NR0B1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NR0B1
Entrez Gene ID	190
Full Name	nuclear receptor subfamily 0 group B member 1
Synonyms	AHC,AHCH,AHX,DAX-1,DAX1,DSS,GTD,HHG,NROB1,SRXY2
General protein information	Preferred Names nuclear receptor subfamily 0 group B member 1 Names nuclear receptor subfamily 0 group B member 1 DSS-AHC critical region on the X chromosome protein 1 nuclear hormone receptor nuclear receptor DAX-1 truncated nuclear receptor subfamily 0 group B member 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp21.2
Summary	This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008].
Disorder MIM:	300473
Disorder Html:	Adrenal hypoplasia, congenital, 300200 (3); 46XY sex reversal 2, dosage-sensitive, 300018 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000475.5	NP_000466.2	nuclear receptor subfamily 0 group B member 1
XM_017029338.1	XP_016884827.1	nuclear receptor subfamily 0 group B member 1 isoform X1
NM_000475.4	NP_000466.2	nuclear receptor subfamily 0 group B member 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	NR0B1	NP_000466.2
Canis lupus familiaris (dog)	NR0B1	XP_003640302.1
Gallus gallus (chicken)	NR0B1	NP_989924.1
Bos taurus (cattle)	NR0B1	NP_001192786.1
Mus musculus (house mouse)	Nr0b1	NP_031456.1
Rattus norvegicus (Norway rat)	Nr0b1	NP_445769.1
Pan troglodytes (chimpanzee)	NR0B1	NP_001181864.1
	NR0B1	XP_002806222.1
Danio rerio (zebrafish)	nr0b1	NP_001076416.1
Xenopus tropicalis (tropical clawed frog)	LOC100487043	XP_002933661.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel missense mutation in NR0B1 causes delayed-onset primary adrenal insufficiency in adults.
Oh CM, Chun S, Lee JE, Lee JS, Park S, Gee HY, Kim SW
Clinical genetics92(3)344-346(2017 Sep)

A novel DAX-1 mutation in two male siblings presenting with precocious puberty and late-onset hypogonadotropic hypogonadism.
Liu Y, Yuan J, Zhang H, Jiang Y, Qin G
Journal of pediatric endocrinology & metabolism : JPEM30(3)349-353(2017 Mar)

Epigenetic modifications promote the expression of the orphan nuclear receptor NR0B1 in human lung adenocarcinoma cells.
Lu Y, Liu Y, Liao S, Tu W, Shen Y, Yan Y, Tao D, Lu Y, Ma Y, Yang Y, Zhang S
Oncotarget7(28)43162-43176(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nonsense mutation in the DAX-1 gene is associated with precocious puberty and late-onset hypogonadotropic hypogonadism.
Title: A novel DAX-1 mutation in two male siblings presenting with precocious puberty and late-onset hypogonadotropic hypogonadism.

Based on the level of NR0B1 expression in lung adenocarcinoma cells with different clinical stages, our results indicate that epigenetic modifications promote NR0B1 activation to maintain the self-renewal of cancer cells.
Title: Epigenetic modifications promote the expression of the orphan nuclear receptor NR0B1 in human lung adenocarcinoma cells.

These findings suggested that the mutation of NR0B1 in X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism enhanced the function of DAX1 to repress SF-1 activation, while DAX1 is expected to have additional roles in the pathological mechanism.
Title: X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism: Identification and in?vitro study of a novel small indel in the NR0B1 gene.

This novel mutation (p. V385L) of DAX-1 is the first to be identified in association with secretory azoospermia, thereby highlighting the important role of DAX-1 in spermatogenesis.
Title: A Novel Mutation of DAX-1 Associated with Secretory Azoospermia.

DAX-1 is less specific than Ap2beta, however it is a sensitive marker for translocation positive ARMS and can be helpful in their diagnosis if used in combination with Ap2beta
Title: DAX-1 Expression in Pediatric Rhabdomyosarcomas: Another Immunohistochemical Marker Useful in the Diagnosis of Translocation Positive Alveolar Rhabdomyosarcoma.

