CITED4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CITED4
Entrez Gene ID	163732
Full Name	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
General protein information	Preferred Names Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 Names cbp/p300-interacting transactivator 4 MRG-2 MSG1-related protein 2 transcriptional co-activator 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p34.2\|1p35-p34
Summary	The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011].
Disorder MIM:	606815

mRNA and Protein(s)

mRNA	Protein	Name
NM_133467.2	NP_597724.1	cbp/p300-interacting transactivator 4
NM_133467.3	NP_597724.1	cbp/p300-interacting transactivator 4

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CITED4	XP_001172473.2
Mus musculus (house mouse)	Cited4	NP_062509.1
Homo sapiens (human)	CITED4	NP_597724.1
Bos taurus (cattle)	CITED4	NP_001074195.1
Rattus norvegicus (Norway rat)	Cited4	NP_446151.1

Gene Ontology
Bibliography

Related articles in PubMed

C/EBPB-CITED4 in Exercised Heart.
Ding S, Gan T, Song M, Dai Q, Huang H, Xu Y, Zhong C
Advances in experimental medicine and biology1000247-259(2017)

CITED4 gene silencing in colorectal cancer cells modulates adherens/tight junction gene expression and reduces cell proliferation.
Rogers MA, Kalter V, Marcias G, Zapatka M, Barbus S, Lichter P
Journal of cancer research and clinical oncology142(1)225-37(2016 Jan)

Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer.
Huang KT, Takano EA, Mikeska T, Byrne DJ, Dobrovic A, Fox SB
Breast cancer research and treatment130(1)319-29(2011 Nov)

Mutational analysis of the CITED4 gene in glioblastomas.
Torres-Mart?n M, Franco-Hernandez C, Martinez-Glez V, de Campos JM, Isla A, Casartelli C, Rey JA
Cancer genetics and cytogenetics185(2)114-6(2008 Sep)

Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q.
Tews B, Roerig P, Hartmann C, Hahn M, Felsberg J, Blaschke B, Sabel M, Kunitz A, Toedt G, Neben K, Benner A, von Deimling A, Reifenberger G, Lichter P
Oncogene26(34)5010-6(2007 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Upregulation of CITED4 is associated with colorectal cancer.
Title: CITED4 gene silencing in colorectal cancer cells modulates adherens/tight junction gene expression and reduces cell proliferation.

Demethylation and histone modification can potentially reactivate CITED4 gene expression in some breast cancers and lead to changes in tumour behaviour.
Title: Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer.

Observational study of gene-disease association. (HuGE Navigator)
Title: A large-scale candidate gene association study of age at menarche and age at natural menopause.

mutational study of CITED4 in 24 glial tumors (22 primary glioblastomas, 1 low-grade astrocytoma & its recurrent secondary glioblastoma)
Title: Mutational analysis of the CITED4 gene in glioblastomas.

CITED4 is epigenetically silenced in the vast majority of oligodendroglial tumours with 1p and 19q deletions.
Title: Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q.

The following CITED4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CITED4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30411	NM_133467.3 Latest version!	Homo sapiens Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 (CITED4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu30411	NM_133467.2	Homo sapiens Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 (CITED4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CITED4 ( NM_133467.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_597724.1 Homo sapiens Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 (CITED4), mRNA.

Price & Availability↑

CloneID	OHu30411
Clone ID Related Accession (Same CDS sequence)	NM_133467.2 , NM_133467.3
Accession Version	NM_133467.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	cbp/p300-interacting transactivator 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC052559.1. On Nov 20, 2003 this sequence version replaced NM_133467.1. ##Evidence-Data-START## Transcript is intronless :: BC052559.1 [ECO:0000345] ##Evidence-Data-END##

