COX7A1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COX7A1
Entrez Gene ID	1346
Full Name	cytochrome c oxidase subunit 7A1
Synonyms	COX7A,COX7AH,COX7AM
General protein information	Preferred Names cytochrome c oxidase subunit 7A1 Names cytochrome c oxidase subunit 7A1, mitochondrial cytochrome c oxidase subunit VIIa heart/muscle isoform cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) cytochrome c oxidase subunit VIIa-H cytochrome c oxidase subunit VIIa-M cytochrome c oxidase subunit VIIa-heart cytochrome c oxidase subunit VIIa-muscle
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.12
Summary	Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes. [provided by RefSeq, Jul 2008].
Disorder MIM:	123995

mRNA and Protein(s)

mRNA	Protein	Name
NM_001864.4	NP_001855.1	cytochrome c oxidase subunit 7A1, mitochondrial precursor
NM_001864.3	NP_001855.1	cytochrome c oxidase subunit 7A1, mitochondrial precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	COX7A1	NP_788847.1
Mus musculus (house mouse)	Cox7a1	NP_034074.1
	COX7AH	NP_001035368.1
Homo sapiens (human)	COX7A1	NP_001855.1
Pan troglodytes (chimpanzee)	COX7A1	XP_003316382.1
Canis lupus familiaris (dog)	COX7A1	XP_855440.1

Gene Ontology
Bibliography

Related articles in PubMed

Downregulation of cytochrome c oxidase subunit 7A1 expression is important in enhancing cell proliferation in adenocarcinoma cells.
Mishra N, Timilsina U, Ghimire D, Dubey RC, Gaur R
Biochemical and biophysical research communications482(4)713-719(2017 Jan)

Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease.
Boczonadi V, Giunta M, Lane M, Tulinius M, Schara U, Horvath R
The international journal of biochemistry & cell biology6332-40(2015 Jun)

Muscle inflammatory signaling in response to 9 days of physical inactivity in young men with low compared with normal birth weight.
Friedrichsen M, Ribel-Madsen R, Mortensen B, Hansen CN, Alibegovic AC, H?jbjerre L, Sonne MP, Wojtaszewski JF, Stallknecht B, Dela F, Vaag A
European journal of endocrinology167(6)829-38(2012 Dec)

High-resolution melting analysis of 15 genes in 60 patients with cytochrome-c oxidase deficiency.
Vondrackova A, Vesela K, Hansikova H, Docekalova DZ, Rozsypalova E, Zeman J, Tesarova M
Journal of human genetics57(7)442-8(2012 Jul)

Differentiation-promoting culture of competent and noncompetent keratinocytes identifies biomarkers for head and neck cancer.
Ceder R, Haig Y, Merne M, Hansson A, Zheng X, Roberg K, Nees M, Iljin K, Bloor BK, Morgan PR, Fadeel B, Grafstr?m RC
The American journal of pathology180(2)457-72(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

COX7A1 is a novel gene that might play a crucial role in the etiology of lung adenocarcinoma and can serve as a biomarker for lung cancer disease progression
Title: Downregulation of cytochrome c oxidase subunit 7A1 expression is important in enhancing cell proliferation in adenocarcinoma cells.

We demonstrate a developmental isoform switch of COX6A and COX7A subunits in human and mouse skeletal muscle
Title: Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following COX7A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX7A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30796	NM_001864.4 Latest version!	Homo sapiens cytochrome c oxidase subunit 7A1 (COX7A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu30796	NM_001864.3	Homo sapiens cytochrome c oxidase subunit 7A1 (COX7A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COX7A1 ( NM_001864.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001855.1 Homo sapiens cytochrome c oxidase subunit 7A1 (COX7A1), mRNA.

Price & Availability↑

CloneID	OHu30796
Clone ID Related Accession (Same CDS sequence)	NM_001864.4 , NM_001864.3
Accession Version	NM_001864.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 240bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 7A1, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC002757.2. On Nov 23, 2018 this sequence version replaced NM_001864.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: F18996.2, BC002757.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000292907.8/ ENSP00000292907.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGGCCC TTCGGGTGTC CCAGGCGCTG ATCCGCTCCT TCAGCTCCAC CGCCCGGAAC 
CGCTTTCAGA ACCGAGTGCG CGAGAAACAG AAGCTCTTCC AGGAGGACAA TGACATCCCG 
TTGTACCTGA AGGGCGGCAT CGTTGACAAC ATCCTGTACC GAGTGACAAT GACGCTGTGT 
CTGGGCGGCA CTGTCTACAG CTTGTACTCC CTTGGCTGGG CCTCCTTCCC CAGGAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001855.1
CDS	41..280
Translation	MQALRVSQALIRSFSSTARNRFQNRVREKQKLFQEDNDIPLYLKGGIVDNILYRVTMTLCLGGTVYSLYSLGWASFPRN

