Dsc2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dsc2
Entrez Gene ID	291760
Full Name	desmocollin 2
General protein information	Preferred Names desmocollin 2 Names desmocollin-2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18p12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001033688.1	NP_001028860.1	desmocollin-2 precursor
XM_008771935.2	XP_008770157.1	desmocollin-2 isoform X1

Pathways from BioSystems

Homologies

	LOC712942	XP_001102096.2
Homo sapiens (human)	DSC2	NP_077740.1
Mus musculus (house mouse)	Dsc2	NP_038533.1
Gallus gallus (chicken)	DSC2	XP_004939874.1
Canis lupus familiaris (dog)	DSC2	XP_866930.1
Rattus norvegicus (Norway rat)	Dsc2	NP_001028860.1
Xenopus tropicalis (tropical clawed frog)	dsc3	NP_001122136.1
Pan troglodytes (chimpanzee)	DSC2	XP_512077.3
Bos taurus (cattle)	DSC2	NP_001159998.1

Gene Ontology
Bibliography

Related articles in PubMed

Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population.
Gerull B, Kirchner F, Chong JX, Tagoe J, Chandrasekharan K, Strohm O, Waggoner D, Ober C, Duff HJ
Circulation. Cardiovascular genetics6(4)327-36(2013 Aug)

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.
Boj SF, van Es JH, Huch M, Li VS, Jos? A, Hatzis P, Mokry M, Haegebarth A, van den Born M, Chambon P, Voshol P, Dor Y, Cuppen E, Fillat C, Clevers H
Cell151(7)1595-607(2012 Dec)

A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions.
Gehmlich K, Lambiase PD, Asimaki A, Ciaccio EJ, Ehler E, Syrris P, Saffitz JE, McKenna WJ
Heart rhythm8(5)711-8(2011 May)

Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations.
Gehmlich K, Syrris P, Peskett E, Evans A, Ehler E, Asimaki A, Anastasakis A, Tsatsopoulou A, Vouliotis AI, Stefanadis C, Saffitz JE, Protonotarios N, McKenna WJ
Cardiovascular research90(1)77-87(2011 Apr)

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal of proteome research8(3)1304-14(2009 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Dsc2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dsc2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08566	NM_001033688.1 Latest version!	Rattus norvegicus desmocollin 2 (Dsc2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
ORa44970	XM_008771935.2 Latest version!	Rattus norvegicus desmocollin 2 (Dsc2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dsc2 ( NM_001033688.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001028860.1 Rattus norvegicus desmocollin 2 (Dsc2), mRNA.