ATGGCCGACC ACCTGATGCT CGCCGAGGGC TACCGCCTGG TGCAGAGGCC GCCGTCCGCC 
GCGGCCGCCC ATGGCCCTCA TGCGCTCCGG ACTCTGCCGC CGTACGCGGG CCCGGGCCTG 
GACAGTGGGC TGAGGCCGCG GGGGGCTCCG CTGGGGCCGC CGCCGCCCCG CCAACCCGGG 
GCCCTGGCGT ACGGGGCCTT CGGGCCGCCG TCCTCCTTCC AGCCCTTTCC GGCCGTGCCT 
CCGCCGGCCG CGGGCATCGC GCACCTGCAG CCTGTGGCGA CGCCGTACCC CGGCCGCGCG 
GCCGCGCCCC CCAACGCTCC GGGAGGCCCC CCGGGCCCGC AGCCGGCGCC AAGCGCCGCA 
GCCCCGCCGC CGCCCGCGCA CGCCCTGGGC GGCATGGACG CCGAACTCAT CGACGAGGAG 
GCGCTGACGT CGCTGGAGCT GGAGCTCGGG CTGCACCGCG TGCGCGAGCT GCCCGAGCTC 
TTCCTGGGCC AGAGCGAGTT CGACTGCTTC TCGGACTTGG GGTCCGCGCC GCCCGCCGGC 
TCCGTGAGCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_597724.1
CDS	220..774
Translation	MADHLMLAEGYRLVQRPPSAAAAHGPHALRTLPPYAGPGLDSGLRPRGAPLGPPPPRQPGALAYGAFGPPSSFQPFPAVPPPAAGIAHLQPVATPYPGRAAAPPNAPGGPPGPQPAPSAAAPPPPAHALGGMDAELIDEEALTSLELELGLHRVRELPELFLGQSEFDCFSDLGSAPPAGSVSC

Target ORF information:

RefSeq Version	NM_133467.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 (CITED4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133467.2

ORF Insert Sequence:

ATGGCCGACC ACCTGATGCT CGCCGAGGGC TACCGCCTGG TGCAGAGGCC GCCGTCCGCC 
GCGGCCGCCC ATGGCCCTCA TGCGCTCCGG ACTCTGCCGC CGTACGCGGG CCCGGGCCTG 
GACAGTGGGC TGAGGCCGCG GGGGGCTCCG CTGGGGCCGC CGCCGCCCCG CCAACCCGGG 
GCCCTGGCGT ACGGGGCCTT CGGGCCGCCG TCCTCCTTCC AGCCCTTTCC GGCCGTGCCT 
CCGCCGGCCG CGGGCATCGC GCACCTGCAG CCTGTGGCGA CGCCGTACCC CGGCCGCGCG 
GCCGCGCCCC CCAACGCTCC GGGAGGCCCC CCGGGCCCGC AGCCGGCGCC AAGCGCCGCA 
GCCCCGCCGC CGCCCGCGCA CGCCCTGGGC GGCATGGACG CCGAACTCAT CGACGAGGAG 
GCGCTGACGT CGCTGGAGCT GGAGCTCGGG CTGCACCGCG TGCGCGAGCT GCCCGAGCTC 
TTCCTGGGCC AGAGCGAGTT CGACTGCTTC TCGGACTTGG GGTCCGCGCC GCCCGCCGGC 
TCCGTGAGCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CITED4 ( NM_133467.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_597724.1 Homo sapiens Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 (CITED4), mRNA.

