COX10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COX10
Entrez Gene ID	1352
Full Name	COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor
General protein information	Preferred Names COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor Names protoheme IX farnesyltransferase, mitochondrial COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase cytochrome c oxidase assembly homolog 10 cytochrome c oxidase assembly protein cytochrome c oxidase subunit X heme A: farnesyltransferase heme O synthase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p12
Summary	Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008].
Disorder MIM:	602125
Disorder Html:	Mitochondrial complex IV deficiency, 220110 (3); Leigh syndrome due to mitochondrial COX4 deficiency, 256000 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001303.3	NP_001294.2	protoheme IX farnesyltransferase, mitochondrial
NM_001303.4	NP_001294.2	protoheme IX farnesyltransferase, mitochondrial

Pathways from BioSystems

Homologies

	COX10	XP_001114525.1
Rattus norvegicus (Norway rat)	LOC691853	XP_006246895.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008884	XP_319631.4
Pan troglodytes (chimpanzee)	COX10	XP_520888.2
Mus musculus (house mouse)	Cox10	NP_848466.1
Danio rerio (zebrafish)	cox10	NP_001159731.1
Caenorhabditis elegans (roundworm)	CELE_Y46G5A.2	NP_496708.2
Homo sapiens (human)	COX10	NP_001294.2
Canis lupus familiaris (dog)	COX10	XP_546634.3
Gallus gallus (chicken)	COX10	NP_001025871.1
Bos taurus (cattle)	COX10	NP_001091482.1
Drosophila melanogaster (fruit fly)	CG5037	NP_609382.1
Xenopus tropicalis (tropical clawed frog)	cox10	NP_001120053.1

Gene Ontology
Bibliography

Related articles in PubMed

Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6.
Sch?ll S, G?nther SD, Brodesser S, Seeger JM, Tosetti B, Wiegmann K, Pongratz C, Diaz F, Witt A, Andree M, Brinkmann K, Kr?nke M, Wiesner RJ, Kashkar H
Cell death & disease6e1691(2015 Mar)

A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
Service SK, Verweij KJ, Lahti J, Congdon E, Ekelund J, Hintsanen M, R?ikk?nen K, Lehtim?ki T, K?h?nen M, Widen E, Taanila A, Veijola J, Heath AC, Madden PA, Montgomery GW, Sabatti C, J?rvelin MR, Palotie A, Raitakari O, Viikari J, Martin NG, Eriksson JG, Keltikangas-J?rvinen L, Wray NR, Freimer NB
Translational psychiatry2e116(2012 May)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression.
Chen Z, Li Y, Zhang H, Huang P, Luthra R
Oncogene29(30)4362-8(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

On the basis of its pivotal role in regulating cell death upon COX dysfunction, CerS6 might potentially represent a novel target for therapeutic intervention in mitochondrial diseases caused by COX dysfunction.
Title: Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

ISCU and COX10 are target genes of miR-210 related to mitochondrial metabolism
Title: Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression.

Observational study of gene-disease association. (HuGE Navigator)
Title: Analysis of the genes coding for subunit 10 and 15 of cytochrome c oxidase in Alzheimer's disease.

The expression of the AOX, well-tolerated by the cells, compensates for both the growth defect and the pronounced oxidant-sensitivity of COX-deficient human cells.
Title: Expression of the alternative oxidase complements cytochrome c oxidase deficiency in human cells.

The following COX10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19382	NM_001303.4 Latest version!	Homo sapiens cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 (COX10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu19382	NM_001303.3	Homo sapiens COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor (COX10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COX10 ( NM_001303.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001294.2 Homo sapiens COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor (COX10), mRNA.