Price & Availability↑

CloneID	ORa08566
Clone ID Related Accession (Same CDS sequence)	NM_001033688.1
Accession Version	NM_001033688.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2709bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	desmocollin-2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC101864.1. On Sep 25, 2005 this sequence version replaced XM_226120.3. ##Evidence-Data-START## Transcript exon combination :: BC101864.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGCAG CGGGATCCTC GCGCTCCGGG AGCCCTGCCC TCGGCCTGGG ACACCTGTTG 
ACCCTCGCGA TCCTTGCACT TGCCTGTGAT GCTTGTAAAG AAGTCGTCCT CCAGGTCCCC 
TCTGAACTAC CTGCTGGGAA ATTTGTTGGC AGAGTGAACC TGATGGAGTG CCTTAAATCA 
GCAAATGTAA TTCACTTGAG TGATCCTGAT TTCCAAGTCT TCGAAGATGG TTCTGTGTAC 
ACAACCAATT CTGTTGTTTT GTCTTCGGGG CAAAGAAGCT TTACTATTTG GCTTTTCAAC 
ACAGACAGCC AGGAAGAGAG GGAGTTGTCT GTCCATTTAG AGGGCCCTGT AGAGGTCCTA 
AATCAAAGAC TGCATACAGA AAAAGTTCTC CGCCGCGCCA AGAGAAGATG GGCTCCCATC 
CCTTGTTCCA TGATGGAGAA TTCATTGGGT CCCTTCCCAC TTTTCCTTCA ACAGATCCAA 
TCCGACAAAG CTCAAAACTA CACCATATAC TATTCCATCA GCGGTCCAGG AGTTGATAAA 
GAACCCGTAG GCTTATTTCG TATTGATAGA GATACTGGAA ACCTGTATTG CACTGATCGT 
GTAGATCGAG AACAGTATGA CTCCTTTGAG CTGACTGCAT TAGCAATGAC TCCAGATGGG 
TATATGGTAG AGAACCTGCT GACGCTCCTC ATTAAAGTAG AGGATGAGAA CGATAATTAC 
CCGATCTTTA CCCAGAAAGT GTACAGCTTC ACAGTTTTGG AAAACAGTCC ATTTGGTTCT 
CACGTCGGGG AGGTCTGTGC AACAGACAAG GATGAGCCGG ACACAATGCA CACTCGTCTG 
AAGTATTCCA TCCTGGAGCA GTCGCCTTCT CCCCCCATGT TATTCACCAT GCATCCCAGG 
ACTGGTGTCA TCACTACCAC CTCCACCCAG CTGGACAGAG AGTTAATTGA CAAGTACCAG 
TTGATAATAA AAGTTCAGGA CATGGATGGC CAGTATTTTG GTTTGCAGAC AACAGCGACC 
TGCGTCATTA CTATTGGAGA TGTGAATGAC AACTTGCCAA CATTCACGCG TACTACGTAC 
GTGACATCAG TGGAAGAAAA TACGGTCAAT GTGGAACTCT TACGTCTTTC TGTTCAAGAT 
AAAGATTTAG TTAACTCTCC TAATTGGAGA GCTAATTACA CCATTTTAAA GGGCAACGAA 
AATGGAAATT TTAAAATCAA AACAGATCCC CAAACCAATG AAGGCATTCT GTGCGTGATT 
ATGCCTCTGG ACTATGAAGA ACGGCAACGG GTGACCCTGG AAATTGGCGT AGTTAATGAA 
GCCCCGTACA CTAGACAGGC TGGTTCAAAG TCATCCATGA GCACAGCTAC AGTGACTGTC 
AACGTGAAAA ATCAGGATGA GGGCCCTGAG TGTATCCCTC AAACGCAAAC TGTGAGGATT 
CGAGAAAATG TACCAATTGG TACTAGAAAC GATGGGTATA AAGCATATGA CCCAGAGACC 
AAAAACAGCA TTGGCATAAG GTACAGGAAG TTAAGTGACC CAAAAGGATG GATCACTGTT 
