DSC2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DSC2
Entrez Gene ID	1824
Full Name	desmocollin 2
Synonyms	ARVD11,CDHF2,DG2,DGII/III,DSC3
General protein information	Preferred Names desmocollin 2 Names desmocollin-2 cadherin family member 2 desmosomal glycoprotein II/III
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q12.1
Summary	This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
Disorder MIM:	125645
Disorder Html:	Arrhythmogenic right ventricular dysplasia 11, 610476 (3); Arrhythmogenic right ventricular dysplasia 11 with mild palmoplantar keratoderma and woolly hair, 610476 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_024422.4	NP_077740.1	desmocollin-2 isoform Dsc2a preproprotein
NM_004949.5	NP_004940.1	desmocollin-2 isoform Dsc2b preproprotein
XM_005258206.4	XP_005258263.1	desmocollin-2 isoform X1
NM_024422.6	NP_077740.1	desmocollin-2 isoform Dsc2a preproprotein
NM_004949.4	NP_004940.1	desmocollin-2 isoform Dsc2b preproprotein

Pathways from BioSystems

Homologies

	LOC712942	XP_001102096.2
Homo sapiens (human)	DSC2	NP_077740.1
Mus musculus (house mouse)	Dsc2	NP_038533.1
Gallus gallus (chicken)	DSC2	XP_004939874.1
Canis lupus familiaris (dog)	DSC2	XP_866930.1
Rattus norvegicus (Norway rat)	Dsc2	NP_001028860.1
Xenopus tropicalis (tropical clawed frog)	dsc3	NP_001122136.1
Pan troglodytes (chimpanzee)	DSC2	XP_512077.3
Bos taurus (cattle)	DSC2	NP_001159998.1

Gene Ontology
Bibliography

Related articles in PubMed

Plakophilin3 increases desmosome assembly, size and stability by increasing expression of desmocollin2.
Gurjar M, Raychaudhuri K, Mahadik S, Reddy D, Atak A, Shetty T, Rao K, Karkhanis MS, Gosavi P, Sehgal L, Gupta S, Dalal SN
Biochemical and biophysical research communications495(1)768-774(2018 01)

Whole-Exome Sequencing Identifies a Novel Mutation of Desmocollin 2 in a Chinese Family With Arrhythmogenic Right Ventricular Cardiomyopathy.
Liu JS, Fan LL, Li JJ, Xiang R
The American journal of cardiology119(9)1485-1489(2017 May)

Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodeling.
Brodehl A, Belke DD, Garnett L, Martens K, Abdelfatah N, Rodriguez M, Diao C, Chen YX, Gordon PM, Nygren A, Gerull B
PloS one12(3)e0174019(2017)

Functional Promoter Variant in Desmocollin-2 Contributes to Arrhythmogenic Right Ventricular Cardiomyopathy.
Christensen AH, Schmitz B, Andersen CB, Bundgaard H, Brand SM, Svendsen JH
Circulation. Cardiovascular genetics9(4)384-7(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins.
Title: Plakophilin3 increases desmosome assembly, size and stability by increasing expression of desmocollin2.

A novel missense mutation (c.1090 G > A/p.V364 M) of DSC2 was identified in a Chinese family with arrhythmogenic right ventricular cardiomyopathy.
Title: Whole-Exome Sequencing Identifies a Novel Mutation of Desmocollin 2 in a Chinese Family With Arrhythmogenic Right Ventricular Cardiomyopathy.

The cardiac specific DSC2 transgenic mice develop severe biventricular cardiomyopathy.
Title: Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodeling.

Oxidized low-density lipoprotein attenuated desmoglein 1 and desmocollin 2 expression in human umbilical vein endothelial cells.
Title: Oxidized low-density lipoprotein attenuated desmoglein 1 and desmocollin 2 expression via LOX-1/Ca(2+)/PKC-? signal in human umbilical vein endothelial cells.

Homozygous founder mutation in DSC2 gene identified among Italian arrhythmogenic cardiomyopathy probands, providing evidence of the occurrence of recessive DSC2 mutations presenting with biventricular forms of the disease.
Title: Homozygous Desmocollin-2 Mutations and Arrhythmogenic Cardiomyopathy.

The following DSC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DSC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16552	NM_024422.6 Latest version!	Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu18926	NM_004949.5 Latest version!	Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$594.30 $849.00
OHu51108	XM_005258206.4 Latest version!	Homo sapiens desmocollin 2 (DSC2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu16552	NM_024422.4	Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu18926	NM_004949.4	Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$594.30 $849.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DSC2 ( NM_024422.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_077740.1 Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2a, mRNA.

Price & Availability↑

CloneID	OHu16552
Clone ID Related Accession (Same CDS sequence)	NM_024422.4 , NM_024422.6
Accession Version	NM_024422.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2706bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	desmocollin-2 isoform Dsc2a preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC382631.1, BC063291.1, X56807.1 and BE350090.1. On Feb 19, 2015 this sequence version replaced NM_024422.3. Transcript Variant: This variant (Dsc2a, also known as DGII) encodes the longer isoform (Dsc2a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063291.1, SRR1660805.55743.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCAG CCCGCCCCTC CGGCTCCTGG AACGGAGCCC TCTGCCGGCT GCTCCTGCTG 
ACCCTCGCGA TCTTAATATT TGCCAGTGAT GCCTGCAAAA ATGTGACATT ACATGTTCCC 
TCCAAACTAG ATGCCGAGAA ACTTGTTGGT AGAGTTAACC TGAAAGAGTG CTTTACAGCT 
GCAAATCTAA TTCATTCAAG TGATCCTGAC TTCCAAATTT TGGAGGATGG TTCAGTCTAT 
ACAACAAATA CTATTCTATT GTCCTCGGAG AAGAGAAGTT TTACCATATT ACTTTCCAAC 
ACTGAGAACC AAGAAAAGAA GAAAATATTT GTCTTTTTGG AGCATCAAAC AAAGGTCCTA 
AAGAAAAGAC ATACTAAAGA AAAAGTTCTA AGGCGCGCCA AGAGAAGATG GGCTCCAATT 
CCTTGTTCGA TGCTAGAAAA CTCCTTGGGT CCTTTTCCAC TTTTCCTTCA ACAGGTTCAA 
TCTGACACGG CCCAAAACTA TACCATATAC TATTCCATAA GAGGTCCTGG AGTTGACCAA 
GAACCTCGGA ATTTATTTTA TGTGGAGAGA GACACTGGAA ACTTGTATTG TACTCGTCCT 
GTAGATCGTG AGCAGTATGA ATCTTTTGAG ATAATTGCCT TTGCAACAAC TCCAGATGGG 
TATACTCCAG AACTTCCACT GCCCCTAATA ATCAAAATAG AGGATGAAAA TGATAACTAC 
CCAATTTTTA CAGAAGAAAC TTATACTTTT ACAATTTTTG AAAATTGCAG AGTGGGCACT 
ACTGTGGGAC AAGTGTGTGC TACTGACAAA GATGAGCCTG ACACGATGCA CACACGCCTG 
AAGTACTCCA TCATTGGGCA GGTGCCACCA TCACCCACCC TATTTTCTAT GCATCCAACT 
ACAGGCGTGA TCACCACAAC ATCATCTCAG CTAGACAGAG AGTTAATTGA CAAGTACCAG 
TTGAAAATAA AAGTACAAGA CATGGATGGT CAGTATTTTG GTCTACAGAC AACTTCAACT 
TGTATCATTA ACATTGATGA TGTAAATGAC CACTTGCCAA CATTTACTCG TACTTCTTAT 
GTGACATCAG TGGAAGAAAA TACAGTTGAT GTGGAAATCT TACGAGTTAC TGTTGAGGAT 
AAGGACTTAG TGAATACTGC TAACTGGAGA GCTAATTATA CCATTTTAAA GGGCAATGAA 
AATGGCAATT TTAAAATTGT AACAGATGCC AAAACCAATG AAGGAGTTCT TTGTGTAGTT 
AAGCCTTTGA ATTATGAAGA AAAGCAACAG ATGATCTTGC AAATTGGTGT AGTTAATGAA 
GCTCCATTTT CCAGAGAGGC TAGTCCAAGA TCAGCCATGA GCACAGCAAC AGTTACTGTT 
AATGTAGAAG ATCAGGATGA GGGCCCTGAG TGTAACCCTC CAATACAGAC TGTTCGCATG 
AAAGAAAATG CAGAAGTGGG AACAACAAGC AATGGATATA AAGCATATGA CCCAGAAACA 
AGAAGTAGCA GTGGCATAAG GTATAAGAAA TTAACTGATC CAACAGGGTG GGTCACCATT 
GATGAAAATA CAGGATCAAT CAAAGTTTTC AGAAGCCTGG ATAGAGAGGC AGAGACCATC 
AAAAATGGCA TATATAATAT TACAGTCCTT GCATCAGACC AAGGAGGGAG AACATGTACG 
GGGACACTGG GCATTATACT TCAAGACGTG AATGATAACA GCCCATTCAT ACCTAAAAAG 
ACAGTGATCA TCTGCAAACC CACCATGTCA TCTGCGGAGA TTGTTGCGGT TGATCCTGAT 
GAGCCTATCC ATGGCCCACC CTTTGACTTT AGTCTGGAGA GTTCTACTTC AGAAGTACAG 
AGAATGTGGA GACTGAAAGC AATTAATGAT ACAGCAGCAC GTCTTTCCTA TCAGAATGAT 
CCTCCATTTG GCTCATATGT AGTACCTATA ACAGTGAGAG ATAGACTTGG CATGTCTAGT 
GTCACTTCAT TGGATGTTAC ACTGTGTGAC TGCATTACCG AAAATGACTG CACACATCGT 
GTAGATCCAA GGATTGGCGG TGGAGGAGTA CAACTTGGAA AGTGGGCCAT CCTTGCAATA 
TTGTTGGGCA TAGCATTGCT CTTTTGCATC CTGTTTACGC TGGTCTGTGG GGCTTCTGGG 
ACGTCTAAAC AACCAAAAGT AATTCCTGAT GATTTAGCCC AGCAGAACCT AATTGTATCA 
AACACAGAAG CTCCTGGAGA TGACAAAGTG TATTCTGCGA ATGGCTTCAC AACCCAAACT 
GTGGGCGCTT CTGCTCAGGG AGTTTGTGGC ACCGTGGGAT CAGGAATCAA AAACGGAGGT 
CAGGAGACCA TCGAAATGGT GAAAGGAGGA CACCAGACCT CGGAATCCTG CCGGGGGGCT 
GGCCACCATC ACACCCTGGA CTCCTGCAGG GGAGGACACA CGGAGGTGGA CAACTGCAGA 
TACACTTACT CGGAGTGGCA CAGTTTTACT CAGCCCCGTC TTGGTGAAAA AGTGTATCTG 
TGTAATCAAG ATGAAAATCA CAAGCATGCC CAAGACTATG TCCTGACATA TAACTATGAA 
GGAAGAGGAT CGGTGGCTGG GTCTGTAGGT TGTTGCAGTG AACGACAAGA AGAAGATGGG 
CTTGAATTTT TGGATAATTT GGAGCCCAAA TTTAGGACAC TAGCAGAAGC ATGCATGAAG 
AGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077740.1
CDS	462..3167
Translation	MEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTLVCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKVYLCNQDENHKHAQDYVLTYNYEGRGSVAGSVGCCSERQEEDGLEFLDNLEPKFRTLAEACMKR

