KHDC3L cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KHDC3L
Entrez Gene ID	154288
Full Name	KH domain containing 3 like, subcortical maternal complex member
Synonyms	C6orf221,ECAT1,HYDM2
General protein information	Preferred Names KH domain containing 3 like, subcortical maternal complex member Names KHDC3-like protein ES cell-associated transcript 1 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q13
Summary	The protein encoded by this gene belongs to the KHDC1 family, members of which contain an atypical KH domain that may not bind RNA like canonical KH domains. This gene is specifically expressed in the oocytes, and recent studies suggest that it may function as a regulator of genomic imprinting in the oocyte. Mutations in this gene are associated with recurrent biparental complete hydatidiform mole. [provided by RefSeq, Dec 2011].
Disorder MIM:	611687
Disorder Html:	Hydatidiform mole, recurrent, 2, 614293 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001017361.3	NP_001017361.1	KHDC3-like protein
NM_001017361.2	NP_001017361.1	KHDC3-like protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	KHDC3L	NP_001230792.1
	LOC715808	XP_001112378.1
Homo sapiens (human)	KHDC3L	NP_001017361.1
Mus musculus (house mouse)	Khdc3	NP_080166.1
Rattus norvegicus (Norway rat)	Khdc3	NP_001100307.1
Canis lupus familiaris (dog)	LOC481879	XP_539000.3
Bos taurus (cattle)	KHDC3L	XP_002690064.2

Gene Ontology
Bibliography

Related articles in PubMed

ECAT1 is essential for human oocyte maturation and pre-implantation development of the resulting embryos.
Liu C, Li M, Li T, Zhao H, Huang J, Wang Y, Gao Q, Yu Y, Shi Q
Scientific reports638192(2016 Dec)

TLE6 mutation causes the earliest known human embryonic lethality.
Alazami AM, Awad SM, Coskun S, Al-Hassan S, Hijazi H, Abdulwahab FM, Poizat C, Alkuraya FS
Genome biology16240(2015 Nov)

No evidence for mutations in NLRP7, NLRP2 or KHDC3L in women with unexplained recurrent pregnancy loss or infertility.
Aghajanova L, Mahadevan S, Altm?e S, Stavreus-Evers A, Regan L, Sebire N, Dixon P, Fisher RA, Van den Veyver IB
Human reproduction (Oxford, England)30(1)232-8(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NLRP7 and KHDC3L localize to the cytoskeleton and are predominant at the cortical region in growing oocytes.
Title: NLRP7 and KHDC3L, the two maternal-effect proteins responsible for recurrent hydatidiform moles, co-localize to the oocyte cytoskeleton.

No disease-causing mutations were identified in NLRP2, NLRP7 and KHDC3L in cohorts of unexplained infertility and recurrent pregnancy loss.
Title: No evidence for mutations in NLRP7, NLRP2 or KHDC3L in women with unexplained recurrent pregnancy loss or infertility.

The absence of mutations in women with Androgenetic complete hydatidiform moles supports a role for NLRP7 or KHDC3L in Biparental hydatidiform moles only.
Title: No evidence for mutations in NLRP7 and KHDC3L in women with androgenetic hydatidiform moles.

Investigation of the association between molar pregnancy and recurrent miscarriages regarding changes in the NLRP7 and C6orf221/KHDC3L genes.
Title: NLRP7 or KHDC3L genes and the etiology of molar pregnancies and recurrent miscarriage.

Data indicate there was no KHDC3L mutation found in recurrent and sporadic hydatidiform moles Chinese patients.
Title: Absence of KHDC3L mutations in Chinese patients with recurrent and sporadic hydatidiform moles.

The following KHDC3L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KHDC3L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18544	NM_001017361.3 Latest version!	Homo sapiens KH domain containing 3 like, subcortical maternal complex member (KHDC3L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18544	NM_001017361.2	Homo sapiens KH domain containing 3 like, subcortical maternal complex member (KHDC3L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KHDC3L ( NM_001017361.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001017361.1 Homo sapiens KH domain containing 3 like, subcortical maternal complex member (KHDC3L), mRNA.

