BHLHE23 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BHLHE23
Entrez Gene ID	128408
Full Name	basic helix-loop-helix family member e23
Synonyms	BETA4,BHLHB4,Beta3b,bA305P22.3
General protein information	Preferred Names basic helix-loop-helix family member e23 Names class E basic helix-loop-helix protein 23 basic helix-loop-helix domain containing, class B, 4 class B basic helix-loop-helix protein 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.33
Summary	This gene encodes a member of the basic helix-loop-helix transcription factor family. Members of this family contain two highly conserved and functionally distinct domains: the basic domain targets sequence-specific DNA binding, while the helix-loop-helix domain facilitates protein interaction. Studies of a related gene in mouse suggest that the encoded protein may function as a transcriptional repressor in the pancreas and brain, and that it is required for normal retinal function. [provided by RefSeq, May 2013].
Disorder MIM:	609331

mRNA and Protein(s)

mRNA	Protein	Name
NM_080606.3	NP_542173.2	class E basic helix-loop-helix protein 23
NM_080606.4	NP_542173.2	class E basic helix-loop-helix protein 23

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Bhlhe23	NP_542372.2
Danio rerio (zebrafish)	bhlhe23	NP_001025304.1
Rattus norvegicus (Norway rat)	Bhlhe23	NP_001102681.1
Gallus gallus (chicken)	BHLHE23	NP_989835.1
Pan troglodytes (chimpanzee)	BHLHE23	XP_525382.3
Homo sapiens (human)	BHLHE23	NP_542173.2
Bos taurus (cattle)	BHLHE23	XP_005214980.1

Gene Ontology
Bibliography

Related articles in PubMed

Classification and evolutionary analysis of the basic helix-loop-helix gene family in the green anole lizard, Anolis carolinensis.
Liu A, Wang Y, Zhang D, Wang X, Song H, Dang C, Yao Q, Chen K
Molecular genetics and genomics : MGG288(7-8)365-80(2013 Aug)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.
Stevens JD, Roalson EH, Skinner MK
Differentiation; research in biological diversity76(9)1006-22(2008 Nov)

The transcription factor Bhlhb4 is required for rod bipolar cell maturation.
Bramblett DE, Pennesi ME, Wu SM, Tsai MJ
Neuron43(6)779-93(2004 Sep)

Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening.
McLellan AS, Langlands K, Kealey T
Mechanisms of development119 Suppl 1S285-91(2002 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Following specific binding to and internalization into HER2-overexpressing tumor cells, the e23sFv-Fdt-casp6 protein induced tumor cell apoptosis and inhibited the proliferation of HER2-overexpressing A172 and U251MG cells in vitro, but not in U87MG cells with undetectable HER2
Title: HER2-targeted recombinant protein immuno-caspase-6 effectively induces apoptosis in HER2-overexpressing GBM cells in?vitro and in?vivo.

Knockout mouse retinal dysfunction resembles human congenital stationary night blindness.
Title: The transcription factor Bhlhb4 is required for rod bipolar cell maturation.

Mouse Bhlhe23 can function as a transcriptional repressor.
Title: BHLHB4 is a bHLH transcriptional regulator in pancreas and brain that marks the dimesencephalic boundary.

The following BHLHE23 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BHLHE23 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00665	NM_080606.4 Latest version!	Homo sapiens basic helix-loop-helix family member e23 (BHLHE23), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu00665	NM_080606.3	Homo sapiens basic helix-loop-helix family member e23 (BHLHE23), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BHLHE23 ( NM_080606.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_542173.2 Homo sapiens basic helix-loop-helix family member e23 (BHLHE23), mRNA.