Target ORF information:

RefSeq Version	NM_024422.4
Organism	Homo sapiens(human)
Definition	Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024422.4

ORF Insert Sequence:

ATGGAGGCAG CCCGCCCCTC CGGCTCCTGG AACGGAGCCC TCTGCCGGCT GCTCCTGCTG 
ACCCTCGCGA TCTTAATATT TGCCAGTGAT GCCTGCAAAA ATGTGACATT ACATGTTCCC 
TCCAAACTAG ATGCCGAGAA ACTTGTTGGT AGAGTTAACC TGAAAGAGTG CTTTACAGCT 
GCAAATCTAA TTCATTCAAG TGATCCTGAC TTCCAAATTT TGGAGGATGG TTCAGTCTAT 
ACAACAAATA CTATTCTATT GTCCTCGGAG AAGAGAAGTT TTACCATATT ACTTTCCAAC 
ACTGAGAACC AAGAAAAGAA GAAAATATTT GTCTTTTTGG AGCATCAAAC AAAGGTCCTA 
AAGAAAAGAC ATACTAAAGA AAAAGTTCTA AGGCGCGCCA AGAGAAGATG GGCTCCAATT 
CCTTGTTCGA TGCTAGAAAA CTCCTTGGGT CCTTTTCCAC TTTTCCTTCA ACAGGTTCAA 
TCTGACACGG CCCAAAACTA TACCATATAC TATTCCATAA GAGGTCCTGG AGTTGACCAA 
GAACCTCGGA ATTTATTTTA TGTGGAGAGA GACACTGGAA ACTTGTATTG TACTCGTCCT 
GTAGATCGTG AGCAGTATGA ATCTTTTGAG ATAATTGCCT TTGCAACAAC TCCAGATGGG 
TATACTCCAG AACTTCCACT GCCCCTAATA ATCAAAATAG AGGATGAAAA TGATAACTAC 
CCAATTTTTA CAGAAGAAAC TTATACTTTT ACAATTTTTG AAAATTGCAG AGTGGGCACT 
ACTGTGGGAC AAGTGTGTGC TACTGACAAA GATGAGCCTG ACACGATGCA CACACGCCTG 
AAGTACTCCA TCATTGGGCA GGTGCCACCA TCACCCACCC TATTTTCTAT GCATCCAACT 
ACAGGCGTGA TCACCACAAC ATCATCTCAG CTAGACAGAG AGTTAATTGA CAAGTACCAG 
TTGAAAATAA AAGTACAAGA CATGGATGGT CAGTATTTTG GTCTACAGAC AACTTCAACT 
TGTATCATTA ACATTGATGA TGTAAATGAC CACTTGCCAA CATTTACTCG TACTTCTTAT 
GTGACATCAG TGGAAGAAAA TACAGTTGAT GTGGAAATCT TACGAGTTAC TGTTGAGGAT 
AAGGACTTAG TGAATACTGC TAACTGGAGA GCTAATTATA CCATTTTAAA GGGCAATGAA 
AATGGCAATT TTAAAATTGT AACAGATGCC AAAACCAATG AAGGAGTTCT TTGTGTAGTT 
AAGCCTTTGA ATTATGAAGA AAAGCAACAG ATGATCTTGC AAATTGGTGT AGTTAATGAA 
GCTCCATTTT CCAGAGAGGC TAGTCCAAGA TCAGCCATGA GCACAGCAAC AGTTACTGTT 
AATGTAGAAG ATCAGGATGA GGGCCCTGAG TGTAACCCTC CAATACAGAC TGTTCGCATG 
AAAGAAAATG CAGAAGTGGG AACAACAAGC AATGGATATA AAGCATATGA CCCAGAAACA 
AGAAGTAGCA GTGGCATAAG GTATAAGAAA TTAACTGATC CAACAGGGTG GGTCACCATT 
GATGAAAATA CAGGATCAAT CAAAGTTTTC AGAAGCCTGG ATAGAGAGGC AGAGACCATC 
AAAAATGGCA TATATAATAT TACAGTCCTT GCATCAGACC AAGGAGGGAG AACATGTACG 
GGGACACTGG GCATTATACT TCAAGACGTG AATGATAACA GCCCATTCAT ACCTAAAAAG 
ACAGTGATCA TCTGCAAACC CACCATGTCA TCTGCGGAGA TTGTTGCGGT TGATCCTGAT 
GAGCCTATCC ATGGCCCACC CTTTGACTTT AGTCTGGAGA GTTCTACTTC AGAAGTACAG 
AGAATGTGGA GACTGAAAGC AATTAATGAT ACAGCAGCAC GTCTTTCCTA TCAGAATGAT 
CCTCCATTTG GCTCATATGT AGTACCTATA ACAGTGAGAG ATAGACTTGG CATGTCTAGT 
GTCACTTCAT TGGATGTTAC ACTGTGTGAC TGCATTACCG AAAATGACTG CACACATCGT 
GTAGATCCAA GGATTGGCGG TGGAGGAGTA CAACTTGGAA AGTGGGCCAT CCTTGCAATA 
TTGTTGGGCA TAGCATTGCT CTTTTGCATC CTGTTTACGC TGGTCTGTGG GGCTTCTGGG 
ACGTCTAAAC AACCAAAAGT AATTCCTGAT GATTTAGCCC AGCAGAACCT AATTGTATCA 
AACACAGAAG CTCCTGGAGA TGACAAAGTG TATTCTGCGA ATGGCTTCAC AACCCAAACT 
GTGGGCGCTT CTGCTCAGGG AGTTTGTGGC ACCGTGGGAT CAGGAATCAA AAACGGAGGT 
CAGGAGACCA TCGAAATGGT GAAAGGAGGA CACCAGACCT CGGAATCCTG CCGGGGGGCT 
GGCCACCATC ACACCCTGGA CTCCTGCAGG GGAGGACACA CGGAGGTGGA CAACTGCAGA 
TACACTTACT CGGAGTGGCA CAGTTTTACT CAGCCCCGTC TTGGTGAAAA AGTGTATCTG 
TGTAATCAAG ATGAAAATCA CAAGCATGCC CAAGACTATG TCCTGACATA TAACTATGAA 
GGAAGAGGAT CGGTGGCTGG GTCTGTAGGT TGTTGCAGTG AACGACAAGA AGAAGATGGG 
CTTGAATTTT TGGATAATTT GGAGCCCAAA TTTAGGACAC TAGCAGAAGC ATGCATGAAG 
AGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DSC2 ( NM_024422.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_077740.1 Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2a, mRNA.

