CCR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCR1
Entrez Gene ID	1230
Full Name	C-C motif chemokine receptor 1
Synonyms	CD191,CKR-1,CKR1,CMKBR1,HM145,MIP1aR,SCYAR1
General protein information	Preferred Names C-C motif chemokine receptor 1 Names C-C chemokine receptor type 1 C-C CKR-1 CC-CKR-1 CCR-1 LD78 receptor MIP-1alpha-R RANTES receptor RANTES-R chemokine (C-C motif) receptor 1 macrophage inflammatory protein 1-alpha receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p21.31
Summary	This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008].
Disorder MIM:	601159

mRNA and Protein(s)

mRNA	Protein	Name
NM_001295.3	NP_001286.1	C-C chemokine receptor type 1
NM_001295.2	NP_001286.1	C-C chemokine receptor type 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CCR1	NP_001286.1
Pan troglodytes (chimpanzee)	CCR1	XP_516415.2
	CCR1	NP_001028030.1
Canis lupus familiaris (dog)	CCR1	NP_001033695.1
Rattus norvegicus (Norway rat)	Ccr1	NP_065417.1
Bos taurus (cattle)	CCR1	NP_001071307.1
Mus musculus (house mouse)	Ccr1	NP_034042.3

Gene Ontology
Bibliography

Related articles in PubMed

C-C chemokine receptor type 1 mediates osteopontin-promoted metastasis in hepatocellular carcinoma.
Zhu Y, Gao XM, Yang J, Xu D, Zhang Y, Lu M, Zhang Z, Sheng YY, Li JH, Yu XX, Zheng Y, Dong QZ, Qin LX
Cancer science(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggest that CCR1/CCR2B could be involved in clearing EBV-infected latency III B cells in immunocompetent individuals via directing the migration of these cells and attracting the chemokines-expressing immune cells.
Title: Expression of the chemokine receptors CCR1 and CCR2B is up-regulated in peripheral blood B cells upon EBV infection and in established lymphoblastoid cell lines.

Data suggest that the interplay between CCR1 upregulation and inactivation of CXCR4 signaling (the CCR1/CXCR4 axis) drives the egress of multiple myeloma PCs from the bone marrow, leading to disease dissemination.
Title: HIF-2? Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1.

Study indicates that two distinct micro-environmental factors, CD40L and Mphis, signal via CCR1 to induce AKT activation resulting in translational stabilization of MCL-1, and hence can contribute to CLL cell survival.
Title: Macrophages confer survival signals via CCR1-dependent translational MCL-1 induction in chronic lymphocytic leukemia.

Basophil migration into skin lesions of Systemic Lupus Erythematosus patients were observed, but not in normal skin tissue. This migration was related to the upregulation of chemokine receptors CCR1 and CCR2 on basophils.
Title: Basophil Recruitment to Skin Lesions of Patients with Systemic Lupus Erythematosus Mediated by CCR1 and CCR2.

during renal transplantation, CD4+ and CD8+ T cells expressing CCR1 were increased in patients who developed renal allograft dysfunction
Title: Increased levels of CD4(+) and CD8(+) T cells expressing CCR1 in patients developing allograft dysfunction; a cohort study.

The following CCR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16487	NM_001295.3 Latest version!	Homo sapiens C-C motif chemokine receptor 1 (CCR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu16487	NM_001295.2	Homo sapiens C-C motif chemokine receptor 1 (CCR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCR1 ( NM_001295.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001286.1 Homo sapiens C-C motif chemokine receptor 1 (CCR1), mRNA.

Price & Availability↑

CloneID	OHu16487
Clone ID Related Accession (Same CDS sequence)	NM_001295.3 , NM_001295.2
Accession Version	NM_001295.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1068bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	C-C chemokine receptor type 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX337412.2, BC064991.1, CK903574.1 and AI089760.1. On Nov 23, 2018 this sequence version replaced NM_001295.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.272171.1, SRR1660803.95966.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000296140.4/ ENSP00000296140.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAAACTC CAAACACCAC AGAGGACTAT GACACGACCA CAGAGTTTGA CTATGGGGAT 
GCAACTCCGT GCCAGAAGGT GAACGAGAGG GCCTTTGGGG CCCAACTGCT GCCCCCTCTG 
TACTCCTTGG TATTTGTCAT TGGCCTGGTT GGAAACATCC TGGTGGTCCT GGTCCTTGTG 
CAATACAAGA GGCTAAAAAA CATGACCAGC ATCTACCTCC TGAACCTGGC CATTTCTGAC 
CTGCTCTTCC TGTTCACGCT TCCCTTCTGG ATCGACTACA AGTTGAAGGA TGACTGGGTT 
TTTGGTGATG CCATGTGTAA GATCCTCTCT GGGTTTTATT ACACAGGCTT GTACAGCGAG 
ATCTTTTTCA TCATCCTGCT GACGATTGAC AGGTACCTGG CCATCGTCCA CGCCGTGTTT 
GCCTTGCGGG CACGGACCGT CACTTTTGGT GTCATCACCA GCATCATCAT TTGGGCCCTG 
GCCATCTTGG CTTCCATGCC AGGCTTATAC TTTTCCAAGA CCCAATGGGA ATTCACTCAC 
CACACCTGCA GCCTTCACTT TCCTCACGAA AGCCTACGAG AGTGGAAGCT GTTTCAGGCT 
CTGAAACTGA ACCTCTTTGG GCTGGTATTG CCTTTGTTGG TCATGATCAT CTGCTACACA 
GGGATTATAA AGATTCTGCT AAGACGACCA AATGAGAAGA AATCCAAAGC TGTCCGTTTG 
ATTTTTGTCA TCATGATCAT CTTTTTTCTC TTTTGGACCC CCTACAATTT GACTATACTT 
ATTTCTGTTT TCCAAGACTT CCTGTTCACC CATGAGTGTG AGCAGAGCAG ACATTTGGAC 
CTGGCTGTGC AAGTGACGGA GGTGATCGCC TACACGCACT GCTGTGTCAA CCCAGTGATC 
TACGCCTTCG TTGGTGAGAG GTTCCGGAAG TACCTGCGGC AGTTGTTCCA CAGGCGTGTG 
GCTGTGCACC TGGTTAAATG GCTCCCCTTC CTCTCCGTGG ACAGGCTGGA GAGGGTCAGC 
TCCACATCTC CCTCCACAGG GGAGCATGAA CTCTCTGCTG GGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001286.1
CDS	44..1111
Translation	METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF

Target ORF information:

RefSeq Version	NM_001295.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine receptor 1 (CCR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001295.3

ORF Insert Sequence:

ATGGAAACTC CAAACACCAC AGAGGACTAT GACACGACCA CAGAGTTTGA CTATGGGGAT 
GCAACTCCGT GCCAGAAGGT GAACGAGAGG GCCTTTGGGG CCCAACTGCT GCCCCCTCTG 
TACTCCTTGG TATTTGTCAT TGGCCTGGTT GGAAACATCC TGGTGGTCCT GGTCCTTGTG 
CAATACAAGA GGCTAAAAAA CATGACCAGC ATCTACCTCC TGAACCTGGC CATTTCTGAC 
CTGCTCTTCC TGTTCACGCT TCCCTTCTGG ATCGACTACA AGTTGAAGGA TGACTGGGTT 
TTTGGTGATG CCATGTGTAA GATCCTCTCT GGGTTTTATT ACACAGGCTT GTACAGCGAG 
ATCTTTTTCA TCATCCTGCT GACGATTGAC AGGTACCTGG CCATCGTCCA CGCCGTGTTT 
GCCTTGCGGG CACGGACCGT CACTTTTGGT GTCATCACCA GCATCATCAT TTGGGCCCTG 
GCCATCTTGG CTTCCATGCC AGGCTTATAC TTTTCCAAGA CCCAATGGGA ATTCACTCAC 
CACACCTGCA GCCTTCACTT TCCTCACGAA AGCCTACGAG AGTGGAAGCT GTTTCAGGCT 
CTGAAACTGA ACCTCTTTGG GCTGGTATTG CCTTTGTTGG TCATGATCAT CTGCTACACA 
GGGATTATAA AGATTCTGCT AAGACGACCA AATGAGAAGA AATCCAAAGC TGTCCGTTTG 
ATTTTTGTCA TCATGATCAT CTTTTTTCTC TTTTGGACCC CCTACAATTT GACTATACTT 
ATTTCTGTTT TCCAAGACTT CCTGTTCACC CATGAGTGTG AGCAGAGCAG ACATTTGGAC 
CTGGCTGTGC AAGTGACGGA GGTGATCGCC TACACGCACT GCTGTGTCAA CCCAGTGATC 
TACGCCTTCG TTGGTGAGAG GTTCCGGAAG TACCTGCGGC AGTTGTTCCA CAGGCGTGTG 
GCTGTGCACC TGGTTAAATG GCTCCCCTTC CTCTCCGTGG ACAGGCTGGA GAGGGTCAGC 
TCCACATCTC CCTCCACAGG GGAGCATGAA CTCTCTGCTG GGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCR1 ( NM_001295.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001286.1 Homo sapiens C-C motif chemokine receptor 1 (CCR1), mRNA.