Price & Availability↑

CloneID	OHu18544
Clone ID Related Accession (Same CDS sequence)	NM_001017361.3 , NM_001017361.2
Accession Version	NM_001017361.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Homo sapiens(human)
Product	KHDC3-like protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC019205.4, AB211062.1 and AI638315.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001017361.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB211062.1, BC132844.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370367.4/ ENSP00000359392.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACGCTC CCAGGCGGTT TCCGACGCTC GTGCAACTGA TGCAGCCAAA AGCAATGCCA 
GTGGAGGTGC TCGGTCACCT CCCTAAGCGG TTCTCCTGGT TCCACTCTGA GTTCCTGAAG 
AATCCGAAGG TAGTTCGCCT TGAGGTTTGG CTGGTGGAAA AGATCTTCGG CCGGGGCGGA 
GAACGCATCC CGCACGTCCA GGGTATGTCC CAAATCTTGA TTCACGTGAA TCGATTGGAC 
CCTAACGGCG AGGCTGAGAT CTTGGTATTT GGGAGGCCTT CTTACCAGGA GGACACAATC 
AAGATGATCA TGAACCTGGC TGACTATCAC CGCCAGCTCC AGGCGAAAGG CTCAGGAAAG 
GCCCTCGCCC AGGATGTCGC CACTCAGAAG GCCGAGACCC AGCGGTCTTC AATAGAAGTC 
CGGGAGGCCG GGACGCAGCG TTCGGTGGAG GTCCGGGAGG CCGGGACCCA GCGTTCGGTG 
GAAGTCCAGG AGGTCGGGAC ACAGGGTTCT CCGGTGGAGG TGCAGGAGGC CGGGACCCAG 
CAGTCTCTCC AGGCTGCCAA CAAGTCGGGG ACCCAGCGAT CCCCCGAAGC TGCCAGCAAG 
GCAGTGACCC AGCGGTTTCG CGAGGATGCC CGGGACCCAG TTACTAGATT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017361.1
CDS	73..726
Translation	MDAPRRFPTLVQLMQPKAMPVEVLGHLPKRFSWFHSEFLKNPKVVRLEVWLVEKIFGRGGERIPHVQGMSQILIHVNRLDPNGEAEILVFGRPSYQEDTIKMIMNLADYHRQLQAKGSGKALAQDVATQKAETQRSSIEVREAGTQRSVEVREAGTQRSVEVQEVGTQGSPVEVQEAGTQQSLQAANKSGTQRSPEAASKAVTQRFREDARDPVTRL

Target ORF information:

RefSeq Version	NM_001017361.3
Organism	Homo sapiens(human)
Definition	Homo sapiens KH domain containing 3 like, subcortical maternal complex member (KHDC3L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017361.3

ORF Insert Sequence:

ATGGACGCTC CCAGGCGGTT TCCGACGCTC GTGCAACTGA TGCAGCCAAA AGCAATGCCA 
GTGGAGGTGC TCGGTCACCT CCCTAAGCGG TTCTCCTGGT TCCACTCTGA GTTCCTGAAG 
AATCCGAAGG TAGTTCGCCT TGAGGTTTGG CTGGTGGAAA AGATCTTCGG CCGGGGCGGA 
GAACGCATCC CGCACGTCCA GGGTATGTCC CAAATCTTGA TTCACGTGAA TCGATTGGAC 
CCTAACGGCG AGGCTGAGAT CTTGGTATTT GGGAGGCCTT CTTACCAGGA GGACACAATC 
AAGATGATCA TGAACCTGGC TGACTATCAC CGCCAGCTCC AGGCGAAAGG CTCAGGAAAG 
GCCCTCGCCC AGGATGTCGC CACTCAGAAG GCCGAGACCC AGCGGTCTTC AATAGAAGTC 
CGGGAGGCCG GGACGCAGCG TTCGGTGGAG GTCCGGGAGG CCGGGACCCA GCGTTCGGTG 
GAAGTCCAGG AGGTCGGGAC ACAGGGTTCT CCGGTGGAGG TGCAGGAGGC CGGGACCCAG 
CAGTCTCTCC AGGCTGCCAA CAAGTCGGGG ACCCAGCGAT CCCCCGAAGC TGCCAGCAAG 
GCAGTGACCC AGCGGTTTCG CGAGGATGCC CGGGACCCAG TTACTAGATT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KHDC3L ( NM_001017361.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001017361.1 Homo sapiens KH domain containing 3 like, subcortical maternal complex member (KHDC3L), mRNA.