Price & Availability↑

CloneID	OHu16552
Clone ID Related Accession (Same CDS sequence)	NM_024422.4 , NM_024422.6
Accession Version	NM_024422.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2706bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	desmocollin-2 isoform Dsc2a preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC382631.1, BC063291.1, X56807.1, BE350090.1 and AC012417.13. On May 20, 2019 this sequence version replaced NM_024422.5. Transcript Variant: This variant (Dsc2a, also known as DGII) encodes the longer isoform (Dsc2a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063291.1, SRR1660805.55743.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000280904.11/ ENSP00000280904.6 RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCAG CCCGCCCCTC CGGCTCCTGG AACGGAGCCC TCTGCCGGCT GCTCCTGCTG 
ACCCTCGCGA TCTTAATATT TGCCAGTGAT GCCTGCAAAA ATGTGACATT ACATGTTCCC 
TCCAAACTAG ATGCCGAGAA ACTTGTTGGT AGAGTTAACC TGAAAGAGTG CTTTACAGCT 
GCAAATCTAA TTCATTCAAG TGATCCTGAC TTCCAAATTT TGGAGGATGG TTCAGTCTAT 
ACAACAAATA CTATTCTATT GTCCTCGGAG AAGAGAAGTT TTACCATATT ACTTTCCAAC 
ACTGAGAACC AAGAAAAGAA GAAAATATTT GTCTTTTTGG AGCATCAAAC AAAGGTCCTA 
AAGAAAAGAC ATACTAAAGA AAAAGTTCTA AGGCGCGCCA AGAGAAGATG GGCTCCAATT 
CCTTGTTCGA TGCTAGAAAA CTCCTTGGGT CCTTTTCCAC TTTTCCTTCA ACAGGTTCAA 
TCTGACACGG CCCAAAACTA TACCATATAC TATTCCATAA GAGGTCCTGG AGTTGACCAA 
GAACCTCGGA ATTTATTTTA TGTGGAGAGA GACACTGGAA ACTTGTATTG TACTCGTCCT 
GTAGATCGTG AGCAGTATGA ATCTTTTGAG ATAATTGCCT TTGCAACAAC TCCAGATGGG 
TATACTCCAG AACTTCCACT GCCCCTAATA ATCAAAATAG AGGATGAAAA TGATAACTAC 
CCAATTTTTA CAGAAGAAAC TTATACTTTT ACAATTTTTG AAAATTGCAG AGTGGGCACT 
ACTGTGGGAC AAGTGTGTGC TACTGACAAA GATGAGCCTG ACACGATGCA CACACGCCTG 
AAGTACTCCA TCATTGGGCA GGTGCCACCA TCACCCACCC TATTTTCTAT GCATCCAACT 
ACAGGCGTGA TCACCACAAC ATCATCTCAG CTAGACAGAG AGTTAATTGA CAAGTACCAG 
TTGAAAATAA AAGTACAAGA CATGGATGGT CAGTATTTTG GTCTACAGAC AACTTCAACT 
TGTATCATTA ACATTGATGA TGTAAATGAC CACTTGCCAA CATTTACTCG TACTTCTTAT 
GTGACATCAG TGGAAGAAAA TACAGTTGAT GTGGAAATCT TACGAGTTAC TGTTGAGGAT 
AAGGACTTAG TGAATACTGC TAACTGGAGA GCTAATTATA CCATTTTAAA GGGCAATGAA 
AATGGCAATT TTAAAATTGT AACAGATGCC AAAACCAATG AAGGAGTTCT TTGTGTAGTT 
AAGCCTTTGA ATTATGAAGA AAAGCAACAG ATGATCTTGC AAATTGGTGT AGTTAATGAA 
GCTCCATTTT CCAGAGAGGC TAGTCCAAGA TCAGCCATGA GCACAGCAAC AGTTACTGTT 
AATGTAGAAG ATCAGGATGA GGGCCCTGAG TGTAACCCTC CAATACAGAC TGTTCGCATG 
AAAGAAAATG CAGAAGTGGG AACAACAAGC AATGGATATA AAGCATATGA CCCAGAAACA 
AGAAGTAGCA GTGGCATAAG GTATAAGAAA TTAACTGATC CAACAGGGTG GGTCACCATT 
GATGAAAATA CAGGATCAAT CAAAGTTTTC AGAAGCCTGG ATAGAGAGGC AGAGACCATC 
AAAAATGGCA TATATAATAT TACAGTCCTT GCATCAGACC AAGGAGGGAG AACATGTACG 
GGGACACTGG GCATTATACT TCAAGACGTG AATGATAACA GCCCATTCAT ACCTAAAAAG 
ACAGTGATCA TCTGCAAACC CACCATGTCA TCTGCGGAGA TTGTTGCGGT TGATCCTGAT 
GAGCCTATCC ATGGCCCACC CTTTGACTTT AGTCTGGAGA GTTCTACTTC AGAAGTACAG 
AGAATGTGGA GACTGAAAGC AATTAATGAT ACAGCAGCAC GTCTTTCCTA TCAGAATGAT 
CCTCCATTTG GCTCATATGT AGTACCTATA ACAGTGAGAG ATAGACTTGG CATGTCTAGT 
GTCACTTCAT TGGATGTTAC ACTGTGTGAC TGCATTACCG AAAATGACTG CACACATCGT 
GTAGATCCAA GGATTGGCGG TGGAGGAGTA CAACTTGGAA AGTGGGCCAT CCTTGCAATA 
TTGTTGGGCA TAGCATTGCT CTTTTGCATC CTGTTTACGC TGGTCTGTGG GGCTTCTGGG 
ACGTCTAAAC AACCAAAAGT AATTCCTGAT GATTTAGCCC AGCAGAACCT AATTGTATCA 
AACACAGAAG CTCCTGGAGA TGACAAAGTG TATTCTGCGA ATGGCTTCAC AACCCAAACT 
GTGGGCGCTT CTGCTCAGGG AGTTTGTGGC ACCGTGGGAT CAGGAATCAA AAACGGAGGT 
CAGGAGACCA TCGAAATGGT GAAAGGAGGA CACCAGACCT CGGAATCCTG CCGGGGGGCT 
GGCCACCATC ACACCCTGGA CTCCTGCAGG GGAGGACACA CGGAGGTGGA CAACTGCAGA 
TACACTTACT CGGAGTGGCA CAGTTTTACT CAGCCCCGTC TTGGTGAAAA AGTGTATCTG 
TGTAATCAAG ATGAAAATCA CAAGCATGCC CAAGACTATG TCCTGACATA TAACTATGAA 
GGAAGAGGAT CGGTGGCTGG GTCTGTAGGT TGTTGCAGTG AACGACAAGA AGAAGATGGG 
CTTGAATTTT TGGATAATTT GGAGCCCAAA TTTAGGACAC TAGCAGAAGC ATGCATGAAG 
AGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077740.1
CDS	451..3156
Translation	MEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTLVCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKVYLCNQDENHKHAQDYVLTYNYEGRGSVAGSVGCCSERQEEDGLEFLDNLEPKFRTLAEACMKR

Target ORF information:

RefSeq Version	NM_024422.6
Organism	Homo sapiens(human)
Definition	Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024422.6

ORF Insert Sequence:

