OR7D4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OR7D4
Entrez Gene ID	125958
Full Name	olfactory receptor family 7 subfamily D member 4
Synonyms	OR19-7,OR19-B,OR19B,OR7D4P,hg105
General protein information	Preferred Names olfactory receptor family 7 subfamily D member 4 Names olfactory receptor 7D4 odorant receptor family 7 subfamily D member 4 RT olfactory receptor OR19-7 olfactory receptor, family 7, subfamily D, member 4 pseudogene
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.2
Summary	Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].
Disorder MIM:	611538

mRNA and Protein(s)

mRNA	Protein	Name
NM_001005191.2	NP_001005191.1	olfactory receptor 7D4

Pathways from BioSystems

Homologies

	OR7D4	NP_001161801.1
Mus musculus (house mouse)	Olfr39	NP_667036.2
Rattus norvegicus (Norway rat)	Olr1186	NP_001000862.1
Homo sapiens (human)	OR7D4	NP_001005191.1
Pan troglodytes (chimpanzee)	OR7D4	NP_001161837.1
Canis lupus familiaris (dog)	LOC484973	XP_542091.2
Bos taurus (cattle)	LOC785624	XP_002688729.1

Gene Ontology
Bibliography

Related articles in PubMed

Bayesian informed evidence against modulation of androstadienone-effects by genotypic receptor variants and participant sex: A study assessing Stroop interference control, mood and olfaction.
Hornung J, Noack H, Thomas M, Farger G, Nieratschker V, Freiherr J, Derntl B
Hormones and behavior9845-54(2017 Dec)

Global Survey of Variation in a Human Olfactory Receptor Gene Reveals Signatures of Non-Neutral Evolution.
Hoover KC, Gokcumen O, Qureshy Z, Bruguera E, Savangsuksa A, Cobb M, Matsunami H
Chemical senses40(7)481-8(2015 Sep)

Association between olfactory receptor genes, eating behavior traits and adiposity: results from the Quebec Family Study.
Choquette AC, Bouchard L, Drapeau V, Lemieux S, Tremblay A, Bouchard C, Vohl MC, P?russe L
Physiology & behavior105(3)772-6(2012 Feb)

Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone.
Lunde K, Egelandsdal B, Skuterud E, Mainland JD, Lea T, Hersleth M, Matsunami H
PloS one7(5)e35259(2012)

Odor perception between heterosexual partners: its association with depression, anxiety, and genetic variation in odorant receptor OR7D4.
Sookoian S, Burgue?o A, Gianotti TF, Marillet G, Pirola CJ
Biological psychology86(3)153-7(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest non-neutral evolution for an olfactory receptor gene
Title: Global Survey of Variation in a Human Olfactory Receptor Gene Reveals Signatures of Non-Neutral Evolution.

This study suggested that OR7D4 sequence variant (rs2878329 G>A) showed evidence of association with reduced levels of adiposity (p=0.03), cognitive dietary restraint (p=0.05) and susceptibility to hunger (p=0.008).
Title: Association between olfactory receptor genes, eating behavior traits and adiposity: results from the Quebec Family Study.

Data is consistent with the idea that OR7D4 genotype predicts the sensory perception of meat containing androstenone and that genetic variation in an odorant receptor can alter food preferences.
Title: Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone.

The results suggested that odor perception between heterosexual partners may have an impact on the development of depression and anxiety, and that it might be influenced by genetic variation in OR7D4.
Title: Odor perception between heterosexual partners: its association with depression, anxiety, and genetic variation in odorant receptor OR7D4.

Genotypic variation in OR7D4 accounts for a significant proportion of the valence (pleasantness or unpleasantness) and intensity variance in perception of these steroidal odours
Title: Genetic variation in a human odorant receptor alters odour perception.

The following OR7D4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OR7D4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu18693	NM_001005191.2 Latest version!	Homo sapiens olfactory receptor family 7 subfamily D member 4 (OR7D4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OR7D4 ( NM_001005191.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001005191.1 Homo sapiens olfactory receptor family 7 subfamily D member 4 (OR7D4), mRNA.