Price & Availability↑

CloneID	OHu19382
Clone ID Related Accession (Same CDS sequence)	NM_001303.3 , NM_001303.4
Accession Version	NM_001303.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1332bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	protoheme IX farnesyltransferase, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005389.1, AK312718.1, BC000060.2, DA200545.1, U09466.1 and BQ184586.1. This sequence is a reference standard in the RefSeqGene project. On Apr 10, 2008 this sequence version replaced NM_001303.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.132565.1, SRR1660803.262075.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGCAT CTCCGCACAC TCTCTCCTCA CGCCTCCTGA CAGGTTGCGT AGGAGGCTCT 
GTCTGGTATC TTGAAAGAAG AACTATACAG GACTCCCCTC ACAAGTTCTT ACATCTTCTC 
AGGAATGTCA ATAAGCAGTG GATTACATTT CAGCACTTTA GCTTCCTCAA ACGCATGTAT 
GTCACACAGC TGAACAGAAG CCACAACCAG CAAGTAAGAC CCAAGCCAGA ACCAGTAGCA 
TCTCCTTTCC TTGAAAAAAC ATCTTCAGGT CAAGCCAAAG CAGAAATATA TGAGATGAGA 
CCTCTCTCAC CGCCCAGCCT ATCTTTGTCC AGAAAGCCAA ATGAAAAGGA ATTGATAGAA 
CTAGAGCCAG ACTCAGTAAT TGAAGACTCA ATAGATGTAG GGAAAGAGAC AAAAGAGGAA 
AAGCGGTGGA AAGAGATGAA GCTGCAAGTG TATGATTTGC CAGGAATTTT GGCTCGACTA 
TCCAAAATCA AACTCACAGC TCTGGTTGTA AGTACCACTG CAGCTGGATT TGCATTGGCT 
CCGGGCCCTT TTGACTGGCC CTGTTTCCTG CTTACTTCTG TTGGGACAGG CCTTGCATCC 
TGTGCTGCCA ACTCCATCAA TCAGTTTTTT GAGGTGCCAT TTGACTCAAA CATGAATAGG 
ACAAAGAACA GACCGCTGGT TCGTGGACAG ATCAGCCCAT TGCTAGCTGT GTCCTTTGCC 
ACTTGTTGTG CTGTTCCGGG AGTTGCCATT CTGACCTTGG GGGTGAATCC ACTCACAGGA 
GCCCTGGGGC TCTTCAACAT TTTCCTGTAT ACCTGCTGCT ACACACCACT GAAAAGGATC 
AGCATTGCCA ACACATGGGT CGGAGCTGTG GTTGGGGCCA TCCCGCCTGT CATGGGCTGG 
ACAGCGGCCA CGGGCAGCCT CGATGCTGGC GCATTTCTCC TGGGAGGAAT CCTCTACTCC 
TGGCAGTTTC CTCATTTCAA CGCCCTGAGC TGGGGCCTCC GTGAAGACTA CTCCCGGGGC 
GGCTACTGCA TGATGTCGGT CACCCACCCG GGCCTGTGCC GGCGCGTGGC GCTGCGCCAC 
TGCCTGGCCC TGCTCGTGCT GTCCGCAGCA GCCCCTGTGC TGGACATCAC CACATGGACC 
TTCCCCATCA TGGCCCTTCC CATCAATGCG TACATCTCCT ACCTCGGCTT CCGCTTCTAC 
GTGGACGCAG ACCGCAGGAG CTCGCGGAGA CTGTTCTTCT GCAGCCTGTG GCACCTGCCG 
CTGCTGCTGC TGCTCATGCT CACCTGCAAG CGGCCGAGCG GAGGCGGGGA CGCAGGGCCC 
CCTCCCAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001294.2
CDS	205..1536
Translation	MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITFQHFSFLKRMYVTQLNRSHNQQVRPKPEPVASPFLEKTSSGQAKAEIYEMRPLSPPSLSLSRKPNEKELIELEPDSVIEDSIDVGKETKEEKRWKEMKLQVYDLPGILARLSKIKLTALVVSTTAAGFALAPGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLLLMLTCKRPSGGGDAGPPPS

Target ORF information:

RefSeq Version	NM_001303.3
Organism	Homo sapiens(human)
Definition	Homo sapiens COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor (COX10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303.3