ATGGAGGCAG CCCGCCCCTC CGGCTCCTGG AACGGAGCCC TCTGCCGGCT GCTCCTGCTG 
ACCCTCGCGA TCTTAATATT TGCCAGTGAT GCCTGCAAAA ATGTGACATT ACATGTTCCC 
TCCAAACTAG ATGCCGAGAA ACTTGTTGGT AGAGTTAACC TGAAAGAGTG CTTTACAGCT 
GCAAATCTAA TTCATTCAAG TGATCCTGAC TTCCAAATTT TGGAGGATGG TTCAGTCTAT 
ACAACAAATA CTATTCTATT GTCCTCGGAG AAGAGAAGTT TTACCATATT ACTTTCCAAC 
ACTGAGAACC AAGAAAAGAA GAAAATATTT GTCTTTTTGG AGCATCAAAC AAAGGTCCTA 
AAGAAAAGAC ATACTAAAGA AAAAGTTCTA AGGCGCGCCA AGAGAAGATG GGCTCCAATT 
CCTTGTTCGA TGCTAGAAAA CTCCTTGGGT CCTTTTCCAC TTTTCCTTCA ACAGGTTCAA 
TCTGACACGG CCCAAAACTA TACCATATAC TATTCCATAA GAGGTCCTGG AGTTGACCAA 
GAACCTCGGA ATTTATTTTA TGTGGAGAGA GACACTGGAA ACTTGTATTG TACTCGTCCT 
GTAGATCGTG AGCAGTATGA ATCTTTTGAG ATAATTGCCT TTGCAACAAC TCCAGATGGG 
TATACTCCAG AACTTCCACT GCCCCTAATA ATCAAAATAG AGGATGAAAA TGATAACTAC 
CCAATTTTTA CAGAAGAAAC TTATACTTTT ACAATTTTTG AAAATTGCAG AGTGGGCACT 
ACTGTGGGAC AAGTGTGTGC TACTGACAAA GATGAGCCTG ACACGATGCA CACACGCCTG 
AAGTACTCCA TCATTGGGCA GGTGCCACCA TCACCCACCC TATTTTCTAT GCATCCAACT 
ACAGGCGTGA TCACCACAAC ATCATCTCAG CTAGACAGAG AGTTAATTGA CAAGTACCAG 
TTGAAAATAA AAGTACAAGA CATGGATGGT CAGTATTTTG GTCTACAGAC AACTTCAACT 
TGTATCATTA ACATTGATGA TGTAAATGAC CACTTGCCAA CATTTACTCG TACTTCTTAT 
GTGACATCAG TGGAAGAAAA TACAGTTGAT GTGGAAATCT TACGAGTTAC TGTTGAGGAT 
AAGGACTTAG TGAATACTGC TAACTGGAGA GCTAATTATA CCATTTTAAA GGGCAATGAA 
AATGGCAATT TTAAAATTGT AACAGATGCC AAAACCAATG AAGGAGTTCT TTGTGTAGTT 
AAGCCTTTGA ATTATGAAGA AAAGCAACAG ATGATCTTGC AAATTGGTGT AGTTAATGAA 
GCTCCATTTT CCAGAGAGGC TAGTCCAAGA TCAGCCATGA GCACAGCAAC AGTTACTGTT 
AATGTAGAAG ATCAGGATGA GGGCCCTGAG TGTAACCCTC CAATACAGAC TGTTCGCATG 
AAAGAAAATG CAGAAGTGGG AACAACAAGC AATGGATATA AAGCATATGA CCCAGAAACA 
AGAAGTAGCA GTGGCATAAG GTATAAGAAA TTAACTGATC CAACAGGGTG GGTCACCATT 
GATGAAAATA CAGGATCAAT CAAAGTTTTC AGAAGCCTGG ATAGAGAGGC AGAGACCATC 
AAAAATGGCA TATATAATAT TACAGTCCTT GCATCAGACC AAGGAGGGAG AACATGTACG 
GGGACACTGG GCATTATACT TCAAGACGTG AATGATAACA GCCCATTCAT ACCTAAAAAG 
ACAGTGATCA TCTGCAAACC CACCATGTCA TCTGCGGAGA TTGTTGCGGT TGATCCTGAT 
GAGCCTATCC ATGGCCCACC CTTTGACTTT AGTCTGGAGA GTTCTACTTC AGAAGTACAG 
AGAATGTGGA GACTGAAAGC AATTAATGAT ACAGCAGCAC GTCTTTCCTA TCAGAATGAT 
CCTCCATTTG GCTCATATGT AGTACCTATA ACAGTGAGAG ATAGACTTGG CATGTCTAGT 
GTCACTTCAT TGGATGTTAC ACTGTGTGAC TGCATTACCG AAAATGACTG CACACATCGT 
GTAGATCCAA GGATTGGCGG TGGAGGAGTA CAACTTGGAA AGTGGGCCAT CCTTGCAATA 
TTGTTGGGCA TAGCATTGCT CTTTTGCATC CTGTTTACGC TGGTCTGTGG GGCTTCTGGG 
ACGTCTAAAC AACCAAAAGT AATTCCTGAT GATTTAGCCC AGCAGAACCT AATTGTATCA 
AACACAGAAG CTCCTGGAGA TGACAAAGTG TATTCTGCGA ATGGCTTCAC AACCCAAACT 
GTGGGCGCTT CTGCTCAGGG AGTTTGTGGC ACCGTGGGAT CAGGAATCAA AAACGGAGGT 
CAGGAGACCA TCGAAATGGT GAAAGGAGGA CACCAGACCT CGGAATCCTG CCGGGGGGCT 
GGCCACCATC ACACCCTGGA CTCCTGCAGG GGAGGACACA CGGAGGTGGA CAACTGCAGA 
TACACTTACT CGGAGTGGCA CAGTTTTACT CAGCCCCGTC TTGGTGAAAA AGTGTATCTG 
TGTAATCAAG ATGAAAATCA CAAGCATGCC CAAGACTATG TCCTGACATA TAACTATGAA 
GGAAGAGGAT CGGTGGCTGG GTCTGTAGGT TGTTGCAGTG AACGACAAGA AGAAGATGGG 
CTTGAATTTT TGGATAATTT GGAGCCCAAA TTTAGGACAC TAGCAGAAGC ATGCATGAAG 
AGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DSC2 ( NM_004949.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004940.1 Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2b, mRNA.

