CYP2A7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CYP2A7
Entrez Gene ID	1549
Full Name	cytochrome P450 family 2 subfamily A member 7
Synonyms	CPA7,CPAD,CYP2A,CYPIIA7,P450-IIA4
General protein information	Preferred Names cytochrome P450 family 2 subfamily A member 7 Names cytochrome P450 2A7 cytochrome P450 IIA4 cytochrome P450, family 2, subfamily A, polypeptide 7 cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7 cytochrome P450IIA4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.2
Summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008].
Disorder MIM:	608054

mRNA and Protein(s)

mRNA	Protein	Name
XM_017026383.1	XP_016881872.1	cytochrome P450 2A7 isoform X1
NM_000764.2	NP_000755.2	cytochrome P450 2A7 isoform 1 precursor
NM_030589.2	NP_085079.2	cytochrome P450 2A7 isoform 2 precursor

Pathways from BioSystems

Homologies

Caenorhabditis elegans (roundworm)	cyp-36A1	NP_492267.1
Xenopus tropicalis (tropical clawed frog)	LOC101730237	XP_004917147.1
Homo sapiens (human)	CYP2A13	NP_000757.2
	CYP2A24	NP_001035305.1
Xenopus tropicalis (tropical clawed frog)	cyp2a6	NP_001010998.1
Xenopus tropicalis (tropical clawed frog)	LOC100496861	XP_002939423.1
Homo sapiens (human)	CYP2A6	NP_000753.3
Homo sapiens (human)	CYP2A7	NP_000755.2
Mus musculus (house mouse)	Cyp2a4	NP_034127.2
Rattus norvegicus (Norway rat)	Cyp2a3	NP_036674.1
Xenopus tropicalis (tropical clawed frog)	LOC100170416	NP_001123668.1
Mus musculus (house mouse)	Cyp2a5	NP_031838.2
Xenopus tropicalis (tropical clawed frog)	cyp2f2	NP_001010999.1
Xenopus tropicalis (tropical clawed frog)	LOC548374	XP_002939424.2
Xenopus tropicalis (tropical clawed frog)	LOC100486002	XP_004917148.1

Gene Ontology
Bibliography

Related articles in PubMed

Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers.
Walker LC, Marquart L, Pearson JF, Wiggins GA, O'Mara TA, Parsons MT, , Barrowdale D, McGuffog L, Dennis J, Benitez J, Slavin TP, Radice P, Frost D, , Godwin AK, Meindl A, Schmutzler RK, , Isaacs C, Peshkin BN, Caldes T, Hogervorst FB, , Lazaro C, Jakubowska A, Montagna M, , Chen X, Offit K, Hulick PJ, Andrulis IL, Lindblom A, Nussbaum RL, Nathanson KL, Chenevix-Trench G, Antoniou AC, Couch FJ, Spurdle AB
European journal of human genetics : EJHG25(4)432-438(2017 04)

CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126.
Nakano M, Fukushima Y, Yokota S, Fukami T, Takamiya M, Aoki Y, Yokoi T, Nakajima M
Drug metabolism and disposition: the biological fate of chemicals43(5)703-12(2015 May)

Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.
Chiang HC, Wang CK, Tsou TC
Respiration; international review of thoracic diseases84(4)319-26(2012)

CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.
Fukami T, Nakajima M, Sakai H, McLeod HL, Yokoi T
The pharmacogenomics journal6(6)401-12(2006 Nov-Dec)

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.
Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW
Pharmacogenetics14(1)1-18(2004 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CNV deletion at the CYP2A7 is associated with decreased ovarian cancer risk in BRCA1 carriers.
Title: Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers.

CYP2A7 affects CYP2A6 expression by competing for miR-126* binding.
Title: CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126.

Observational study of genotype prevalence and genetic testing. (HuGE Navigator)
Title: CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.

Observational study of genotype prevalence. (HuGE Navigator)
Title: Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.

CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism
Title: CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.