Target ORF information:

RefSeq Version	NM_001864.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 7A1 (COX7A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001864.4

ORF Insert Sequence:

ATGCAGGCCC TTCGGGTGTC CCAGGCGCTG ATCCGCTCCT TCAGCTCCAC CGCCCGGAAC 
CGCTTTCAGA ACCGAGTGCG CGAGAAACAG AAGCTCTTCC AGGAGGACAA TGACATCCCG 
TTGTACCTGA AGGGCGGCAT CGTTGACAAC ATCCTGTACC GAGTGACAAT GACGCTGTGT 
CTGGGCGGCA CTGTCTACAG CTTGTACTCC CTTGGCTGGG CCTCCTTCCC CAGGAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX7A1 ( NM_001864.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001855.1 Homo sapiens cytochrome c oxidase subunit 7A1 (COX7A1), mRNA.

Price & Availability↑

CloneID	OHu30796
Clone ID Related Accession (Same CDS sequence)	NM_001864.4 , NM_001864.3
Accession Version	NM_001864.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 240bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 7A1, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC002757.2 and AC002984.1. On Jan 13, 2015 this sequence version replaced NM_001864.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002757.2, BE393484.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGGCCC TTCGGGTGTC CCAGGCGCTG ATCCGCTCCT TCAGCTCCAC CGCCCGGAAC 
CGCTTTCAGA ACCGAGTGCG CGAGAAACAG AAGCTCTTCC AGGAGGACAA TGACATCCCG 
TTGTACCTGA AGGGCGGCAT CGTTGACAAC ATCCTGTACC GAGTGACAAT GACGCTGTGT 
CTGGGCGGCA CTGTCTACAG CTTGTACTCC CTTGGCTGGG CCTCCTTCCC CAGGAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001855.1
CDS	463..702
Translation	MQALRVSQALIRSFSSTARNRFQNRVREKQKLFQEDNDIPLYLKGGIVDNILYRVTMTLCLGGTVYSLYSLGWASFPRN

Target ORF information:

RefSeq Version	NM_001864.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 7A1 (COX7A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001864.3

ORF Insert Sequence:

ATGCAGGCCC TTCGGGTGTC CCAGGCGCTG ATCCGCTCCT TCAGCTCCAC CGCCCGGAAC 
CGCTTTCAGA ACCGAGTGCG CGAGAAACAG AAGCTCTTCC AGGAGGACAA TGACATCCCG 
TTGTACCTGA AGGGCGGCAT CGTTGACAAC ATCCTGTACC GAGTGACAAT GACGCTGTGT 
CTGGGCGGCA CTGTCTACAG CTTGTACTCC CTTGGCTGGG CCTCCTTCCC CAGGAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Downregulation of cytochrome c oxidase subunit 7A1 expression is important in enhancing cell proliferation in adenocarcinoma cells.
Biochemical and biophysical research communications482(4)713-719(2017 Jan)
Mishra N,Timilsina U,Ghimire D,Dubey RC,Gaur R

Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease.
The international journal of biochemistry & cell biology6332-40(2015 Jun)
Boczonadi V,Giunta M,Lane M,Tulinius M,Schara U,Horvath R

Muscle inflammatory signaling in response to 9 days of physical inactivity in young men with low compared with normal birth weight.
European journal of endocrinology167(6)829-38(2012 Dec)
Friedrichsen M,Ribel-Madsen R,Mortensen B,Hansen CN,Alibegovic AC,H?jbjerre L,Sonne MP,Wojtaszewski JF,Stallknecht B,Dela F,Vaag A

High-resolution melting analysis of 15 genes in 60 patients with cytochrome-c oxidase deficiency.
Journal of human genetics57(7)442-8(2012 Jul)
Vondrackova A,Vesela K,Hansikova H,Docekalova DZ,Rozsypalova E,Zeman J,Tesarova M

Differentiation-promoting culture of competent and noncompetent keratinocytes identifies biomarkers for head and neck cancer.
The American journal of pathology180(2)457-72(2012 Feb)
Ceder R,Haig Y,Merne M,Hansson A,Zheng X,Roberg K,Nees M,Iljin K,Bloor BK,Morgan PR,Fadeel B,Grafstr?m RC

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COX7A1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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