Price & Availability↑

CloneID	OHu18693
Clone ID Related Accession (Same CDS sequence)	NM_001005191.2
Accession Version	NM_001005191.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	olfactory receptor 7D4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC137147.1. This sequence is a reference standard in the RefSeqGene project. On Nov 25, 2010 this sequence version replaced NM_001005191.1. ##Evidence-Data-START## Transcript is intronless :: BC137147.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGAAGCAG AAAACCTTAC AGAATTATCA AAATTTCTCC TCCTGGGACT CTCAGATGAT 
CCTGAACTGC AGCCCGTCCT CTTTGGGCTG TTCCTGTCCA TGTACCTGGT CACGGTGCTG 
GGGAACCTGC TCATCATTCT GGCCGTCAGC TCTGACTCCC ACCTCCACAC CCCCATGTAC 
TTCTTCCTCT CCAACCTGTC CTTTGTTGAC ATCTGTTTCA TCTCCACCAC AGTCCCCAAG 
ATGCTAGTGA GCATCCAGGC ACGGAGCAAA GACATCTCCT ACATGGGGTG CCTCACTCAG 
GTGTATTTTT TAATGATGTT TGCTGGAATG GATACTTTCC TACTGGCCGT GATGGCCTAT 
GACCGGTTTG TGGCCATCTG CCACCCACTG CACTACACGG TCATCATGAA CCCCTGCCTC 
TGTGGCCTCC TGGTTCTGGC ATCTTGGTTC ATCATTTTCT GGTTCTCCCT GGTTCATATT 
CTACTGATGA AGAGGTTGAC CTTCTCCACA GGCACTGAGA TTCCGCATTT CTTCTGTGAA 
CCGGCTCAGG TCCTCAAGGT GGCCTGCTCT AACACCCTCC TCAATAACAT TGTCTTGTAT 
GTGGCCACGG CACTGCTGGG TGTGTTTCCT GTAGCTGGGA TCCTCTTCTC CTACTCTCAG 
ATTGTCTCCT CCTTAATGGG AATGTCCTCC ACCAAGGGCA AGTACAAAGC CTTTTCCACC 
TGTGGATCTC ACCTCTGTGT GGTCTCCTTG TTCTATGGAA CAGGACTTGG GGTCTATCTG 
AGTTCTGCTG TGACCCATTC TTCCCAGAGC AGCTCCACCG CCTCAGTGAT GTACGCCATG 
GTCACCCCCA TGCTGAACCC CTTCATCTAC AGCCTGAGGA ACAAGGATGT GAAGGGGGCC 
CTGGAAAGAC TCCTCAGCAG GGCCGACTCT TGTCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005191.1
CDS	35..973
Translation	MEAENLTELSKFLLLGLSDDPELQPVLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFVDICFISTTVPKMLVSIQARSKDISYMGCLTQVYFLMMFAGMDTFLLAVMAYDRFVAICHPLHYTVIMNPCLCGLLVLASWFIIFWFSLVHILLMKRLTFSTGTEIPHFFCEPAQVLKVACSNTLLNNIVLYVATALLGVFPVAGILFSYSQIVSSLMGMSSTKGKYKAFSTCGSHLCVVSLFYGTGLGVYLSSAVTHSSQSSSTASVMYAMVTPMLNPFIYSLRNKDVKGALERLLSRADSCP

Target ORF information:

RefSeq Version	NM_001005191.2
Organism	Homo sapiens(human)
Definition	Homo sapiens olfactory receptor family 7 subfamily D member 4 (OR7D4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005191.2

ORF Insert Sequence:

ATGGAAGCAG AAAACCTTAC AGAATTATCA AAATTTCTCC TCCTGGGACT CTCAGATGAT 
CCTGAACTGC AGCCCGTCCT CTTTGGGCTG TTCCTGTCCA TGTACCTGGT CACGGTGCTG 
GGGAACCTGC TCATCATTCT GGCCGTCAGC TCTGACTCCC ACCTCCACAC CCCCATGTAC 
TTCTTCCTCT CCAACCTGTC CTTTGTTGAC ATCTGTTTCA TCTCCACCAC AGTCCCCAAG 
ATGCTAGTGA GCATCCAGGC ACGGAGCAAA GACATCTCCT ACATGGGGTG CCTCACTCAG 
GTGTATTTTT TAATGATGTT TGCTGGAATG GATACTTTCC TACTGGCCGT GATGGCCTAT 
GACCGGTTTG TGGCCATCTG CCACCCACTG CACTACACGG TCATCATGAA CCCCTGCCTC 
TGTGGCCTCC TGGTTCTGGC ATCTTGGTTC ATCATTTTCT GGTTCTCCCT GGTTCATATT 
CTACTGATGA AGAGGTTGAC CTTCTCCACA GGCACTGAGA TTCCGCATTT CTTCTGTGAA 
CCGGCTCAGG TCCTCAAGGT GGCCTGCTCT AACACCCTCC TCAATAACAT TGTCTTGTAT 
GTGGCCACGG CACTGCTGGG TGTGTTTCCT GTAGCTGGGA TCCTCTTCTC CTACTCTCAG 
ATTGTCTCCT CCTTAATGGG AATGTCCTCC ACCAAGGGCA AGTACAAAGC CTTTTCCACC 
TGTGGATCTC ACCTCTGTGT GGTCTCCTTG TTCTATGGAA CAGGACTTGG GGTCTATCTG 
AGTTCTGCTG TGACCCATTC TTCCCAGAGC AGCTCCACCG CCTCAGTGAT GTACGCCATG 
GTCACCCCCA TGCTGAACCC CTTCATCTAC AGCCTGAGGA ACAAGGATGT GAAGGGGGCC 
CTGGAAAGAC TCCTCAGCAG GGCCGACTCT TGTCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Bayesian informed evidence against modulation of androstadienone-effects by genotypic receptor variants and participant sex: A study assessing Stroop interference control, mood and olfaction.
Hormones and behavior9845-54(2017 Dec)
Hornung J,Noack H,Thomas M,Farger G,Nieratschker V,Freiherr J,Derntl B

Global Survey of Variation in a Human Olfactory Receptor Gene Reveals Signatures of Non-Neutral Evolution.
Chemical senses40(7)481-8(2015 Sep)
Hoover KC,Gokcumen O,Qureshy Z,Bruguera E,Savangsuksa A,Cobb M,Matsunami H

Association between olfactory receptor genes, eating behavior traits and adiposity: results from the Quebec Family Study.
Physiology & behavior105(3)772-6(2012 Feb)
Choquette AC,Bouchard L,Drapeau V,Lemieux S,Tremblay A,Bouchard C,Vohl MC,P?russe L

Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone.
PloS one7(5)e35259(2012)
Lunde K,Egelandsdal B,Skuterud E,Mainland JD,Lea T,Hersleth M,Matsunami H

Odor perception between heterosexual partners: its association with depression, anxiety, and genetic variation in odorant receptor OR7D4.
Biological psychology86(3)153-7(2011 Mar)
Sookoian S,Burgue?o A,Gianotti TF,Marillet G,Pirola CJ

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OR7D4 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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