Cox7a1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cox7a1
Entrez Gene ID	12865
Full Name	cytochrome c oxidase subunit VIIa 1
Synonyms	COX7A,COX7AH,COX7AM
General protein information	Preferred Names cytochrome c oxidase subunit VIIa 1 Names cytochrome c oxidase subunit 7A1, mitochondrial cytochrome c oxidase subunit VIIa-H cytochrome c oxidase subunit VIIa-M cytochrome c oxidase subunit VIIa-heart cytochrome c oxidase subunit VIIa-muscle
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 B1\|7 17.31 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009944.3	NP_034074.1	cytochrome c oxidase subunit 7A1, mitochondrial precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	COX7A1	NP_788847.1
Mus musculus (house mouse)	Cox7a1	NP_034074.1
	COX7AH	NP_001035368.1
Homo sapiens (human)	COX7A1	NP_001855.1
Pan troglodytes (chimpanzee)	COX7A1	XP_003316382.1
Canis lupus familiaris (dog)	COX7A1	XP_855440.1

Gene Ontology
Bibliography

Related articles in PubMed

Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues.
Singh R, Braga M, Reddy ST, Lee SJ, Parveen M, Grijalva V, Vergnes L, Pervin S
Endocrinology158(5)1217-1230(2017 May)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

The brown and brite adipocyte marker Cox7a1 is not required for non-shivering thermogenesis in mice.
Maurer SF, Fromme T, Grossman LI, H?ttemann M, Klingenspor M
Scientific reports517704(2015 Dec)

Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease.
Boczonadi V, Giunta M, Lane M, Tulinius M, Schara U, Horvath R
The international journal of biochemistry & cell biology6332-40(2015 Jun)

Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes.
Hwang HJ, Lynn SG, Vengellur A, Saini Y, Grier EA, Ferguson-Miller SM, LaPres JJ
Biochemistry54(24)3739-48(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We conclude that brown adipose tissue function in mice does not require the presence of Cox7a1
Title: The brown and brite adipocyte marker Cox7a1 is not required for non-shivering thermogenesis in mice.

We demonstrate a developmental isoform switch of COX6A and COX7A subunits in human and mouse skeletal muscle
Title: Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease.

Data (including data from cells of transgenic mouse embryos) suggest Hif1a (hypoxia inducible factor 1 alpha subunit) up-regulates transcription of heart/muscle isoform Cox7a1 under hypoxia; hypoxic induction of isoform Cox4i2 is HIF1a-independent.
Title: Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes.

Deletion of the Cox7a1 isoform results in reduced muscle bioenergetics and hindlimb capillarity
Title: Deletion of heart-type cytochrome c oxidase subunit 7a1 impairs skeletal muscle angiogenesis and oxidative phosphorylation.

The authors show that homozygous and heterozygous Cox7a1 knockout mice, although viable, have reduced Cox activity and develop a dilated cardiomyopathy at 6 weeks of age.
Title: Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy.

The following Cox7a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cox7a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18777	NM_009944.3 Latest version!	Mus musculus cytochrome c oxidase subunit 7A1 (Cox7a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cox7a1 ( NM_009944.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034074.1 Mus musculus cytochrome c oxidase subunit 7A1 (Cox7a1), mRNA.

Price & Availability↑

CloneID	OMu18777
Clone ID Related Accession (Same CDS sequence)	NM_009944.3
Accession Version	NM_009944.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 243bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	cytochrome c oxidase subunit 7A1, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK079950.1 and BC060974.1. On Dec 22, 2005 this sequence version replaced NM_009944.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC060974.1, BU555231.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGAGGGCCC TACGGGTCTC CCAGGCTCTG GTCCGGTCTT TTAGCTCATC TACCAGAAGC 
CACTTAGAAA ACCGTGTGGC AGAGAAGCAG AAGCTCTTCC AGGCCGACAA TGACCTCCCA 
GTACACTTGA AAGGCGGGGG AATGGACAAC GTCCTGTACA GACTGACCAT GACGCTGACT 
CTGGGGGGCA CTGCCTACTG CTTATACTGC TTGGGCTGGG CCTCCTTCCC CCACAAGAAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034074.1
CDS	61..303
Translation	MRALRVSQALVRSFSSSTRSHLENRVAEKQKLFQADNDLPVHLKGGGMDNVLYRLTMTLTLGGTAYCLYCLGWASFPHKK

Target ORF information:

RefSeq Version	NM_009944.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cytochrome c oxidase subunit 7A1 (Cox7a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009944.3

ORF Insert Sequence:

ATGAGGGCCC TACGGGTCTC CCAGGCTCTG GTCCGGTCTT TTAGCTCATC TACCAGAAGC 
CACTTAGAAA ACCGTGTGGC AGAGAAGCAG AAGCTCTTCC AGGCCGACAA TGACCTCCCA 
GTACACTTGA AAGGCGGGGG AATGGACAAC GTCCTGTACA GACTGACCAT GACGCTGACT 
CTGGGGGGCA CTGCCTACTG CTTATACTGC TTGGGCTGGG CCTCCTTCCC CCACAAGAAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues.
Endocrinology158(5)1217-1230(2017 May)
Singh R,Braga M,Reddy ST,Lee SJ,Parveen M,Grijalva V,Vergnes L,Pervin S

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

The brown and brite adipocyte marker Cox7a1 is not required for non-shivering thermogenesis in mice.
Scientific reports517704(2015 Dec)
Maurer SF,Fromme T,Grossman LI,H?ttemann M,Klingenspor M

Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease.
The international journal of biochemistry & cell biology6332-40(2015 Jun)
Boczonadi V,Giunta M,Lane M,Tulinius M,Schara U,Horvath R

Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes.
Biochemistry54(24)3739-48(2015 Jun)
Hwang HJ,Lynn SG,Vengellur A,Saini Y,Grier EA,Ferguson-Miller SM,LaPres JJ

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Cox7a1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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