The following NR0B1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NR0B1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28295	NM_000475.5 Latest version!	Homo sapiens nuclear receptor subfamily 0 group B member 1 (NR0B1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu99191	XM_017029338.1 Latest version!	Homo sapiens nuclear receptor subfamily 0 group B member 1 (NR0B1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
View Old Accession Versions >>
OHu28295	NM_000475.4	Homo sapiens nuclear receptor subfamily 0 group B member 1 (NR0B1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NR0B1 ( NM_000475.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000466.2 Homo sapiens nuclear receptor subfamily 0 group B member 1 (NR0B1), mRNA.

Price & Availability↑

CloneID	OHu28295
Clone ID Related Accession (Same CDS sequence)	NM_000475.5 , NM_000475.4
Accession Version	NM_000475.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1413bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Homo sapiens(human)
Product	nuclear receptor subfamily 0 group B member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005926.1, BI772108.1, BC011564.1, AW612655.1 and AC005185.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_000475.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: S74720.1, BC011564.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000378970.5/ ENSP00000368253.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGGCG AGAACCACCA GTGGCAGGGC AGCATCCTCT ACAACATGCT TATGAGCGCG 
AAGCAAACGC GCGCGGCTCC TGAGGCTCCA GAGACGCGGC TGGTGGATCA GTGCTGGGGC 
TGTTCGTGCG GCGATGAGCC CGGGGTGGGC AGAGAGGGGC TGCTGGGCGG GCGGAACGTG 
GCGCTCCTGT ACCGCTGCTG CTTTTGCGGT AAAGACCACC CACGGCAGGG CAGCATCCTC 
TACAGCATGC TGACGAGCGC AAAGCAAACG TACGCGGCAC CGAAGGCGCC CGAGGCGACG 
CTGGGTCCGT GCTGGGGCTG TTCGTGCGGC TCTGATCCCG GGGTGGGCAG AGCGGGGCTT 
CCGGGTGGGC GGCCCGTGGC ACTCCTGTAC CGCTGCTGCT TTTGTGGTGA AGACCACCCG 
CGGCAGGGCA GCATCCTCTA CAGCTTGCTC ACTAGCTCAA AGCAAACGCA CGTGGCTCCG 
GCAGCGCCCG AGGCACGGCC AGGGGGCGCG TGGTGGGACC GCTCCTACTT CGCGCAGAGG 
CCAGGGGGTA AAGAGGCGCT ACCAGGCGGG CGGGCCACGG CGCTTCTGTA CCGCTGCTGC 
TTTTGCGGTG AAGACCACCC GCAGCAGGGC AGCACCCTCT ACTGCGTGCC CACGAGCACA 
AATCAAGCGC AGGCGGCTCC GGAGGAGCGG CCGAGGGCCC CCTGGTGGGA CACCTCCTCT 
GGTGCGCTGC GGCCGGTGGC GCTCAAGAGT CCACAGGTGG TCTGCGAGGC AGCCTCAGCG 
GGCCTGTTGA AGACGCTGCG CTTCGTCAAG TACTTGCCCT GCTTCCAGGT GCTGCCCCTG 
GACCAGCAGC TGGTGCTGGT GCGCAACTGC TGGGCGTCCC TGCTCATGCT TGAGCTGGCC 
CAGGACCGCT TGCAGTTCGA GACTGTGGAA GTCTCGGAGC CCAGCATGCT GCAGAAGATC 
CTCACCACCA GGCGGCGGGA GACCGGGGGC AACGAGCCAC TGCCCGTGCC CACGCTGCAG 
CACCATTTGG CACCGCCGGC GGAGGCCAGG AAGGTGCCCT CCGCCTCCCA GGTCCAAGCC 
ATCAAGTGCT TTCTTTCCAA ATGCTGGAGT CTGAACATCA GTACCAAGGA GTACGCCTAC 
CTCAAGGGGA CCGTGCTCTT TAACCCGGAC GTGCCGGGCC TGCAGTGCGT GAAGTACATT 
CAGGGACTCC AGTGGGGAAC TCAGCAAATA CTCAGTGAAC ACACCAGGAT GACGCACCAA 
GGGCCCCATG ACAGATTCAT CGAACTTAAT AGTACCCTTT TCCTGCTGAG ATTCATCAAT 
GCCAATGTCA TTGCTGAACT GTTCTTCAGG CCCATCATCG GCACAGTCAG CATGGATGAT 
ATGATGCTGG AAATGCTCTG TACAAAGATA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000466.2
CDS	28..1440
Translation	MAGENHQWQGSILYNMLMSAKQTRAAPEAPETRLVDQCWGCSCGDEPGVGREGLLGGRNVALLYRCCFCGKDHPRQGSILYSMLTSAKQTYAAPKAPEATLGPCWGCSCGSDPGVGRAGLPGGRPVALLYRCCFCGEDHPRQGSILYSLLTSSKQTHVAPAAPEARPGGAWWDRSYFAQRPGGKEALPGGRATALLYRCCFCGEDHPQQGSTLYCVPTSTNQAQAAPEERPRAPWWDTSSGALRPVALKSPQVVCEAASAGLLKTLRFVKYLPCFQVLPLDQQLVLVRNCWASLLMLELAQDRLQFETVEVSEPSMLQKILTTRRRETGGNEPLPVPTLQHHLAPPAEARKVPSASQVQAIKCFLSKCWSLNISTKEYAYLKGTVLFNPDVPGLQCVKYIQGLQWGTQQILSEHTRMTHQGPHDRFIELNSTLFLLRFINANVIAELFFRPIIGTVSMDDMMLEMLCTKI

