Snapin cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Snapin
Entrez Gene ID	20615
Full Name	SNAP-associated protein
Synonyms	25kDa,AA407989,AV026596,Bloc1s7,Snap25bp,Snapap
General protein information	Preferred Names SNAP-associated protein Names SNARE-associated protein Snapin BLOC-1 subunit 7 biogenesis of lysosome-related organelles complex 1 subunit 7 synaptosomal-associated protein 25 binding protein synaptosomal-associated protein, 25 kDa, binding protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 F1

mRNA and Protein(s)

mRNA	Protein	Name
NM_133854.3	NP_598615.1	SNARE-associated protein Snapin

Pathways from BioSystems

Homologies

Homo sapiens (human)	SNAPIN	NP_036569.1
	SNAPIN	XP_001111730.1
Rattus norvegicus (Norway rat)	Snapin	NP_001164047.1
Danio rerio (zebrafish)	snapin	NP_001038613.1
Gallus gallus (chicken)	SNAPIN	XP_003642675.1
Bos taurus (cattle)	SNAPIN	NP_001076879.1
Mus musculus (house mouse)	Snapin	NP_598615.1
Pan troglodytes (chimpanzee)	SNAPIN	XP_003949614.1
Canis lupus familiaris (dog)	SNAPIN	XP_547578.1

Gene Ontology
Bibliography

Related articles in PubMed

Structural and Functional Characterization of the Interaction of Snapin with the Dopamine Transporter: Differential Modulation of Psychostimulant Actions.
Erdozain AM, De Gois S, Bernard V, Gorgievski V, Pietrancosta N, Dumas S, Macedo CE, Vanhoutte P, Ortega JE, Meana JJ, Tzavara ET, Vialou V, Giros B
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology(2017 Sep)

Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer's disease neurons.
Tammineni P, Ye X, Feng T, Aikal D, Cai Q
eLife6(2017 Jan)

Physical and functional interaction of Snapin with Cav1.3 calcium channel impacts channel protein trafficking in atrial myocytes.
Sun XL, Yuan JF, Jin T, Cheng XQ, Wang Q, Guo J, Zhang W, Zhang Y, Lu L, Zhang Z
Cellular signalling30118-129(2017 Jan)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Regulation of synaptic activity by snapin-mediated endolysosomal transport and sorting.
Di Giovanni J, Sheng ZH
The EMBO journal34(15)2059-77(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results provide the evidence of a direct regulatory role of Snapin on Cav1.3 channels in atrial myocytes.
Title: Physical and functional interaction of Snapin with Cav1.3 calcium channel impacts channel protein trafficking in atrial myocytes.

Snapin-dysbindin interaction regulates synaptic vesicle positional priming through BLOC-1/AP-3-dependent sorting.
Title: Regulation of synaptic activity by snapin-mediated endolysosomal transport and sorting.

Snapin reduces APP processing by enhancing BACE1 lysosomal degradation.
Title: Snapin-mediated BACE1 retrograde transport is essential for its degradation in lysosomes and regulation of APP processing in neurons.

Snapin accelerates exocytosis at low intracellular calcium concentration in mouse chromaffin cells.
Title: Snapin accelerates exocytosis at low intracellular calcium concentration in mouse chromaffin cells.

Transmembrane prostatic acid phosphatase (TMPAP) interacts with snapin and deficient mice develop prostate adenocarcinoma.
Title: Transmembrane prostatic acid phosphatase (TMPAP) interacts with snapin and deficient mice develop prostate adenocarcinoma.

The following Snapin gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Snapin cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19293	NM_133854.3 Latest version!	Mus musculus SNAP-associated protein (Snapin), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Snapin ( NM_133854.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598615.1 Mus musculus SNAP-associated protein (Snapin), mRNA.

Price & Availability↑

CloneID	OMu19293
Clone ID Related Accession (Same CDS sequence)	NM_133854.3
Accession Version	NM_133854.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Mus musculus(house mouse)
Product	SNARE-associated protein Snapin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK050151.1, AK048007.1 and AC160552.13. On Jun 17, 2009 this sequence version replaced NM_133854.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK077840.1, SRR1660821.42937.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGCGG CTGGTTCCGC TGCTGTGTCA GGGGCCGGGA CCCCAGTGGC GGGGCCCACA 
GGCCGCGACC TCTTTGCCGA GGGGCTCCTG GAGTTCCTGC GACCCGCGGT GCAGCAGCTC 
GACTCTCACG TGCACGCGGT CAGAGAAAGC CAAGTAGAGC TCCGGGAACA AATTGACAAC 
CTAGCTACAG AACTGTGCCG GATCAATGAG GATCAGAAAG TGGCCCTGGA TCTGGACCCC 
TATGTTAAGA AGCTGCTTAA TGCCAGGCGA CGAGTTGTCT TGGTCAACAA TATTTTACAG 
AATGCACAGG AACGACTAAG GCGGTTAAAC CACAGCGTGG CCAAGGAAAC AGCTCGCAGG 
AGAGCTATGC TGGATTCAGG AGTTTACCCT CCTGGTTCTC CAAGCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598615.1
CDS	40..450
Translation	MAAAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGVYPPGSPSK

Target ORF information:

RefSeq Version	NM_133854.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus SNAP-associated protein (Snapin), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133854.3

ORF Insert Sequence:

ATGGCCGCGG CTGGTTCCGC TGCTGTGTCA GGGGCCGGGA CCCCAGTGGC GGGGCCCACA 
GGCCGCGACC TCTTTGCCGA GGGGCTCCTG GAGTTCCTGC GACCCGCGGT GCAGCAGCTC 
GACTCTCACG TGCACGCGGT CAGAGAAAGC CAAGTAGAGC TCCGGGAACA AATTGACAAC 
CTAGCTACAG AACTGTGCCG GATCAATGAG GATCAGAAAG TGGCCCTGGA TCTGGACCCC 
TATGTTAAGA AGCTGCTTAA TGCCAGGCGA CGAGTTGTCT TGGTCAACAA TATTTTACAG 
AATGCACAGG AACGACTAAG GCGGTTAAAC CACAGCGTGG CCAAGGAAAC AGCTCGCAGG 
AGAGCTATGC TGGATTCAGG AGTTTACCCT CCTGGTTCTC CAAGCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural and Functional Characterization of the Interaction of Snapin with the Dopamine Transporter: Differential Modulation of Psychostimulant Actions.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology(2017 Sep)
Erdozain AM,De Gois S,Bernard V,Gorgievski V,Pietrancosta N,Dumas S,Macedo CE,Vanhoutte P,Ortega JE,Meana JJ,Tzavara ET,Vialou V,Giros B

Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer's disease neurons.
eLife6(2017 Jan)
Tammineni P,Ye X,Feng T,Aikal D,Cai Q

Physical and functional interaction of Snapin with Cav1.3 calcium channel impacts channel protein trafficking in atrial myocytes.
Cellular signalling30118-129(2017 Jan)
Sun XL,Yuan JF,Jin T,Cheng XQ,Wang Q,Guo J,Zhang W,Zhang Y,Lu L,Zhang Z

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Regulation of synaptic activity by snapin-mediated endolysosomal transport and sorting.
The EMBO journal34(15)2059-77(2015 Aug)
Di Giovanni J,Sheng ZH

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Snapin cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報