EMP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EMP2
Entrez Gene ID	2013
Full Name	epithelial membrane protein 2
Synonyms	XMP
General protein information	Preferred Names epithelial membrane protein 2 Names epithelial membrane protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.13
Summary	This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). [provided by RefSeq, Mar 2015].
Disorder MIM:	602334
Disorder Html:	Nephrotic syndrome, type 10, 615861 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_006720864.3	XP_006720927.1	epithelial membrane protein 2 isoform X1
XM_006720864.2	XP_006720927.1	epithelial membrane protein 2 isoform X1
NM_001424.5	NP_001415.1	epithelial membrane protein 2 precursor
NM_001424.6	NP_001415.1	epithelial membrane protein 2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	EMP2	NP_001415.1
Canis lupus familiaris (dog)	EMP2	XP_005621610.1
Mus musculus (house mouse)	Emp2	NP_031955.2
Pan troglodytes (chimpanzee)	EMP2	NP_001098709.1
Gallus gallus (chicken)	EMP2	XP_414935.1
Xenopus tropicalis (tropical clawed frog)	emp2	NP_001025557.1
	EMP2	XP_002802441.1
Rattus norvegicus (Norway rat)	Emp2	NP_001007722.1
Danio rerio (zebrafish)	emp2	NP_001004119.1
Bos taurus (cattle)	EMP2	NP_001068792.1

Gene Ontology
Bibliography

Related articles in PubMed

EMP2 is a novel therapeutic target for endometrial cancer stem cells.
Kiyohara MH, Dillard C, Tsui J, Kim SR, Lu J, Sachdev D, Goodglick L, Tong M, Torous VF, Aryasomayajula C, Wang W, Najafzadeh P, Gordon LK, Braun J, McDermott S, Wicha MS, Wadehra M
Oncogene36(42)5793-5807(2017 Oct)

Tissue microarray analysis for epithelial membrane protein-2 as a novel biomarker for gliomas.
Chung LK, Pelargos PE, Chan AM, Demos JV, Lagman C, Sheppard JP, Nguyen T, Chang YL, Hojat SA, Prins RM, Liau LM, Nghiemphu L, Lai A, Cloughesy TF, Yong WH, Gordon LK, Wadehra M, Yang I
Brain tumor pathology(2017 Sep)

EMP2 re-expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinoma.
Tang M, Liu RY, Zhou C, Yuan MZ, Wu DM, Yuan Z, Zhang P, Lang JY
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(3)1010428317695972(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High EMP2 expression is associated with endometrial cancer.
Title: EMP2 is a novel therapeutic target for endometrial cancer stem cells.

Experiments in vitro using human trophoblast cells lines indicate that EMP2 modulates angiogenesis by altering HIF-1alpha expression. The results reveal a novel role for EMP2 in regulating trophoblast function and vascular development in mice and humans, and suggest that it may be a new biomarker for placental insufficiency.
Title: Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency.

These results support that loss of EMP2 is common, and its re-expression may serve as an approach to enhance radiation sensitivity in nasopharyngeal carcinoma.
Title: EMP2 re-expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinoma.

a novel SNP x SNP interaction between rs2267668 in PPARdelta and rs7191411 in EMP2 that has significant impact on circulating HDL-C levels in the Singaporean Chinese population.
Title: Interaction Between Peroxisome Proliferator Activated Receptor ? and Epithelial Membrane Protein 2 Polymorphisms Influences HDL-C Levels in the Chinese Population.

All studied ERMs and PVR membranes express EMP2. Levels of EMP2 trended higher in all PVR subgroups than in ERMs, especially in inflammatory and traumatic PVR.
Title: Epithelial Membrane Protein-2 in Human Proliferative Vitreoretinopathy and Epiretinal Membranes.

The following EMP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EMP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28633	NM_001424.6 Latest version!	Homo sapiens epithelial membrane protein 2 (EMP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu28633	XM_006720864.3 Latest version!	Homo sapiens epithelial membrane protein 2 (EMP2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu28633	XM_006720864.2	Homo sapiens epithelial membrane protein 2 (EMP2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu28633	NM_001424.5	Homo sapiens epithelial membrane protein 2 (EMP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EMP2 ( NM_001424.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001415.1 Homo sapiens epithelial membrane protein 2 (EMP2), mRNA.

