CYP2A6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CYP2A6
Entrez Gene ID	1548
Full Name	cytochrome P450 family 2 subfamily A member 6
Synonyms	CPA6,CYP2A,CYP2A3,CYPIIA6,P450C2A,P450PB
General protein information	Preferred Names cytochrome P450 family 2 subfamily A member 6 Names cytochrome P450 2A6 1,4-cineole 2-exo-monooxygenase coumarin 7-hydroxylase cytochrome P450 IIA3 cytochrome P450(I) cytochrome P450, family 2, subfamily A, polypeptide 6 cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6 flavoprotein-linked monooxygenase xenobiotic monooxygenase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.2
Summary	This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008].
Disorder MIM:	122720
Disorder Html:	Coumarin resistance, 122700 (3); {Nicotine addiction, protection from}, 188890 (3); {Lung cancer, resistance to}, 211980 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000762.5	NP_000753.3	cytochrome P450 2A6 precursor
NM_000762.6	NP_000753.3	cytochrome P450 2A6 precursor

Pathways from BioSystems

Homologies

Caenorhabditis elegans (roundworm)	cyp-36A1	NP_492267.1
Xenopus tropicalis (tropical clawed frog)	LOC101730237	XP_004917147.1
Homo sapiens (human)	CYP2A13	NP_000757.2
	CYP2A24	NP_001035305.1
Xenopus tropicalis (tropical clawed frog)	cyp2a6	NP_001010998.1
Xenopus tropicalis (tropical clawed frog)	LOC100496861	XP_002939423.1
Homo sapiens (human)	CYP2A6	NP_000753.3
Homo sapiens (human)	CYP2A7	NP_000755.2
Mus musculus (house mouse)	Cyp2a4	NP_034127.2
Rattus norvegicus (Norway rat)	Cyp2a3	NP_036674.1
Xenopus tropicalis (tropical clawed frog)	LOC100170416	NP_001123668.1
Mus musculus (house mouse)	Cyp2a5	NP_031838.2
Xenopus tropicalis (tropical clawed frog)	cyp2f2	NP_001010999.1
Xenopus tropicalis (tropical clawed frog)	LOC548374	XP_002939424.2
Xenopus tropicalis (tropical clawed frog)	LOC100486002	XP_004917148.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences.
Chenoweth MJ, Ware JJ, Zhu AZX, Cole CB, Cox LS, Nollen N, Ahluwalia JS, Benowitz NL, Schnoll RA, Hawk LW Jr, Cinciripini PM, George TP, Lerman C, Knight J, Tyndale RF,
Addiction (Abingdon, England)(2017 Sep)

Race/Ethnicity and the Pharmacogenetics of Reported Suicidality With Efavirenz Among Clinical Trials Participants.
Mollan KR, Tierney C, Hellwege JN, Eron JJ, Hudgens MG, Gulick RM, Haubrich R, Sax PE, Campbell TB, Daar ES, Robertson KR, Ventura D, Ma Q, Edwards DRV, Haas DW,
The Journal of infectious diseases216(5)554-564(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CYP2B6/CYP2A6 genotypes were associated with increased reported suicidality among AIDS patients who had been randomly assigned to receive efavirenz-containing regimens in clinical trials. Strength of association varied by race/ethnicity.
Title: Race/Ethnicity and the Pharmacogenetics of Reported Suicidality With Efavirenz Among Clinical Trials Participants.

study demonstrated a strong dose-dependent association between reduced CYP2A6 activity determined by genotypes and reduced risk of lung cancer
Title: CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study.

CYP2A6 genetic variation alters striatal-cingulate circuits, network hubs, and executive processing in smokers. Because the CYP2A6 effect was seen only in smokers, these data suggest that the rate of nicotine metabolism-and thus the concentration of nicotine presented to the brain over the course of nicotine addiction-shapes brain circuits that, among other functions, compute reward and impulsivity processes.
Title: CYP2A6 Genetic Variation Alters Striatal-Cingulate Circuits, Network Hubs, and Executive Processing in Smokers.

findings suggest that CYP1A2 alleles or haplotypes were not predictive of metabolic phenotypes in the Nigerian population; carriers of CYP2A6*9/*17 genotype are likely to be poor metabolisers of CYP2A6 substrates and may experience adverse reactions or poor efficacy while using drugs metabolised mainly by CYP2A6
Title: Relationship between metabolic phenotypes and genotypes of CYP1A2 and CYP2A6 in the Nigerian population.

