CST9 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CST9
Entrez Gene ID	128822
Full Name	cystatin 9
Synonyms	CLM,CTES7A
General protein information	Preferred Names cystatin 9 Names cystatin-9 cystatin-like molecule testatin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20p11.21
Summary	The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted protein that may play a role in hematopoietic differentiation or inflammation. [provided by RefSeq, Jul 2008].
Disorder MIM:	616543

mRNA and Protein(s)

mRNA	Protein	Name
NM_001008693.2	NP_001008693.2	cystatin-9 precursor
NM_001008693.3	NP_001008693.2	cystatin-9 precursor

Pathways from BioSystems

Homologies

	CST9	XP_001097191.1
Homo sapiens (human)	CST9	NP_001008693.2
Pan troglodytes (chimpanzee)	CST9	XP_525288.1

Gene Ontology
Bibliography

Related articles in PubMed

Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis.
Eaves-Pyles T, Patel J, Arigi E, Cong Y, Cao A, Garg N, Dhiman M, Pyles RB, Arulanandam B, Miller AL, Popov VL, Soong L, Carlsen ED, Coletta C, Szabo C, Almeida IC
Molecular medicine (Cambridge, Mass.)19263-75(2013 Aug)

Evolution and human tissue expression of the Cres/Testatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cystatins.
Frygelius J, Arvestad L, Wedell A, T?h?nen V
Evolution & development12(3)329-42(2010 May-Jun)

New loci associated with kidney function and chronic kidney disease.
K?ttgen A, Pattaro C, B?ger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, O'Connell JR, Li M, Schmidt H, Tanaka T, Isaacs A, Ketkar S, Hwang SJ, Johnson AD, Dehghan A, Teumer A, Par? G, Atkinson EJ, Zeller T, Lohman K, Cornelis MC, Probst-Hensch NM, Kronenberg F, T?njes A, Hayward C, Aspelund T, Eiriksdottir G, Launer LJ, Harris TB, Rampersaud E, Mitchell BD, Arking DE, Boerwinkle E, Struchalin M, Cavalieri M, Singleton A, Giallauria F, Metter J, de Boer IH, Haritunians T, Lumley T, Siscovick D, Psaty BM, Zillikens MC, Oostra BA, Feitosa M, Province M, de Andrade M, Turner ST, Schillert A, Ziegler A, Wild PS, Schnabel RB, Wilde S, Munzel TF, Leak TS, Illig T, Klopp N, Meisinger C, Wichmann HE, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Schreiber S, Aulchenko YS, Felix JF, Rivadeneira F, Uitterlinden AG, Hofman A, Imboden M, Nitsch D, Brandst?tter A, Kollerits B, Kedenko L, M?gi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, V?lzke H, Kroemer HK, Nauck M, V?lker U, Polasek O, Vitart V, Badola S, Parker AN, Ridker PM, Kardia SL, Blankenberg S, Liu Y, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Shlipak MG, van Duijn CM, Borecki I, Kr?mer BK, Rudan I, Gyllensten U, Wilson JF, Witteman JC, Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM, Fox CS
Nature genetics42(5)376-84(2010 May)

A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study.
Hwang SJ, Yang Q, Meigs JB, Pearce EN, Fox CS
BMC medical genetics8 Suppl 1S10(2007 Sep)

A genomic analysis of rat proteases and protease inhibitors.
Puente XS, L?pez-Ot?n C
Genome research14(4)609-22(2004 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The current report is the first to show the immunomodulatory and antimicrobial functions of rCST9 against Francisella tularensis.
Title: Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis.

Data report the cloning of a novel human cystatin-like molecule (CLM) from human bone marrow stromal cell (BMSC) cDNA library.
Title: Molecular cloning and characterization of a novel cystatin-like molecule, CLM, from human bone marrow stromal cells.

The following CST9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CST9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12407	NM_001008693.3 Latest version!	Homo sapiens cystatin 9 (CST9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu12407	NM_001008693.2	Homo sapiens cystatin 9 (CST9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CST9 ( NM_001008693.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001008693.2 Homo sapiens cystatin 9 (CST9), mRNA.