AATGAAGATT CAGGATCAAT CACCATTTTC CGAACTCTGG ATCGGGAGGC TGAGACCATC 
AGAAACGGCA TCTACAATAT TACAGTCCTT GCATTAGACG CAGACGGGAG AAGCTGTACG 
GGAACTCTGG GAATCTTACT TGAAGATGTG AATGACAACG GCCCATTCAT ACCCAAGCAG 
ACAGTGGTGA TATGCAGGGC TACCATGTCC TCTGCTGAAA TTGTTGCGGT TGACCCTGAT 
GAGCCAGCAA ATGGTCCACC ATTTGATTTT AGTTTGGAGA GTTCTGATTC AGAAGTACGG 
AGGAGGTGGA AGTTGACAAG AATCAATGAT ACTGCTGCTA GTCTTTCCTA TCAGAATGAC 
CCTGCGTTTG ATTCCTACGT AATTCCCGTC CGAGTTACAG ACAGGTTTGG TCTGTCCTCA 
GTCACGTCAC TGAATGTCGT TGTATGTGAC TGCATCACTG AAAGTGACTG CACATACCGC 
ACTGGAGAAA GGACTGGCTA TGCTGACGTG AGACTTGGAC CATGGGCTAT CCTTGCTATA 
CTGCTGGGCG TAGCCTTGCT ACTTTGTATC CTGTTTACCT TAGTCTGTAG TGTTTCCCGG 
GCATCAAAAC AACAGAAAAT TCTTCCCGAT GACTTAGCTC AGCAGAACCT AATTGTATCA 
AACACCGAGG CTCCTGGAGA TGACAAAGTC TATTCCGCAA ATGGCTTCAC AGCTCAAACT 
GCGGGAGCTT CTGGGCAGAC AACATTCACA ACCGTGGGAG CTGGAGTCAA AAGTACAGGG 
CAAGAGACCA TTGAGATGGT AAAAGGAGGA CAGCGCACAC TGGACTCCCG CAGGGCGACC 
GGCTATCACC ACCATACCAT GGATCCTGGC AGGGGAGGGC ATGTGGAGGT GGACAATTAC 
AGATACACCT ACTCTGAGTG GCACAATTTC ACTCAGCCCC GACTTGGTGA GAAGGTGCAG 
TTTTGCCATG AGGATGACAA CCAGAAGCTT GCCCAAGACT ATGTCCTCAC ATACAACTAT 
GAGGGAAAAG GCTCGGCTGC TGGCTCTGTG GGTTGCTGTA GCGACCTACA GGAAGAAGAC 
GGGCTTGAGT TTTTGGACCA TCTGGAGCCT AAATTTAGGA CATTAGCAGA AGTATGTGCA 
AAGAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028860.1
CDS	225..2933
Translation	MAAAGSSRSGSPALGLGHLLTLAILALACDACKEVVLQVPSELPAGKFVGRVNLMECLKSANVIHLSDPDFQVFEDGSVYTTNSVVLSSGQRSFTIWLFNTDSQEERELSVHLEGPVEVLNQRLHTEKVLRRAKRRWAPIPCSMMENSLGPFPLFLQQIQSDKAQNYTIYYSISGPGVDKEPVGLFRIDRDTGNLYCTDRVDREQYDSFELTALAMTPDGYMVENLLTLLIKVEDENDNYPIFTQKVYSFTVLENSPFGSHVGEVCATDKDEPDTMHTRLKYSILEQSPSPPMLFTMHPRTGVITTTSTQLDRELIDKYQLIIKVQDMDGQYFGLQTTATCVITIGDVNDNLPTFTRTTYVTSVEENTVNVELLRLSVQDKDLVNSPNWRANYTILKGNENGNFKIKTDPQTNEGILCVIMPLDYEERQRVTLEIGVVNEAPYTRQAGSKSSMSTATVTVNVKNQDEGPECIPQTQTVRIRENVPIGTRNDGYKAYDPETKNSIGIRYRKLSDPKGWITVNEDSGSITIFRTLDREAETIRNGIYNITVLALDADGRSCTGTLGILLEDVNDNGPFIPKQTVVICRATMSSAEIVAVDPDEPANGPPFDFSLESSDSEVRRRWKLTRINDTAASLSYQNDPAFDSYVIPVRVTDRFGLSSVTSLNVVVCDCITESDCTYRTGERTGYADVRLGPWAILAILLGVALLLCILFTLVCSVSRASKQQKILPDDLAQQNLIVSNTEAPGDDKVYSANGFTAQTAGASGQTTFTTVGAGVKSTGQETIEMVKGGQRTLDSRRATGYHHHTMDPGRGGHVEVDNYRYTYSEWHNFTQPRLGEKVQFCHEDDNQKLAQDYVLTYNYEGKGSAAGSVGCCSDLQEEDGLEFLDHLEPKFRTLAEVCAKR