CYP2A6 activity provides information on lung cancer risk that is not captured by smoking history.
Title: Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study.

The following CYP2A6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYP2A6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26077	NM_000762.6 Latest version!	Homo sapiens cytochrome P450 family 2 subfamily A member 6 (CYP2A6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu26077	NM_000762.5	Homo sapiens cytochrome P450 family 2 subfamily A member 6 (CYP2A6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CYP2A6 ( NM_000762.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000753.3 Homo sapiens cytochrome P450 family 2 subfamily A member 6 (CYP2A6), mRNA.

Price & Availability↑

CloneID	OHu26077
Clone ID Related Accession (Same CDS sequence)	NM_000762.5 , NM_000762.6
Accession Version	NM_000762.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1485bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	cytochrome P450 2A6 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA641580.1, BC096254.1, BC096256.1 and X13897.1. This sequence is a reference standard in the RefSeqGene project. On Jun 4, 2008 this sequence version replaced NM_000762.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X13897.1, M33318.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGGCCT CAGGGATGCT TCTGGTGGCC TTGCTGGTCT GCCTGACTGT AATGGTCTTG 
ATGTCTGTTT GGCAGCAGAG GAAGAGCAAG GGGAAGCTGC CTCCGGGACC CACCCCATTG 
CCCTTCATTG GAAACTACCT GCAGCTGAAC ACAGAGCAGA TGTACAACTC CCTCATGAAG 
ATCAGTGAGC GCTATGGCCC CGTGTTCACC ATTCACTTGG GGCCCCGGCG GGTCGTGGTG 
CTGTGTGGAC ATGATGCCGT CAGGGAGGCT CTGGTGGACC AGGCTGAGGA GTTCAGCGGG 
CGAGGCGAGC AAGCCACCTT CGACTGGGTC TTCAAAGGCT ATGGCGTGGT ATTCAGCAAC 
GGGGAGCGCG CCAAGCAGCT CCGGCGCTTC TCCATCGCCA CCCTGCGGGA CTTCGGGGTG 
GGCAAGCGAG GCATCGAGGA GCGCATCCAG GAGGAGGCGG GCTTCCTCAT CGACGCCCTC 
CGGGGCACTG GCGGCGCCAA TATCGATCCC ACCTTCTTCC TGAGCCGCAC AGTCTCCAAT 
GTCATCAGCT CCATTGTCTT TGGGGACCGC TTTGACTATA AGGACAAAGA GTTCCTGTCA 
CTGTTGCGCA TGATGCTAGG AATCTTCCAG TTCACGTCAA CCTCCACGGG GCAGCTCTAT 
GAGATGTTCT CTTCGGTGAT GAAACACCTG CCAGGACCAC AGCAACAGGC CTTTCAGTTG 
CTGCAAGGGC TGGAGGACTT CATAGCCAAG AAGGTGGAGC ACAACCAGCG CACGCTGGAT 
CCCAATTCCC CACGGGACTT CATTGACTCC TTTCTCATCC GCATGCAGGA GGAGGAGAAG 
AACCCCAACA CGGAGTTCTA CTTGAAAAAC CTGGTGATGA CCACGTTGAA CCTCTTCATT 
GGGGGCACCG AGACCGTCAG CACCACCCTG CGCTATGGCT TCTTGCTGCT CATGAAGCAC 
CCAGAGGTGG AGGCCAAGGT CCATGAGGAG ATTGACAGAG TGATCGGCAA GAACCGGCAG 
CCCAAGTTTG AGGACCGGGC CAAGATGCCC TACATGGAGG CAGTGATCCA CGAGATCCAA 
AGATTTGGAG ACGTGATCCC CATGAGTTTG GCCCGCAGAG TCAAAAAGGA CACCAAGTTT 
CGGGATTTCT TCCTCCCTAA GGGCACCGAA GTGTACCCTA TGCTGGGCTC TGTGCTGAGA 
GACCCCAGTT TCTTCTCCAA CCCCCAGGAC TTCAATCCCC AGCACTTCCT GAATGAGAAG 
GGGCAGTTTA AGAAGAGTGA TGCTTTTGTG CCCTTTTCCA TCGGAAAGCG GAACTGTTTC 
GGAGAAGGCC TGGCCAGAAT GGAGCTCTTT CTCTTCTTCA CCACCGTCAT GCAGAACTTC 
CGCCTCAAGT CCTCCCAGTC ACCTAAGGAC ATTGACGTGT CCCCCAAACA CGTGGGCTTT 
GCCACGATCC CACGAAACTA CACCATGAGC TTCCTGCCCC GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000753.3
CDS	22..1506
Translation	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR

Target ORF information:

RefSeq Version	NM_000762.5
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome P450 family 2 subfamily A member 6 (CYP2A6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000762.5

ORF Insert Sequence:

ATGCTGGCCT CAGGGATGCT TCTGGTGGCC TTGCTGGTCT GCCTGACTGT AATGGTCTTG 
ATGTCTGTTT GGCAGCAGAG GAAGAGCAAG GGGAAGCTGC CTCCGGGACC CACCCCATTG 
CCCTTCATTG GAAACTACCT GCAGCTGAAC ACAGAGCAGA TGTACAACTC CCTCATGAAG 
ATCAGTGAGC GCTATGGCCC CGTGTTCACC ATTCACTTGG GGCCCCGGCG GGTCGTGGTG 
CTGTGTGGAC ATGATGCCGT CAGGGAGGCT CTGGTGGACC AGGCTGAGGA GTTCAGCGGG 
CGAGGCGAGC AAGCCACCTT CGACTGGGTC TTCAAAGGCT ATGGCGTGGT ATTCAGCAAC 
GGGGAGCGCG CCAAGCAGCT CCGGCGCTTC TCCATCGCCA CCCTGCGGGA CTTCGGGGTG 
GGCAAGCGAG GCATCGAGGA GCGCATCCAG GAGGAGGCGG GCTTCCTCAT CGACGCCCTC 
CGGGGCACTG GCGGCGCCAA TATCGATCCC ACCTTCTTCC TGAGCCGCAC AGTCTCCAAT 
GTCATCAGCT CCATTGTCTT TGGGGACCGC TTTGACTATA AGGACAAAGA GTTCCTGTCA 
CTGTTGCGCA TGATGCTAGG AATCTTCCAG TTCACGTCAA CCTCCACGGG GCAGCTCTAT 
GAGATGTTCT CTTCGGTGAT GAAACACCTG CCAGGACCAC AGCAACAGGC CTTTCAGTTG 
CTGCAAGGGC TGGAGGACTT CATAGCCAAG AAGGTGGAGC ACAACCAGCG CACGCTGGAT 
CCCAATTCCC CACGGGACTT CATTGACTCC TTTCTCATCC GCATGCAGGA GGAGGAGAAG 
AACCCCAACA CGGAGTTCTA CTTGAAAAAC CTGGTGATGA CCACGTTGAA CCTCTTCATT 
GGGGGCACCG AGACCGTCAG CACCACCCTG CGCTATGGCT TCTTGCTGCT CATGAAGCAC 
CCAGAGGTGG AGGCCAAGGT CCATGAGGAG ATTGACAGAG TGATCGGCAA GAACCGGCAG 
CCCAAGTTTG AGGACCGGGC CAAGATGCCC TACATGGAGG CAGTGATCCA CGAGATCCAA 
AGATTTGGAG ACGTGATCCC CATGAGTTTG GCCCGCAGAG TCAAAAAGGA CACCAAGTTT 
CGGGATTTCT TCCTCCCTAA GGGCACCGAA GTGTACCCTA TGCTGGGCTC TGTGCTGAGA 
GACCCCAGTT TCTTCTCCAA CCCCCAGGAC TTCAATCCCC AGCACTTCCT GAATGAGAAG 
GGGCAGTTTA AGAAGAGTGA TGCTTTTGTG CCCTTTTCCA TCGGAAAGCG GAACTGTTTC 
GGAGAAGGCC TGGCCAGAAT GGAGCTCTTT CTCTTCTTCA CCACCGTCAT GCAGAACTTC 
CGCCTCAAGT CCTCCCAGTC ACCTAAGGAC ATTGACGTGT CCCCCAAACA CGTGGGCTTT 
GCCACGATCC CACGAAACTA CACCATGAGC TTCCTGCCCC GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYP2A6 ( NM_000762.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_000753.3 Homo sapiens cytochrome P450 family 2 subfamily A member 6 (CYP2A6), mRNA.