Price & Availability↑

CloneID	OHu12407
Clone ID Related Accession (Same CDS sequence)	NM_001008693.2 , NM_001008693.3
Accession Version	NM_001008693.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	cystatin-9 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL121894.26. On Apr 11, 2009 this sequence version replaced NM_001008693.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AF494536.1, DN996766.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCGAGTC CGCAGAGGAG GAAGGCTATG CCCTGGGCAC TGTCACTGCT TCTCATGGGC 
TTCCAGCTCC TGGTGACTTA TGCCTGGTGT TCTGAAGAGG AAATGGGTGG TAATAATAAA 
ATAGTCCAGG ATCCTATGTT CCTCGCCACA GTGGAGTTTG CCTTGAACAC TTTCAACGTG 
CAGAGCAAGG AGGAGCATGC CTACAGGCTG TTGCGCGTCC TGAGTTCATG GAGGGAGGAT 
AGCATGGACA GAAAGTGGCG AGGTAAGATG GTGTTCTCCA TGAATCTGCA ACTGCGCCAA 
ACCGTATGTA GGAAATTTGA AGATGACATT GACAACTGCC CTTTTCAAGA AAGCCTGGAG 
CTGAACAACG TAAGACAGGG CATCAGCTTT CCTCAGGTCC ACAGCTGTGG ATGCTGCATG 
GGGTGTGGTG TGGGCACAGG AGCAGCTGAC AAAGCCATTC CGAGGGACAA AGGGAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008693.2
CDS	110..589
Translation	MSSPQRRKAMPWALSLLLMGFQLLVTYAWCSEEEMGGNNKIVQDPMFLATVEFALNTFNVQSKEEHAYRLLRVLSSWREDSMDRKWRGKMVFSMNLQLRQTVCRKFEDDIDNCPFQESLELNNVRQGISFPQVHSCGCCMGCGVGTGAADKAIPRDKGK

Target ORF information:

RefSeq Version	NM_001008693.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cystatin 9 (CST9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008693.2

ORF Insert Sequence:

ATGTCGAGTC CGCAGAGGAG GAAGGCTATG CCCTGGGCAC TGTCACTGCT TCTCATGGGC 
TTCCAGCTCC TGGTGACTTA TGCCTGGTGT TCTGAAGAGG AAATGGGTGG TAATAATAAA 
ATAGTCCAGG ATCCTATGTT CCTCGCCACA GTGGAGTTTG CCTTGAACAC TTTCAACGTG 
CAGAGCAAGG AGGAGCATGC CTACAGGCTG TTGCGCGTCC TGAGTTCATG GAGGGAGGAT 
AGCATGGACA GAAAGTGGCG AGGTAAGATG GTGTTCTCCA TGAATCTGCA ACTGCGCCAA 
ACCGTATGTA GGAAATTTGA AGATGACATT GACAACTGCC CTTTTCAAGA AAGCCTGGAG 
CTGAACAACG TAAGACAGGG CATCAGCTTT CCTCAGGTCC ACAGCTGTGG ATGCTGCATG 
GGGTGTGGTG TGGGCACAGG AGCAGCTGAC AAAGCCATTC CGAGGGACAA AGGGAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CST9 ( NM_001008693.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001008693.2 Homo sapiens cystatin 9 (CST9), mRNA.

Price & Availability↑

CloneID	OHu12407
Clone ID Related Accession (Same CDS sequence)	NM_001008693.2 , NM_001008693.3
Accession Version	NM_001008693.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	cystatin-9 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL121894.26. On Nov 22, 2019 this sequence version replaced NM_001008693.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AF494536.1, BC137303.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCGAGTC CGCAGAGGAG GAAGGCTATG CCCTGGGCAC TGTCACTGCT TCTCATGGGC 
TTCCAGCTCC TGGTGACTTA TGCCTGGTGT TCTGAAGAGG AAATGGGTGG TAATAATAAA 
ATAGTCCAGG ATCCTATGTT CCTCGCCACA GTGGAGTTTG CCTTGAACAC TTTCAACGTG 
CAGAGCAAGG AGGAGCATGC CTACAGGCTG TTGCGCGTCC TGAGTTCATG GAGGGAGGAT 
AGCATGGACA GAAAGTGGCG AGGTAAGATG GTGTTCTCCA TGAATCTGCA ACTGCGCCAA 
ACCGTATGTA GGAAATTTGA AGATGACATT GACAACTGCC CTTTTCAAGA AAGCCTGGAG 
CTGAACAACG TAAGACAGGG CATCAGCTTT CCTCAGGTCC ACAGCTGTGG ATGCTGCATG 
GGGTGTGGTG TGGGCACAGG AGCAGCTGAC AAAGCCATTC CGAGGGACAA AGGGAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008693.2
CDS	54..533
Translation	MSSPQRRKAMPWALSLLLMGFQLLVTYAWCSEEEMGGNNKIVQDPMFLATVEFALNTFNVQSKEEHAYRLLRVLSSWREDSMDRKWRGKMVFSMNLQLRQTVCRKFEDDIDNCPFQESLELNNVRQGISFPQVHSCGCCMGCGVGTGAADKAIPRDKGK

