Cited4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cited4
Entrez Gene ID	56222
Full Name	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
Synonyms	MRG-2,Mrg2
General protein information	Preferred Names Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 Names cbp/p300-interacting transactivator 4 cited4 msg1-related protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 D2.2\|4 56.52 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_019563.2	NP_062509.1	cbp/p300-interacting transactivator 4

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CITED4	XP_001172473.2
Mus musculus (house mouse)	Cited4	NP_062509.1
Homo sapiens (human)	CITED4	NP_597724.1
Bos taurus (cattle)	CITED4	NP_001074195.1
Rattus norvegicus (Norway rat)	Cited4	NP_446151.1

Gene Ontology
Bibliography

Related articles in PubMed

Cited4 is related to cardiogenic induction and maintenance of proliferation capacity of embryonic stem cell-derived cardiomyocytes during in vitro cardiogenesis.
Miake J, Notsu T, Higaki K, Hidaka K, Morisaki T, Yamamoto K, Hisatome I
PloS one12(8)e0183225(2017)

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Garland G, Murray SA, Sundberg BA, Schofield PN, Pratt CH
PloS one12(7)e0180682(2017)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Spatiotemporal regulation of GLI target genes in the mammalian limb bud.
Lewandowski JP, Du F, Zhang S, Powell MB, Falkenstein KN, Ji H, Vokes SA
Developmental biology406(1)92-103(2015 Oct)

CBP-CITED4 is required for luteinizing hormone-triggered target gene expression during ovulation.
Zhang YL, Xia Y, Yu C, Richards JS, Liu J, Fan HY
Molecular human reproduction20(9)850-60(2014 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that the Cited4 gene is related to cardiac differentiation and maintenance of proliferation capacity of embryonic stem cell-derived cardiomyocytes during in vitro cardiogenesis
Title: Cited4 is related to cardiogenic induction and maintenance of proliferation capacity of embryonic stem cell-derived cardiomyocytes during in vitro cardiogenesis.

Data (including data from knockout mice) suggest Cited4 and CBP/Crebbp are required for LH (luteinizing hormone) and MAP kinase signaling to trigger ovulation via regulation of gene expression and histone acetylation in pre-ovulatory follicles.
Title: CBP-CITED4 is required for luteinizing hormone-triggered target gene expression during ovulation.

The following Cited4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cited4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58242	NM_019563.2 Latest version!	Mus musculus Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 (Cited4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cited4 ( NM_019563.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062509.1 Mus musculus Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 (Cited4), mRNA.

Price & Availability↑

CloneID	OMu58242
Clone ID Related Accession (Same CDS sequence)	NM_019563.2
Accession Version	NM_019563.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	cbp/p300-interacting transactivator 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL606924.14. On Sep 1, 2006 this sequence version replaced NM_019563.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK012136.1, AK154030.1 [ECO:0000345] ##Evidence-Data-END##

ATGGCCGACC ACCTGATGCT CGCCGAGGGC TACTGCCTGC TACAGGTGCC GCCGCACACC 
CACGGCCCGC ACGCTCCCCG GACTCTGCAG CCATACGCAG GCCCGGGCAT GGACAGCGGT 
CTGCGGCCGC GGGGGGCTCC GCTGGGACCG CCGCCGCCAC CCGGGACCCT GGCATACGGC 
TCCTTCGGGT CGCCGGTCTC TTTCCAGCCC TTCCCCGTCT CGCAGTCGCC GGGCGCCGGT 
AGCACGCACC TGCAGTCTGC AGCCACACCG TCCCCGGGCC GCATCCCGGC GCCCCCGGCA 
GCCGCTGGAG GGCCCTCACC TCTGCAGCCG GCGCCCGGAG CCGCAGCCTC GTTGCCGCCG 
CCGCCGCCGC CACCCGCCCT GGGCTGCATG GACACCGAGC TCATCGACGA AGAGGCGCTG 
ACGTCGCTGG AACTCGAGCT CGGGTTGCAC CGCGTACGCG AGCTGCCGGA GCTCTTCCTC 
GGCCAGAGCG AGTTCGATTG CTTCTCAGAC CTGGGGTCAG CGCCGGCCGC CGGCTCGGTG 
AGCTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062509.1
CDS	241..789
Translation	MADHLMLAEGYCLLQVPPHTHGPHAPRTLQPYAGPGMDSGLRPRGAPLGPPPPPGTLAYGSFGSPVSFQPFPVSQSPGAGSTHLQSAATPSPGRIPAPPAAAGGPSPLQPAPGAAASLPPPPPPPALGCMDTELIDEEALTSLELELGLHRVRELPELFLGQSEFDCFSDLGSAPAAGSVSC

Target ORF information:

RefSeq Version	NM_019563.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 (Cited4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019563.2

ORF Insert Sequence:

ATGGCCGACC ACCTGATGCT CGCCGAGGGC TACTGCCTGC TACAGGTGCC GCCGCACACC 
CACGGCCCGC ACGCTCCCCG GACTCTGCAG CCATACGCAG GCCCGGGCAT GGACAGCGGT 
CTGCGGCCGC GGGGGGCTCC GCTGGGACCG CCGCCGCCAC CCGGGACCCT GGCATACGGC 
TCCTTCGGGT CGCCGGTCTC TTTCCAGCCC TTCCCCGTCT CGCAGTCGCC GGGCGCCGGT 
AGCACGCACC TGCAGTCTGC AGCCACACCG TCCCCGGGCC GCATCCCGGC GCCCCCGGCA 
GCCGCTGGAG GGCCCTCACC TCTGCAGCCG GCGCCCGGAG CCGCAGCCTC GTTGCCGCCG 
CCGCCGCCGC CACCCGCCCT GGGCTGCATG GACACCGAGC TCATCGACGA AGAGGCGCTG 
ACGTCGCTGG AACTCGAGCT CGGGTTGCAC CGCGTACGCG AGCTGCCGGA GCTCTTCCTC 
GGCCAGAGCG AGTTCGATTG CTTCTCAGAC CTGGGGTCAG CGCCGGCCGC CGGCTCGGTG 
AGCTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cited4 is related to cardiogenic induction and maintenance of proliferation capacity of embryonic stem cell-derived cardiomyocytes during in vitro cardiogenesis.
PloS one12(8)e0183225(2017)
Miake J,Notsu T,Higaki K,Hidaka K,Morisaki T,Yamamoto K,Hisatome I

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
PloS one12(7)e0180682(2017)
Sundberg JP,Dadras SS,Silva KA,Kennedy VE,Garland G,Murray SA,Sundberg BA,Schofield PN,Pratt CH

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Spatiotemporal regulation of GLI target genes in the mammalian limb bud.
Developmental biology406(1)92-103(2015 Oct)
Lewandowski JP,Du F,Zhang S,Powell MB,Falkenstein KN,Ji H,Vokes SA

CBP-CITED4 is required for luteinizing hormone-triggered target gene expression during ovulation.
Molecular human reproduction20(9)850-60(2014 Sep)
Zhang YL,Xia Y,Yu C,Richards JS,Liu J,Fan HY