Price & Availability↑

CloneID	OHu28633
Clone ID Related Accession (Same CDS sequence)	XM_006720864.3 , XM_006720864.2 , NM_001424.5 , NM_001424.6
Accession Version	NM_001424.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-03
Organism	Homo sapiens(human)
Product	epithelial membrane protein 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY116508.1, BF981157.1, BC009687.1, AK096403.1, AF190163.1, DA646653.1, BF982173.1, AL600791.1, AC027277.5, AK127600.1, BC016019.1, BP395690.1, BU951297.1 and AA854747.1. This sequence is a reference standard in the RefSeqGene project. On Mar 15, 2015 this sequence version replaced NM_001424.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2155770 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTGGTGC TTCTTGCTTT CATCATCGCC TTCCACATCA CCTCTGCAGC CTTGCTGTTC 
ATTGCCACCG TCGACAATGC CTGGTGGGTA GGAGATGAGT TTTTTGCAGA TGTCTGGAGA 
ATATGTACCA ACAACACGAA TTGCACAGTC ATCAATGACA GCTTTCAAGA GTACTCCACG 
CTGCAGGCGG TCCAGGCCAC CATGATCCTC TCCACCATTC TCTGCTGCAT CGCCTTCTTC 
ATCTTCGTGC TCCAGCTCTT CCGCCTGAAG CAGGGAGAGA GGTTTGTCCT AACCTCCATC 
ATCCAGCTAA TGTCATGTCT GTGTGTCATG ATTGCGGCCT CCATTTATAC AGACAGGCGT 
GAAGACATTC ACGACAAAAA CGCGAAATTC TATCCCGTGA CCAGAGAAGG CAGCTACGGC 
TACTCCTACA TCCTGGCGTG GGTGGCCTTC GCCTGCACCT TCATCAGCGG CATGATGTAC 
CTGATACTGA GGAAGCGCAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001415.1
CDS	229..732
Translation	MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQEYSTLQAVQATMILSTILCCIAFFIFVLQLFRLKQGERFVLTSIIQLMSCLCVMIAASIYTDRREDIHDKNAKFYPVTREGSYGYSYILAWVAFACTFISGMMYLILRKRK

Target ORF information:

RefSeq Version	NM_001424.5
Organism	Homo sapiens(human)
Definition	Homo sapiens epithelial membrane protein 2 (EMP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001424.5

ORF Insert Sequence:

ATGTTGGTGC TTCTTGCTTT CATCATCGCC TTCCACATCA CCTCTGCAGC CTTGCTGTTC 
ATTGCCACCG TCGACAATGC CTGGTGGGTA GGAGATGAGT TTTTTGCAGA TGTCTGGAGA 
ATATGTACCA ACAACACGAA TTGCACAGTC ATCAATGACA GCTTTCAAGA GTACTCCACG 
CTGCAGGCGG TCCAGGCCAC CATGATCCTC TCCACCATTC TCTGCTGCAT CGCCTTCTTC 
ATCTTCGTGC TCCAGCTCTT CCGCCTGAAG CAGGGAGAGA GGTTTGTCCT AACCTCCATC 
ATCCAGCTAA TGTCATGTCT GTGTGTCATG ATTGCGGCCT CCATTTATAC AGACAGGCGT 
GAAGACATTC ACGACAAAAA CGCGAAATTC TATCCCGTGA CCAGAGAAGG CAGCTACGGC 
TACTCCTACA TCCTGGCGTG GGTGGCCTTC GCCTGCACCT TCATCAGCGG CATGATGTAC 
CTGATACTGA GGAAGCGCAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EMP2 ( NM_001424.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_001415.1 Homo sapiens epithelial membrane protein 2 (EMP2), mRNA.

Price & Availability↑

CloneID	OHu28633
Clone ID Related Accession (Same CDS sequence)	XM_006720864.3 , XM_006720864.2 , NM_001424.5 , NM_001424.6
Accession Version	NM_001424.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	epithelial membrane protein 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF981157.1, BC009687.1, AK096403.1, AF190163.1, DA646653.1, BF982173.1, AL600791.1, AC027277.5, AK127600.1, BC016019.1, BP395690.1, BU951297.1 and AA854747.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001424.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG546881.1, SRR1803617.41477.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155770 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000359543.8/ ENSP00000352540.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTGGTGC TTCTTGCTTT CATCATCGCC TTCCACATCA CCTCTGCAGC CTTGCTGTTC 
ATTGCCACCG TCGACAATGC CTGGTGGGTA GGAGATGAGT TTTTTGCAGA TGTCTGGAGA 
ATATGTACCA ACAACACGAA TTGCACAGTC ATCAATGACA GCTTTCAAGA GTACTCCACG 
CTGCAGGCGG TCCAGGCCAC CATGATCCTC TCCACCATTC TCTGCTGCAT CGCCTTCTTC 
ATCTTCGTGC TCCAGCTCTT CCGCCTGAAG CAGGGAGAGA GGTTTGTCCT AACCTCCATC 
ATCCAGCTAA TGTCATGTCT GTGTGTCATG ATTGCGGCCT CCATTTATAC AGACAGGCGT 
GAAGACATTC ACGACAAAAA CGCGAAATTC TATCCCGTGA CCAGAGAAGG CAGCTACGGC 
TACTCCTACA TCCTGGCGTG GGTGGCCTTC GCCTGCACCT TCATCAGCGG CATGATGTAC 
CTGATACTGA GGAAGCGCAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001415.1
CDS	111..614
Translation	MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQEYSTLQAVQATMILSTILCCIAFFIFVLQLFRLKQGERFVLTSIIQLMSCLCVMIAASIYTDRREDIHDKNAKFYPVTREGSYGYSYILAWVAFACTFISGMMYLILRKRK