Price & Availability↑

CloneID	OHu00665
Clone ID Related Accession (Same CDS sequence)	NM_080606.3 , NM_080606.4
Accession Version	NM_080606.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-22
Organism	Homo sapiens(human)
Product	class E basic helix-loop-helix protein 23
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC137288.1 and AL121673.41. On May 17, 2019 this sequence version replaced NM_080606.3. ##Evidence-Data-START## Transcript is intronless :: BC137288.1, BK000274.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000612929.2/ ENSP00000480998.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAGCATCC GCCCACCCGG CGAGCCCCCG AGCCCAGGCG GCGCGGCCAT GGCCGAGCTC 
AAGTCGCTGT CGGGGGACGC GTACCTGGCA CTAAGCCACG GCTACGCGGC GGCGGCTGCG 
GGTCTCGCCT ACGGGGCGGC GCGAGAACCC GAAGCGGCCC GCGGCTACGG CACTCCGGGC 
CCGGGCGGCG ACCTCCCCGC GGCGCCTGCA CCTCGCGCCC CAGCTCAGGC GGCGGAGAGC 
AGCGGCGAAC AGAGCGGGGA CGAGGACGAC GCCTTCGAGC AGCGGCGGCG GCGGCGCGGG 
CCAGGGAGCG CGGCGGACGG GCGGCGGCGG CCGCGAGAGC AGCGGTCTCT GCGGCTCAGC 
ATCAACGCGC GCGAGCGGCG GCGCATGCAC GACCTAAACG ACGCGCTGGA CGGGCTGCGA 
GCCGTCATCC CCTACGCGCA CAGCCCGTCG GTGCGCAAGC TCTCCAAGAT CGCCACGCTG 
CTGCTCGCCA AGAACTATAT CCTCATGCAG GCGCAGGCCC TGGACGAGAT GCGGCGCCTG 
GTGGCCTTCC TCAACCAGGG CCAGGGCCTG GCCGCGCCCG TAAACGCCGC GCCCTTGACG 
CCCTTCGGCC AGGCCACTGT GTGCCCCTTC TCCGCAGGCG CCGCCCTGGG GCCCTGCCCT 
GACAAGTGCG CCGCCTTCTC CGGGACGCCC TCCGCGCTTT GCAAACACTG TCACGAGAAG 
CCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542173.2
CDS	191..916
Translation	MSIRPPGEPPSPGGAAMAELKSLSGDAYLALSHGYAAAAAGLAYGAAREPEAARGYGTPGPGGDLPAAPAPRAPAQAAESSGEQSGDEDDAFEQRRRRRGPGSAADGRRRPREQRSLRLSINARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALDEMRRLVAFLNQGQGLAAPVNAAPLTPFGQATVCPFSAGAALGPCPDKCAAFSGTPSALCKHCHEKP

Target ORF information:

RefSeq Version	NM_080606.4
Organism	Homo sapiens(human)
Definition	Homo sapiens basic helix-loop-helix family member e23 (BHLHE23), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080606.4

ORF Insert Sequence:

ATGAGCATCC GCCCACCCGG CGAGCCCCCG AGCCCAGGCG GCGCGGCCAT GGCCGAGCTC 
AAGTCGCTGT CGGGGGACGC GTACCTGGCA CTAAGCCACG GCTACGCGGC GGCGGCTGCG 
GGTCTCGCCT ACGGGGCGGC GCGAGAACCC GAAGCGGCCC GCGGCTACGG CACTCCGGGC 
CCGGGCGGCG ACCTCCCCGC GGCGCCTGCA CCTCGCGCCC CAGCTCAGGC GGCGGAGAGC 
AGCGGCGAAC AGAGCGGGGA CGAGGACGAC GCCTTCGAGC AGCGGCGGCG GCGGCGCGGG 
CCAGGGAGCG CGGCGGACGG GCGGCGGCGG CCGCGAGAGC AGCGGTCTCT GCGGCTCAGC 
ATCAACGCGC GCGAGCGGCG GCGCATGCAC GACCTAAACG ACGCGCTGGA CGGGCTGCGA 
GCCGTCATCC CCTACGCGCA CAGCCCGTCG GTGCGCAAGC TCTCCAAGAT CGCCACGCTG 
CTGCTCGCCA AGAACTATAT CCTCATGCAG GCGCAGGCCC TGGACGAGAT GCGGCGCCTG 
GTGGCCTTCC TCAACCAGGG CCAGGGCCTG GCCGCGCCCG TAAACGCCGC GCCCTTGACG 
CCCTTCGGCC AGGCCACTGT GTGCCCCTTC TCCGCAGGCG CCGCCCTGGG GCCCTGCCCT 
GACAAGTGCG CCGCCTTCTC CGGGACGCCC TCCGCGCTTT GCAAACACTG TCACGAGAAG 
CCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BHLHE23 ( NM_080606.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_542173.2 Homo sapiens basic helix-loop-helix family member e23 (BHLHE23), mRNA.

Price & Availability↑

CloneID	OHu00665
Clone ID Related Accession (Same CDS sequence)	NM_080606.3 , NM_080606.4
Accession Version	NM_080606.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-22
Organism	Homo sapiens(human)
Product	class E basic helix-loop-helix protein 23
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC137288.1. On Sep 19, 2008 this sequence version replaced NM_080606.2. ##Evidence-Data-START## Transcript is intronless :: BC137288.1 [ECO:0000345] ##Evidence-Data-END##