Price & Availability↑

CloneID	OHu16487
Clone ID Related Accession (Same CDS sequence)	NM_001295.3 , NM_001295.2
Accession Version	NM_001295.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1068bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	C-C chemokine receptor type 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX337412.2, BC064991.1, CK903574.1 and AI089760.1. On Oct 4, 2004 this sequence version replaced NM_001295.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX337412.2, SRR1660803.38788.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAACTC CAAACACCAC AGAGGACTAT GACACGACCA CAGAGTTTGA CTATGGGGAT 
GCAACTCCGT GCCAGAAGGT GAACGAGAGG GCCTTTGGGG CCCAACTGCT GCCCCCTCTG 
TACTCCTTGG TATTTGTCAT TGGCCTGGTT GGAAACATCC TGGTGGTCCT GGTCCTTGTG 
CAATACAAGA GGCTAAAAAA CATGACCAGC ATCTACCTCC TGAACCTGGC CATTTCTGAC 
CTGCTCTTCC TGTTCACGCT TCCCTTCTGG ATCGACTACA AGTTGAAGGA TGACTGGGTT 
TTTGGTGATG CCATGTGTAA GATCCTCTCT GGGTTTTATT ACACAGGCTT GTACAGCGAG 
ATCTTTTTCA TCATCCTGCT GACGATTGAC AGGTACCTGG CCATCGTCCA CGCCGTGTTT 
GCCTTGCGGG CACGGACCGT CACTTTTGGT GTCATCACCA GCATCATCAT TTGGGCCCTG 
GCCATCTTGG CTTCCATGCC AGGCTTATAC TTTTCCAAGA CCCAATGGGA ATTCACTCAC 
CACACCTGCA GCCTTCACTT TCCTCACGAA AGCCTACGAG AGTGGAAGCT GTTTCAGGCT 
CTGAAACTGA ACCTCTTTGG GCTGGTATTG CCTTTGTTGG TCATGATCAT CTGCTACACA 
GGGATTATAA AGATTCTGCT AAGACGACCA AATGAGAAGA AATCCAAAGC TGTCCGTTTG 
ATTTTTGTCA TCATGATCAT CTTTTTTCTC TTTTGGACCC CCTACAATTT GACTATACTT 
ATTTCTGTTT TCCAAGACTT CCTGTTCACC CATGAGTGTG AGCAGAGCAG ACATTTGGAC 
CTGGCTGTGC AAGTGACGGA GGTGATCGCC TACACGCACT GCTGTGTCAA CCCAGTGATC 
TACGCCTTCG TTGGTGAGAG GTTCCGGAAG TACCTGCGGC AGTTGTTCCA CAGGCGTGTG 
GCTGTGCACC TGGTTAAATG GCTCCCCTTC CTCTCCGTGG ACAGGCTGGA GAGGGTCAGC 
TCCACATCTC CCTCCACAGG GGAGCATGAA CTCTCTGCTG GGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001286.1
CDS	72..1139
Translation	METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF

Target ORF information:

RefSeq Version	NM_001295.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine receptor 1 (CCR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001295.2

ORF Insert Sequence:

ATGGAAACTC CAAACACCAC AGAGGACTAT GACACGACCA CAGAGTTTGA CTATGGGGAT 
GCAACTCCGT GCCAGAAGGT GAACGAGAGG GCCTTTGGGG CCCAACTGCT GCCCCCTCTG 
TACTCCTTGG TATTTGTCAT TGGCCTGGTT GGAAACATCC TGGTGGTCCT GGTCCTTGTG 
CAATACAAGA GGCTAAAAAA CATGACCAGC ATCTACCTCC TGAACCTGGC CATTTCTGAC 
CTGCTCTTCC TGTTCACGCT TCCCTTCTGG ATCGACTACA AGTTGAAGGA TGACTGGGTT 
TTTGGTGATG CCATGTGTAA GATCCTCTCT GGGTTTTATT ACACAGGCTT GTACAGCGAG 
ATCTTTTTCA TCATCCTGCT GACGATTGAC AGGTACCTGG CCATCGTCCA CGCCGTGTTT 
GCCTTGCGGG CACGGACCGT CACTTTTGGT GTCATCACCA GCATCATCAT TTGGGCCCTG 
GCCATCTTGG CTTCCATGCC AGGCTTATAC TTTTCCAAGA CCCAATGGGA ATTCACTCAC 
CACACCTGCA GCCTTCACTT TCCTCACGAA AGCCTACGAG AGTGGAAGCT GTTTCAGGCT 
CTGAAACTGA ACCTCTTTGG GCTGGTATTG CCTTTGTTGG TCATGATCAT CTGCTACACA 
GGGATTATAA AGATTCTGCT AAGACGACCA AATGAGAAGA AATCCAAAGC TGTCCGTTTG 
ATTTTTGTCA TCATGATCAT CTTTTTTCTC TTTTGGACCC CCTACAATTT GACTATACTT 
ATTTCTGTTT TCCAAGACTT CCTGTTCACC CATGAGTGTG AGCAGAGCAG ACATTTGGAC 
CTGGCTGTGC AAGTGACGGA GGTGATCGCC TACACGCACT GCTGTGTCAA CCCAGTGATC 
TACGCCTTCG TTGGTGAGAG GTTCCGGAAG TACCTGCGGC AGTTGTTCCA CAGGCGTGTG 
GCTGTGCACC TGGTTAAATG GCTCCCCTTC CTCTCCGTGG ACAGGCTGGA GAGGGTCAGC 
TCCACATCTC CCTCCACAGG GGAGCATGAA CTCTCTGCTG GGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

C-C chemokine receptor type 1 mediates osteopontin-promoted metastasis in hepatocellular carcinoma.
Cancer science(2017 Dec)
Zhu Y,Gao XM,Yang J,Xu D,Zhang Y,Lu M,Zhang Z,Sheng YY,Li JH,Yu XX,Zheng Y,Dong QZ,Qin LX

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CCR1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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