Price & Availability↑

CloneID	OHu18544
Clone ID Related Accession (Same CDS sequence)	NM_001017361.3 , NM_001017361.2
Accession Version	NM_001017361.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	KHDC3-like protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB211062.1 and AI638315.1. This sequence is a reference standard in the RefSeqGene project. On Jan 12, 2008 this sequence version replaced NM_001017361.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB211062.1, BC132844.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGCTC CCAGGCGGTT TCCGACGCTC GTGCAACTGA TGCAGCCAAA AGCAATGCCA 
GTGGAGGTGC TCGGTCACCT CCCTAAGCGG TTCTCCTGGT TCCACTCTGA GTTCCTGAAG 
AATCCGAAGG TAGTTCGCCT TGAGGTTTGG CTGGTGGAAA AGATCTTCGG CCGGGGCGGA 
GAACGCATCC CGCACGTCCA GGGTATGTCC CAAATCTTGA TTCACGTGAA TCGATTGGAC 
CCTAACGGCG AGGCTGAGAT CTTGGTATTT GGGAGGCCTT CTTACCAGGA GGACACAATC 
AAGATGATCA TGAACCTGGC TGACTATCAC CGCCAGCTCC AGGCGAAAGG CTCAGGAAAG 
GCCCTCGCCC AGGATGTCGC CACTCAGAAG GCCGAGACCC AGCGGTCTTC AATAGAAGTC 
CGGGAGGCCG GGACGCAGCG TTCGGTGGAG GTCCGGGAGG CCGGGACCCA GCGTTCGGTG 
GAAGTCCAGG AGGTCGGGAC ACAGGGTTCT CCGGTGGAGG TGCAGGAGGC CGGGACCCAG 
CAGTCTCTCC AGGCTGCCAA CAAGTCGGGG ACCCAGCGAT CCCCCGAAGC TGCCAGCAAG 
GCAGTGACCC AGCGGTTTCG CGAGGATGCC CGGGACCCAG TTACTAGATT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017361.1
CDS	54..707
Translation	MDAPRRFPTLVQLMQPKAMPVEVLGHLPKRFSWFHSEFLKNPKVVRLEVWLVEKIFGRGGERIPHVQGMSQILIHVNRLDPNGEAEILVFGRPSYQEDTIKMIMNLADYHRQLQAKGSGKALAQDVATQKAETQRSSIEVREAGTQRSVEVREAGTQRSVEVQEVGTQGSPVEVQEAGTQQSLQAANKSGTQRSPEAASKAVTQRFREDARDPVTRL

Target ORF information:

RefSeq Version	NM_001017361.2
Organism	Homo sapiens(human)
Definition	Homo sapiens KH domain containing 3 like, subcortical maternal complex member (KHDC3L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017361.2

ORF Insert Sequence:

ATGGACGCTC CCAGGCGGTT TCCGACGCTC GTGCAACTGA TGCAGCCAAA AGCAATGCCA 
GTGGAGGTGC TCGGTCACCT CCCTAAGCGG TTCTCCTGGT TCCACTCTGA GTTCCTGAAG 
AATCCGAAGG TAGTTCGCCT TGAGGTTTGG CTGGTGGAAA AGATCTTCGG CCGGGGCGGA 
GAACGCATCC CGCACGTCCA GGGTATGTCC CAAATCTTGA TTCACGTGAA TCGATTGGAC 
CCTAACGGCG AGGCTGAGAT CTTGGTATTT GGGAGGCCTT CTTACCAGGA GGACACAATC 
AAGATGATCA TGAACCTGGC TGACTATCAC CGCCAGCTCC AGGCGAAAGG CTCAGGAAAG 
GCCCTCGCCC AGGATGTCGC CACTCAGAAG GCCGAGACCC AGCGGTCTTC AATAGAAGTC 
CGGGAGGCCG GGACGCAGCG TTCGGTGGAG GTCCGGGAGG CCGGGACCCA GCGTTCGGTG 
GAAGTCCAGG AGGTCGGGAC ACAGGGTTCT CCGGTGGAGG TGCAGGAGGC CGGGACCCAG 
CAGTCTCTCC AGGCTGCCAA CAAGTCGGGG ACCCAGCGAT CCCCCGAAGC TGCCAGCAAG 
GCAGTGACCC AGCGGTTTCG CGAGGATGCC CGGGACCCAG TTACTAGATT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ECAT1 is essential for human oocyte maturation and pre-implantation development of the resulting embryos.
Scientific reports638192(2016 Dec)
Liu C,Li M,Li T,Zhao H,Huang J,Wang Y,Gao Q,Yu Y,Shi Q

TLE6 mutation causes the earliest known human embryonic lethality.
Genome biology16240(2015 Nov)
Alazami AM,Awad SM,Coskun S,Al-Hassan S,Hijazi H,Abdulwahab FM,Poizat C,Alkuraya FS

No evidence for mutations in NLRP7, NLRP2 or KHDC3L in women with unexplained recurrent pregnancy loss or infertility.
Human reproduction (Oxford, England)30(1)232-8(2015 Jan)
Aghajanova L,Mahadevan S,Altm?e S,Stavreus-Evers A,Regan L,Sebire N,Dixon P,Fisher RA,Van den Veyver IB

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KHDC3L cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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