Target ORF information:

RefSeq Version	NM_001033688.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus desmocollin 2 (Dsc2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033688.1

ORF Insert Sequence:

ATGGCGGCAG CGGGATCCTC GCGCTCCGGG AGCCCTGCCC TCGGCCTGGG ACACCTGTTG 
ACCCTCGCGA TCCTTGCACT TGCCTGTGAT GCTTGTAAAG AAGTCGTCCT CCAGGTCCCC 
TCTGAACTAC CTGCTGGGAA ATTTGTTGGC AGAGTGAACC TGATGGAGTG CCTTAAATCA 
GCAAATGTAA TTCACTTGAG TGATCCTGAT TTCCAAGTCT TCGAAGATGG TTCTGTGTAC 
ACAACCAATT CTGTTGTTTT GTCTTCGGGG CAAAGAAGCT TTACTATTTG GCTTTTCAAC 
ACAGACAGCC AGGAAGAGAG GGAGTTGTCT GTCCATTTAG AGGGCCCTGT AGAGGTCCTA 
AATCAAAGAC TGCATACAGA AAAAGTTCTC CGCCGCGCCA AGAGAAGATG GGCTCCCATC 
CCTTGTTCCA TGATGGAGAA TTCATTGGGT CCCTTCCCAC TTTTCCTTCA ACAGATCCAA 
TCCGACAAAG CTCAAAACTA CACCATATAC TATTCCATCA GCGGTCCAGG AGTTGATAAA 
GAACCCGTAG GCTTATTTCG TATTGATAGA GATACTGGAA ACCTGTATTG CACTGATCGT 
GTAGATCGAG AACAGTATGA CTCCTTTGAG CTGACTGCAT TAGCAATGAC TCCAGATGGG 
TATATGGTAG AGAACCTGCT GACGCTCCTC ATTAAAGTAG AGGATGAGAA CGATAATTAC 
CCGATCTTTA CCCAGAAAGT GTACAGCTTC ACAGTTTTGG AAAACAGTCC ATTTGGTTCT 
CACGTCGGGG AGGTCTGTGC AACAGACAAG GATGAGCCGG ACACAATGCA CACTCGTCTG 
AAGTATTCCA TCCTGGAGCA GTCGCCTTCT CCCCCCATGT TATTCACCAT GCATCCCAGG 
ACTGGTGTCA TCACTACCAC CTCCACCCAG CTGGACAGAG AGTTAATTGA CAAGTACCAG 
TTGATAATAA AAGTTCAGGA CATGGATGGC CAGTATTTTG GTTTGCAGAC AACAGCGACC 
TGCGTCATTA CTATTGGAGA TGTGAATGAC AACTTGCCAA CATTCACGCG TACTACGTAC 
GTGACATCAG TGGAAGAAAA TACGGTCAAT GTGGAACTCT TACGTCTTTC TGTTCAAGAT 
AAAGATTTAG TTAACTCTCC TAATTGGAGA GCTAATTACA CCATTTTAAA GGGCAACGAA 
AATGGAAATT TTAAAATCAA AACAGATCCC CAAACCAATG AAGGCATTCT GTGCGTGATT 
ATGCCTCTGG ACTATGAAGA ACGGCAACGG GTGACCCTGG AAATTGGCGT AGTTAATGAA 
GCCCCGTACA CTAGACAGGC TGGTTCAAAG TCATCCATGA GCACAGCTAC AGTGACTGTC 
AACGTGAAAA ATCAGGATGA GGGCCCTGAG TGTATCCCTC AAACGCAAAC TGTGAGGATT 
CGAGAAAATG TACCAATTGG TACTAGAAAC GATGGGTATA AAGCATATGA CCCAGAGACC 
AAAAACAGCA TTGGCATAAG GTACAGGAAG TTAAGTGACC CAAAAGGATG GATCACTGTT 
AATGAAGATT CAGGATCAAT CACCATTTTC CGAACTCTGG ATCGGGAGGC TGAGACCATC 
AGAAACGGCA TCTACAATAT TACAGTCCTT GCATTAGACG CAGACGGGAG AAGCTGTACG 
GGAACTCTGG GAATCTTACT TGAAGATGTG AATGACAACG GCCCATTCAT ACCCAAGCAG 
ACAGTGGTGA TATGCAGGGC TACCATGTCC TCTGCTGAAA TTGTTGCGGT TGACCCTGAT 
GAGCCAGCAA ATGGTCCACC ATTTGATTTT AGTTTGGAGA GTTCTGATTC AGAAGTACGG 
AGGAGGTGGA AGTTGACAAG AATCAATGAT ACTGCTGCTA GTCTTTCCTA TCAGAATGAC 
CCTGCGTTTG ATTCCTACGT AATTCCCGTC CGAGTTACAG ACAGGTTTGG TCTGTCCTCA 
GTCACGTCAC TGAATGTCGT TGTATGTGAC TGCATCACTG AAAGTGACTG CACATACCGC 