ATGAGCATCC GCCCACCCGG CGAGCCCCCG AGCCCAGGCG GCGCGGCCAT GGCCGAGCTC 
AAGTCGCTGT CGGGGGACGC GTACCTGGCA CTAAGCCACG GCTACGCGGC GGCGGCTGCG 
GGTCTCGCCT ACGGGGCGGC GCGAGAACCC GAAGCGGCCC GCGGCTACGG CACTCCGGGC 
CCGGGCGGCG ACCTCCCCGC GGCGCCTGCA CCTCGCGCCC CAGCTCAGGC GGCGGAGAGC 
AGCGGCGAAC AGAGCGGGGA CGAGGACGAC GCCTTCGAGC AGCGGCGGCG GCGGCGCGGG 
CCAGGGAGCG CGGCGGACGG GCGGCGGCGG CCGCGAGAGC AGCGGTCTCT GCGGCTCAGC 
ATCAACGCGC GCGAGCGGCG GCGCATGCAC GACCTAAACG ACGCGCTGGA CGGGCTGCGA 
GCCGTCATCC CCTACGCGCA CAGCCCGTCG GTGCGCAAGC TCTCCAAGAT CGCCACGCTG 
CTGCTCGCCA AGAACTATAT CCTCATGCAG GCGCAGGCCC TGGACGAGAT GCGGCGCCTG 
GTGGCCTTCC TCAACCAGGG CCAGGGCCTG GCCGCGCCCG TAAACGCCGC GCCCTTGACG 
CCCTTCGGCC AGGCCACTGT GTGCCCCTTC TCCGCAGGCG CCGCCCTGGG GCCCTGCCCT 
GACAAGTGCG CCGCCTTCTC CGGGACGCCC TCCGCGCTTT GCAAACACTG TCACGAGAAG 
CCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542173.2
CDS	262..987
Translation	MSIRPPGEPPSPGGAAMAELKSLSGDAYLALSHGYAAAAAGLAYGAAREPEAARGYGTPGPGGDLPAAPAPRAPAQAAESSGEQSGDEDDAFEQRRRRRGPGSAADGRRRPREQRSLRLSINARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALDEMRRLVAFLNQGQGLAAPVNAAPLTPFGQATVCPFSAGAALGPCPDKCAAFSGTPSALCKHCHEKP

Target ORF information:

RefSeq Version	NM_080606.3
Organism	Homo sapiens(human)
Definition	Homo sapiens basic helix-loop-helix family member e23 (BHLHE23), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080606.3

ORF Insert Sequence:

ATGAGCATCC GCCCACCCGG CGAGCCCCCG AGCCCAGGCG GCGCGGCCAT GGCCGAGCTC 
AAGTCGCTGT CGGGGGACGC GTACCTGGCA CTAAGCCACG GCTACGCGGC GGCGGCTGCG 
GGTCTCGCCT ACGGGGCGGC GCGAGAACCC GAAGCGGCCC GCGGCTACGG CACTCCGGGC 
CCGGGCGGCG ACCTCCCCGC GGCGCCTGCA CCTCGCGCCC CAGCTCAGGC GGCGGAGAGC 
AGCGGCGAAC AGAGCGGGGA CGAGGACGAC GCCTTCGAGC AGCGGCGGCG GCGGCGCGGG 
CCAGGGAGCG CGGCGGACGG GCGGCGGCGG CCGCGAGAGC AGCGGTCTCT GCGGCTCAGC 
ATCAACGCGC GCGAGCGGCG GCGCATGCAC GACCTAAACG ACGCGCTGGA CGGGCTGCGA 
GCCGTCATCC CCTACGCGCA CAGCCCGTCG GTGCGCAAGC TCTCCAAGAT CGCCACGCTG 
CTGCTCGCCA AGAACTATAT CCTCATGCAG GCGCAGGCCC TGGACGAGAT GCGGCGCCTG 
GTGGCCTTCC TCAACCAGGG CCAGGGCCTG GCCGCGCCCG TAAACGCCGC GCCCTTGACG 
CCCTTCGGCC AGGCCACTGT GTGCCCCTTC TCCGCAGGCG CCGCCCTGGG GCCCTGCCCT 
GACAAGTGCG CCGCCTTCTC CGGGACGCCC TCCGCGCTTT GCAAACACTG TCACGAGAAG 
CCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Classification and evolutionary analysis of the basic helix-loop-helix gene family in the green anole lizard, Anolis carolinensis.
Molecular genetics and genomics : MGG288(7-8)365-80(2013 Aug)
Liu A,Wang Y,Zhang D,Wang X,Song H,Dang C,Yao Q,Chen K

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.
Differentiation; research in biological diversity76(9)1006-22(2008 Nov)
Stevens JD,Roalson EH,Skinner MK

The transcription factor Bhlhb4 is required for rod bipolar cell maturation.
Neuron43(6)779-93(2004 Sep)
Bramblett DE,Pennesi ME,Wu SM,Tsai MJ

Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening.
Mechanisms of development119 Suppl 1S285-91(2002 Dec)
McLellan AS,Langlands K,Kealey T