ORF Insert Sequence:

ATGGCCGCAT CTCCGCACAC TCTCTCCTCA CGCCTCCTGA CAGGTTGCGT AGGAGGCTCT 
GTCTGGTATC TTGAAAGAAG AACTATACAG GACTCCCCTC ACAAGTTCTT ACATCTTCTC 
AGGAATGTCA ATAAGCAGTG GATTACATTT CAGCACTTTA GCTTCCTCAA ACGCATGTAT 
GTCACACAGC TGAACAGAAG CCACAACCAG CAAGTAAGAC CCAAGCCAGA ACCAGTAGCA 
TCTCCTTTCC TTGAAAAAAC ATCTTCAGGT CAAGCCAAAG CAGAAATATA TGAGATGAGA 
CCTCTCTCAC CGCCCAGCCT ATCTTTGTCC AGAAAGCCAA ATGAAAAGGA ATTGATAGAA 
CTAGAGCCAG ACTCAGTAAT TGAAGACTCA ATAGATGTAG GGAAAGAGAC AAAAGAGGAA 
AAGCGGTGGA AAGAGATGAA GCTGCAAGTG TATGATTTGC CAGGAATTTT GGCTCGACTA 
TCCAAAATCA AACTCACAGC TCTGGTTGTA AGTACCACTG CAGCTGGATT TGCATTGGCT 
CCGGGCCCTT TTGACTGGCC CTGTTTCCTG CTTACTTCTG TTGGGACAGG CCTTGCATCC 
TGTGCTGCCA ACTCCATCAA TCAGTTTTTT GAGGTGCCAT TTGACTCAAA CATGAATAGG 
ACAAAGAACA GACCGCTGGT TCGTGGACAG ATCAGCCCAT TGCTAGCTGT GTCCTTTGCC 
ACTTGTTGTG CTGTTCCGGG AGTTGCCATT CTGACCTTGG GGGTGAATCC ACTCACAGGA 
GCCCTGGGGC TCTTCAACAT TTTCCTGTAT ACCTGCTGCT ACACACCACT GAAAAGGATC 
AGCATTGCCA ACACATGGGT CGGAGCTGTG GTTGGGGCCA TCCCGCCTGT CATGGGCTGG 
ACAGCGGCCA CGGGCAGCCT CGATGCTGGC GCATTTCTCC TGGGAGGAAT CCTCTACTCC 
TGGCAGTTTC CTCATTTCAA CGCCCTGAGC TGGGGCCTCC GTGAAGACTA CTCCCGGGGC 
GGCTACTGCA TGATGTCGGT CACCCACCCG GGCCTGTGCC GGCGCGTGGC GCTGCGCCAC 
TGCCTGGCCC TGCTCGTGCT GTCCGCAGCA GCCCCTGTGC TGGACATCAC CACATGGACC 
TTCCCCATCA TGGCCCTTCC CATCAATGCG TACATCTCCT ACCTCGGCTT CCGCTTCTAC 
GTGGACGCAG ACCGCAGGAG CTCGCGGAGA CTGTTCTTCT GCAGCCTGTG GCACCTGCCG 
CTGCTGCTGC TGCTCATGCT CACCTGCAAG CGGCCGAGCG GAGGCGGGGA CGCAGGGCCC 
CCTCCCAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX10 ( NM_001303.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001294.2 Homo sapiens cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 (COX10), mRNA.