ACTGGAGAAA GGACTGGCTA TGCTGACGTG AGACTTGGAC CATGGGCTAT CCTTGCTATA 
CTGCTGGGCG TAGCCTTGCT ACTTTGTATC CTGTTTACCT TAGTCTGTAG TGTTTCCCGG 
GCATCAAAAC AACAGAAAAT TCTTCCCGAT GACTTAGCTC AGCAGAACCT AATTGTATCA 
AACACCGAGG CTCCTGGAGA TGACAAAGTC TATTCCGCAA ATGGCTTCAC AGCTCAAACT 
GCGGGAGCTT CTGGGCAGAC AACATTCACA ACCGTGGGAG CTGGAGTCAA AAGTACAGGG 
CAAGAGACCA TTGAGATGGT AAAAGGAGGA CAGCGCACAC TGGACTCCCG CAGGGCGACC 
GGCTATCACC ACCATACCAT GGATCCTGGC AGGGGAGGGC ATGTGGAGGT GGACAATTAC 
AGATACACCT ACTCTGAGTG GCACAATTTC ACTCAGCCCC GACTTGGTGA GAAGGTGCAG 
TTTTGCCATG AGGATGACAA CCAGAAGCTT GCCCAAGACT ATGTCCTCAC ATACAACTAT 
GAGGGAAAAG GCTCGGCTGC TGGCTCTGTG GGTTGCTGTA GCGACCTACA GGAAGAAGAC 
GGGCTTGAGT TTTTGGACCA TCTGGAGCCT AAATTTAGGA CATTAGCAGA AGTATGTGCA 
AAGAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dsc2 ( XM_008771935.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008770157.1 Rattus norvegicus desmocollin 2 (Dsc2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa44970
Clone ID Related Accession (Same CDS sequence)	XM_008771935.2
Accession Version	XM_008771935.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2547bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	desmocollin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008771935.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCAG CGGGATCCTC GCGCTCCGGG AGCCCTGCCC TCGGCCTGGG ACACCTGTTG 
ACCCTCGCGA TCCTTGCACT TGCCTGTGAT GCTTGTAAAG AAGTCGTCCT CCAGGTCCCC 
TCTGAACTAC CTGCTGGGAA ATTTGTTGGC AGAGTGAACC TGATGGAGTG CCTTAAATCA 
GCAAATGTAA TTCACTTGAG TGATCCTGAT TTCCAAGTCT TCGAAGATGG TTCTGTGTAC 
ACAACCAATT CTGTTGTTTT GTCTTCGGGG CAAAGAAGCT TTACTATTTG GCTTTTCAAC 
ACAGACAGCC AGGAAGAGAG GGAGTTGTCT GTCCATTTAG AGGGCCCTGT AGAGGTCCTA 
AATCAAAGAC TGCATACAGA AAAAGTTCTC CGCCGCGCCA AGAGAAGATG GCTCCCATCC 
CTTTGTTCCA TGATGGAGAA TTCATTTGGG TCCTTCCCAC TTTTCCTTCA ACAGATCCAA 
TCCGACAAAG CTCAAAACTA CACCATATAC TATTCCATCA GCGGTCCAGG AGTTGATAAA 
GAACCCGTAG GCTTATTTCG TATTGATAGA GATACTGGAA ACCTGTATTG CACTGATCGT 
GTAGATCGAG AACAGTATGA CTCCTTTGAG CTGACTGCAT TAGCAATGAC TCCAGATGGG 
TATATGGTAG AGAACCTGCT GACGCTCCTC ATTAAAGTAG AGGATGAGAA CGATAATTAC 
CCGATCTTTA CCCAGAAAGT GTACAGCTTC ACAGTTTTGG AAAACAGTCC ATTTGGTTCT 
CACGTCGGGG AGGTCTGTGC AACAGACAAG GATGAGCCGG ACACAATGCA CACTCGTCTG 
AAGTACTCCA TCCTGGAGCA GTCGCCTTCT CCCCCCATGT TATTCACCAT GCATCCCAGG 
ACTGGTGTCA TCACTACCAC CTCCACCCAG CTGGACAGAG AGTTAATTGA CAAGTACCAG 
TTGATAATAA AAGTTCAGGA CATGGATGGC CAGTATTTTG GTTTGCAGAC AACAGCGACC 
TGCGTCATTA CTATTGGAGA TGTGAATGAC AACTTGCCAA CATTCACGCG TACTACGTAC 
GTGACATCAG TGGAAGAAAA TACGGTCAAT GTGGAACTCT TACGTCTTTC TGTTCAAGAT 