Target ORF information:

RefSeq Version	NM_001424.6
Organism	Homo sapiens(human)
Definition	Homo sapiens epithelial membrane protein 2 (EMP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001424.6

ORF Insert Sequence:

ATGTTGGTGC TTCTTGCTTT CATCATCGCC TTCCACATCA CCTCTGCAGC CTTGCTGTTC 
ATTGCCACCG TCGACAATGC CTGGTGGGTA GGAGATGAGT TTTTTGCAGA TGTCTGGAGA 
ATATGTACCA ACAACACGAA TTGCACAGTC ATCAATGACA GCTTTCAAGA GTACTCCACG 
CTGCAGGCGG TCCAGGCCAC CATGATCCTC TCCACCATTC TCTGCTGCAT CGCCTTCTTC 
ATCTTCGTGC TCCAGCTCTT CCGCCTGAAG CAGGGAGAGA GGTTTGTCCT AACCTCCATC 
ATCCAGCTAA TGTCATGTCT GTGTGTCATG ATTGCGGCCT CCATTTATAC AGACAGGCGT 
GAAGACATTC ACGACAAAAA CGCGAAATTC TATCCCGTGA CCAGAGAAGG CAGCTACGGC 
TACTCCTACA TCCTGGCGTG GGTGGCCTTC GCCTGCACCT TCATCAGCGG CATGATGTAC 
CTGATACTGA GGAAGCGCAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EMP2 ( XM_006720864.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006720927.1 Homo sapiens epithelial membrane protein 2 (EMP2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu28633
Clone ID Related Accession (Same CDS sequence)	XM_006720864.3 , XM_006720864.2 , NM_001424.5 , NM_001424.6
Accession Version	XM_006720864.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	epithelial membrane protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006720864.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGGTGC TTCTTGCTTT CATCATCGCC TTCCACATCA CCTCTGCAGC CTTGCTGTTC 
ATTGCCACCG TCGACAATGC CTGGTGGGTA GGAGATGAGT TTTTTGCAGA TGTCTGGAGA 
ATATGTACCA ACAACACGAA TTGCACAGTC ATCAATGACA GCTTTCAAGA GTACTCCACG 
CTGCAGGCGG TCCAGGCCAC CATGATCCTC TCCACCATTC TCTGCTGCAT CGCCTTCTTC 
ATCTTCGTGC TCCAGCTCTT CCGCCTGAAG CAGGGAGAGA GGTTTGTCCT AACCTCCATC 
ATCCAGCTAA TGTCATGTCT GTGTGTCATG ATTGCGGCCT CCATTTATAC AGACAGGCGT 
GAAGACATTC ACGACAAAAA CGCGAAATTC TATCCCGTGA CCAGAGAAGG CAGCTACGGC 
TACTCCTACA TCCTGGCGTG GGTGGCCTTC GCCTGCACCT TCATCAGCGG CATGATGTAC 
CTGATACTGA GGAAGCGCAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006720927.1
CDS	223..726
Translation	MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQEYSTLQAVQATMILSTILCCIAFFIFVLQLFRLKQGERFVLTSIIQLMSCLCVMIAASIYTDRREDIHDKNAKFYPVTREGSYGYSYILAWVAFACTFISGMMYLILRKRK

Target ORF information:

RefSeq Version	XM_006720864.3
Organism	Homo sapiens(human)
Definition	Homo sapiens epithelial membrane protein 2 (EMP2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006720864.3

ORF Insert Sequence:

ATGTTGGTGC TTCTTGCTTT CATCATCGCC TTCCACATCA CCTCTGCAGC CTTGCTGTTC 
ATTGCCACCG TCGACAATGC CTGGTGGGTA GGAGATGAGT TTTTTGCAGA TGTCTGGAGA 
ATATGTACCA ACAACACGAA TTGCACAGTC ATCAATGACA GCTTTCAAGA GTACTCCACG 
CTGCAGGCGG TCCAGGCCAC CATGATCCTC TCCACCATTC TCTGCTGCAT CGCCTTCTTC 
ATCTTCGTGC TCCAGCTCTT CCGCCTGAAG CAGGGAGAGA GGTTTGTCCT AACCTCCATC 
ATCCAGCTAA TGTCATGTCT GTGTGTCATG ATTGCGGCCT CCATTTATAC AGACAGGCGT 
GAAGACATTC ACGACAAAAA CGCGAAATTC TATCCCGTGA CCAGAGAAGG CAGCTACGGC 
TACTCCTACA TCCTGGCGTG GGTGGCCTTC GCCTGCACCT TCATCAGCGG CATGATGTAC 
CTGATACTGA GGAAGCGCAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EMP2 ( XM_006720864.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006720927.1 Homo sapiens epithelial membrane protein 2 (EMP2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu28633
Clone ID Related Accession (Same CDS sequence)	XM_006720864.3 , XM_006720864.2 , NM_001424.5 , NM_001424.6
Accession Version	XM_006720864.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	epithelial membrane protein 2 isoform X1
Comment

ATGTTGGTGC TTCTTGCTTT CATCATCGCC TTCCACATCA CCTCTGCAGC CTTGCTGTTC 
ATTGCCACCG TCGACAATGC CTGGTGGGTA GGAGATGAGT TTTTTGCAGA TGTCTGGAGA 
ATATGTACCA ACAACACGAA TTGCACAGTC ATCAATGACA GCTTTCAAGA GTACTCCACG 
CTGCAGGCGG TCCAGGCCAC CATGATCCTC TCCACCATTC TCTGCTGCAT CGCCTTCTTC 
ATCTTCGTGC TCCAGCTCTT CCGCCTGAAG CAGGGAGAGA GGTTTGTCCT AACCTCCATC 
ATCCAGCTAA TGTCATGTCT GTGTGTCATG ATTGCGGCCT CCATTTATAC AGACAGGCGT 
GAAGACATTC ACGACAAAAA CGCGAAATTC TATCCCGTGA CCAGAGAAGG CAGCTACGGC 
TACTCCTACA TCCTGGCGTG GGTGGCCTTC GCCTGCACCT TCATCAGCGG CATGATGTAC 
CTGATACTGA GGAAGCGCAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006720927.1
Translation	MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQEYSTLQAVQATMILSTILCCIAFFIFVLQLFRLKQGERFVLTSIIQLMSCLCVMIAASIYTDRREDIHDKNAKFYPVTREGSYGYSYILAWVAFACTFISGMMYLILRKRK

Target ORF information:

RefSeq Version	XM_006720864.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens epithelial membrane protein 2 (EMP2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006720864.2

ORF Insert Sequence:

ATGTTGGTGC TTCTTGCTTT CATCATCGCC TTCCACATCA CCTCTGCAGC CTTGCTGTTC 
ATTGCCACCG TCGACAATGC CTGGTGGGTA GGAGATGAGT TTTTTGCAGA TGTCTGGAGA 
ATATGTACCA ACAACACGAA TTGCACAGTC ATCAATGACA GCTTTCAAGA GTACTCCACG 
CTGCAGGCGG TCCAGGCCAC CATGATCCTC TCCACCATTC TCTGCTGCAT CGCCTTCTTC 
ATCTTCGTGC TCCAGCTCTT CCGCCTGAAG CAGGGAGAGA GGTTTGTCCT AACCTCCATC 
ATCCAGCTAA TGTCATGTCT GTGTGTCATG ATTGCGGCCT CCATTTATAC AGACAGGCGT 
GAAGACATTC ACGACAAAAA CGCGAAATTC TATCCCGTGA CCAGAGAAGG CAGCTACGGC 
TACTCCTACA TCCTGGCGTG GGTGGCCTTC GCCTGCACCT TCATCAGCGG CATGATGTAC 
CTGATACTGA GGAAGCGCAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

EMP2 is a novel therapeutic target for endometrial cancer stem cells.
Oncogene36(42)5793-5807(2017 Oct)
Kiyohara MH,Dillard C,Tsui J,Kim SR,Lu J,Sachdev D,Goodglick L,Tong M,Torous VF,Aryasomayajula C,Wang W,Najafzadeh P,Gordon LK,Braun J,McDermott S,Wicha MS,Wadehra M

Tissue microarray analysis for epithelial membrane protein-2 as a novel biomarker for gliomas.
Brain tumor pathology(2017 Sep)
Chung LK,Pelargos PE,Chan AM,Demos JV,Lagman C,Sheppard JP,Nguyen T,Chang YL,Hojat SA,Prins RM,Liau LM,Nghiemphu L,Lai A,Cloughesy TF,Yong WH,Gordon LK,Wadehra M,Yang I

EMP2 re-expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(3)1010428317695972(2017 Mar)
Tang M,Liu RY,Zhou C,Yuan MZ,Wu DM,Yuan Z,Zhang P,Lang JY

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EMP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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