FGF5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FGF5
Entrez Gene ID	2250
Full Name	fibroblast growth factor 5
Synonyms	HBGF-5,Smag-82,TCMGLY
General protein information	Preferred Names fibroblast growth factor 5 Names fibroblast growth factor 5 heparin-binding growth factor 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q21.21
Summary	The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	165190
Disorder Html:	Trichomegaly, 190330 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004464.3	NP_004455.2	fibroblast growth factor 5 isoform 1 precursor
NM_033143.2	NP_149134.1	fibroblast growth factor 5 isoform 2 precursor
NM_001291812.1	NP_001278741.1	fibroblast growth factor 5 isoform 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	FGF5	NP_004455.2
Pan troglodytes (chimpanzee)	FGF5	XP_526572.2
Danio rerio (zebrafish)	fgf5	NP_001009561.1
Bos taurus (cattle)	FGF5	NP_001071479.2
Mus musculus (house mouse)	Fgf5	NP_034333.1
	FGF5	XP_001089996.1
Xenopus tropicalis (tropical clawed frog)	fgf5	XP_002934055.1
Rattus norvegicus (Norway rat)	Fgf5	NP_071547.1
Canis lupus familiaris (dog)	FGF5	NP_001041594.1
Gallus gallus (chicken)	FGF5	XP_001233791.2

Gene Ontology
Bibliography

Related articles in PubMed

Exosomal miR-9-3p suppresses HBGF-5 expression and is a functional biomarker in hepatocellular carcinoma.
Tang J, Li Y, Liu K, Zhu Q, Yang WH, Xiong LK, Guo DL
Minerva medica109(1)15-23(2018 Feb)

Associations between microRNA binding site SNPs in FGFs and FGFRs and the risk of non-syndromic orofacial cleft.
Li D, Zhang H, Ma L, Han Y, Xu M, Wang Z, Jiang H, Zhang W, Wang L, Pan Y
Scientific reports631054(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FGF5 facilitates cell proliferation through ERK1/2 activation, and it influences the osteogenic differentiation of tonsil-derived mesenchymal stem cells.
Title: Role of Fibroblast Growth Factor-5 on the Proliferation of Human Tonsil-Derived Mesenchymal Stem Cells.

These findings collectively demonstrate a tumor suppressor role of miR-188-5p in HCC progression via targeting FGF5
Title: MicroRNA-188-5p suppresses tumor cell proliferation and metastasis by directly targeting FGF5 in hepatocellular carcinoma.

High BMI increases the effect of the blood pressure-increasing allele at rs1458038 near FGF5 in a Chinese population.
Title: Variant Near FGF5 Has Stronger Effects on Blood Pressure in Chinese With a Higher Body Mass Index.

FGF5 is a crucial regulator of hair growth in humans.
Title: FGF5 is a crucial regulator of hair length in humans.

In Chinese children, no association of CSK rs1378942, MTHFR rs1801133, CYP17A1 rs1004467, STK39 rs3754777 and FGF5 rs16998073 with BP/risk of hypertension.
Title: Association of common variants in/near six genes (ATP2B1, CSK, MTHFR, CYP17A1, STK39 and FGF5) with blood pressure/hypertension risk in Chinese children.

The following FGF5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FGF5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19554	NM_004464.3 Latest version!	Homo sapiens fibroblast growth factor 5 (FGF5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu25976	NM_033143.2 Latest version!	Homo sapiens fibroblast growth factor 5 (FGF5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17697	NM_001291812.1 Latest version!	Homo sapiens fibroblast growth factor 5 (FGF5), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FGF5 ( NM_004464.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004455.2 Homo sapiens fibroblast growth factor 5 (FGF5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19554
Clone ID Related Accession (Same CDS sequence)	NM_004464.3
Accession Version	NM_004464.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 807bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	fibroblast growth factor 5 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA461028.1, DR004226.1, BC074859.2, AK090557.1, AF171928.1, BG252761.1 and BQ001160.1. This sequence is a reference standard in the RefSeqGene project. On Aug 17, 2005 this sequence version replaced NM_004464.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.230910.1, SRR1660803.104099.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142670 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein regulatory uORF :: PMID: 2005884 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGCTTGT CCTTCCTCCT CCTCCTCTTC TTCAGCCACC TGATCCTCAG CGCCTGGGCT 
CACGGGGAGA AGCGTCTCGC CCCCAAAGGG CAACCCGGAC CCGCTGCCAC TGATAGGAAC 
CCTAGAGGCT CCAGCAGCAG ACAGAGCAGC AGTAGCGCTA TGTCTTCCTC TTCTGCCTCC 
TCCTCCCCCG CAGCTTCTCT GGGCAGCCAA GGAAGTGGCT TGGAGCAGAG CAGTTTCCAG 
TGGAGCCCCT CGGGGCGCCG GACCGGCAGC CTCTACTGCA GAGTGGGCAT CGGTTTCCAT 
CTGCAGATCT ACCCGGATGG CAAAGTCAAT GGATCCCACG AAGCCAATAT GTTAAGTGTT 
TTGGAAATAT TTGCTGTGTC TCAGGGGATT GTAGGAATAC GAGGAGTTTT CAGCAACAAA 
TTTTTAGCGA TGTCAAAAAA AGGAAAACTC CATGCAAGTG CCAAGTTCAC AGATGACTGC 
AAGTTCAGGG AGCGTTTTCA AGAAAATAGC TATAATACCT ATGCCTCAGC AATACATAGA 
ACTGAAAAAA CAGGGCGGGA GTGGTATGTG GCCCTGAATA AAAGAGGAAA AGCCAAACGA 
GGGTGCAGCC CCCGGGTTAA ACCCCAGCAT ATCTCTACCC ATTTTCTGCC AAGATTCAAG 
CAGTCGGAGC AGCCAGAACT TTCTTTCACG GTTACTGTTC CTGAAAAGAA AAAGCCACCT 
AGCCCTATCA AGCCAAAGAT TCCCCTTTCT GCACCTCGGA AAAATACCAA CTCAGTGAAA 
TACAGACTCA AGTTTCGCTT TGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004455.2
CDS	238..1044
Translation	MSLSFLLLLFFSHLILSAWAHGEKRLAPKGQPGPAATDRNPRGSSSRQSSSSAMSSSSASSSPAASLGSQGSGLEQSSFQWSPSGRRTGSLYCRVGIGFHLQIYPDGKVNGSHEANMLSVLEIFAVSQGIVGIRGVFSNKFLAMSKKGKLHASAKFTDDCKFRERFQENSYNTYASAIHRTEKTGREWYVALNKRGKAKRGCSPRVKPQHISTHFLPRFKQSEQPELSFTVTVPEKKKPPSPIKPKIPLSAPRKNTNSVKYRLKFRFG