Price & Availability↑

CloneID	OHu30411
Clone ID Related Accession (Same CDS sequence)	NM_133467.2 , NM_133467.3
Accession Version	NM_133467.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	cbp/p300-interacting transactivator 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC119677.2 and BC052559.1. On May 17, 2019 this sequence version replaced NM_133467.2. ##Evidence-Data-START## Transcript is intronless :: DRR138524.1067215.1, DRR138519.45024.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000372638.4/ ENSP00000361721.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCGACC ACCTGATGCT CGCCGAGGGC TACCGCCTGG TGCAGAGGCC GCCGTCCGCC 
GCGGCCGCCC ATGGCCCTCA TGCGCTCCGG ACTCTGCCGC CGTACGCGGG CCCGGGCCTG 
GACAGTGGGC TGAGGCCGCG GGGGGCTCCG CTGGGGCCGC CGCCGCCCCG CCAACCCGGG 
GCCCTGGCGT ACGGGGCCTT CGGGCCGCCG TCCTCCTTCC AGCCCTTTCC GGCCGTGCCT 
CCGCCGGCCG CGGGCATCGC GCACCTGCAG CCTGTGGCGA CGCCGTACCC CGGCCGCGCG 
GCCGCGCCCC CCAACGCTCC GGGAGGCCCC CCGGGCCCGC AGCCGGCGCC AAGCGCCGCA 
GCCCCGCCGC CGCCCGCGCA CGCCCTGGGC GGCATGGACG CCGAACTCAT CGACGAGGAG 
GCGCTGACGT CGCTGGAGCT GGAGCTCGGG CTGCACCGCG TGCGCGAGCT GCCCGAGCTC 
TTCCTGGGCC AGAGCGAGTT CGACTGCTTC TCGGACTTGG GGTCCGCGCC GCCCGCCGGC 
TCCGTGAGCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_597724.1
CDS	237..791
Translation	MADHLMLAEGYRLVQRPPSAAAAHGPHALRTLPPYAGPGLDSGLRPRGAPLGPPPPRQPGALAYGAFGPPSSFQPFPAVPPPAAGIAHLQPVATPYPGRAAAPPNAPGGPPGPQPAPSAAAPPPPAHALGGMDAELIDEEALTSLELELGLHRVRELPELFLGQSEFDCFSDLGSAPPAGSVSC

Target ORF information:

RefSeq Version	NM_133467.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 (CITED4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133467.3

ORF Insert Sequence:

ATGGCCGACC ACCTGATGCT CGCCGAGGGC TACCGCCTGG TGCAGAGGCC GCCGTCCGCC 
GCGGCCGCCC ATGGCCCTCA TGCGCTCCGG ACTCTGCCGC CGTACGCGGG CCCGGGCCTG 
GACAGTGGGC TGAGGCCGCG GGGGGCTCCG CTGGGGCCGC CGCCGCCCCG CCAACCCGGG 
GCCCTGGCGT ACGGGGCCTT CGGGCCGCCG TCCTCCTTCC AGCCCTTTCC GGCCGTGCCT 
CCGCCGGCCG CGGGCATCGC GCACCTGCAG CCTGTGGCGA CGCCGTACCC CGGCCGCGCG 
GCCGCGCCCC CCAACGCTCC GGGAGGCCCC CCGGGCCCGC AGCCGGCGCC AAGCGCCGCA 
GCCCCGCCGC CGCCCGCGCA CGCCCTGGGC GGCATGGACG CCGAACTCAT CGACGAGGAG 
GCGCTGACGT CGCTGGAGCT GGAGCTCGGG CTGCACCGCG TGCGCGAGCT GCCCGAGCTC 
TTCCTGGGCC AGAGCGAGTT CGACTGCTTC TCGGACTTGG GGTCCGCGCC GCCCGCCGGC 
TCCGTGAGCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

C/EBPB-CITED4 in Exercised Heart.
Advances in experimental medicine and biology1000247-259(2017)
Ding S,Gan T,Song M,Dai Q,Huang H,Xu Y,Zhong C

CITED4 gene silencing in colorectal cancer cells modulates adherens/tight junction gene expression and reduces cell proliferation.
Journal of cancer research and clinical oncology142(1)225-37(2016 Jan)
Rogers MA,Kalter V,Marcias G,Zapatka M,Barbus S,Lichter P

Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer.
Breast cancer research and treatment130(1)319-29(2011 Nov)
Huang KT,Takano EA,Mikeska T,Byrne DJ,Dobrovic A,Fox SB

Mutational analysis of the CITED4 gene in glioblastomas.
Cancer genetics and cytogenetics185(2)114-6(2008 Sep)
Torres-Mart?n M,Franco-Hernandez C,Martinez-Glez V,de Campos JM,Isla A,Casartelli C,Rey JA

Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q.
Oncogene26(34)5010-6(2007 Jul)
Tews B,Roerig P,Hartmann C,Hahn M,Felsberg J,Blaschke B,Sabel M,Kunitz A,Toedt G,Neben K,Benner A,von Deimling A,Reifenberger G,Lichter P

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CITED4 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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