HUS1B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HUS1B
Entrez Gene ID	135458
Full Name	HUS1 checkpoint clamp component B
General protein information	Preferred Names HUS1 checkpoint clamp component B Names checkpoint protein HUS1B HUS1 checkpoint homolog b hHUS1B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p25.3
Summary	The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008]. COMPLETENESS: complete on the 3' end.
Disorder MIM:	609713

mRNA and Protein(s)

mRNA	Protein	Name
NM_148959.3	NP_683762.2	checkpoint protein HUS1B

Pathways from BioSystems

Homologies

	LOC706408	XP_001089517.1
Homo sapiens (human)	HUS1B	NP_683762.2
Pan troglodytes (chimpanzee)	HUS1B	XP_001158954.1
Mus musculus (house mouse)	Hus1b	NP_694712.1

Gene Ontology
Bibliography

Related articles in PubMed

The HUS1B promoter is hypomethylated in the placentas of low-birth-weight infants.
Rumbajan JM, Yamaguchi Y, Nakabayashi K, Higashimoto K, Yatsuki H, Nishioka K, Matsuoka K, Aoki S, Toda S, Takeda S, Seki H, Hatada I, Hata K, Soejima H, Joh K
Gene583(2)141-6(2016 Jun)

Clamping down on mammalian meiosis.
Lyndaker AM, Vasileva A, Wolgemuth DJ, Weiss RS, Lieberman HB
Cell cycle (Georgetown, Tex.)12(19)3135-45(2013 Oct)

Linkage and association of successful aging to the 6q25 region in large Amish kindreds.
Edwards DR, Gilbert JR, Hicks JE, Myers JL, Jiang L, Cummings AC, Guo S, Gallins PJ, Konidari I, Caywood L, Reinhart-Mercer L, Fuzzell D, Knebusch C, Laux R, Jackson CE, Pericak-Vance MA, Haines JL, Scott WK
Age (Dordrecht, Netherlands)35(4)1467-77(2013 Aug)

A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis31(7)1259-63(2010 Jul)

Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene.
Dufault VM, Oestreich AJ, Vroman BT, Karnitz LM
Genomics82(6)644-51(2003 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The HUS1B promoter is hypomethylated in the placentas of low-birth-weight infants.
Title: The HUS1B promoter is hypomethylated in the placentas of low-birth-weight infants.

Observational study of gene-disease association. (HuGE Navigator)
Title: A Large-scale genetic association study of esophageal adenocarcinoma risk.

HUS1B directly interacts with RAD1, but not RAD9 or HUS1, whereas HUS1 can bind RAD1, RAD9, and another molecule of HUS1, suggesting that HUS1B cannot simply substitute for HUS1 in the complex.
Title: Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1.

The following HUS1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HUS1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu31052	NM_148959.3 Latest version!	Homo sapiens HUS1 checkpoint clamp component B (HUS1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HUS1B ( NM_148959.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_683762.2 Homo sapiens HUS1 checkpoint clamp component B (HUS1B), mRNA.

Price & Availability↑

CloneID	OHu31052
Clone ID Related Accession (Same CDS sequence)	NM_148959.3
Accession Version	NM_148959.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 837bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	checkpoint protein HUS1B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC101699.1 and AL357054.14. On Nov 25, 2005 this sequence version replaced NM_148959.2. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGTTTC GCGCCAAGAT CACCGGCAAA GGCTGTCTAG AGCTGTTCAT TCACGTCAGC 
GGCACCGTCG CGAGGCTAGC GAAGGTCTGC GTGCTCCGCG TGCGCCCTGA CAGCCTGTGC 
TTCGGCCCCG CGGGTTCCGG CGGCCTCCAC GAGGCCAGGC TGTGGTGCGA GGTGCGGCAG 
GGGGCCTTCC AGCAGTTTCG CATGGAAGGT GTCTCGGAAG ATCTCGATGA GATCCACCTG 
GAGCTGACGG CGGAGCACCT GTCCCGGGCG GCGAGAAGCG CAGCGGGCGC GTCCTCCCTG 
AAGCTGCAGC TGACCCACAA GCGCCGCCCC TCCCTCACGG TGGCGGTGGA GCTGGTCTCG 
TCCCTGGGCC GCGCTCGCAG CGTGGTGCAC GATCTGCCCG TGCGGGTGCT TCCCAGGAGA 
GTGTGGCGGG ACTGCCTGCC GCCCAGCCTG CGCGCCTCCG ACGCGAGCAT CCGCCTGCCG 
CGCTGGAGGA CGCTGAGGAG CATCGTGGAG AGGATGGCGA ACGTGGGCAG TCACGTGCTG 
GTGGAAGCAA ACCTCAGTGG CAGGATGACC CTGAGTATAG AGACGGAGGT GGTGTCCATT 
CAAAGTTATT TTAAAAATCT TGGAAACCCT CCCCAGTCGG CTGTGGGTGT GCCTGAAAAC 
AGAGACCTGG AGAGCATGGT GCAAGTGCGG GTGGACAATC GGAAGCTTCT GCAGTTTTTG 
GAGGGACAGC AAATACATCC TACGACGGCC CTGTGCAATA TTTGGGACAA TACTCTTCTT 
CAGCTTGTTT TGGTTCAAGA AGATGTCTCT CTTCAGTATT TCATTCCTGC CTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_683762.2
CDS	21..857
Translation	MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCFGPAGSGGLHEARLWCEVRQGAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASSLKLQLTHKRRPSLTVAVELVSSLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVERMANVGSHVLVEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKLLQFLEGQQIHPTTALCNIWDNTLLQLVLVQEDVSLQYFIPAL