AAAGATTTAG TTAACTCTCC TAATTGGAGA GCTAATTACA CCATTTTAAA GGGCAACGAA 
AATGGAAATT TTAAAATCAA AACAGATCCC CAAACCAATG AAGGCATTCT GTGCGTGATT 
ATGCCTCTGG ACTATGAAGA ACGGCAACGG GTGACCCTGG AAATTGGCGT AGTTAATGAA 
GCCCCGTACA CTAGACAGGC TGGTTCAAAG TCATCCATGA GCACAGCTAC AGTGACTGTC 
AACGTGAAAA ATCAGGATGA GGGCCCTGAG TGTATCCCTC AAACGCAAAC TGTGAGGATT 
CGAGAAAATG TACCAATTGG TACTAGAAAC GATGGGTATA AAGCATATGA CCCAGAGACC 
AAAAACAGCA TTGGCATAAG GTACAGGAAG TTAAGTGACC CAAAAGGATG GATCACTGTT 
AATGAAGATT CAGGATCAAT CACCATTTTC CGAACTCTGG ATCGGGAGGC TGAGACCATC 
AGAAACGGCA TCTACAATAT TACAGTCCTT GCATTAGATG CAGACGGGAG AAGCTGTACG 
GGAACTCTGG GAATCTTACT TGAAGATGTG AATGACAACG GCCCATTCAT ACCCAAGCAG 
ACAGTGGTGA TATGCAGGGC TACCATGTCC TCTGCTGAAA TTGTTGCGGT TGACCCTGAT 
GAGCCAGCAA ATGGTCCACC ATTTGATTTT AGTTTGGAGA GTTCTGATTC AGAAGTACGG 
AGGAGGTGGA AGTTGACAAG AATCAATGAT ACAGCTGCTA GTCTTTCCTA TCAGAATGAC 
CCTGCGTTTG ATTCCTACGT AATTCCCGTC CGAGTTACAG ACAGGTTTGG TCTGTCCTCA 
GTCACGTCAC TGAATGTCGT TGTATGTGAC TGCATCACTG AAAGTGACTG CACATACCGC 
ACTGGAGAAA GGACTGGCTA TGCTGACGTG AGACTTGGAC CATGGGCTAT CCTTGCTATA 
CTGCTGGGCG TAGCCTTGCT ACTTTGTATC CTGTTTACCT TAGTCTGTAG TGTTTCCCGG 
GCATCAAAAC AACAGAAAAT TCTTCCCGAT GACTTAGCTC AGCAGAACCT AATTGTATCA 
AACACCGAGG CTCCTGGAGA TGACAAAGTC TATTCCGCAA ATGGCTTCAC AGCTCAAACT 
GCGGGAGCTT CTGGGCAGAC AACATTCACA ACCTTGGGAG CTGGAGTCAA AAGTACAGGG 
CAAGAGACCA TTGAGATGGT AAAAGGAGGA CAGCGCACAC TGGACTCCCG CAGGGCGACC 
GGCTATCACC ACCATACCAT GGATCCTGGC AGGGGAGGGC ATGTGGAGGT GGACAATTAC 
AGATACACCT ACTCTGAGTG GCACAATTTC ACTCAGCCCC GACTTGGTGA GGAAACCATT 
AGAGGACACA CTCTGATTAA AAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008770157.1
CDS	282..2828
Translation	MAAAGSSRSGSPALGLGHLLTLAILALACDACKEVVLQVPSELPAGKFVGRVNLMECLKSANVIHLSDPDFQVFEDGSVYTTNSVVLSSGQRSFTIWLFNTDSQEERELSVHLEGPVEVLNQRLHTEKVLRRAKRRWLPSLCSMMENSFGSFPLFLQQIQSDKAQNYTIYYSISGPGVDKEPVGLFRIDRDTGNLYCTDRVDREQYDSFELTALAMTPDGYMVENLLTLLIKVEDENDNYPIFTQKVYSFTVLENSPFGSHVGEVCATDKDEPDTMHTRLKYSILEQSPSPPMLFTMHPRTGVITTTSTQLDRELIDKYQLIIKVQDMDGQYFGLQTTATCVITIGDVNDNLPTFTRTTYVTSVEENTVNVELLRLSVQDKDLVNSPNWRANYTILKGNENGNFKIKTDPQTNEGILCVIMPLDYEERQRVTLEIGVVNEAPYTRQAGSKSSMSTATVTVNVKNQDEGPECIPQTQTVRIRENVPIGTRNDGYKAYDPETKNSIGIRYRKLSDPKGWITVNEDSGSITIFRTLDREAETIRNGIYNITVLALDADGRSCTGTLGILLEDVNDNGPFIPKQTVVICRATMSSAEIVAVDPDEPANGPPFDFSLESSDSEVRRRWKLTRINDTAASLSYQNDPAFDSYVIPVRVTDRFGLSSVTSLNVVVCDCITESDCTYRTGERTGYADVRLGPWAILAILLGVALLLCILFTLVCSVSRASKQQKILPDDLAQQNLIVSNTEAPGDDKVYSANGFTAQTAGASGQTTFTTLGAGVKSTGQETIEMVKGGQRTLDSRRATGYHHHTMDPGRGGHVEVDNYRYTYSEWHNFTQPRLGEETIRGHTLIKN