Target ORF information:

RefSeq Version	NM_000475.5
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor subfamily 0 group B member 1 (NR0B1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000475.5

ORF Insert Sequence:

ATGGCGGGCG AGAACCACCA GTGGCAGGGC AGCATCCTCT ACAACATGCT TATGAGCGCG 
AAGCAAACGC GCGCGGCTCC TGAGGCTCCA GAGACGCGGC TGGTGGATCA GTGCTGGGGC 
TGTTCGTGCG GCGATGAGCC CGGGGTGGGC AGAGAGGGGC TGCTGGGCGG GCGGAACGTG 
GCGCTCCTGT ACCGCTGCTG CTTTTGCGGT AAAGACCACC CACGGCAGGG CAGCATCCTC 
TACAGCATGC TGACGAGCGC AAAGCAAACG TACGCGGCAC CGAAGGCGCC CGAGGCGACG 
CTGGGTCCGT GCTGGGGCTG TTCGTGCGGC TCTGATCCCG GGGTGGGCAG AGCGGGGCTT 
CCGGGTGGGC GGCCCGTGGC ACTCCTGTAC CGCTGCTGCT TTTGTGGTGA AGACCACCCG 
CGGCAGGGCA GCATCCTCTA CAGCTTGCTC ACTAGCTCAA AGCAAACGCA CGTGGCTCCG 
GCAGCGCCCG AGGCACGGCC AGGGGGCGCG TGGTGGGACC GCTCCTACTT CGCGCAGAGG 
CCAGGGGGTA AAGAGGCGCT ACCAGGCGGG CGGGCCACGG CGCTTCTGTA CCGCTGCTGC 
TTTTGCGGTG AAGACCACCC GCAGCAGGGC AGCACCCTCT ACTGCGTGCC CACGAGCACA 
AATCAAGCGC AGGCGGCTCC GGAGGAGCGG CCGAGGGCCC CCTGGTGGGA CACCTCCTCT 
GGTGCGCTGC GGCCGGTGGC GCTCAAGAGT CCACAGGTGG TCTGCGAGGC AGCCTCAGCG 
GGCCTGTTGA AGACGCTGCG CTTCGTCAAG TACTTGCCCT GCTTCCAGGT GCTGCCCCTG 
GACCAGCAGC TGGTGCTGGT GCGCAACTGC TGGGCGTCCC TGCTCATGCT TGAGCTGGCC 
CAGGACCGCT TGCAGTTCGA GACTGTGGAA GTCTCGGAGC CCAGCATGCT GCAGAAGATC 
CTCACCACCA GGCGGCGGGA GACCGGGGGC AACGAGCCAC TGCCCGTGCC CACGCTGCAG 
CACCATTTGG CACCGCCGGC GGAGGCCAGG AAGGTGCCCT CCGCCTCCCA GGTCCAAGCC 
ATCAAGTGCT TTCTTTCCAA ATGCTGGAGT CTGAACATCA GTACCAAGGA GTACGCCTAC 
CTCAAGGGGA CCGTGCTCTT TAACCCGGAC GTGCCGGGCC TGCAGTGCGT GAAGTACATT 
CAGGGACTCC AGTGGGGAAC TCAGCAAATA CTCAGTGAAC ACACCAGGAT GACGCACCAA 
GGGCCCCATG ACAGATTCAT CGAACTTAAT AGTACCCTTT TCCTGCTGAG ATTCATCAAT 
GCCAATGTCA TTGCTGAACT GTTCTTCAGG CCCATCATCG GCACAGTCAG CATGGATGAT 
ATGATGCTGG AAATGCTCTG TACAAAGATA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NR0B1 ( NM_000475.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000466.2 Homo sapiens nuclear receptor subfamily 0 group B member 1 (NR0B1), mRNA.