Price & Availability↑

CloneID	OHu26077
Clone ID Related Accession (Same CDS sequence)	NM_000762.5 , NM_000762.6
Accession Version	NM_000762.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1485bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	cytochrome P450 2A6 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA641580.1, BC096254.1, BC096256.1 and X13897.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000762.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK312964.1, SRR5189664.143627.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000301141.10/ ENSP00000301141.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGGCCT CAGGGATGCT TCTGGTGGCC TTGCTGGTCT GCCTGACTGT AATGGTCTTG 
ATGTCTGTTT GGCAGCAGAG GAAGAGCAAG GGGAAGCTGC CTCCGGGACC CACCCCATTG 
CCCTTCATTG GAAACTACCT GCAGCTGAAC ACAGAGCAGA TGTACAACTC CCTCATGAAG 
ATCAGTGAGC GCTATGGCCC CGTGTTCACC ATTCACTTGG GGCCCCGGCG GGTCGTGGTG 
CTGTGTGGAC ATGATGCCGT CAGGGAGGCT CTGGTGGACC AGGCTGAGGA GTTCAGCGGG 
CGAGGCGAGC AAGCCACCTT CGACTGGGTC TTCAAAGGCT ATGGCGTGGT ATTCAGCAAC 
GGGGAGCGCG CCAAGCAGCT CCGGCGCTTC TCCATCGCCA CCCTGCGGGA CTTCGGGGTG 
GGCAAGCGAG GCATCGAGGA GCGCATCCAG GAGGAGGCGG GCTTCCTCAT CGACGCCCTC 
CGGGGCACTG GCGGCGCCAA TATCGATCCC ACCTTCTTCC TGAGCCGCAC AGTCTCCAAT 
GTCATCAGCT CCATTGTCTT TGGGGACCGC TTTGACTATA AGGACAAAGA GTTCCTGTCA 
CTGTTGCGCA TGATGCTAGG AATCTTCCAG TTCACGTCAA CCTCCACGGG GCAGCTCTAT 
GAGATGTTCT CTTCGGTGAT GAAACACCTG CCAGGACCAC AGCAACAGGC CTTTCAGTTG 
CTGCAAGGGC TGGAGGACTT CATAGCCAAG AAGGTGGAGC ACAACCAGCG CACGCTGGAT 
CCCAATTCCC CACGGGACTT CATTGACTCC TTTCTCATCC GCATGCAGGA GGAGGAGAAG 
AACCCCAACA CGGAGTTCTA CTTGAAAAAC CTGGTGATGA CCACGTTGAA CCTCTTCATT 
GGGGGCACCG AGACCGTCAG CACCACCCTG CGCTATGGCT TCTTGCTGCT CATGAAGCAC 
CCAGAGGTGG AGGCCAAGGT CCATGAGGAG ATTGACAGAG TGATCGGCAA GAACCGGCAG 
CCCAAGTTTG AGGACCGGGC CAAGATGCCC TACATGGAGG CAGTGATCCA CGAGATCCAA 
AGATTTGGAG ACGTGATCCC CATGAGTTTG GCCCGCAGAG TCAAAAAGGA CACCAAGTTT 
CGGGATTTCT TCCTCCCTAA GGGCACCGAA GTGTACCCTA TGCTGGGCTC TGTGCTGAGA 
GACCCCAGTT TCTTCTCCAA CCCCCAGGAC TTCAATCCCC AGCACTTCCT GAATGAGAAG 
GGGCAGTTTA AGAAGAGTGA TGCTTTTGTG CCCTTTTCCA TCGGAAAGCG GAACTGTTTC 
GGAGAAGGCC TGGCCAGAAT GGAGCTCTTT CTCTTCTTCA CCACCGTCAT GCAGAACTTC 
CGCCTCAAGT CCTCCCAGTC ACCTAAGGAC ATTGACGTGT CCCCCAAACA CGTGGGCTTT 
GCCACGATCC CACGAAACTA CACCATGAGC TTCCTGCCCC GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000753.3
CDS	22..1506
Translation	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR

Target ORF information:

RefSeq Version	NM_000762.6
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome P450 family 2 subfamily A member 6 (CYP2A6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000762.6

ORF Insert Sequence:

ATGCTGGCCT CAGGGATGCT TCTGGTGGCC TTGCTGGTCT GCCTGACTGT AATGGTCTTG 
ATGTCTGTTT GGCAGCAGAG GAAGAGCAAG GGGAAGCTGC CTCCGGGACC CACCCCATTG 
CCCTTCATTG GAAACTACCT GCAGCTGAAC ACAGAGCAGA TGTACAACTC CCTCATGAAG 
ATCAGTGAGC GCTATGGCCC CGTGTTCACC ATTCACTTGG GGCCCCGGCG GGTCGTGGTG 
CTGTGTGGAC ATGATGCCGT CAGGGAGGCT CTGGTGGACC AGGCTGAGGA GTTCAGCGGG 
CGAGGCGAGC AAGCCACCTT CGACTGGGTC TTCAAAGGCT ATGGCGTGGT ATTCAGCAAC 
GGGGAGCGCG CCAAGCAGCT CCGGCGCTTC TCCATCGCCA CCCTGCGGGA CTTCGGGGTG 
GGCAAGCGAG GCATCGAGGA GCGCATCCAG GAGGAGGCGG GCTTCCTCAT CGACGCCCTC 
CGGGGCACTG GCGGCGCCAA TATCGATCCC ACCTTCTTCC TGAGCCGCAC AGTCTCCAAT 
GTCATCAGCT CCATTGTCTT TGGGGACCGC TTTGACTATA AGGACAAAGA GTTCCTGTCA 
CTGTTGCGCA TGATGCTAGG AATCTTCCAG TTCACGTCAA CCTCCACGGG GCAGCTCTAT 
GAGATGTTCT CTTCGGTGAT GAAACACCTG CCAGGACCAC AGCAACAGGC CTTTCAGTTG 
CTGCAAGGGC TGGAGGACTT CATAGCCAAG AAGGTGGAGC ACAACCAGCG CACGCTGGAT 
CCCAATTCCC CACGGGACTT CATTGACTCC TTTCTCATCC GCATGCAGGA GGAGGAGAAG 
AACCCCAACA CGGAGTTCTA CTTGAAAAAC CTGGTGATGA CCACGTTGAA CCTCTTCATT 
GGGGGCACCG AGACCGTCAG CACCACCCTG CGCTATGGCT TCTTGCTGCT CATGAAGCAC 
CCAGAGGTGG AGGCCAAGGT CCATGAGGAG ATTGACAGAG TGATCGGCAA GAACCGGCAG 
CCCAAGTTTG AGGACCGGGC CAAGATGCCC TACATGGAGG CAGTGATCCA CGAGATCCAA 
AGATTTGGAG ACGTGATCCC CATGAGTTTG GCCCGCAGAG TCAAAAAGGA CACCAAGTTT 
CGGGATTTCT TCCTCCCTAA GGGCACCGAA GTGTACCCTA TGCTGGGCTC TGTGCTGAGA 
GACCCCAGTT TCTTCTCCAA CCCCCAGGAC TTCAATCCCC AGCACTTCCT GAATGAGAAG 
GGGCAGTTTA AGAAGAGTGA TGCTTTTGTG CCCTTTTCCA TCGGAAAGCG GAACTGTTTC 
GGAGAAGGCC TGGCCAGAAT GGAGCTCTTT CTCTTCTTCA CCACCGTCAT GCAGAACTTC 
CGCCTCAAGT CCTCCCAGTC ACCTAAGGAC ATTGACGTGT CCCCCAAACA CGTGGGCTTT 
GCCACGATCC CACGAAACTA CACCATGAGC TTCCTGCCCC GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences.
Addiction (Abingdon, England)(2017 Sep)
Chenoweth MJ,Ware JJ,Zhu AZX,Cole CB,Cox LS,Nollen N,Ahluwalia JS,Benowitz NL,Schnoll RA,Hawk LW Jr,Cinciripini PM,George TP,Lerman C,Knight J,Tyndale RF,

Race/Ethnicity and the Pharmacogenetics of Reported Suicidality With Efavirenz Among Clinical Trials Participants.
The Journal of infectious diseases216(5)554-564(2017 Sep)
Mollan KR,Tierney C,Hellwege JN,Eron JJ,Hudgens MG,Gulick RM,Haubrich R,Sax PE,Campbell TB,Daar ES,Robertson KR,Ventura D,Ma Q,Edwards DRV,Haas DW,

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

CYP2A6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報