Target ORF information:

RefSeq Version	XM_008771935.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus desmocollin 2 (Dsc2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008771935.2

ORF Insert Sequence:

ATGGCGGCAG CGGGATCCTC GCGCTCCGGG AGCCCTGCCC TCGGCCTGGG ACACCTGTTG 
ACCCTCGCGA TCCTTGCACT TGCCTGTGAT GCTTGTAAAG AAGTCGTCCT CCAGGTCCCC 
TCTGAACTAC CTGCTGGGAA ATTTGTTGGC AGAGTGAACC TGATGGAGTG CCTTAAATCA 
GCAAATGTAA TTCACTTGAG TGATCCTGAT TTCCAAGTCT TCGAAGATGG TTCTGTGTAC 
ACAACCAATT CTGTTGTTTT GTCTTCGGGG CAAAGAAGCT TTACTATTTG GCTTTTCAAC 
ACAGACAGCC AGGAAGAGAG GGAGTTGTCT GTCCATTTAG AGGGCCCTGT AGAGGTCCTA 
AATCAAAGAC TGCATACAGA AAAAGTTCTC CGCCGCGCCA AGAGAAGATG GCTCCCATCC 
CTTTGTTCCA TGATGGAGAA TTCATTTGGG TCCTTCCCAC TTTTCCTTCA ACAGATCCAA 
TCCGACAAAG CTCAAAACTA CACCATATAC TATTCCATCA GCGGTCCAGG AGTTGATAAA 
GAACCCGTAG GCTTATTTCG TATTGATAGA GATACTGGAA ACCTGTATTG CACTGATCGT 
GTAGATCGAG AACAGTATGA CTCCTTTGAG CTGACTGCAT TAGCAATGAC TCCAGATGGG 
TATATGGTAG AGAACCTGCT GACGCTCCTC ATTAAAGTAG AGGATGAGAA CGATAATTAC 
CCGATCTTTA CCCAGAAAGT GTACAGCTTC ACAGTTTTGG AAAACAGTCC ATTTGGTTCT 
CACGTCGGGG AGGTCTGTGC AACAGACAAG GATGAGCCGG ACACAATGCA CACTCGTCTG 
AAGTACTCCA TCCTGGAGCA GTCGCCTTCT CCCCCCATGT TATTCACCAT GCATCCCAGG 
ACTGGTGTCA TCACTACCAC CTCCACCCAG CTGGACAGAG AGTTAATTGA CAAGTACCAG 
TTGATAATAA AAGTTCAGGA CATGGATGGC CAGTATTTTG GTTTGCAGAC AACAGCGACC 
TGCGTCATTA CTATTGGAGA TGTGAATGAC AACTTGCCAA CATTCACGCG TACTACGTAC 
GTGACATCAG TGGAAGAAAA TACGGTCAAT GTGGAACTCT TACGTCTTTC TGTTCAAGAT 
AAAGATTTAG TTAACTCTCC TAATTGGAGA GCTAATTACA CCATTTTAAA GGGCAACGAA 
AATGGAAATT TTAAAATCAA AACAGATCCC CAAACCAATG AAGGCATTCT GTGCGTGATT 
ATGCCTCTGG ACTATGAAGA ACGGCAACGG GTGACCCTGG AAATTGGCGT AGTTAATGAA 
GCCCCGTACA CTAGACAGGC TGGTTCAAAG TCATCCATGA GCACAGCTAC AGTGACTGTC 
AACGTGAAAA ATCAGGATGA GGGCCCTGAG TGTATCCCTC AAACGCAAAC TGTGAGGATT 
CGAGAAAATG TACCAATTGG TACTAGAAAC GATGGGTATA AAGCATATGA CCCAGAGACC 
AAAAACAGCA TTGGCATAAG GTACAGGAAG TTAAGTGACC CAAAAGGATG GATCACTGTT 
AATGAAGATT CAGGATCAAT CACCATTTTC CGAACTCTGG ATCGGGAGGC TGAGACCATC 
AGAAACGGCA TCTACAATAT TACAGTCCTT GCATTAGATG CAGACGGGAG AAGCTGTACG 