Price & Availability↑

CloneID	OHu18926
Clone ID Related Accession (Same CDS sequence)	NM_004949.5 , NM_004949.4
Accession Version	NM_004949.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2544bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	desmocollin-2 isoform Dsc2b preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC382631.1, X56807.1, BC063291.1, BE350090.1 and AC012417.13. On May 20, 2019 this sequence version replaced NM_004949.4. Transcript Variant: This variant (Dsc2b, also known as DGIII) contains an additional exon at the 3' end compared to transcript variant Dsc2a. This results in a frame-shift and a shorter isoform (Dsc2b) with a distinct C-terminus compared to isoform Dsc2a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.81249.1, X56807.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCAG CCCGCCCCTC CGGCTCCTGG AACGGAGCCC TCTGCCGGCT GCTCCTGCTG 
ACCCTCGCGA TCTTAATATT TGCCAGTGAT GCCTGCAAAA ATGTGACATT ACATGTTCCC 
TCCAAACTAG ATGCCGAGAA ACTTGTTGGT AGAGTTAACC TGAAAGAGTG CTTTACAGCT 
GCAAATCTAA TTCATTCAAG TGATCCTGAC TTCCAAATTT TGGAGGATGG TTCAGTCTAT 
ACAACAAATA CTATTCTATT GTCCTCGGAG AAGAGAAGTT TTACCATATT ACTTTCCAAC 
ACTGAGAACC AAGAAAAGAA GAAAATATTT GTCTTTTTGG AGCATCAAAC AAAGGTCCTA 
AAGAAAAGAC ATACTAAAGA AAAAGTTCTA AGGCGCGCCA AGAGAAGATG GGCTCCAATT 
CCTTGTTCGA TGCTAGAAAA CTCCTTGGGT CCTTTTCCAC TTTTCCTTCA ACAGGTTCAA 
TCTGACACGG CCCAAAACTA TACCATATAC TATTCCATAA GAGGTCCTGG AGTTGACCAA 
GAACCTCGGA ATTTATTTTA TGTGGAGAGA GACACTGGAA ACTTGTATTG TACTCGTCCT 
GTAGATCGTG AGCAGTATGA ATCTTTTGAG ATAATTGCCT TTGCAACAAC TCCAGATGGG 
TATACTCCAG AACTTCCACT GCCCCTAATA ATCAAAATAG AGGATGAAAA TGATAACTAC 
CCAATTTTTA CAGAAGAAAC TTATACTTTT ACAATTTTTG AAAATTGCAG AGTGGGCACT 
ACTGTGGGAC AAGTGTGTGC TACTGACAAA GATGAGCCTG ACACGATGCA CACACGCCTG 
AAGTACTCCA TCATTGGGCA GGTGCCACCA TCACCCACCC TATTTTCTAT GCATCCAACT 
ACAGGCGTGA TCACCACAAC ATCATCTCAG CTAGACAGAG AGTTAATTGA CAAGTACCAG 
TTGAAAATAA AAGTACAAGA CATGGATGGT CAGTATTTTG GTCTACAGAC AACTTCAACT 
TGTATCATTA ACATTGATGA TGTAAATGAC CACTTGCCAA CATTTACTCG TACTTCTTAT 
GTGACATCAG TGGAAGAAAA TACAGTTGAT GTGGAAATCT TACGAGTTAC TGTTGAGGAT 
AAGGACTTAG TGAATACTGC TAACTGGAGA GCTAATTATA CCATTTTAAA GGGCAATGAA 
AATGGCAATT TTAAAATTGT AACAGATGCC AAAACCAATG AAGGAGTTCT TTGTGTAGTT 
AAGCCTTTGA ATTATGAAGA AAAGCAACAG ATGATCTTGC AAATTGGTGT AGTTAATGAA 
GCTCCATTTT CCAGAGAGGC TAGTCCAAGA TCAGCCATGA GCACAGCAAC AGTTACTGTT 
AATGTAGAAG ATCAGGATGA GGGCCCTGAG TGTAACCCTC CAATACAGAC TGTTCGCATG 
AAAGAAAATG CAGAAGTGGG AACAACAAGC AATGGATATA AAGCATATGA CCCAGAAACA 
AGAAGTAGCA GTGGCATAAG GTATAAGAAA TTAACTGATC CAACAGGGTG GGTCACCATT 
GATGAAAATA CAGGATCAAT CAAAGTTTTC AGAAGCCTGG ATAGAGAGGC AGAGACCATC 
AAAAATGGCA TATATAATAT TACAGTCCTT GCATCAGACC AAGGAGGGAG AACATGTACG 
GGGACACTGG GCATTATACT TCAAGACGTG AATGATAACA GCCCATTCAT ACCTAAAAAG 
ACAGTGATCA TCTGCAAACC CACCATGTCA TCTGCGGAGA TTGTTGCGGT TGATCCTGAT 
GAGCCTATCC ATGGCCCACC CTTTGACTTT AGTCTGGAGA GTTCTACTTC AGAAGTACAG 
AGAATGTGGA GACTGAAAGC AATTAATGAT ACAGCAGCAC GTCTTTCCTA TCAGAATGAT 
CCTCCATTTG GCTCATATGT AGTACCTATA ACAGTGAGAG ATAGACTTGG CATGTCTAGT 
GTCACTTCAT TGGATGTTAC ACTGTGTGAC TGCATTACCG AAAATGACTG CACACATCGT 
GTAGATCCAA GGATTGGCGG TGGAGGAGTA CAACTTGGAA AGTGGGCCAT CCTTGCAATA 
TTGTTGGGCA TAGCATTGCT CTTTTGCATC CTGTTTACGC TGGTCTGTGG GGCTTCTGGG 
ACGTCTAAAC AACCAAAAGT AATTCCTGAT GATTTAGCCC AGCAGAACCT AATTGTATCA 
AACACAGAAG CTCCTGGAGA TGACAAAGTG TATTCTGCGA ATGGCTTCAC AACCCAAACT 
GTGGGCGCTT CTGCTCAGGG AGTTTGTGGC ACCGTGGGAT CAGGAATCAA AAACGGAGGT 
CAGGAGACCA TCGAAATGGT GAAAGGAGGA CACCAGACCT CGGAATCCTG CCGGGGGGCT 
GGCCACCATC ACACCCTGGA CTCCTGCAGG GGAGGACACA CGGAGGTGGA CAACTGCAGA 
TACACTTACT CGGAGTGGCA CAGTTTTACT CAGCCCCGTC TTGGTGAAGA ATCCATTAGA 
GGACACACTC TGATTAAAAA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004940.1
CDS	451..2994
Translation	MEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTLVCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEESIRGHTLIKN

Target ORF information:

RefSeq Version	NM_004949.5
Organism	Homo sapiens(human)
Definition	Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004949.5

ORF Insert Sequence:

ATGGAGGCAG CCCGCCCCTC CGGCTCCTGG AACGGAGCCC TCTGCCGGCT GCTCCTGCTG 
ACCCTCGCGA TCTTAATATT TGCCAGTGAT GCCTGCAAAA ATGTGACATT ACATGTTCCC 
TCCAAACTAG ATGCCGAGAA ACTTGTTGGT AGAGTTAACC TGAAAGAGTG CTTTACAGCT 
GCAAATCTAA TTCATTCAAG TGATCCTGAC TTCCAAATTT TGGAGGATGG TTCAGTCTAT 
ACAACAAATA CTATTCTATT GTCCTCGGAG AAGAGAAGTT TTACCATATT ACTTTCCAAC 
ACTGAGAACC AAGAAAAGAA GAAAATATTT GTCTTTTTGG AGCATCAAAC AAAGGTCCTA 
AAGAAAAGAC ATACTAAAGA AAAAGTTCTA AGGCGCGCCA AGAGAAGATG GGCTCCAATT 
CCTTGTTCGA TGCTAGAAAA CTCCTTGGGT CCTTTTCCAC TTTTCCTTCA ACAGGTTCAA 
TCTGACACGG CCCAAAACTA TACCATATAC TATTCCATAA GAGGTCCTGG AGTTGACCAA 
GAACCTCGGA ATTTATTTTA TGTGGAGAGA GACACTGGAA ACTTGTATTG TACTCGTCCT 
GTAGATCGTG AGCAGTATGA ATCTTTTGAG ATAATTGCCT TTGCAACAAC TCCAGATGGG 
TATACTCCAG AACTTCCACT GCCCCTAATA ATCAAAATAG AGGATGAAAA TGATAACTAC 
CCAATTTTTA CAGAAGAAAC TTATACTTTT ACAATTTTTG AAAATTGCAG AGTGGGCACT 
ACTGTGGGAC AAGTGTGTGC TACTGACAAA GATGAGCCTG ACACGATGCA CACACGCCTG 
AAGTACTCCA TCATTGGGCA GGTGCCACCA TCACCCACCC TATTTTCTAT GCATCCAACT 
ACAGGCGTGA TCACCACAAC ATCATCTCAG CTAGACAGAG AGTTAATTGA CAAGTACCAG 
TTGAAAATAA AAGTACAAGA CATGGATGGT CAGTATTTTG GTCTACAGAC AACTTCAACT 
TGTATCATTA ACATTGATGA TGTAAATGAC CACTTGCCAA CATTTACTCG TACTTCTTAT 
GTGACATCAG TGGAAGAAAA TACAGTTGAT GTGGAAATCT TACGAGTTAC TGTTGAGGAT 
AAGGACTTAG TGAATACTGC TAACTGGAGA GCTAATTATA CCATTTTAAA GGGCAATGAA 
AATGGCAATT TTAAAATTGT AACAGATGCC AAAACCAATG AAGGAGTTCT TTGTGTAGTT 
AAGCCTTTGA ATTATGAAGA AAAGCAACAG ATGATCTTGC AAATTGGTGT AGTTAATGAA 
GCTCCATTTT CCAGAGAGGC TAGTCCAAGA TCAGCCATGA GCACAGCAAC AGTTACTGTT 
AATGTAGAAG ATCAGGATGA GGGCCCTGAG TGTAACCCTC CAATACAGAC TGTTCGCATG 
AAAGAAAATG CAGAAGTGGG AACAACAAGC AATGGATATA AAGCATATGA CCCAGAAACA 
AGAAGTAGCA GTGGCATAAG GTATAAGAAA TTAACTGATC CAACAGGGTG GGTCACCATT 
GATGAAAATA CAGGATCAAT CAAAGTTTTC AGAAGCCTGG ATAGAGAGGC AGAGACCATC 
AAAAATGGCA TATATAATAT TACAGTCCTT GCATCAGACC AAGGAGGGAG AACATGTACG 
GGGACACTGG GCATTATACT TCAAGACGTG AATGATAACA GCCCATTCAT ACCTAAAAAG 
ACAGTGATCA TCTGCAAACC CACCATGTCA TCTGCGGAGA TTGTTGCGGT TGATCCTGAT 
GAGCCTATCC ATGGCCCACC CTTTGACTTT AGTCTGGAGA GTTCTACTTC AGAAGTACAG 
AGAATGTGGA GACTGAAAGC AATTAATGAT ACAGCAGCAC GTCTTTCCTA TCAGAATGAT 
CCTCCATTTG GCTCATATGT AGTACCTATA ACAGTGAGAG ATAGACTTGG CATGTCTAGT 
GTCACTTCAT TGGATGTTAC ACTGTGTGAC TGCATTACCG AAAATGACTG CACACATCGT 
GTAGATCCAA GGATTGGCGG TGGAGGAGTA CAACTTGGAA AGTGGGCCAT CCTTGCAATA 
TTGTTGGGCA TAGCATTGCT CTTTTGCATC CTGTTTACGC TGGTCTGTGG GGCTTCTGGG 
ACGTCTAAAC AACCAAAAGT AATTCCTGAT GATTTAGCCC AGCAGAACCT AATTGTATCA 
AACACAGAAG CTCCTGGAGA TGACAAAGTG TATTCTGCGA ATGGCTTCAC AACCCAAACT 
GTGGGCGCTT CTGCTCAGGG AGTTTGTGGC ACCGTGGGAT CAGGAATCAA AAACGGAGGT 
CAGGAGACCA TCGAAATGGT GAAAGGAGGA CACCAGACCT CGGAATCCTG CCGGGGGGCT 
GGCCACCATC ACACCCTGGA CTCCTGCAGG GGAGGACACA CGGAGGTGGA CAACTGCAGA 
TACACTTACT CGGAGTGGCA CAGTTTTACT CAGCCCCGTC TTGGTGAAGA ATCCATTAGA 
GGACACACTC TGATTAAAAA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DSC2 ( NM_004949.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004940.1 Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2b, mRNA.