Price & Availability↑

CloneID	OHu28295
Clone ID Related Accession (Same CDS sequence)	NM_000475.5 , NM_000475.4
Accession Version	NM_000475.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1413bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	nuclear receptor subfamily 0 group B member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI772108.1, BC011564.1 and AW612655.1. This sequence is a reference standard in the RefSeqGene project. On May 30, 2008 this sequence version replaced NM_000475.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AW612655.1, S74720.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGGCG AGAACCACCA GTGGCAGGGC AGCATCCTCT ACAACATGCT TATGAGCGCG 
AAGCAAACGC GCGCGGCTCC TGAGGCTCCA GAGACGCGGC TGGTGGATCA GTGCTGGGGC 
TGTTCGTGCG GCGATGAGCC CGGGGTGGGC AGAGAGGGGC TGCTGGGCGG GCGGAACGTG 
GCGCTCCTGT ACCGCTGCTG CTTTTGCGGT AAAGACCACC CACGGCAGGG CAGCATCCTC 
TACAGCATGC TGACGAGCGC AAAGCAAACG TACGCGGCAC CGAAGGCGCC CGAGGCGACG 
CTGGGTCCGT GCTGGGGCTG TTCGTGCGGC TCTGATCCCG GGGTGGGCAG AGCGGGGCTT 
CCGGGTGGGC GGCCCGTGGC ACTCCTGTAC CGCTGCTGCT TTTGTGGTGA AGACCACCCG 
CGGCAGGGCA GCATCCTCTA CAGCTTGCTC ACTAGCTCAA AGCAAACGCA CGTGGCTCCG 
GCAGCGCCCG AGGCACGGCC AGGGGGCGCG TGGTGGGACC GCTCCTACTT CGCGCAGAGG 
CCAGGGGGTA AAGAGGCGCT ACCAGGCGGG CGGGCCACGG CGCTTCTGTA CCGCTGCTGC 
TTTTGCGGTG AAGACCACCC GCAGCAGGGC AGCACCCTCT ACTGCGTGCC CACGAGCACA 
AATCAAGCGC AGGCGGCTCC GGAGGAGCGG CCGAGGGCCC CCTGGTGGGA CACCTCCTCT 
GGTGCGCTGC GGCCGGTGGC GCTCAAGAGT CCACAGGTGG TCTGCGAGGC AGCCTCAGCG 
GGCCTGTTGA AGACGCTGCG CTTCGTCAAG TACTTGCCCT GCTTCCAGGT GCTGCCCCTG 
GACCAGCAGC TGGTGCTGGT GCGCAACTGC TGGGCGTCCC TGCTCATGCT TGAGCTGGCC 
CAGGACCGCT TGCAGTTCGA GACTGTGGAA GTCTCGGAGC CCAGCATGCT GCAGAAGATC 
CTCACCACCA GGCGGCGGGA GACCGGGGGC AACGAGCCAC TGCCCGTGCC CACGCTGCAG 
CACCATTTGG CACCGCCGGC GGAGGCCAGG AAGGTGCCCT CCGCCTCCCA GGTCCAAGCC 
ATCAAGTGCT TTCTTTCCAA ATGCTGGAGT CTGAACATCA GTACCAAGGA GTACGCCTAC 
CTCAAGGGGA CCGTGCTCTT TAACCCGGAC GTGCCGGGCC TGCAGTGCGT GAAGTACATT 
CAGGGACTCC AGTGGGGAAC TCAGCAAATA CTCAGTGAAC ACACCAGGAT GACGCACCAA 
GGGCCCCATG ACAGATTCAT CGAACTTAAT AGTACCCTTT TCCTGCTGAG ATTCATCAAT 
GCCAATGTCA TTGCTGAACT GTTCTTCAGG CCCATCATCG GCACAGTCAG CATGGATGAT 
ATGATGCTGG AAATGCTCTG TACAAAGATA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000466.2
CDS	16..1428
Translation	MAGENHQWQGSILYNMLMSAKQTRAAPEAPETRLVDQCWGCSCGDEPGVGREGLLGGRNVALLYRCCFCGKDHPRQGSILYSMLTSAKQTYAAPKAPEATLGPCWGCSCGSDPGVGRAGLPGGRPVALLYRCCFCGEDHPRQGSILYSLLTSSKQTHVAPAAPEARPGGAWWDRSYFAQRPGGKEALPGGRATALLYRCCFCGEDHPQQGSTLYCVPTSTNQAQAAPEERPRAPWWDTSSGALRPVALKSPQVVCEAASAGLLKTLRFVKYLPCFQVLPLDQQLVLVRNCWASLLMLELAQDRLQFETVEVSEPSMLQKILTTRRRETGGNEPLPVPTLQHHLAPPAEARKVPSASQVQAIKCFLSKCWSLNISTKEYAYLKGTVLFNPDVPGLQCVKYIQGLQWGTQQILSEHTRMTHQGPHDRFIELNSTLFLLRFINANVIAELFFRPIIGTVSMDDMMLEMLCTKI

