNARE associated protein snapin biogenesis of lysosomal organelles complex-1, subunit 7 biogenesis of lysosome-related organelles complex 1 subunit 7 synaptosomal-associated protein 25-binding protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012].
Disorder MIM:	607007

mRNA and Protein(s)

mRNA	Protein	Name
NM_012437.6	NP_036569.1	SNARE-associated protein Snapin
NM_012437.5	NP_036569.1	SNARE-associated protein Snapin

Pathways from BioSystems

Homologies

Homo sapiens (human)	SNAPIN	NP_036569.1
	SNAPIN	XP_001111730.1
Rattus norvegicus (Norway rat)	Snapin	NP_001164047.1
Danio rerio (zebrafish)	snapin	NP_001038613.1
Gallus gallus (chicken)	SNAPIN	XP_003642675.1
Bos taurus (cattle)	SNAPIN	NP_001076879.1
Mus musculus (house mouse)	Snapin	NP_598615.1
Pan troglodytes (chimpanzee)	SNAPIN	XP_003949614.1
Canis lupus familiaris (dog)	SNAPIN	XP_547578.1

Gene Ontology
Bibliography

Related articles in PubMed

Snapin promotes HIV-1 transmission from dendritic cells by dampening TLR8 signaling.
Khatamzas E, Hipp MM, Gaughan D, Pichulik T, Leslie A, Fernandes RA, Muraro D, Booth S, Zausmer K, Sun MY, Kessler B, Rowland-Jones S, Cerundolo V, Simmons A
The EMBO journal36(20)2998-3011(2017 10)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages.
Shi B, Huang QQ, Birkett R, Doyle R, Dorfleutner A, Stehlik C, He C, Pope RM
Autophagy13(2)285-301(2017 Feb)

Physical and functional interaction of Snapin with Cav1.3 calcium channel impacts channel protein trafficking in atrial myocytes.
Sun XL, Yuan JF, Jin T, Cheng XQ, Wang Q, Guo J, Zhang W, Zhang Y, Lu L, Zhang Z
Cellular signalling30118-129(2017 Jan)

Host protein Snapin interacts with human cytomegalovirus pUL130 and affects viral DNA replication.
Wang G, Ren G, Cui X, Lu Z, Ma Y, Qi Y, Huang Y, Liu Z, Sun Z, Ruan Q
Journal of biosciences41(2)173-82(2016 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Inhibition of Snapin enhanced localization of HIV-1 with TLR8(+) early endosomes, triggered a pro-inflammatory response, and inhibited trans-infection of CD4(+) T cells.
Title: Snapin promotes HIV-1 transmission from dendritic cells by dampening TLR8 signaling.

These observations suggest an important role for SNAPIN and autophagy in the homeostasis of macrophages, particularly long-lived tissue resident macrophages.
Title: SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages.

These results provide the evidence of a direct regulatory role of Snapin on Cav1.3 channels in atrial myocytes.
Title: Physical and functional interaction of Snapin with Cav1.3 calcium channel impacts channel protein trafficking in atrial myocytes.

Taken together, these results suggest that Snapin, the pUL130 interacting protein, has a role in modulating HCMV DNA synthesis.
Title: Host protein Snapin interacts with human cytomegalovirus pUL130 and affects viral DNA replication.

Disruption of Snapin-PKR2 interaction did not affect PKR2 signaling, but increased the ligand-induced degradation, implying a role of Snapin in the trafficking of PKR2.
Title: Snapin interacts with G-protein coupled receptor PKR2.

The following SNAPIN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SNAPIN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu56032	NM_012437.6 Latest version!	Homo sapiens SNAP associated protein (SNAPIN), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu56032	NM_012437.5	Homo sapiens SNAP associated protein (SNAPIN), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SNAPIN ( NM_012437.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_036569.1 Homo sapiens SNAP associated protein (SNAPIN), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu56032
Clone ID Related Accession (Same CDS sequence)	NM_012437.6 , NM_012437.5
Accession Version	NM_012437.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	SNARE-associated protein Snapin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI117540.1, BC000761.2 and AI018675.1. On May 17, 2019 this sequence version replaced NM_012437.5. Transcript Variant: This variant (1) represents the longest transcript and encodes the supported protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.202315.1, SRR1803615.16338.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368685.6/ ENSP00000357674.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGGGG CTGGTTCCGC CGCTGTATCG GGGGCAGGGA CCCCGGTGGC GGGGCCCACA 
GGCCGCGACC TTTTCGCCGA AGGGCTGCTG GAGTTCCTGC GACCCGCTGT GCAGCAGCTC 
GACTCTCACG TACACGCCGT CAGAGAGAGC CAGGTAGAGC TCCGGGAACA AATTGACAAC 
CTAGCCACAG AACTGTGCCG CATAAATGAG GATCAGAAGG TGGCCCTGGA TCTTGACCCC 
TATGTTAAGA AGCTACTTAA TGCCCGGCGA CGCGTTGTCT TGGTTAACAA CATTCTACAG 
AATGCTCAGG AACGACTGAG ACGGCTAAAC CACAGTGTTG CCAAGGAAAC AGCCCGCAGG 
AGAGCAATGC TGGATTCGGG AATTTACCCC CCTGGCTCCC CAGGCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036569.1
CDS	42..452
Translation	MAGAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGIYPPGSPGK

Target ORF information:

RefSeq Version	NM_012437.6
Organism	Homo sapiens(human)
Definition	Homo sapiens SNAP associated protein (SNAPIN), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012437.6

ORF Insert Sequence:

ATGGCGGGGG CTGGTTCCGC CGCTGTATCG GGGGCAGGGA CCCCGGTGGC GGGGCCCACA 
GGCCGCGACC TTTTCGCCGA AGGGCTGCTG GAGTTCCTGC GACCCGCTGT GCAGCAGCTC 
GACTCTCACG TACACGCCGT CAGAGAGAGC CAGGTAGAGC TCCGGGAACA AATTGACAAC 
CTAGCCACAG AACTGTGCCG CATAAATGAG GATCAGAAGG TGGCCCTGGA TCTTGACCCC 
TATGTTAAGA AGCTACTTAA TGCCCGGCGA CGCGTTGTCT TGGTTAACAA CATTCTACAG 
AATGCTCAGG AACGACTGAG ACGGCTAAAC CACAGTGTTG CCAAGGAAAC AGCCCGCAGG 
AGAGCAATGC TGGATTCGGG AATTTACCCC CCTGGCTCCC CAGGCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNAPIN ( NM_012437.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_036569.1 Homo sapiens SNAP associated protein (SNAPIN), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu56032
Clone ID Related Accession (Same CDS sequence)	NM_012437.6 , NM_012437.5
Accession Version	NM_012437.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	SNARE-associated protein Snapin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI117540.1, BC000761.2 and AI018675.1. On Jun 21, 2012 this sequence version replaced NM_012437.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the supported protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.205334.1, AK024555.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGGGG CTGGTTCCGC CGCTGTATCG GGGGCAGGGA CCCCGGTGGC GGGGCCCACA 
GGCCGCGACC TTTTCGCCGA AGGGCTGCTG GAGTTCCTGC GACCCGCTGT GCAGCAGCTC 
GACTCTCACG TACACGCCGT CAGAGAGAGC CAGGTAGAGC TCCGGGAACA AATTGACAAC 
CTAGCCACAG AACTGTGCCG CATAAATGAG GATCAGAAGG TGGCCCTGGA TCTTGACCCC 
TATGTTAAGA AGCTACTTAA TGCCCGGCGA CGCGTTGTCT TGGTTAACAA CATTCTACAG 
AATGCTCAGG AACGACTGAG ACGGCTAAAC CACAGTGTTG CCAAGGAAAC AGCCCGCAGG 
AGAGCAATGC TGGATTCGGG AATTTACCCC CCTGGCTCCC CAGGCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036569.1
CDS	91..501
Translation	MAGAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGIYPPGSPGK

Target ORF information:

RefSeq Version	NM_012437.5
Organism	Homo sapiens(human)
Definition	Homo sapiens SNAP associated protein (SNAPIN), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012437.5

ORF Insert Sequence:

ATGGCGGGGG CTGGTTCCGC CGCTGTATCG GGGGCAGGGA CCCCGGTGGC GGGGCCCACA 
GGCCGCGACC TTTTCGCCGA AGGGCTGCTG GAGTTCCTGC GACCCGCTGT GCAGCAGCTC 
GACTCTCACG TACACGCCGT CAGAGAGAGC CAGGTAGAGC TCCGGGAACA AATTGACAAC 
CTAGCCACAG AACTGTGCCG CATAAATGAG GATCAGAAGG TGGCCCTGGA TCTTGACCCC 
TATGTTAAGA AGCTACTTAA TGCCCGGCGA CGCGTTGTCT TGGTTAACAA CATTCTACAG 
AATGCTCAGG AACGACTGAG ACGGCTAAAC CACAGTGTTG CCAAGGAAAC AGCCCGCAGG 
AGAGCAATGC TGGATTCGGG AATTTACCCC CCTGGCTCCC CAGGCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Snapin promotes HIV-1 transmission from dendritic cells by dampening TLR8 signaling.
The EMBO journal36(20)2998-3011(2017 10)
Khatamzas E,Hipp MM,Gaughan D,Pichulik T,Leslie A,Fernandes RA,Muraro D,Booth S,Zausmer K,Sun MY,Kessler B,Rowland-Jones S,Cerundolo V,Simmons A

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages.
Autophagy13(2)285-301(2017 Feb)
Shi B,Huang QQ,Birkett R,Doyle R,Dorfleutner A,Stehlik C,He C,Pope RM

Physical and functional interaction of Snapin with Cav1.3 calcium channel impacts channel protein trafficking in atrial myocytes.
Cellular signalling30118-129(2017 Jan)
Sun XL,Yuan JF,Jin T,Cheng XQ,Wang Q,Guo J,Zhang W,Zhang Y,Lu L,Zhang Z

Host protein Snapin interacts with human cytomegalovirus pUL130 and affects viral DNA replication.
Journal of biosciences41(2)173-82(2016 Jun)
Wang G,Ren G,Cui X,Lu Z,Ma Y,Qi Y,Huang Y,Liu Z,Sun Z,Ruan Q

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SNAPIN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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