The following CYP2A7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYP2A7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19556	NM_000764.2 Latest version!	Homo sapiens cytochrome P450 family 2 subfamily A member 7 (CYP2A7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu19609	NM_030589.2 Latest version!	Homo sapiens cytochrome P450 family 2 subfamily A member 7 (CYP2A7), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu88265	XM_017026383.1 Latest version!	Homo sapiens cytochrome P450 family 2 subfamily A member 7 (CYP2A7), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CYP2A7 ( NM_000764.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000755.2 Homo sapiens cytochrome P450 family 2 subfamily A member 7 (CYP2A7), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19556
Clone ID Related Accession (Same CDS sequence)	NM_000764.2
Accession Version	NM_000764.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1485bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	cytochrome P450 2A7 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U22029.1. This sequence is a reference standard in the RefSeqGene project. On Aug 10, 2001 this sequence version replaced NM_000764.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U22029.1, M33317.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465408 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGGCCT CAGGGCTGCT TCTGGTGGCC TTGCTGGCCT GCCTGACTGT GATGGTCTTG 
ATGTCTGTCT GGCAGCAGAG GAAGAGCAGG GGGAAGCTGC CTCCGGGACC CACCCCACTG 
CCCTTCATTG GAAACTACCT CCAGCTGAAC ACAGAGCACA TATGTGACTC CATCATGAAG 
TTCAGTGAGT GCTATGGCCC CGTGTTCACC ATTCACTTGG GGCCCCGGCG GGTCGTGGTG 
CTGTGTGGAC ATGATGCCGT CAGGGAGGCT CTGGTGGACC AGGCTGAGGA GTTCAGCGGG 
CGAGGCGAGC AAGCCACCTT CGACTGGGTC TTCAAAGGCT ATGGCGTGGC GTTCAGCAAC 
GGGGAGCGCG CCAAGCAGCT CCTGCGCTTT GCCATCGCCA CCCTGAGGGA CTTCGGGGTG 
GGCAAGCGAG GCATCGAGGA GCGCATCCAG GAGGAGTCGG GCTTCCTCAT CGAGGCCATC 
CGGAGCACGC ACGGCGCCAA TATCGATCCC ACCTTCTTCC TGAGCCGCAC AGTCTCCAAT 
GTCATCAGCT CCATTGTCTT TGGGGACCGC TTTGACTATG AGGACAAAGA GTTCCTGTCA 
CTGCTGAGCA TGATGCTAGG AATCTTCCAG TTCACGTCAA CCTCCACGGG GCAGCTCTAT 
GAGATGTTCT CTTCGGTGAT GAAACACCTG CCAGGACCAC AGCAACAGGC CTTTAAGTTG 
CTGCAAGGGC TGGAGGACTT CATAGCCAAG AAGGTGGAGC ACAACCAGCG CACGCTGGAT 
CCCAATTCCC CACAGGACTT CATCGACTCC TTTCTCATCC ACATGCAGGA GGAGGAGAAG 
AACCCCAACA CGGAGTTCTA CTTGAAGAAC CTGATGATGA GCACGTTGAA CCTCTTCATT 
GCAGGCACCG AGACGGTCAG CACCACCCTG CGCTATGGCT TCTTGCTGCT CATGAAGCAC 
CCAGAGGTGG AGGCCAAGGT CCATGAGGAG ATTGACAGAG TGATCGGCAA GAACCGGCAG 
CCCAAGTTTG AGGACCGGAC CAAGATGCCC TACATGGAGG CAGTGATCCA CGAGATCCAA 
AGATTTGGAG ACGTGATCCC CATGAGTTTG GCCCGCAGGG TTAAAAAGGA CACCAAGTTT 
CGGGATTTTT TCCTCCCTAA GGGCACCGAA GTGTTCCCTA TGCTGGGCTC CGTGCTGAGA 
GACCCCAGCT TCTTCTCCAA CCCTCAGGAC TTCAATCCCC AGCATTTCCT GGATGACAAG 
GGGCAGTTTA AGAAGAGTGA TGCTTTTGTG CCCTTTTCCA TCGGAAAGCG GAACTGTTTC 
GGAGAAGGCC TGGCCAGAAT GGAGCTCTTT CTCTTCTTCA CCACCGTCAT GCAGAACTTC 
CGCCTCAAGT CCTCCCAGTC ACCTAAGGAC ATTGACGTGT CCCCCAAACA CGTGGTCTTT 
GCCACGATCC CACGAAACTA CACCATGAGC TTCCTGCCCC GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000755.2
CDS	543..2027
Translation	MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYTMSFLPR

Target ORF information:

RefSeq Version	NM_000764.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome P450 family 2 subfamily A member 7 (CYP2A7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000764.2