Target ORF information:

RefSeq Version	NM_004464.3
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 5 (FGF5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004464.3

ORF Insert Sequence:

ATGAGCTTGT CCTTCCTCCT CCTCCTCTTC TTCAGCCACC TGATCCTCAG CGCCTGGGCT 
CACGGGGAGA AGCGTCTCGC CCCCAAAGGG CAACCCGGAC CCGCTGCCAC TGATAGGAAC 
CCTAGAGGCT CCAGCAGCAG ACAGAGCAGC AGTAGCGCTA TGTCTTCCTC TTCTGCCTCC 
TCCTCCCCCG CAGCTTCTCT GGGCAGCCAA GGAAGTGGCT TGGAGCAGAG CAGTTTCCAG 
TGGAGCCCCT CGGGGCGCCG GACCGGCAGC CTCTACTGCA GAGTGGGCAT CGGTTTCCAT 
CTGCAGATCT ACCCGGATGG CAAAGTCAAT GGATCCCACG AAGCCAATAT GTTAAGTGTT 
TTGGAAATAT TTGCTGTGTC TCAGGGGATT GTAGGAATAC GAGGAGTTTT CAGCAACAAA 
TTTTTAGCGA TGTCAAAAAA AGGAAAACTC CATGCAAGTG CCAAGTTCAC AGATGACTGC 
AAGTTCAGGG AGCGTTTTCA AGAAAATAGC TATAATACCT ATGCCTCAGC AATACATAGA 
ACTGAAAAAA CAGGGCGGGA GTGGTATGTG GCCCTGAATA AAAGAGGAAA AGCCAAACGA 
GGGTGCAGCC CCCGGGTTAA ACCCCAGCAT ATCTCTACCC ATTTTCTGCC AAGATTCAAG 
CAGTCGGAGC AGCCAGAACT TTCTTTCACG GTTACTGTTC CTGAAAAGAA AAAGCCACCT 
AGCCCTATCA AGCCAAAGAT TCCCCTTTCT GCACCTCGGA AAAATACCAA CTCAGTGAAA 
TACAGACTCA AGTTTCGCTT TGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGF5 ( NM_033143.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_149134.1 Homo sapiens fibroblast growth factor 5 (FGF5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu25976
Clone ID Related Accession (Same CDS sequence)	NM_033143.2
Accession Version	NM_033143.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	fibroblast growth factor 5 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA461028.1, DR004226.1, AF171928.1, AK090557.1, BG252761.1 and BQ001160.1. On Aug 17, 2005 this sequence version replaced NM_033143.1. Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2, also referred to as 'FGF-5S' or 'short isoform') is shorter and has a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF171928.1, SRR1660809.188920.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142670, SAMEA2146982 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## regulatory uORF :: PMID: 2005884 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGCTTGT CCTTCCTCCT CCTCCTCTTC TTCAGCCACC TGATCCTCAG CGCCTGGGCT 
CACGGGGAGA AGCGTCTCGC CCCCAAAGGG CAACCCGGAC CCGCTGCCAC TGATAGGAAC 
CCTAGAGGCT CCAGCAGCAG ACAGAGCAGC AGTAGCGCTA TGTCTTCCTC TTCTGCCTCC 
TCCTCCCCCG CAGCTTCTCT GGGCAGCCAA GGAAGTGGCT TGGAGCAGAG CAGTTTCCAG 
TGGAGCCCCT CGGGGCGCCG GACCGGCAGC CTCTACTGCA GAGTGGGCAT CGGTTTCCAT 
CTGCAGATCT ACCCGGATGG CAAAGTCAAT GGATCCCACG AAGCCAATAT GTTAAGCCAA 
GTTCACAGAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_149134.1
CDS	238..609
Translation	MSLSFLLLLFFSHLILSAWAHGEKRLAPKGQPGPAATDRNPRGSSSRQSSSSAMSSSSASSSPAASLGSQGSGLEQSSFQWSPSGRRTGSLYCRVGIGFHLQIYPDGKVNGSHEANMLSQVHR