Price & Availability↑

CloneID	OHu19382
Clone ID Related Accession (Same CDS sequence)	NM_001303.3 , NM_001303.4
Accession Version	NM_001303.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1332bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	protoheme IX farnesyltransferase, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005389.1, AK312718.1, BC000060.2, DA200545.1 and U09466.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001303.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.262075.1, SRR1803611.231070.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000261643.8/ ENSP00000261643.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGCAT CTCCGCACAC TCTCTCCTCA CGCCTCCTGA CAGGTTGCGT AGGAGGCTCT 
GTCTGGTATC TTGAAAGAAG AACTATACAG GACTCCCCTC ACAAGTTCTT ACATCTTCTC 
AGGAATGTCA ATAAGCAGTG GATTACATTT CAGCACTTTA GCTTCCTCAA ACGCATGTAT 
GTCACACAGC TGAACAGAAG CCACAACCAG CAAGTAAGAC CCAAGCCAGA ACCAGTAGCA 
TCTCCTTTCC TTGAAAAAAC ATCTTCAGGT CAAGCCAAAG CAGAAATATA TGAGATGAGA 
CCTCTCTCAC CGCCCAGCCT ATCTTTGTCC AGAAAGCCAA ATGAAAAGGA ATTGATAGAA 
CTAGAGCCAG ACTCAGTAAT TGAAGACTCA ATAGATGTAG GGAAAGAGAC AAAAGAGGAA 
AAGCGGTGGA AAGAGATGAA GCTGCAAGTG TATGATTTGC CAGGAATTTT GGCTCGACTA 
TCCAAAATCA AACTCACAGC TCTGGTTGTA AGTACCACTG CAGCTGGATT TGCATTGGCT 
CCGGGCCCTT TTGACTGGCC CTGTTTCCTG CTTACTTCTG TTGGGACAGG CCTTGCATCC 
TGTGCTGCCA ACTCCATCAA TCAGTTTTTT GAGGTGCCAT TTGACTCAAA CATGAATAGG 
ACAAAGAACA GACCGCTGGT TCGTGGACAG ATCAGCCCAT TGCTAGCTGT GTCCTTTGCC 
ACTTGTTGTG CTGTTCCGGG AGTTGCCATT CTGACCTTGG GGGTGAATCC ACTCACAGGA 
GCCCTGGGGC TCTTCAACAT TTTCCTGTAT ACCTGCTGCT ACACACCACT GAAAAGGATC 
AGCATTGCCA ACACATGGGT CGGAGCTGTG GTTGGGGCCA TCCCGCCTGT CATGGGCTGG 
ACAGCGGCCA CGGGCAGCCT CGATGCTGGC GCATTTCTCC TGGGAGGAAT CCTCTACTCC 
TGGCAGTTTC CTCATTTCAA CGCCCTGAGC TGGGGCCTCC GTGAAGACTA CTCCCGGGGC 
GGCTACTGCA TGATGTCGGT CACCCACCCG GGCCTGTGCC GGCGCGTGGC GCTGCGCCAC 
TGCCTGGCCC TGCTCGTGCT GTCCGCAGCA GCCCCTGTGC TGGACATCAC CACATGGACC 
TTCCCCATCA TGGCCCTTCC CATCAATGCG TACATCTCCT ACCTCGGCTT CCGCTTCTAC 
GTGGACGCAG ACCGCAGGAG CTCGCGGAGA CTGTTCTTCT GCAGCCTGTG GCACCTGCCG 
CTGCTGCTGC TGCTCATGCT CACCTGCAAG CGGCCGAGCG GAGGCGGGGA CGCAGGGCCC 
CCTCCCAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001294.2
CDS	103..1434
Translation	MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITFQHFSFLKRMYVTQLNRSHNQQVRPKPEPVASPFLEKTSSGQAKAEIYEMRPLSPPSLSLSRKPNEKELIELEPDSVIEDSIDVGKETKEEKRWKEMKLQVYDLPGILARLSKIKLTALVVSTTAAGFALAPGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLLLMLTCKRPSGGGDAGPPPS

Target ORF information:

RefSeq Version	NM_001303.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 (COX10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303.4

ORF Insert Sequence:

ATGGCCGCAT CTCCGCACAC TCTCTCCTCA CGCCTCCTGA CAGGTTGCGT AGGAGGCTCT 
GTCTGGTATC TTGAAAGAAG AACTATACAG GACTCCCCTC ACAAGTTCTT ACATCTTCTC 
AGGAATGTCA ATAAGCAGTG GATTACATTT CAGCACTTTA GCTTCCTCAA ACGCATGTAT 
GTCACACAGC TGAACAGAAG CCACAACCAG CAAGTAAGAC CCAAGCCAGA ACCAGTAGCA 
TCTCCTTTCC TTGAAAAAAC ATCTTCAGGT CAAGCCAAAG CAGAAATATA TGAGATGAGA 
CCTCTCTCAC CGCCCAGCCT ATCTTTGTCC AGAAAGCCAA ATGAAAAGGA ATTGATAGAA 
CTAGAGCCAG ACTCAGTAAT TGAAGACTCA ATAGATGTAG GGAAAGAGAC AAAAGAGGAA 
AAGCGGTGGA AAGAGATGAA GCTGCAAGTG TATGATTTGC CAGGAATTTT GGCTCGACTA 
TCCAAAATCA AACTCACAGC TCTGGTTGTA AGTACCACTG CAGCTGGATT TGCATTGGCT 
CCGGGCCCTT TTGACTGGCC CTGTTTCCTG CTTACTTCTG TTGGGACAGG CCTTGCATCC 
TGTGCTGCCA ACTCCATCAA TCAGTTTTTT GAGGTGCCAT TTGACTCAAA CATGAATAGG 
ACAAAGAACA GACCGCTGGT TCGTGGACAG ATCAGCCCAT TGCTAGCTGT GTCCTTTGCC 
ACTTGTTGTG CTGTTCCGGG AGTTGCCATT CTGACCTTGG GGGTGAATCC ACTCACAGGA 
GCCCTGGGGC TCTTCAACAT TTTCCTGTAT ACCTGCTGCT ACACACCACT GAAAAGGATC 
AGCATTGCCA ACACATGGGT CGGAGCTGTG GTTGGGGCCA TCCCGCCTGT CATGGGCTGG 
ACAGCGGCCA CGGGCAGCCT CGATGCTGGC GCATTTCTCC TGGGAGGAAT CCTCTACTCC 
TGGCAGTTTC CTCATTTCAA CGCCCTGAGC TGGGGCCTCC GTGAAGACTA CTCCCGGGGC 
GGCTACTGCA TGATGTCGGT CACCCACCCG GGCCTGTGCC GGCGCGTGGC GCTGCGCCAC 
TGCCTGGCCC TGCTCGTGCT GTCCGCAGCA GCCCCTGTGC TGGACATCAC CACATGGACC 
TTCCCCATCA TGGCCCTTCC CATCAATGCG TACATCTCCT ACCTCGGCTT CCGCTTCTAC 
GTGGACGCAG ACCGCAGGAG CTCGCGGAGA CTGTTCTTCT GCAGCCTGTG GCACCTGCCG 
CTGCTGCTGC TGCTCATGCT CACCTGCAAG CGGCCGAGCG GAGGCGGGGA CGCAGGGCCC 
CCTCCCAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6.
Cell death & disease6e1691(2015 Mar)
Sch?ll S,G?nther SD,Brodesser S,Seeger JM,Tosetti B,Wiegmann K,Pongratz C,Diaz F,Witt A,Andree M,Brinkmann K,Kr?nke M,Wiesner RJ,Kashkar H

A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
Translational psychiatry2e116(2012 May)
Service SK,Verweij KJ,Lahti J,Congdon E,Ekelund J,Hintsanen M,R?ikk?nen K,Lehtim?ki T,K?h?nen M,Widen E,Taanila A,Veijola J,Heath AC,Madden PA,Montgomery GW,Sabatti C,J?rvelin MR,Palotie A,Raitakari O,Viikari J,Martin NG,Eriksson JG,Keltikangas-J?rvinen L,Wray NR,Freimer NB

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression.
Oncogene29(30)4362-8(2010 Jul)
Chen Z,Li Y,Zhang H,Huang P,Luthra R

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COX10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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