ORF Insert Sequence:

ATGCTGGCCT CAGGGCTGCT TCTGGTGGCC TTGCTGGCCT GCCTGACTGT GATGGTCTTG 
ATGTCTGTCT GGCAGCAGAG GAAGAGCAGG GGGAAGCTGC CTCCGGGACC CACCCCACTG 
CCCTTCATTG GAAACTACCT CCAGCTGAAC ACAGAGCACA TATGTGACTC CATCATGAAG 
TTCAGTGAGT GCTATGGCCC CGTGTTCACC ATTCACTTGG GGCCCCGGCG GGTCGTGGTG 
CTGTGTGGAC ATGATGCCGT CAGGGAGGCT CTGGTGGACC AGGCTGAGGA GTTCAGCGGG 
CGAGGCGAGC AAGCCACCTT CGACTGGGTC TTCAAAGGCT ATGGCGTGGC GTTCAGCAAC 
GGGGAGCGCG CCAAGCAGCT CCTGCGCTTT GCCATCGCCA CCCTGAGGGA CTTCGGGGTG 
GGCAAGCGAG GCATCGAGGA GCGCATCCAG GAGGAGTCGG GCTTCCTCAT CGAGGCCATC 
CGGAGCACGC ACGGCGCCAA TATCGATCCC ACCTTCTTCC TGAGCCGCAC AGTCTCCAAT 
GTCATCAGCT CCATTGTCTT TGGGGACCGC TTTGACTATG AGGACAAAGA GTTCCTGTCA 
CTGCTGAGCA TGATGCTAGG AATCTTCCAG TTCACGTCAA CCTCCACGGG GCAGCTCTAT 
GAGATGTTCT CTTCGGTGAT GAAACACCTG CCAGGACCAC AGCAACAGGC CTTTAAGTTG 
CTGCAAGGGC TGGAGGACTT CATAGCCAAG AAGGTGGAGC ACAACCAGCG CACGCTGGAT 
CCCAATTCCC CACAGGACTT CATCGACTCC TTTCTCATCC ACATGCAGGA GGAGGAGAAG 
AACCCCAACA CGGAGTTCTA CTTGAAGAAC CTGATGATGA GCACGTTGAA CCTCTTCATT 
GCAGGCACCG AGACGGTCAG CACCACCCTG CGCTATGGCT TCTTGCTGCT CATGAAGCAC 
CCAGAGGTGG AGGCCAAGGT CCATGAGGAG ATTGACAGAG TGATCGGCAA GAACCGGCAG 
CCCAAGTTTG AGGACCGGAC CAAGATGCCC TACATGGAGG CAGTGATCCA CGAGATCCAA 
AGATTTGGAG ACGTGATCCC CATGAGTTTG GCCCGCAGGG TTAAAAAGGA CACCAAGTTT 
CGGGATTTTT TCCTCCCTAA GGGCACCGAA GTGTTCCCTA TGCTGGGCTC CGTGCTGAGA 
GACCCCAGCT TCTTCTCCAA CCCTCAGGAC TTCAATCCCC AGCATTTCCT GGATGACAAG 
GGGCAGTTTA AGAAGAGTGA TGCTTTTGTG CCCTTTTCCA TCGGAAAGCG GAACTGTTTC 
GGAGAAGGCC TGGCCAGAAT GGAGCTCTTT CTCTTCTTCA CCACCGTCAT GCAGAACTTC 
CGCCTCAAGT CCTCCCAGTC ACCTAAGGAC ATTGACGTGT CCCCCAAACA CGTGGTCTTT 
GCCACGATCC CACGAAACTA CACCATGAGC TTCCTGCCCC GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYP2A7 ( NM_030589.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_085079.2 Homo sapiens cytochrome P450 family 2 subfamily A member 7 (CYP2A7), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu19609
Clone ID Related Accession (Same CDS sequence)	NM_030589.2