Price & Availability↑

CloneID	OHu18926
Clone ID Related Accession (Same CDS sequence)	NM_004949.5 , NM_004949.4
Accession Version	NM_004949.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2544bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	desmocollin-2 isoform Dsc2b preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC382631.1, X56807.1, BC063291.1 and BE350090.1. On Feb 19, 2015 this sequence version replaced NM_004949.3. Transcript Variant: This variant (Dsc2b, also known as DGIII) contains an additional exon at the 3' end compared to transcript variant Dsc2a. This results in a frame-shift and a shorter isoform (Dsc2b) with a distinct C-terminus compared to isoform Dsc2a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.81249.1, X56807.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCAG CCCGCCCCTC CGGCTCCTGG AACGGAGCCC TCTGCCGGCT GCTCCTGCTG 
ACCCTCGCGA TCTTAATATT TGCCAGTGAT GCCTGCAAAA ATGTGACATT ACATGTTCCC 
TCCAAACTAG ATGCCGAGAA ACTTGTTGGT AGAGTTAACC TGAAAGAGTG CTTTACAGCT 
GCAAATCTAA TTCATTCAAG TGATCCTGAC TTCCAAATTT TGGAGGATGG TTCAGTCTAT 
ACAACAAATA CTATTCTATT GTCCTCGGAG AAGAGAAGTT TTACCATATT ACTTTCCAAC 
ACTGAGAACC AAGAAAAGAA GAAAATATTT GTCTTTTTGG AGCATCAAAC AAAGGTCCTA 
AAGAAAAGAC ATACTAAAGA AAAAGTTCTA AGGCGCGCCA AGAGAAGATG GGCTCCAATT 
CCTTGTTCGA TGCTAGAAAA CTCCTTGGGT CCTTTTCCAC TTTTCCTTCA ACAGGTTCAA 
TCTGACACGG CCCAAAACTA TACCATATAC TATTCCATAA GAGGTCCTGG AGTTGACCAA 
GAACCTCGGA ATTTATTTTA TGTGGAGAGA GACACTGGAA ACTTGTATTG TACTCGTCCT 
GTAGATCGTG AGCAGTATGA ATCTTTTGAG ATAATTGCCT TTGCAACAAC TCCAGATGGG 
TATACTCCAG AACTTCCACT GCCCCTAATA ATCAAAATAG AGGATGAAAA TGATAACTAC 
CCAATTTTTA CAGAAGAAAC TTATACTTTT ACAATTTTTG AAAATTGCAG AGTGGGCACT 
ACTGTGGGAC AAGTGTGTGC TACTGACAAA GATGAGCCTG ACACGATGCA CACACGCCTG 
AAGTACTCCA TCATTGGGCA GGTGCCACCA TCACCCACCC TATTTTCTAT GCATCCAACT 
ACAGGCGTGA TCACCACAAC ATCATCTCAG CTAGACAGAG AGTTAATTGA CAAGTACCAG 
TTGAAAATAA AAGTACAAGA CATGGATGGT CAGTATTTTG GTCTACAGAC AACTTCAACT 
TGTATCATTA ACATTGATGA TGTAAATGAC CACTTGCCAA CATTTACTCG TACTTCTTAT 
GTGACATCAG TGGAAGAAAA TACAGTTGAT GTGGAAATCT TACGAGTTAC TGTTGAGGAT 
AAGGACTTAG TGAATACTGC TAACTGGAGA GCTAATTATA CCATTTTAAA GGGCAATGAA 
AATGGCAATT TTAAAATTGT AACAGATGCC AAAACCAATG AAGGAGTTCT TTGTGTAGTT 
AAGCCTTTGA ATTATGAAGA AAAGCAACAG ATGATCTTGC AAATTGGTGT AGTTAATGAA 
GCTCCATTTT CCAGAGAGGC TAGTCCAAGA TCAGCCATGA GCACAGCAAC AGTTACTGTT 
AATGTAGAAG ATCAGGATGA GGGCCCTGAG TGTAACCCTC CAATACAGAC TGTTCGCATG 
AAAGAAAATG CAGAAGTGGG AACAACAAGC AATGGATATA AAGCATATGA CCCAGAAACA 
AGAAGTAGCA GTGGCATAAG GTATAAGAAA TTAACTGATC CAACAGGGTG GGTCACCATT 
GATGAAAATA CAGGATCAAT CAAAGTTTTC AGAAGCCTGG ATAGAGAGGC AGAGACCATC 
AAAAATGGCA TATATAATAT TACAGTCCTT GCATCAGACC AAGGAGGGAG AACATGTACG 
GGGACACTGG GCATTATACT TCAAGACGTG AATGATAACA GCCCATTCAT ACCTAAAAAG 
ACAGTGATCA TCTGCAAACC CACCATGTCA TCTGCGGAGA TTGTTGCGGT TGATCCTGAT 
GAGCCTATCC ATGGCCCACC CTTTGACTTT AGTCTGGAGA GTTCTACTTC AGAAGTACAG 
AGAATGTGGA GACTGAAAGC AATTAATGAT ACAGCAGCAC GTCTTTCCTA TCAGAATGAT 
CCTCCATTTG GCTCATATGT AGTACCTATA ACAGTGAGAG ATAGACTTGG CATGTCTAGT 
GTCACTTCAT TGGATGTTAC ACTGTGTGAC TGCATTACCG AAAATGACTG CACACATCGT 
GTAGATCCAA GGATTGGCGG TGGAGGAGTA CAACTTGGAA AGTGGGCCAT CCTTGCAATA 
TTGTTGGGCA TAGCATTGCT CTTTTGCATC CTGTTTACGC TGGTCTGTGG GGCTTCTGGG 
ACGTCTAAAC AACCAAAAGT AATTCCTGAT GATTTAGCCC AGCAGAACCT AATTGTATCA 
AACACAGAAG CTCCTGGAGA TGACAAAGTG TATTCTGCGA ATGGCTTCAC AACCCAAACT 
GTGGGCGCTT CTGCTCAGGG AGTTTGTGGC ACCGTGGGAT CAGGAATCAA AAACGGAGGT 
CAGGAGACCA TCGAAATGGT GAAAGGAGGA CACCAGACCT CGGAATCCTG CCGGGGGGCT 
GGCCACCATC ACACCCTGGA CTCCTGCAGG GGAGGACACA CGGAGGTGGA CAACTGCAGA 
TACACTTACT CGGAGTGGCA CAGTTTTACT CAGCCCCGTC TTGGTGAAGA ATCCATTAGA 
GGACACACTC TGATTAAAAA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004940.1
CDS	462..3005
Translation	MEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTLVCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEESIRGHTLIKN

Target ORF information:

RefSeq Version	NM_004949.4
Organism	Homo sapiens(human)
Definition	Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004949.4

ORF Insert Sequence:

ATGGAGGCAG CCCGCCCCTC CGGCTCCTGG AACGGAGCCC TCTGCCGGCT GCTCCTGCTG 
ACCCTCGCGA TCTTAATATT TGCCAGTGAT GCCTGCAAAA ATGTGACATT ACATGTTCCC 
TCCAAACTAG ATGCCGAGAA ACTTGTTGGT AGAGTTAACC TGAAAGAGTG CTTTACAGCT 
GCAAATCTAA TTCATTCAAG TGATCCTGAC TTCCAAATTT TGGAGGATGG TTCAGTCTAT 
ACAACAAATA CTATTCTATT GTCCTCGGAG AAGAGAAGTT TTACCATATT ACTTTCCAAC 
ACTGAGAACC AAGAAAAGAA GAAAATATTT GTCTTTTTGG AGCATCAAAC AAAGGTCCTA 
AAGAAAAGAC ATACTAAAGA AAAAGTTCTA AGGCGCGCCA AGAGAAGATG GGCTCCAATT 
CCTTGTTCGA TGCTAGAAAA CTCCTTGGGT CCTTTTCCAC TTTTCCTTCA ACAGGTTCAA 
TCTGACACGG CCCAAAACTA TACCATATAC TATTCCATAA GAGGTCCTGG AGTTGACCAA 
GAACCTCGGA ATTTATTTTA TGTGGAGAGA GACACTGGAA ACTTGTATTG TACTCGTCCT 
GTAGATCGTG AGCAGTATGA ATCTTTTGAG ATAATTGCCT TTGCAACAAC TCCAGATGGG 
TATACTCCAG AACTTCCACT GCCCCTAATA ATCAAAATAG AGGATGAAAA TGATAACTAC 
CCAATTTTTA CAGAAGAAAC TTATACTTTT ACAATTTTTG AAAATTGCAG AGTGGGCACT 
ACTGTGGGAC AAGTGTGTGC TACTGACAAA GATGAGCCTG ACACGATGCA CACACGCCTG 
AAGTACTCCA TCATTGGGCA GGTGCCACCA TCACCCACCC TATTTTCTAT GCATCCAACT 
ACAGGCGTGA TCACCACAAC ATCATCTCAG CTAGACAGAG AGTTAATTGA CAAGTACCAG 
TTGAAAATAA AAGTACAAGA CATGGATGGT CAGTATTTTG GTCTACAGAC AACTTCAACT 
TGTATCATTA ACATTGATGA TGTAAATGAC CACTTGCCAA CATTTACTCG TACTTCTTAT 
GTGACATCAG TGGAAGAAAA TACAGTTGAT GTGGAAATCT TACGAGTTAC TGTTGAGGAT 
AAGGACTTAG TGAATACTGC TAACTGGAGA GCTAATTATA CCATTTTAAA GGGCAATGAA 
AATGGCAATT TTAAAATTGT AACAGATGCC AAAACCAATG AAGGAGTTCT TTGTGTAGTT 
AAGCCTTTGA ATTATGAAGA AAAGCAACAG ATGATCTTGC AAATTGGTGT AGTTAATGAA 
GCTCCATTTT CCAGAGAGGC TAGTCCAAGA TCAGCCATGA GCACAGCAAC AGTTACTGTT 
AATGTAGAAG ATCAGGATGA GGGCCCTGAG TGTAACCCTC CAATACAGAC TGTTCGCATG 
AAAGAAAATG CAGAAGTGGG AACAACAAGC AATGGATATA AAGCATATGA CCCAGAAACA 
AGAAGTAGCA GTGGCATAAG GTATAAGAAA TTAACTGATC CAACAGGGTG GGTCACCATT 
GATGAAAATA CAGGATCAAT CAAAGTTTTC AGAAGCCTGG ATAGAGAGGC AGAGACCATC 
AAAAATGGCA TATATAATAT TACAGTCCTT GCATCAGACC AAGGAGGGAG AACATGTACG 
GGGACACTGG GCATTATACT TCAAGACGTG AATGATAACA GCCCATTCAT ACCTAAAAAG 
ACAGTGATCA TCTGCAAACC CACCATGTCA TCTGCGGAGA TTGTTGCGGT TGATCCTGAT 
GAGCCTATCC ATGGCCCACC CTTTGACTTT AGTCTGGAGA GTTCTACTTC AGAAGTACAG 
AGAATGTGGA GACTGAAAGC AATTAATGAT ACAGCAGCAC GTCTTTCCTA TCAGAATGAT 
CCTCCATTTG GCTCATATGT AGTACCTATA ACAGTGAGAG ATAGACTTGG CATGTCTAGT 
GTCACTTCAT TGGATGTTAC ACTGTGTGAC TGCATTACCG AAAATGACTG CACACATCGT 
GTAGATCCAA GGATTGGCGG TGGAGGAGTA CAACTTGGAA AGTGGGCCAT CCTTGCAATA 
TTGTTGGGCA TAGCATTGCT CTTTTGCATC CTGTTTACGC TGGTCTGTGG GGCTTCTGGG 
ACGTCTAAAC AACCAAAAGT AATTCCTGAT GATTTAGCCC AGCAGAACCT AATTGTATCA 
AACACAGAAG CTCCTGGAGA TGACAAAGTG TATTCTGCGA ATGGCTTCAC AACCCAAACT 
GTGGGCGCTT CTGCTCAGGG AGTTTGTGGC ACCGTGGGAT CAGGAATCAA AAACGGAGGT 
CAGGAGACCA TCGAAATGGT GAAAGGAGGA CACCAGACCT CGGAATCCTG CCGGGGGGCT 
GGCCACCATC ACACCCTGGA CTCCTGCAGG GGAGGACACA CGGAGGTGGA CAACTGCAGA 
TACACTTACT CGGAGTGGCA CAGTTTTACT CAGCCCCGTC TTGGTGAAGA ATCCATTAGA 
GGACACACTC TGATTAAAAA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DSC2 ( XM_005258206.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005258263.1 Homo sapiens desmocollin 2 (DSC2), transcript variant X1, mRNA.

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CloneID	OHu51108
Clone ID Related Accession (Same CDS sequence)	XM_005258206.4
Accession Version	XM_005258206.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2277bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	desmocollin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005258206.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTAGAAA ACTCCTTGGG TCCTTTTCCA CTTTTCCTTC AACAGGTTCA ATCTGACACG 
GCCCAAAACT ATACCATATA CTATTCCATA AGAGGTCCTG GAGTTGACCA AGAACCTCGG 
AATTTATTTT ATGTGGAGAG AGACACTGGA AACTTGTATT GTACTCGTCC TGTAGATCGT 
GAGCAGTATG AATCTTTTGA GATAATTGCC TTTGCAACAA CTCCAGATGG GTATACTCCA 
GAACTTCCAC TGCCCCTAAT AATCAAAATA GAGGATGAAA ATGATAACTA CCCAATTTTT 
ACAGAAGAAA CTTATACTTT TACAATTTTT GAAAATTGCA GAGTGGGCAC TACTGTGGGA 
CAAGTGTGTG CTACTGACAA AGATGAGCCT GACACGATGC ACACACGCCT GAAGTACTCC 
ATCATTGGGC AGGTGCCACC ATCACCCACC CTATTTTCTA TGCATCCAAC TACAGGCGTG 
ATCACCACAA CATCATCTCA GCTAGACAGA GAGTTAATTG ACAAGTACCA GTTGAAAATA 
AAAGTACAAG ACATGGATGG TCAGTATTTT GGTCTACAGA CAACTTCAAC TTGTATCATT 
AACATTGATG ATGTAAATGA CCACTTGCCA ACATTTACTC GTACTTCTTA TGTGACATCA 
GTGGAAGAAA ATACAGTTGA TGTGGAAATC TTACGAGTTA CTGTTGAGGA TAAGGACTTA 
GTGAATACTG CTAACTGGAG AGCTAATTAT ACCATTTTAA AGGGCAATGA AAATGGCAAT 
TTTAAAATTG TAACAGATGC CAAAACCAAT GAAGGAGTTC TTTGTGTAGT TAAGCCTTTG 
AATTATGAAG AAAAGCAACA GATGATCTTG CAAATTGGTG TAGTTAATGA AGCTCCATTT 
TCCAGAGAGG CTAGTCCAAG ATCAGCCATG AGCACAGCAA CAGTTACTGT TAATGTAGAA 
GATCAGGATG AGGGCCCTGA GTGTAACCCT CCAATACAGA CTGTTCGCAT GAAAGAAAAT 
GCAGAAGTGG GAACAACAAG CAATGGATAT AAAGCATATG ACCCAGAAAC AAGAAGTAGC 
AGTGGCATAA GGTATAAGAA ATTAACTGAT CCAACAGGGT GGGTCACCAT TGATGAAAAT 
ACAGGATCAA TCAAAGTTTT CAGAAGCCTG GATAGAGAGG CAGAGACCAT CAAAAATGGC 
ATATATAATA TTACAGTCCT TGCATCAGAC CAAGGAGGGA GAACATGTAC GGGGACACTG 
GGCATTATAC TTCAAGACGT GAATGATAAC AGCCCATTCA TACCTAAAAA GACAGTGATC 
ATCTGCAAAC CCACCATGTC ATCTGCGGAG ATTGTTGCGG TTGATCCTGA TGAGCCTATC 
CATGGCCCAC CCTTTGACTT TAGTCTGGAG AGTTCTACTT CAGAAGTACA GAGAATGTGG 
AGACTGAAAG CAATTAATGA TACAGCAGCA CGTCTTTCCT ATCAGAATGA TCCTCCATTT 
GGCTCATATG TAGTACCTAT AACAGTGAGA GATAGACTTG GCATGTCTAG TGTCACTTCA 
TTGGATGTTA CACTGTGTGA CTGCATTACC GAAAATGACT GCACACATCG TGTAGATCCA 
AGGATTGGCG GTGGAGGAGT ACAACTTGGA AAGTGGGCCA TCCTTGCAAT ATTGTTGGGC 
ATAGCATTGC TCTTTTGCAT CCTGTTTACG CTGGTCTGTG GGGCTTCTGG GACGTCTAAA 
CAACCAAAAG TAATTCCTGA TGATTTAGCC CAGCAGAACC TAATTGTATC AAACACAGAA 
GCTCCTGGAG ATGACAAAGT GTATTCTGCG AATGGCTTCA CAACCCAAAC TGTGGGCGCT 
TCTGCTCAGG GAGTTTGTGG CACCGTGGGA TCAGGAATCA AAAACGGAGG TCAGGAGACC 
ATCGAAATGG TGAAAGGAGG ACACCAGACC TCGGAATCCT GCCGGGGGGC TGGCCACCAT 
CACACCCTGG ACTCCTGCAG GGGAGGACAC ACGGAGGTGG ACAACTGCAG ATACACTTAC 
TCGGAGTGGC ACAGTTTTAC TCAGCCCCGT CTTGGTGAAA AAGTGTATCT GTGTAATCAA 
GATGAAAATC ACAAGCATGC CCAAGACTAT GTCCTGACAT ATAACTATGA AGGAAGAGGA 
TCGGTGGCTG GGTCTGTAGG TTGTTGCAGT GAACGACAAG AAGAAGATGG GCTTGAATTT 
TTGGATAATT TGGAGCCCAA ATTTAGGACA CTAGCAGAAG CATGCATGAA GAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005258263.1
CDS	392..2668
Translation	MLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTLVCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKVYLCNQDENHKHAQDYVLTYNYEGRGSVAGSVGCCSERQEEDGLEFLDNLEPKFRTLAEACMKR