Target ORF information:

RefSeq Version	NM_033143.2
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 5 (FGF5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033143.2

ORF Insert Sequence:

ATGAGCTTGT CCTTCCTCCT CCTCCTCTTC TTCAGCCACC TGATCCTCAG CGCCTGGGCT 
CACGGGGAGA AGCGTCTCGC CCCCAAAGGG CAACCCGGAC CCGCTGCCAC TGATAGGAAC 
CCTAGAGGCT CCAGCAGCAG ACAGAGCAGC AGTAGCGCTA TGTCTTCCTC TTCTGCCTCC 
TCCTCCCCCG CAGCTTCTCT GGGCAGCCAA GGAAGTGGCT TGGAGCAGAG CAGTTTCCAG 
TGGAGCCCCT CGGGGCGCCG GACCGGCAGC CTCTACTGCA GAGTGGGCAT CGGTTTCCAT 
CTGCAGATCT ACCCGGATGG CAAAGTCAAT GGATCCCACG AAGCCAATAT GTTAAGCCAA 
GTTCACAGAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGF5 ( NM_001291812.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001278741.1 Homo sapiens fibroblast growth factor 5 (FGF5), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu17697
Clone ID Related Accession (Same CDS sequence)	NM_001291812.1
Accession Version	NM_001291812.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	fibroblast growth factor 5 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC021127.9, AK090557.1 and BQ001160.1. Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK090557.1, DA021096.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159912 [ECO:0000348] ##Evidence-Data-END##

ATGTCAAAAA AAGGAAAACT CCATGCAAGT GCCAAGTTCA CAGATGACTG CAAGTTCAGG 
GAGCGTTTTC AAGAAAATAG CTATAATACC TATGCCTCAG CAATACATAG AACTGAAAAA 
ACAGGGCGGG AGTGGTATGT GGCCCTGAAT AAAAGAGGAA AAGCCAAACG AGGGTGCAGC 
CCCCGGGTTA AACCCCAGCA TATCTCTACC CATTTTCTGC CAAGATTCAA GCAGTCGGAG 
CAGCCAGAAC TTTCTTTCAC GGTTACTGTT CCTGAAAAGA AAAAGCCACC TAGCCCTATC 
AAGCCAAAGA TTCCCCTTTC TGCACCTCGG AAAAATACCA ACTCAGTGAA ATACAGACTC 
AAGTTTCGCT TTGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001278741.1
CDS	379..756
Translation	MSKKGKLHASAKFTDDCKFRERFQENSYNTYASAIHRTEKTGREWYVALNKRGKAKRGCSPRVKPQHISTHFLPRFKQSEQPELSFTVTVPEKKKPPSPIKPKIPLSAPRKNTNSVKYRLKFRFG

Target ORF information:

RefSeq Version	NM_001291812.1
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 5 (FGF5), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001291812.1

ORF Insert Sequence:

ATGTCAAAAA AAGGAAAACT CCATGCAAGT GCCAAGTTCA CAGATGACTG CAAGTTCAGG 
GAGCGTTTTC AAGAAAATAG CTATAATACC TATGCCTCAG CAATACATAG AACTGAAAAA 
ACAGGGCGGG AGTGGTATGT GGCCCTGAAT AAAAGAGGAA AAGCCAAACG AGGGTGCAGC 
CCCCGGGTTA AACCCCAGCA TATCTCTACC CATTTTCTGC CAAGATTCAA GCAGTCGGAG 
CAGCCAGAAC TTTCTTTCAC GGTTACTGTT CCTGAAAAGA AAAAGCCACC TAGCCCTATC 
AAGCCAAAGA TTCCCCTTTC TGCACCTCGG AAAAATACCA ACTCAGTGAA ATACAGACTC 
AAGTTTCGCT TTGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Exosomal miR-9-3p suppresses HBGF-5 expression and is a functional biomarker in hepatocellular carcinoma.
Minerva medica109(1)15-23(2018 Feb)
Tang J,Li Y,Liu K,Zhu Q,Yang WH,Xiong LK,Guo DL

Associations between microRNA binding site SNPs in FGFs and FGFRs and the risk of non-syndromic orofacial cleft.
Scientific reports631054(2016 Aug)
Li D,Zhang H,Ma L,Han Y,Xu M,Wang Z,Jiang H,Zhang W,Wang L,Pan Y

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

FGF5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報