GGAACTCTGG GAATCTTACT TGAAGATGTG AATGACAACG GCCCATTCAT ACCCAAGCAG 
ACAGTGGTGA TATGCAGGGC TACCATGTCC TCTGCTGAAA TTGTTGCGGT TGACCCTGAT 
GAGCCAGCAA ATGGTCCACC ATTTGATTTT AGTTTGGAGA GTTCTGATTC AGAAGTACGG 
AGGAGGTGGA AGTTGACAAG AATCAATGAT ACAGCTGCTA GTCTTTCCTA TCAGAATGAC 
CCTGCGTTTG ATTCCTACGT AATTCCCGTC CGAGTTACAG ACAGGTTTGG TCTGTCCTCA 
GTCACGTCAC TGAATGTCGT TGTATGTGAC TGCATCACTG AAAGTGACTG CACATACCGC 
ACTGGAGAAA GGACTGGCTA TGCTGACGTG AGACTTGGAC CATGGGCTAT CCTTGCTATA 
CTGCTGGGCG TAGCCTTGCT ACTTTGTATC CTGTTTACCT TAGTCTGTAG TGTTTCCCGG 
GCATCAAAAC AACAGAAAAT TCTTCCCGAT GACTTAGCTC AGCAGAACCT AATTGTATCA 
AACACCGAGG CTCCTGGAGA TGACAAAGTC TATTCCGCAA ATGGCTTCAC AGCTCAAACT 
GCGGGAGCTT CTGGGCAGAC AACATTCACA ACCTTGGGAG CTGGAGTCAA AAGTACAGGG 
CAAGAGACCA TTGAGATGGT AAAAGGAGGA CAGCGCACAC TGGACTCCCG CAGGGCGACC 
GGCTATCACC ACCATACCAT GGATCCTGGC AGGGGAGGGC ATGTGGAGGT GGACAATTAC 
AGATACACCT ACTCTGAGTG GCACAATTTC ACTCAGCCCC GACTTGGTGA GGAAACCATT 
AGAGGACACA CTCTGATTAA AAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population.
Circulation. Cardiovascular genetics6(4)327-36(2013 Aug)
Gerull B,Kirchner F,Chong JX,Tagoe J,Chandrasekharan K,Strohm O,Waggoner D,Ober C,Duff HJ

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.
Cell151(7)1595-607(2012 Dec)
Boj SF,van Es JH,Huch M,Li VS,Jos? A,Hatzis P,Mokry M,Haegebarth A,van den Born M,Chambon P,Voshol P,Dor Y,Cuppen E,Fillat C,Clevers H

A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions.
Heart rhythm8(5)711-8(2011 May)
Gehmlich K,Lambiase PD,Asimaki A,Ciaccio EJ,Ehler E,Syrris P,Saffitz JE,McKenna WJ

Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations.
Cardiovascular research90(1)77-87(2011 Apr)
Gehmlich K,Syrris P,Peskett E,Evans A,Ehler E,Asimaki A,Anastasakis A,Tsatsopoulou A,Vouliotis AI,Stefanadis C,Saffitz JE,Protonotarios N,McKenna WJ

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Journal of proteome research8(3)1304-14(2009 Mar)
Gonzalez-Begne M,Lu B,Han X,Hagen FK,Hand AR,Melvin JE,Yates JR

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Dsc2 cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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