Target ORF information:

RefSeq Version	XM_005258206.4
Organism	Homo sapiens(human)
Definition	Homo sapiens desmocollin 2 (DSC2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005258206.4

ORF Insert Sequence:

ATGCTAGAAA ACTCCTTGGG TCCTTTTCCA CTTTTCCTTC AACAGGTTCA ATCTGACACG 
GCCCAAAACT ATACCATATA CTATTCCATA AGAGGTCCTG GAGTTGACCA AGAACCTCGG 
AATTTATTTT ATGTGGAGAG AGACACTGGA AACTTGTATT GTACTCGTCC TGTAGATCGT 
GAGCAGTATG AATCTTTTGA GATAATTGCC TTTGCAACAA CTCCAGATGG GTATACTCCA 
GAACTTCCAC TGCCCCTAAT AATCAAAATA GAGGATGAAA ATGATAACTA CCCAATTTTT 
ACAGAAGAAA CTTATACTTT TACAATTTTT GAAAATTGCA GAGTGGGCAC TACTGTGGGA 
CAAGTGTGTG CTACTGACAA AGATGAGCCT GACACGATGC ACACACGCCT GAAGTACTCC 
ATCATTGGGC AGGTGCCACC ATCACCCACC CTATTTTCTA TGCATCCAAC TACAGGCGTG 
ATCACCACAA CATCATCTCA GCTAGACAGA GAGTTAATTG ACAAGTACCA GTTGAAAATA 
AAAGTACAAG ACATGGATGG TCAGTATTTT GGTCTACAGA CAACTTCAAC TTGTATCATT 
AACATTGATG ATGTAAATGA CCACTTGCCA ACATTTACTC GTACTTCTTA TGTGACATCA 
GTGGAAGAAA ATACAGTTGA TGTGGAAATC TTACGAGTTA CTGTTGAGGA TAAGGACTTA 
GTGAATACTG CTAACTGGAG AGCTAATTAT ACCATTTTAA AGGGCAATGA AAATGGCAAT 
TTTAAAATTG TAACAGATGC CAAAACCAAT GAAGGAGTTC TTTGTGTAGT TAAGCCTTTG 
AATTATGAAG AAAAGCAACA GATGATCTTG CAAATTGGTG TAGTTAATGA AGCTCCATTT 
TCCAGAGAGG CTAGTCCAAG ATCAGCCATG AGCACAGCAA CAGTTACTGT TAATGTAGAA 
GATCAGGATG AGGGCCCTGA GTGTAACCCT CCAATACAGA CTGTTCGCAT GAAAGAAAAT 
GCAGAAGTGG GAACAACAAG CAATGGATAT AAAGCATATG ACCCAGAAAC AAGAAGTAGC 
AGTGGCATAA GGTATAAGAA ATTAACTGAT CCAACAGGGT GGGTCACCAT TGATGAAAAT 
ACAGGATCAA TCAAAGTTTT CAGAAGCCTG GATAGAGAGG CAGAGACCAT CAAAAATGGC 
ATATATAATA TTACAGTCCT TGCATCAGAC CAAGGAGGGA GAACATGTAC GGGGACACTG 
GGCATTATAC TTCAAGACGT GAATGATAAC AGCCCATTCA TACCTAAAAA GACAGTGATC 
ATCTGCAAAC CCACCATGTC ATCTGCGGAG ATTGTTGCGG TTGATCCTGA TGAGCCTATC 
CATGGCCCAC CCTTTGACTT TAGTCTGGAG AGTTCTACTT CAGAAGTACA GAGAATGTGG 
AGACTGAAAG CAATTAATGA TACAGCAGCA CGTCTTTCCT ATCAGAATGA TCCTCCATTT 
GGCTCATATG TAGTACCTAT AACAGTGAGA GATAGACTTG GCATGTCTAG TGTCACTTCA 
TTGGATGTTA CACTGTGTGA CTGCATTACC GAAAATGACT GCACACATCG TGTAGATCCA 
AGGATTGGCG GTGGAGGAGT ACAACTTGGA AAGTGGGCCA TCCTTGCAAT ATTGTTGGGC 
ATAGCATTGC TCTTTTGCAT CCTGTTTACG CTGGTCTGTG GGGCTTCTGG GACGTCTAAA 
CAACCAAAAG TAATTCCTGA TGATTTAGCC CAGCAGAACC TAATTGTATC AAACACAGAA 
GCTCCTGGAG ATGACAAAGT GTATTCTGCG AATGGCTTCA CAACCCAAAC TGTGGGCGCT 
TCTGCTCAGG GAGTTTGTGG CACCGTGGGA TCAGGAATCA AAAACGGAGG TCAGGAGACC 
ATCGAAATGG TGAAAGGAGG ACACCAGACC TCGGAATCCT GCCGGGGGGC TGGCCACCAT 
CACACCCTGG ACTCCTGCAG GGGAGGACAC ACGGAGGTGG ACAACTGCAG ATACACTTAC 
TCGGAGTGGC ACAGTTTTAC TCAGCCCCGT CTTGGTGAAA AAGTGTATCT GTGTAATCAA 
GATGAAAATC ACAAGCATGC CCAAGACTAT GTCCTGACAT ATAACTATGA AGGAAGAGGA 
TCGGTGGCTG GGTCTGTAGG TTGTTGCAGT GAACGACAAG AAGAAGATGG GCTTGAATTT 
TTGGATAATT TGGAGCCCAA ATTTAGGACA CTAGCAGAAG CATGCATGAA GAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Plakophilin3 increases desmosome assembly, size and stability by increasing expression of desmocollin2.
Biochemical and biophysical research communications495(1)768-774(2018 01)
Gurjar M,Raychaudhuri K,Mahadik S,Reddy D,Atak A,Shetty T,Rao K,Karkhanis MS,Gosavi P,Sehgal L,Gupta S,Dalal SN

Whole-Exome Sequencing Identifies a Novel Mutation of Desmocollin 2 in a Chinese Family With Arrhythmogenic Right Ventricular Cardiomyopathy.
The American journal of cardiology119(9)1485-1489(2017 May)
Liu JS,Fan LL,Li JJ,Xiang R

Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodeling.
PloS one12(3)e0174019(2017)
Brodehl A,Belke DD,Garnett L,Martens K,Abdelfatah N,Rodriguez M,Diao C,Chen YX,Gordon PM,Nygren A,Gerull B

Functional Promoter Variant in Desmocollin-2 Contributes to Arrhythmogenic Right Ventricular Cardiomyopathy.
Circulation. Cardiovascular genetics9(4)384-7(2016 Aug)
Christensen AH,Schmitz B,Andersen CB,Bundgaard H,Brand SM,Svendsen JH

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DSC2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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