Target ORF information:

RefSeq Version	NM_148959.3
Organism	Homo sapiens(human)
Definition	Homo sapiens HUS1 checkpoint clamp component B (HUS1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_148959.3

ORF Insert Sequence:

ATGAAGTTTC GCGCCAAGAT CACCGGCAAA GGCTGTCTAG AGCTGTTCAT TCACGTCAGC 
GGCACCGTCG CGAGGCTAGC GAAGGTCTGC GTGCTCCGCG TGCGCCCTGA CAGCCTGTGC 
TTCGGCCCCG CGGGTTCCGG CGGCCTCCAC GAGGCCAGGC TGTGGTGCGA GGTGCGGCAG 
GGGGCCTTCC AGCAGTTTCG CATGGAAGGT GTCTCGGAAG ATCTCGATGA GATCCACCTG 
GAGCTGACGG CGGAGCACCT GTCCCGGGCG GCGAGAAGCG CAGCGGGCGC GTCCTCCCTG 
AAGCTGCAGC TGACCCACAA GCGCCGCCCC TCCCTCACGG TGGCGGTGGA GCTGGTCTCG 
TCCCTGGGCC GCGCTCGCAG CGTGGTGCAC GATCTGCCCG TGCGGGTGCT TCCCAGGAGA 
GTGTGGCGGG ACTGCCTGCC GCCCAGCCTG CGCGCCTCCG ACGCGAGCAT CCGCCTGCCG 
CGCTGGAGGA CGCTGAGGAG CATCGTGGAG AGGATGGCGA ACGTGGGCAG TCACGTGCTG 
GTGGAAGCAA ACCTCAGTGG CAGGATGACC CTGAGTATAG AGACGGAGGT GGTGTCCATT 
CAAAGTTATT TTAAAAATCT TGGAAACCCT CCCCAGTCGG CTGTGGGTGT GCCTGAAAAC 
AGAGACCTGG AGAGCATGGT GCAAGTGCGG GTGGACAATC GGAAGCTTCT GCAGTTTTTG 
GAGGGACAGC AAATACATCC TACGACGGCC CTGTGCAATA TTTGGGACAA TACTCTTCTT 
CAGCTTGTTT TGGTTCAAGA AGATGTCTCT CTTCAGTATT TCATTCCTGC CTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The HUS1B promoter is hypomethylated in the placentas of low-birth-weight infants.
Gene583(2)141-6(2016 Jun)
Rumbajan JM,Yamaguchi Y,Nakabayashi K,Higashimoto K,Yatsuki H,Nishioka K,Matsuoka K,Aoki S,Toda S,Takeda S,Seki H,Hatada I,Hata K,Soejima H,Joh K

Clamping down on mammalian meiosis.
Cell cycle (Georgetown, Tex.)12(19)3135-45(2013 Oct)
Lyndaker AM,Vasileva A,Wolgemuth DJ,Weiss RS,Lieberman HB

Linkage and association of successful aging to the 6q25 region in large Amish kindreds.
Age (Dordrecht, Netherlands)35(4)1467-77(2013 Aug)
Edwards DR,Gilbert JR,Hicks JE,Myers JL,Jiang L,Cummings AC,Guo S,Gallins PJ,Konidari I,Caywood L,Reinhart-Mercer L,Fuzzell D,Knebusch C,Laux R,Jackson CE,Pericak-Vance MA,Haines JL,Scott WK

A Large-scale genetic association study of esophageal adenocarcinoma risk.
Carcinogenesis31(7)1259-63(2010 Jul)
Liu CY,Wu MC,Chen F,Ter-Minassian M,Asomaning K,Zhai R,Wang Z,Su L,Heist RS,Kulke MH,Lin X,Liu G,Christiani DC

Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene.
Genomics82(6)644-51(2003 Dec)
Dufault VM,Oestreich AJ,Vroman BT,Karnitz LM

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HUS1B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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