Gene Symbol | PPARGC1B |
Entrez Gene ID | 133522 |
Full Name | PPARG coactivator 1 beta |
Synonyms | ERRL1,PERC,PGC-1(beta),PGC1B |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]. |
Disorder MIM: | |
Disorder Html: | {Obesity, variation in}, 601665 (3) |