Target ORF information:

RefSeq Version	NM_000475.4
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor subfamily 0 group B member 1 (NR0B1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000475.4

ORF Insert Sequence:

ATGGCGGGCG AGAACCACCA GTGGCAGGGC AGCATCCTCT ACAACATGCT TATGAGCGCG 
AAGCAAACGC GCGCGGCTCC TGAGGCTCCA GAGACGCGGC TGGTGGATCA GTGCTGGGGC 
TGTTCGTGCG GCGATGAGCC CGGGGTGGGC AGAGAGGGGC TGCTGGGCGG GCGGAACGTG 
GCGCTCCTGT ACCGCTGCTG CTTTTGCGGT AAAGACCACC CACGGCAGGG CAGCATCCTC 
TACAGCATGC TGACGAGCGC AAAGCAAACG TACGCGGCAC CGAAGGCGCC CGAGGCGACG 
CTGGGTCCGT GCTGGGGCTG TTCGTGCGGC TCTGATCCCG GGGTGGGCAG AGCGGGGCTT 
CCGGGTGGGC GGCCCGTGGC ACTCCTGTAC CGCTGCTGCT TTTGTGGTGA AGACCACCCG 
CGGCAGGGCA GCATCCTCTA CAGCTTGCTC ACTAGCTCAA AGCAAACGCA CGTGGCTCCG 
GCAGCGCCCG AGGCACGGCC AGGGGGCGCG TGGTGGGACC GCTCCTACTT CGCGCAGAGG 
CCAGGGGGTA AAGAGGCGCT ACCAGGCGGG CGGGCCACGG CGCTTCTGTA CCGCTGCTGC 
TTTTGCGGTG AAGACCACCC GCAGCAGGGC AGCACCCTCT ACTGCGTGCC CACGAGCACA 
AATCAAGCGC AGGCGGCTCC GGAGGAGCGG CCGAGGGCCC CCTGGTGGGA CACCTCCTCT 
GGTGCGCTGC GGCCGGTGGC GCTCAAGAGT CCACAGGTGG TCTGCGAGGC AGCCTCAGCG 
GGCCTGTTGA AGACGCTGCG CTTCGTCAAG TACTTGCCCT GCTTCCAGGT GCTGCCCCTG 
GACCAGCAGC TGGTGCTGGT GCGCAACTGC TGGGCGTCCC TGCTCATGCT TGAGCTGGCC 
CAGGACCGCT TGCAGTTCGA GACTGTGGAA GTCTCGGAGC CCAGCATGCT GCAGAAGATC 
CTCACCACCA GGCGGCGGGA GACCGGGGGC AACGAGCCAC TGCCCGTGCC CACGCTGCAG 
CACCATTTGG CACCGCCGGC GGAGGCCAGG AAGGTGCCCT CCGCCTCCCA GGTCCAAGCC 
ATCAAGTGCT TTCTTTCCAA ATGCTGGAGT CTGAACATCA GTACCAAGGA GTACGCCTAC 
CTCAAGGGGA CCGTGCTCTT TAACCCGGAC GTGCCGGGCC TGCAGTGCGT GAAGTACATT 
CAGGGACTCC AGTGGGGAAC TCAGCAAATA CTCAGTGAAC ACACCAGGAT GACGCACCAA 
GGGCCCCATG ACAGATTCAT CGAACTTAAT AGTACCCTTT TCCTGCTGAG ATTCATCAAT 
GCCAATGTCA TTGCTGAACT GTTCTTCAGG CCCATCATCG GCACAGTCAG CATGGATGAT 
ATGATGCTGG AAATGCTCTG TACAAAGATA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NR0B1 ( XM_017029338.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016884827.1 Homo sapiens nuclear receptor subfamily 0 group B member 1 (NR0B1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu99191
