FKBP1A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FKBP1A
Entrez Gene ID	2280
Full Name	FK506 binding protein 1A
Synonyms	FKBP-12,FKBP-1A,FKBP1,FKBP12,PKC12,PKCI2,PPIASE
General protein information	Preferred Names FK506 binding protein 1A Names peptidyl-prolyl cis-trans isomerase FKBP1A 12 kDa FK506-binding protein 12 kDa FKBP FK506 binding protein 1A, 12kDa FK506 binding protein12 FK506-binding protein 1 FK506-binding protein 12 FK506-binding protein, T-cell, 12-kD FKBP12-Exip3 PPIase FKBP1A calstabin-1 immunophilin FKBP12 protein kinase C inhibitor 2 rotamase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20p13
Summary	The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008].
Disorder MIM:	186945

mRNA and Protein(s)

mRNA	Protein	Name
NM_000801.4	NP_000792.1	peptidyl-prolyl cis-trans isomerase FKBP1A isoform a
NM_001199786.1	NP_001186715.1	peptidyl-prolyl cis-trans isomerase FKBP1A isoform b
NM_054014.3	NP_463460.1	peptidyl-prolyl cis-trans isomerase FKBP1A isoform a
NM_000801.5	NP_000792.1	peptidyl-prolyl cis-trans isomerase FKBP1A isoform a

Pathways from BioSystems

Homologies

	LOC698165	XP_001086691.2
	FKBP1A	XP_001108820.2
Bos taurus (cattle)	FKBP1A	NP_001030533.1
Canis lupus familiaris (dog)	FKBP1A	NP_001239119.1
Mus musculus (house mouse)	Fkbp1a	NP_032045.1
Homo sapiens (human)	FKBP1A	NP_000792.1
Pan troglodytes (chimpanzee)	FKBP1A	XP_003953710.1
Rattus norvegicus (Norway rat)	Fkbp1a	NP_037234.2
Gallus gallus (chicken)	FKBP1A	NP_989661.1
Danio rerio (zebrafish)	fkbp1ab	NP_001005594.1
Danio rerio (zebrafish)	fkbp1aa	NP_956239.1

Gene Ontology
Bibliography

Related articles in PubMed

FKBP12-immunopositive inclusions in patients with ?-synucleinopathies.
Honjo Y, Ayaki T, Horibe T, Ito H, Takahashi R, Kawakami K
Brain research168039-45(2018 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results identify a novel function for FKBP12 in downregulating MDM2, which directly enhances sensitivity of cancer cells to chemotherapy and nutlin-3 treatment.
Title: FKBP12 enhances sensitivity to chemotherapy-induced cancer cell apoptosis by inhibiting MDM2.

Data show that FKBP12 (FK506 binding protein 1A)conformational transition Is coupled to histidine tautomerization.
Title: Dynamics of Aromatic Side Chains in the Active Site of FKBP12.

Specifically tested on two model systems, the power of iSPOT is demonstrated to accurately predict the structures of a large protein-protein complex (TGFbeta-FKBP12) and a multidomain nuclear receptor homodimer (HNF-4alpha), based on the structures of individual components of the complexes.
Title: Theoretical modeling of multiprotein complexes by iSPOT: Integration of small-angle X-ray scattering, hydroxyl radical footprinting, and computational docking.

Electrostatic effects on the folding stability of FKBP12
Title: Electrostatic effects on the folding stability of FKBP12.

FKBP12 binding is required for full Met activation and everolimus can inhibit Met
Title: Everolimus induces Met inactivation by disrupting the FKBP12/Met complex.

The following FKBP1A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FKBP1A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19996	NM_000801.5 Latest version!	Homo sapiens FKBP prolyl isomerase 1A (FKBP1A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu19996	NM_054014.3 Latest version!	Homo sapiens FKBP prolyl isomerase 1A (FKBP1A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu21483	NM_001199786.1 Latest version!	Homo sapiens FKBP prolyl isomerase 1A (FKBP1A), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu19996	NM_000801.4	Homo sapiens FK506 binding protein 1A (FKBP1A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FKBP1A ( NM_000801.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000792.1 Homo sapiens FK506 binding protein 1A (FKBP1A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19996
Clone ID Related Accession (Same CDS sequence)	NM_000801.4 , NM_054014.3 , NM_000801.5
Accession Version	NM_000801.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	peptidyl-prolyl cis-trans isomerase FKBP1A isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CX870892.1, BC119732.1, AL136531.16 and CA450516.1. On Dec 17, 2010 this sequence version replaced NM_000801.3. Transcript Variant: This variant (1, also known as 12B) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.74576.1, SRR1163657.302047.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGTGC AGGTGGAAAC CATCTCCCCA GGAGACGGGC GCACCTTCCC CAAGCGCGGC 
CAGACCTGCG TGGTGCACTA CACCGGGATG CTTGAAGATG GAAAGAAATT TGATTCCTCC 
CGGGACAGAA ACAAGCCCTT TAAGTTTATG CTAGGCAAGC AGGAGGTGAT CCGAGGCTGG 
GAAGAAGGGG TTGCCCAGAT GAGTGTGGGT CAGAGAGCCA AACTGACTAT ATCTCCAGAT 
TATGCCTATG GTGCCACTGG GCACCCAGGC ATCATCCCAC CACATGCCAC TCTCGTCTTC 
GATGTGGAGC TTCTAAAACT GGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000792.1
CDS	175..501
Translation	MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE

Target ORF information:

RefSeq Version	NM_000801.4
Organism	Homo sapiens(human)
Definition	Homo sapiens FK506 binding protein 1A (FKBP1A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000801.4

ORF Insert Sequence:

ATGGGAGTGC AGGTGGAAAC CATCTCCCCA GGAGACGGGC GCACCTTCCC CAAGCGCGGC 
CAGACCTGCG TGGTGCACTA CACCGGGATG CTTGAAGATG GAAAGAAATT TGATTCCTCC 
CGGGACAGAA ACAAGCCCTT TAAGTTTATG CTAGGCAAGC AGGAGGTGAT CCGAGGCTGG 
GAAGAAGGGG TTGCCCAGAT GAGTGTGGGT CAGAGAGCCA AACTGACTAT ATCTCCAGAT 
TATGCCTATG GTGCCACTGG GCACCCAGGC ATCATCCCAC CACATGCCAC TCTCGTCTTC 
GATGTGGAGC TTCTAAAACT GGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FKBP1A ( NM_054014.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_463460.1 Homo sapiens FKBP prolyl isomerase 1A (FKBP1A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu19996
Clone ID Related Accession (Same CDS sequence)	NM_000801.4 , NM_054014.3 , NM_000801.5
Accession Version	NM_054014.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	peptidyl-prolyl cis-trans isomerase FKBP1A isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CX870892.1, BC005147.2, X52220.1 and CN426120.1. On Dec 17, 2010 this sequence version replaced NM_054014.2. Transcript Variant: This variant (2, also known as 12A) differs in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.228831.1, SRR1660809.76165.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGTGC AGGTGGAAAC CATCTCCCCA GGAGACGGGC GCACCTTCCC CAAGCGCGGC 
CAGACCTGCG TGGTGCACTA CACCGGGATG CTTGAAGATG GAAAGAAATT TGATTCCTCC 
CGGGACAGAA ACAAGCCCTT TAAGTTTATG CTAGGCAAGC AGGAGGTGAT CCGAGGCTGG 
GAAGAAGGGG TTGCCCAGAT GAGTGTGGGT CAGAGAGCCA AACTGACTAT ATCTCCAGAT 
TATGCCTATG GTGCCACTGG GCACCCAGGC ATCATCCCAC CACATGCCAC TCTCGTCTTC 
GATGTGGAGC TTCTAAAACT GGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_463460.1
CDS	175..501
Translation	MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE

Target ORF information:

RefSeq Version	NM_054014.3
Organism	Homo sapiens(human)
Definition	Homo sapiens FKBP prolyl isomerase 1A (FKBP1A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_054014.3

ORF Insert Sequence:

ATGGGAGTGC AGGTGGAAAC CATCTCCCCA GGAGACGGGC GCACCTTCCC CAAGCGCGGC 
CAGACCTGCG TGGTGCACTA CACCGGGATG CTTGAAGATG GAAAGAAATT TGATTCCTCC 
CGGGACAGAA ACAAGCCCTT TAAGTTTATG CTAGGCAAGC AGGAGGTGAT CCGAGGCTGG 
GAAGAAGGGG TTGCCCAGAT GAGTGTGGGT CAGAGAGCCA AACTGACTAT ATCTCCAGAT 
TATGCCTATG GTGCCACTGG GCACCCAGGC ATCATCCCAC CACATGCCAC TCTCGTCTTC 
GATGTGGAGC TTCTAAAACT GGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FKBP1A ( NM_000801.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000792.1 Homo sapiens FKBP prolyl isomerase 1A (FKBP1A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19996
Clone ID Related Accession (Same CDS sequence)	NM_000801.4 , NM_054014.3 , NM_000801.5
Accession Version	NM_000801.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-29
Organism	Homo sapiens(human)
Product	peptidyl-prolyl cis-trans isomerase FKBP1A isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC119732.1, AL136531.16 and CA450516.1. On Dec 7, 2018 this sequence version replaced NM_000801.4. Transcript Variant: This variant (1, also known as 12B) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.163989.1, SRR3476690.532936.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000400137.9/ ENSP00000383003.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGAGTGC AGGTGGAAAC CATCTCCCCA GGAGACGGGC GCACCTTCCC CAAGCGCGGC 
CAGACCTGCG TGGTGCACTA CACCGGGATG CTTGAAGATG GAAAGAAATT TGATTCCTCC 
CGGGACAGAA ACAAGCCCTT TAAGTTTATG CTAGGCAAGC AGGAGGTGAT CCGAGGCTGG 
GAAGAAGGGG TTGCCCAGAT GAGTGTGGGT CAGAGAGCCA AACTGACTAT ATCTCCAGAT 
TATGCCTATG GTGCCACTGG GCACCCAGGC ATCATCCCAC CACATGCCAC TCTCGTCTTC 
GATGTGGAGC TTCTAAAACT GGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000792.1
CDS	57..383
Translation	MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE

Target ORF information:

RefSeq Version	NM_000801.5
Organism	Homo sapiens(human)
Definition	Homo sapiens FKBP prolyl isomerase 1A (FKBP1A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000801.5

ORF Insert Sequence:

ATGGGAGTGC AGGTGGAAAC CATCTCCCCA GGAGACGGGC GCACCTTCCC CAAGCGCGGC 
CAGACCTGCG TGGTGCACTA CACCGGGATG CTTGAAGATG GAAAGAAATT TGATTCCTCC 
CGGGACAGAA ACAAGCCCTT TAAGTTTATG CTAGGCAAGC AGGAGGTGAT CCGAGGCTGG 
GAAGAAGGGG TTGCCCAGAT GAGTGTGGGT CAGAGAGCCA AACTGACTAT ATCTCCAGAT 
TATGCCTATG GTGCCACTGG GCACCCAGGC ATCATCCCAC CACATGCCAC TCTCGTCTTC 
GATGTGGAGC TTCTAAAACT GGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FKBP1A ( NM_001199786.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186715.1 Homo sapiens FKBP prolyl isomerase 1A (FKBP1A), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu21483
Clone ID Related Accession (Same CDS sequence)	NM_001199786.1
Accession Version	NM_001199786.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	peptidyl-prolyl cis-trans isomerase FKBP1A isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CX870892.1, BU540706.1, AL136531.16 and CA450516.1. Transcript Variant: This variant (3) lacks an exon in the coding region, which results in a frameshift compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279866.702.1, SRR1163655.337107.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGTGC AGGTGGAAAC CATCTCCCCA GGAGACGGGC GCACCTTCCC CAAGCGCGGC 
CAGACCTGCG TGGTGCACTA CACCGATGAG TGTGGGTCAG AGAGCCAAAC TGACTATATC 
TCCAGATTAT GCCTATGGTG CCACTGGGCA CCCAGGCATC ATCCCACCAC ATGCCACTCT 
CGTCTTCGAT GTGGAGCTTC TAAAACTGGA ATGACAGGAA TGGCCTCCTC CCTTAGCTCC 
CTGTTCTTGG ATCTGCCATG GAGGGATCTG GTGCCTCCAG ACATGTGCAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186715.1
CDS	175..468
Translation	MGVQVETISPGDGRTFPKRGQTCVVHYTDECGSESQTDYISRLCLWCHWAPRHHPTTCHSRLRCGASKTGMTGMASSLSSLFLDLPWRDLVPPDMCT

Target ORF information:

RefSeq Version	NM_001199786.1
Organism	Homo sapiens(human)
Definition	Homo sapiens FKBP prolyl isomerase 1A (FKBP1A), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199786.1

ORF Insert Sequence:

ATGGGAGTGC AGGTGGAAAC CATCTCCCCA GGAGACGGGC GCACCTTCCC CAAGCGCGGC 
CAGACCTGCG TGGTGCACTA CACCGATGAG TGTGGGTCAG AGAGCCAAAC TGACTATATC 
TCCAGATTAT GCCTATGGTG CCACTGGGCA CCCAGGCATC ATCCCACCAC ATGCCACTCT 
CGTCTTCGAT GTGGAGCTTC TAAAACTGGA ATGACAGGAA TGGCCTCCTC CCTTAGCTCC 
CTGTTCTTGG ATCTGCCATG GAGGGATCTG GTGCCTCCAG ACATGTGCAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FKBP12-immunopositive inclusions in patients with ?-synucleinopathies.
Brain research168039-45(2018 Feb)
Honjo Y,Ayaki T,Horibe T,Ito H,Takahashi R,Kawakami K

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FKBP1A cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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