Fkbp1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fkbp1a
Entrez Gene ID	25639
Full Name	FK506 binding protein 1a
Synonyms	FKBP12,Fkbp2
General protein information	Preferred Names FK506 binding protein 1a Names peptidyl-prolyl cis-trans isomerase FKBP1A 12 kDa FK506-binding protein 12 kDa FKBP FK506 binding protein 2 (13 kDa) FK506-binding protein 1 (12kD) FK506-binding protein 1A FKBP-12 FKBP-1A PPIase FKBP1A immunophilin FKBP12 rotamase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q41
Summary	mediates islet microsome Ca2+ release through binding to ryanodine receptor (RyR) and catalyzes the cis-trans isomerization of peptidyl-prolyl amide peptide bonds [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013102.3	NP_037234.2	peptidyl-prolyl cis-trans isomerase FKBP1A

Pathways from BioSystems

Homologies

	LOC698165	XP_001086691.2
	FKBP1A	XP_001108820.2
Bos taurus (cattle)	FKBP1A	NP_001030533.1
Canis lupus familiaris (dog)	FKBP1A	NP_001239119.1
Mus musculus (house mouse)	Fkbp1a	NP_032045.1
Homo sapiens (human)	FKBP1A	NP_000792.1
Pan troglodytes (chimpanzee)	FKBP1A	XP_003953710.1
Rattus norvegicus (Norway rat)	Fkbp1a	NP_037234.2
Gallus gallus (chicken)	FKBP1A	NP_989661.1
Danio rerio (zebrafish)	fkbp1ab	NP_001005594.1
Danio rerio (zebrafish)	fkbp1aa	NP_956239.1

Gene Ontology
Bibliography

Related articles in PubMed

FKBP12 contributes to ?-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome.
Caraveo G, Soste M, Cappelleti V, Fanning S, van Rossum DB, Whitesell L, Huang Y, Chung CY, Baru V, Zaichick S, Picotti P, Lindquist S
Proceedings of the National Academy of Sciences of the United States of America114(52)E11313-E11322(2017 Dec)

The proteome of the presynaptic active zone from mouse brain.
Weingarten J, Lassek M, Mueller BF, Rohmer M, Lunger I, Baeumlisberger D, Dudek S, Gogesch P, Karas M, Volknandt W
Molecular and cellular neurosciences59106-18(2014 Mar)

FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines.
Liu FL, Liu TY, Kung FL
Journal of biosciences39(1)85-95(2014 Mar)

External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane.
Galic M, Jeong S, Tsai FC, Joubert LM, Wu YI, Hahn KM, Cui Y, Meyer T
Nature cell biology14(8)874-81(2012 Aug)

mTOR signaling in growth control and disease.
Laplante M, Sabatini DM
Cell149(2)274-93(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The effects of FKBP12.6 and another structurally similar molecule, FKBP12, which is far more abundant in heart, on the gating of single sheep RyR2 channels, were investigated.
Title: FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.

FKBP12 regulates H-Ras trafficking by promoting depalmitoylation through cis-trans isomerization of a peptidyl-prolyl bond in proximity to the palmitoylated cysteines.
Title: FKBP12 binds to acylated H-ras and promotes depalmitoylation.

Increased susceptibility to ventricular fibrillation in l-thyroxin-induced cardiomyopathy is related to increase in diastolic Ca(2+) levels, resulting from downregulated FKBP12.6 and upregulated endothelin system
Title: Downregulated FKBP12.6 expression and upregulated endothelin signaling contribute to elevated diastolic calcium and arrhythmogenesis in rat cardiomyopathy produced by l-thyroxin.

FKBP12 is predominantly present during early neointima formation, while mature neointimal atheromas show a relatively low expression without confinement to luminal areas.
Title: Neointimal expression of rapamycin receptor FK506-binding protein FKBP12: postinjury animal and human in-stent restenosis tissue characteristics.

the loss of FKBP12.6 has no significant effect on the conduction and activation of RyR2 or the propensity for spontaneous Ca(2+) release and stress-induced ventricular arrhythmias
Title: Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias.

The following Fkbp1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fkbp1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01985	NM_013102.3 Latest version!	Rattus norvegicus FKBP prolyl isomerase 1A (Fkbp1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fkbp1a ( NM_013102.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037234.2 Rattus norvegicus FKBP prolyl isomerase 1A (Fkbp1a), mRNA.

Price & Availability↑

CloneID	ORa01985
Clone ID Related Accession (Same CDS sequence)	NM_013102.3
Accession Version	NM_013102.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	peptidyl-prolyl cis-trans isomerase FKBP1A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC070519.1. On Aug 31, 2012 this sequence version replaced NM_013102.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070519.1, CF110710.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGAGTGC AGGTGGAGAC CATCTCTTCT GGAGACGGGC GCACCTTCCC GAAGCGCGGC 
CAGACCTGCG TGGTACACTA CACGGGGATG CTTGAAGATG GGAAGAAATT TGACTCCTCT 
CGGGACAGAA ACAAGCCTTT TAAGTTTACA CTAGGCAAGC AGGAGGTGAT CCGAGGCTGG 
GAAGAAGGGG TAGCCCAGAT GAGTGTGGGC CAGAGAGCCA AACTGATAAT CTCCCCAGAC 
TATGCCTATG GAGCCACCGG GCACCCAGGC ATCATCCCAC CACATGCTAC TCTTGTTTTT 
GATGTGGAGC TTCTAAAACT GGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037234.2
CDS	74..400
Translation	MGVQVETISSGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFTLGKQEVIRGWEEGVAQMSVGQRAKLIISPDYAYGATGHPGIIPPHATLVFDVELLKLE

Target ORF information:

RefSeq Version	NM_013102.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FKBP prolyl isomerase 1A (Fkbp1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013102.3

ORF Insert Sequence:

ATGGGAGTGC AGGTGGAGAC CATCTCTTCT GGAGACGGGC GCACCTTCCC GAAGCGCGGC 
CAGACCTGCG TGGTACACTA CACGGGGATG CTTGAAGATG GGAAGAAATT TGACTCCTCT 
CGGGACAGAA ACAAGCCTTT TAAGTTTACA CTAGGCAAGC AGGAGGTGAT CCGAGGCTGG 
GAAGAAGGGG TAGCCCAGAT GAGTGTGGGC CAGAGAGCCA AACTGATAAT CTCCCCAGAC 
TATGCCTATG GAGCCACCGG GCACCCAGGC ATCATCCCAC CACATGCTAC TCTTGTTTTT 
GATGTGGAGC TTCTAAAACT GGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FKBP12 contributes to ?-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome.
Proceedings of the National Academy of Sciences of the United States of America114(52)E11313-E11322(2017 Dec)
Caraveo G,Soste M,Cappelleti V,Fanning S,van Rossum DB,Whitesell L,Huang Y,Chung CY,Baru V,Zaichick S,Picotti P,Lindquist S

The proteome of the presynaptic active zone from mouse brain.
Molecular and cellular neurosciences59106-18(2014 Mar)
Weingarten J,Lassek M,Mueller BF,Rohmer M,Lunger I,Baeumlisberger D,Dudek S,Gogesch P,Karas M,Volknandt W

FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines.
Journal of biosciences39(1)85-95(2014 Mar)
Liu FL,Liu TY,Kung FL

External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane.
Nature cell biology14(8)874-81(2012 Aug)
Galic M,Jeong S,Tsai FC,Joubert LM,Wu YI,Hahn KM,Cui Y,Meyer T

mTOR signaling in growth control and disease.
Cell149(2)274-93(2012 Apr)
Laplante M,Sabatini DM

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Fkbp1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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