Clone ID Related Accession (Same CDS sequence)	XM_017029338.1
Accession Version	XM_017029338.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1203bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	nuclear receptor subfamily 0 group B member 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGGCG AGAACCACCA GTGGCAGGGC AGCATCCTCT ACAACATGCT TATGAGCGCG 
AAGCAAACGC GCGCGGCTCC TGAGGCTCCA GAGACGCGGC TGGTGGATCA GTGCTGGGGC 
TGTTCGTGCG GCGATGAGCC CGGGGTGGGC AGAGAGGGGC TGCTGGGCGG GCGGAACGTG 
GCGCTCCTGT ACCGCTGCTG CTTTTGCGGT AAAGACCACC CACGGCAGGG CAGCATCCTC 
TACAGCATGC TGACGAGCGC AAAGCAAACG TACGCGGCAC CGAAGGCGCC CGAGGCGACG 
CTGGGTCCGT GCTGGGGCTG TTCGTGCGGC TCTGATCCCG GGGTGGGCAG AGCGGGGCTT 
CCGGGTGGGC GGCCCGTGGC ACTCCTGTAC CGCTGCTGCT TTTGTGGTGA AGACCACCCG 
CGGCAGGGCA GCATCCTCTA CAGCTTGCTC ACTAGCTCAA AGCAAACGCA CGTGGCTCCG 
GCAGCGCCCG AGGCACGGCC AGGGGGCGCG TGGTGGGACC GCTCCTACTT CGCGCAGAGG 
CCAGGGGGTA AAGAGGCGCT ACCAGGCGGG CGGGCCACGG CGCTTCTGTA CCGCTGCTGC 
TTTTGCGGTG AAGACCACCC GCAGCAGGGC AGCACCCTCT ACTGCGTGCC CACGAGCACA 
AATCAAGCGC AGGCGGCTCC GGAGGAGCGG CCGAGGGCCC CCTGGTGGGA CACCTCCTCT 
GGTGCGCTGC GGCCGGTGGC GCTCAAGAGT CCACAGGTGG TCTGCGAGGC AGCCTCAGCG 
GGCCTGTTGA AGACGCTGCG CTTCGTCAAG TACTTGCCCT GCTTCCAGGT GCTGCCCCTG 
GACCAGCAGC TGGTGCTGGT GCGCAACTGC TGGGCGTCCC TGCTCATGCT TGAGCTGGCC 
CAGGACCGCT TGCAGTTCGA GACTGTGGAA GTCTCGGAGC CCAGCATGCT GCAGAAGATC 
CTCACCACCA GGCGGCGGGA GACCGGGGGC AACGAGCCAC TGCCCGTGCC CACGCTGCAG 
CACCATTTGG CACCGCCGGC GGAGGCCAGG AAGGTGCCCT CCGCCTCCCA GGTCCAAGCC 
ATCAAGTGCT TTCTTTCCAA ATGCTGGAGT CTGAACATCA GTACCAAGGA GTACGCCTAC 
CTCAAGGGGA CCGTGCTCTT TAACCCGGGA AAAGGGAAGG AAAATGATTG CAATCATCAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016884827.1
CDS	37..1239
Translation	MAGENHQWQGSILYNMLMSAKQTRAAPEAPETRLVDQCWGCSCGDEPGVGREGLLGGRNVALLYRCCFCGKDHPRQGSILYSMLTSAKQTYAAPKAPEATLGPCWGCSCGSDPGVGRAGLPGGRPVALLYRCCFCGEDHPRQGSILYSLLTSSKQTHVAPAAPEARPGGAWWDRSYFAQRPGGKEALPGGRATALLYRCCFCGEDHPQQGSTLYCVPTSTNQAQAAPEERPRAPWWDTSSGALRPVALKSPQVVCEAASAGLLKTLRFVKYLPCFQVLPLDQQLVLVRNCWASLLMLELAQDRLQFETVEVSEPSMLQKILTTRRRETGGNEPLPVPTLQHHLAPPAEARKVPSASQVQAIKCFLSKCWSLNISTKEYAYLKGTVLFNPGKGKENDCNHH