Target ORF information:

RefSeq Version	NM_001008693.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cystatin 9 (CST9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008693.3

ORF Insert Sequence:

ATGTCGAGTC CGCAGAGGAG GAAGGCTATG CCCTGGGCAC TGTCACTGCT TCTCATGGGC 
TTCCAGCTCC TGGTGACTTA TGCCTGGTGT TCTGAAGAGG AAATGGGTGG TAATAATAAA 
ATAGTCCAGG ATCCTATGTT CCTCGCCACA GTGGAGTTTG CCTTGAACAC TTTCAACGTG 
CAGAGCAAGG AGGAGCATGC CTACAGGCTG TTGCGCGTCC TGAGTTCATG GAGGGAGGAT 
AGCATGGACA GAAAGTGGCG AGGTAAGATG GTGTTCTCCA TGAATCTGCA ACTGCGCCAA 
ACCGTATGTA GGAAATTTGA AGATGACATT GACAACTGCC CTTTTCAAGA AAGCCTGGAG 
CTGAACAACG TAAGACAGGG CATCAGCTTT CCTCAGGTCC ACAGCTGTGG ATGCTGCATG 
GGGTGTGGTG TGGGCACAGG AGCAGCTGAC AAAGCCATTC CGAGGGACAA AGGGAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis.
Molecular medicine (Cambridge, Mass.)19263-75(2013 Aug)
Eaves-Pyles T,Patel J,Arigi E,Cong Y,Cao A,Garg N,Dhiman M,Pyles RB,Arulanandam B,Miller AL,Popov VL,Soong L,Carlsen ED,Coletta C,Szabo C,Almeida IC

Evolution and human tissue expression of the Cres/Testatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cystatins.
Evolution & development12(3)329-42(2010 May-Jun)
Frygelius J,Arvestad L,Wedell A,T?h?nen V

New loci associated with kidney function and chronic kidney disease.
Nature genetics42(5)376-84(2010 May)
K?ttgen A,Pattaro C,B?ger CA,Fuchsberger C,Olden M,Glazer NL,Parsa A,Gao X,Yang Q,Smith AV,O'Connell JR,Li M,Schmidt H,Tanaka T,Isaacs A,Ketkar S,Hwang SJ,Johnson AD,Dehghan A,Teumer A,Par? G,Atkinson EJ,Zeller T,Lohman K,Cornelis MC,Probst-Hensch NM,Kronenberg F,T?njes A,Hayward C,Aspelund T,Eiriksdottir G,Launer LJ,Harris TB,Rampersaud E,Mitchell BD,Arking DE,Boerwinkle E,Struchalin M,Cavalieri M,Singleton A,Giallauria F,Metter J,de Boer IH,Haritunians T,Lumley T,Siscovick D,Psaty BM,Zillikens MC,Oostra BA,Feitosa M,Province M,de Andrade M,Turner ST,Schillert A,Ziegler A,Wild PS,Schnabel RB,Wilde S,Munzel TF,Leak TS,Illig T,Klopp N,Meisinger C,Wichmann HE,Koenig W,Zgaga L,Zemunik T,Kolcic I,Minelli C,Hu FB,Johansson A,Igl W,Zaboli G,Wild SH,Wright AF,Campbell H,Ellinghaus D,Schreiber S,Aulchenko YS,Felix JF,Rivadeneira F,Uitterlinden AG,Hofman A,Imboden M,Nitsch D,Brandst?tter A,Kollerits B,Kedenko L,M?gi R,Stumvoll M,Kovacs P,Boban M,Campbell S,Endlich K,V?lzke H,Kroemer HK,Nauck M,V?lker U,Polasek O,Vitart V,Badola S,Parker AN,Ridker PM,Kardia SL,Blankenberg S,Liu Y,Curhan GC,Franke A,Rochat T,Paulweber B,Prokopenko I,Wang W,Gudnason V,Shuldiner AR,Coresh J,Schmidt R,Ferrucci L,Shlipak MG,van Duijn CM,Borecki I,Kr?mer BK,Rudan I,Gyllensten U,Wilson JF,Witteman JC,Pramstaller PP,Rettig R,Hastie N,Chasman DI,Kao WH,Heid IM,Fox CS

A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study.
BMC medical genetics8 Suppl 1S10(2007 Sep)
Hwang SJ,Yang Q,Meigs JB,Pearce EN,Fox CS

A genomic analysis of rat proteases and protease inhibitors.
Genome research14(4)609-22(2004 Apr)
Puente XS,L?pez-Ot?n C

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CST9 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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