Accession Version	NM_030589.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1332bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	cytochrome P450 2A7 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U22029.1. This sequence is a reference standard in the RefSeqGene project. On Aug 10, 2001 this sequence version replaced NM_030589.1. Transcript Variant: This variant (2, also known as CYP2A7AS) lacks exon 2 within the coding region and includes 10 nt from intron 1, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. This variant lacks publicly available transcript support but it is supported by data in PubMedID:7864805. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U22029.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGGCCT CAGGGCTGCT TCTGGTGGCC TTGCTGGCCT GCCTGACTGT GATGGTCTTG 
ATGTCTGTCT GGCAGCAGAG GAAGAGCAGG GGGAAGCTGC CTCCGGGACC CACCCCACTG 
CCCTTCATTG GAAACTACCT CCAGCTGAAC ACAGAGCACA TATGTGACTC CATCATGAAG 
GTGTCCCAAG GCGTGGCGTT CAGCAACGGG GAGCGCGCCA AGCAGCTCCT GCGCTTTGCC 
ATCGCCACCC TGAGGGACTT CGGGGTGGGC AAGCGAGGCA TCGAGGAGCG CATCCAGGAG 
GAGTCGGGCT TCCTCATCGA GGCCATCCGG AGCACGCACG GCGCCAATAT CGATCCCACC 
TTCTTCCTGA GCCGCACAGT CTCCAATGTC ATCAGCTCCA TTGTCTTTGG GGACCGCTTT 
GACTATGAGG ACAAAGAGTT CCTGTCACTG CTGAGCATGA TGCTAGGAAT CTTCCAGTTC 
ACGTCAACCT CCACGGGGCA GCTCTATGAG ATGTTCTCTT CGGTGATGAA ACACCTGCCA 
GGACCACAGC AACAGGCCTT TAAGTTGCTG CAAGGGCTGG AGGACTTCAT AGCCAAGAAG 
GTGGAGCACA ACCAGCGCAC GCTGGATCCC AATTCCCCAC AGGACTTCAT CGACTCCTTT 
CTCATCCACA TGCAGGAGGA GGAGAAGAAC CCCAACACGG AGTTCTACTT GAAGAACCTG 
ATGATGAGCA CGTTGAACCT CTTCATTGCA GGCACCGAGA CGGTCAGCAC CACCCTGCGC 
TATGGCTTCT TGCTGCTCAT GAAGCACCCA GAGGTGGAGG CCAAGGTCCA TGAGGAGATT 
GACAGAGTGA TCGGCAAGAA CCGGCAGCCC AAGTTTGAGG ACCGGACCAA GATGCCCTAC 
ATGGAGGCAG TGATCCACGA GATCCAAAGA TTTGGAGACG TGATCCCCAT GAGTTTGGCC 
CGCAGGGTTA AAAAGGACAC CAAGTTTCGG GATTTTTTCC TCCCTAAGGG CACCGAAGTG 
TTCCCTATGC TGGGCTCCGT GCTGAGAGAC CCCAGCTTCT TCTCCAACCC TCAGGACTTC 
AATCCCCAGC ATTTCCTGGA TGACAAGGGG CAGTTTAAGA AGAGTGATGC TTTTGTGCCC 
TTTTCCATCG GAAAGCGGAA CTGTTTCGGA GAAGGCCTGG CCAGAATGGA GCTCTTTCTC 
TTCTTCACCA CCGTCATGCA GAACTTCCGC CTCAAGTCCT CCCAGTCACC TAAGGACATT 
GACGTGTCCC CCAAACACGT GGTCTTTGCC ACGATCCCAC GAAACTACAC CATGAGCTTC 
CTGCCCCGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_085079.2
CDS	543..1874
Translation	MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQGVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYTMSFLPR

Target ORF information:

RefSeq Version	NM_030589.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome P450 family 2 subfamily A member 7 (CYP2A7), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030589.2

ORF Insert Sequence:

ATGCTGGCCT CAGGGCTGCT TCTGGTGGCC TTGCTGGCCT GCCTGACTGT GATGGTCTTG 
ATGTCTGTCT GGCAGCAGAG GAAGAGCAGG GGGAAGCTGC CTCCGGGACC CACCCCACTG 
CCCTTCATTG GAAACTACCT CCAGCTGAAC ACAGAGCACA TATGTGACTC CATCATGAAG 
GTGTCCCAAG GCGTGGCGTT CAGCAACGGG GAGCGCGCCA AGCAGCTCCT GCGCTTTGCC 
ATCGCCACCC TGAGGGACTT CGGGGTGGGC AAGCGAGGCA TCGAGGAGCG CATCCAGGAG 
GAGTCGGGCT TCCTCATCGA GGCCATCCGG AGCACGCACG GCGCCAATAT CGATCCCACC 
TTCTTCCTGA GCCGCACAGT CTCCAATGTC ATCAGCTCCA TTGTCTTTGG GGACCGCTTT 
GACTATGAGG ACAAAGAGTT CCTGTCACTG CTGAGCATGA TGCTAGGAAT CTTCCAGTTC 
ACGTCAACCT CCACGGGGCA GCTCTATGAG ATGTTCTCTT CGGTGATGAA ACACCTGCCA 
GGACCACAGC AACAGGCCTT TAAGTTGCTG CAAGGGCTGG AGGACTTCAT AGCCAAGAAG 
GTGGAGCACA ACCAGCGCAC GCTGGATCCC AATTCCCCAC AGGACTTCAT CGACTCCTTT 
CTCATCCACA TGCAGGAGGA GGAGAAGAAC CCCAACACGG AGTTCTACTT GAAGAACCTG 
ATGATGAGCA CGTTGAACCT CTTCATTGCA GGCACCGAGA CGGTCAGCAC CACCCTGCGC 
TATGGCTTCT TGCTGCTCAT GAAGCACCCA GAGGTGGAGG CCAAGGTCCA TGAGGAGATT 
GACAGAGTGA TCGGCAAGAA CCGGCAGCCC AAGTTTGAGG ACCGGACCAA GATGCCCTAC 
ATGGAGGCAG TGATCCACGA GATCCAAAGA TTTGGAGACG TGATCCCCAT GAGTTTGGCC 
CGCAGGGTTA AAAAGGACAC CAAGTTTCGG GATTTTTTCC TCCCTAAGGG CACCGAAGTG 
TTCCCTATGC TGGGCTCCGT GCTGAGAGAC CCCAGCTTCT TCTCCAACCC TCAGGACTTC 
AATCCCCAGC ATTTCCTGGA TGACAAGGGG CAGTTTAAGA AGAGTGATGC TTTTGTGCCC 
TTTTCCATCG GAAAGCGGAA CTGTTTCGGA GAAGGCCTGG CCAGAATGGA GCTCTTTCTC 
TTCTTCACCA CCGTCATGCA GAACTTCCGC CTCAAGTCCT CCCAGTCACC TAAGGACATT 
GACGTGTCCC CCAAACACGT GGTCTTTGCC ACGATCCCAC GAAACTACAC CATGAGCTTC 
CTGCCCCGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYP2A7 ( XM_017026383.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881872.1 Homo sapiens cytochrome P450 family 2 subfamily A member 7 (CYP2A7), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu88265
Clone ID Related Accession (Same CDS sequence)	XM_017026383.1
Accession Version	XM_017026383.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	cytochrome P450 2A7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGGCCT CAGGGCTGCT TCTGGTGGCC TTGCTGGCCT GCCTGACTGT GATGGTCTTG 
ATGTCTGTCT GGCAGCAGAG GAAGAGCAGG GGGAAGCTGC CTCCGGGACC CACCCCACTG 
CCCTTCATTG GAAACTACCT CCAGCTGAAC ACAGAGCACA TATGTGACTC CATCATGAAG 
TTCAGTGAGT GCTATGGCCC CGTGTTCACC ATTCACTTGG GGCCCCGGCG GGTCGTGGTG 
CTGTGTGGAC ATGATGCCGT CAGGGAGGCT CTGGTGGACC AGGCTGAGGA GTTCAGCGGG 
CGAGGCGAGC AAGCCACCTT CGACTGGGTC TTCAAAGGCT ATGGCGTGGC GTTCAGCAAC 
GGGGAGCGCG CCAAGCAGCT CCTGCGCTTT GCCATCGCCA CCCTGAGGGA CTTCGGGGTG 
GGCAAGCGAG GCATCGAGGA GCGCATCCAG GAGGAGTCGG GCTTCCTCAT CGAGGCCATC 
CGGAGCACGC ACGGCGCCAA TATCGATCCC ACCTTCTTCC TGAGCCGCAC AGTCTCCAAT 
GTCATCAGCT CCATTGTCTT TGGGGACCGC TTTGACTATG AGGACAAAGA GTTCCTGTCA 
CTGCTGAGCA TGATGCTAGG AATCTTCCAG TTCACGTCAA CCTCCACGGG GCAGCTCTAT 
GAGATGTTCT CTTCGGTGAT GAAACACCTG CCAGGACCAC AGCAACAGGC CTTTAAGTTG 
CTGCAAGGGC TGGAGGACTT CATAGCCAAG AAGGTGGAGC ACAACCAGCG CACGCTGGAT 
CCCAATTCCC CACAGGACTT CATCGACTCC TTTCTCATCC ACATGCAGGA GGCACCGAGA 
CGGTCAGCAC CACCCTGCGC TATGGCTTCT TGCTGCTCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881872.1
CDS	3740..4621
Translation	MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEAPRRSAPPCAMASCCS

Target ORF information:

RefSeq Version	XM_017026383.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome P450 family 2 subfamily A member 7 (CYP2A7), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026383.1

ORF Insert Sequence:

ATGCTGGCCT CAGGGCTGCT TCTGGTGGCC TTGCTGGCCT GCCTGACTGT GATGGTCTTG 
ATGTCTGTCT GGCAGCAGAG GAAGAGCAGG GGGAAGCTGC CTCCGGGACC CACCCCACTG 
CCCTTCATTG GAAACTACCT CCAGCTGAAC ACAGAGCACA TATGTGACTC CATCATGAAG 
TTCAGTGAGT GCTATGGCCC CGTGTTCACC ATTCACTTGG GGCCCCGGCG GGTCGTGGTG 
CTGTGTGGAC ATGATGCCGT CAGGGAGGCT CTGGTGGACC AGGCTGAGGA GTTCAGCGGG 
CGAGGCGAGC AAGCCACCTT CGACTGGGTC TTCAAAGGCT ATGGCGTGGC GTTCAGCAAC 
GGGGAGCGCG CCAAGCAGCT CCTGCGCTTT GCCATCGCCA CCCTGAGGGA CTTCGGGGTG 
GGCAAGCGAG GCATCGAGGA GCGCATCCAG GAGGAGTCGG GCTTCCTCAT CGAGGCCATC 
CGGAGCACGC ACGGCGCCAA TATCGATCCC ACCTTCTTCC TGAGCCGCAC AGTCTCCAAT 
GTCATCAGCT CCATTGTCTT TGGGGACCGC TTTGACTATG AGGACAAAGA GTTCCTGTCA 
CTGCTGAGCA TGATGCTAGG AATCTTCCAG TTCACGTCAA CCTCCACGGG GCAGCTCTAT 
GAGATGTTCT CTTCGGTGAT GAAACACCTG CCAGGACCAC AGCAACAGGC CTTTAAGTTG 
CTGCAAGGGC TGGAGGACTT CATAGCCAAG AAGGTGGAGC ACAACCAGCG CACGCTGGAT 
CCCAATTCCC CACAGGACTT CATCGACTCC TTTCTCATCC ACATGCAGGA GGCACCGAGA 
CGGTCAGCAC CACCCTGCGC TATGGCTTCT TGCTGCTCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers.
European journal of human genetics : EJHG25(4)432-438(2017 04)
Walker LC,Marquart L,Pearson JF,Wiggins GA,O'Mara TA,Parsons MT,,Barrowdale D,McGuffog L,Dennis J,Benitez J,Slavin TP,Radice P,Frost D,,Godwin AK,Meindl A,Schmutzler RK,,Isaacs C,Peshkin BN,Caldes T,Hogervorst FB,,Lazaro C,Jakubowska A,Montagna M,,Chen X,Offit K,Hulick PJ,Andrulis IL,Lindblom A,Nussbaum RL,Nathanson KL,Chenevix-Trench G,Antoniou AC,Couch FJ,Spurdle AB

CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126.
Drug metabolism and disposition: the biological fate of chemicals43(5)703-12(2015 May)
Nakano M,Fukushima Y,Yokota S,Fukami T,Takamiya M,Aoki Y,Yokoi T,Nakajima M

Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.
Respiration; international review of thoracic diseases84(4)319-26(2012)
Chiang HC,Wang CK,Tsou TC

CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.
The pharmacogenomics journal6(6)401-12(2006 Nov-Dec)
Fukami T,Nakajima M,Sakai H,McLeod HL,Yokoi T

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.
Pharmacogenetics14(1)1-18(2004 Jan)
Nelson DR,Zeldin DC,Hoffman SM,Maltais LJ,Wain HM,Nebert DW

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CYP2A7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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