Target ORF information:

RefSeq Version	XM_017029338.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor subfamily 0 group B member 1 (NR0B1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017029338.1

ORF Insert Sequence:

ATGGCGGGCG AGAACCACCA GTGGCAGGGC AGCATCCTCT ACAACATGCT TATGAGCGCG 
AAGCAAACGC GCGCGGCTCC TGAGGCTCCA GAGACGCGGC TGGTGGATCA GTGCTGGGGC 
TGTTCGTGCG GCGATGAGCC CGGGGTGGGC AGAGAGGGGC TGCTGGGCGG GCGGAACGTG 
GCGCTCCTGT ACCGCTGCTG CTTTTGCGGT AAAGACCACC CACGGCAGGG CAGCATCCTC 
TACAGCATGC TGACGAGCGC AAAGCAAACG TACGCGGCAC CGAAGGCGCC CGAGGCGACG 
CTGGGTCCGT GCTGGGGCTG TTCGTGCGGC TCTGATCCCG GGGTGGGCAG AGCGGGGCTT 
CCGGGTGGGC GGCCCGTGGC ACTCCTGTAC CGCTGCTGCT TTTGTGGTGA AGACCACCCG 
CGGCAGGGCA GCATCCTCTA CAGCTTGCTC ACTAGCTCAA AGCAAACGCA CGTGGCTCCG 
GCAGCGCCCG AGGCACGGCC AGGGGGCGCG TGGTGGGACC GCTCCTACTT CGCGCAGAGG 
CCAGGGGGTA AAGAGGCGCT ACCAGGCGGG CGGGCCACGG CGCTTCTGTA CCGCTGCTGC 
TTTTGCGGTG AAGACCACCC GCAGCAGGGC AGCACCCTCT ACTGCGTGCC CACGAGCACA 
AATCAAGCGC AGGCGGCTCC GGAGGAGCGG CCGAGGGCCC CCTGGTGGGA CACCTCCTCT 
GGTGCGCTGC GGCCGGTGGC GCTCAAGAGT CCACAGGTGG TCTGCGAGGC AGCCTCAGCG 
GGCCTGTTGA AGACGCTGCG CTTCGTCAAG TACTTGCCCT GCTTCCAGGT GCTGCCCCTG 
GACCAGCAGC TGGTGCTGGT GCGCAACTGC TGGGCGTCCC TGCTCATGCT TGAGCTGGCC 
CAGGACCGCT TGCAGTTCGA GACTGTGGAA GTCTCGGAGC CCAGCATGCT GCAGAAGATC 
CTCACCACCA GGCGGCGGGA GACCGGGGGC AACGAGCCAC TGCCCGTGCC CACGCTGCAG 
CACCATTTGG CACCGCCGGC GGAGGCCAGG AAGGTGCCCT CCGCCTCCCA GGTCCAAGCC 
ATCAAGTGCT TTCTTTCCAA ATGCTGGAGT CTGAACATCA GTACCAAGGA GTACGCCTAC 
CTCAAGGGGA CCGTGCTCTT TAACCCGGGA AAAGGGAAGG AAAATGATTG CAATCATCAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel missense mutation in NR0B1 causes delayed-onset primary adrenal insufficiency in adults.
Clinical genetics92(3)344-346(2017 Sep)
Oh CM,Chun S,Lee JE,Lee JS,Park S,Gee HY,Kim SW

A novel DAX-1 mutation in two male siblings presenting with precocious puberty and late-onset hypogonadotropic hypogonadism.
Journal of pediatric endocrinology & metabolism : JPEM30(3)349-353(2017 Mar)
Liu Y,Yuan J,Zhang H,Jiang Y,Qin G

Epigenetic modifications promote the expression of the orphan nuclear receptor NR0B1 in human lung adenocarcinoma cells.
Oncotarget7(28)43162-43176(2016 Jul)
Lu Y,Liu Y,Liao S,Tu W,Shen Y,Yan Y,Tao D,Lu Y,Ma Y,Yang Y,Zhang S

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NR0B1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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