Ccr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ccr1
Entrez Gene ID	57301
Full Name	C-C motif chemokine receptor 1
General protein information	Preferred Names C-C motif chemokine receptor 1 Names C-C chemokine receptor type 1 chemokine (C-C motif) receptor 1 macrophage inflammatory protein-1 alpha receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q32

mRNA and Protein(s)

mRNA	Protein	Name
NM_020542.2	NP_065417.1	C-C chemokine receptor type 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CCR1	NP_001286.1
Pan troglodytes (chimpanzee)	CCR1	XP_516415.2
	CCR1	NP_001028030.1
Canis lupus familiaris (dog)	CCR1	NP_001033695.1
Rattus norvegicus (Norway rat)	Ccr1	NP_065417.1
Bos taurus (cattle)	CCR1	NP_001071307.1
Mus musculus (house mouse)	Ccr1	NP_034042.3

Gene Ontology
Bibliography

Related articles in PubMed

The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, ?-arrestin-mediated internalization.
Gilliland CT, Salanga CL, Kawamura T, Trejo J, Handel TM
The Journal of biological chemistry288(45)32194-210(2013 Nov)

RANTES/CCL5-induced pro-angiogenic effects depend on CCR1, CCR5 and glycosaminoglycans.
Suffee N, Hlawaty H, Meddahi-Pelle A, Maillard L, Louedec L, Haddad O, Martin L, Laguillier C, Richard B, Oudar O, Letourneur D, Charnaux N, Sutton A
Angiogenesis15(4)727-44(2012 Dec)

Identification of genes and proteins specifically regulated by costimulation of mast cell Fc? Receptor I and chemokine receptor 1.
Aye CC, Toda M, Morohoshi K, Ono SJ
Experimental and molecular pathology92(3)267-74(2012 Jun)

Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis.
Lionakis MS, Fischer BG, Lim JK, Swamydas M, Wan W, Richard Lee CC, Cohen JI, Scheinberg P, Gao JL, Murphy PM
PLoS pathogens8(8)e1002865(2012)

A novel role for CCL3 (MIP-1?) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function.
Vallet S, Pozzi S, Patel K, Vaghela N, Fulciniti MT, Veiby P, Hideshima T, Santo L, Cirstea D, Scadden DT, Anderson KC, Raje N
Leukemia25(7)1174-81(2011 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

demonstrate that specific receptors of RANTES/CCL5 such as G protein-coupled receptors CCR1 and CCR5, and heparan sulfate proteoglycans, SDC-1, SDC-4 or CD-44, play a major role in RANTES/CCL5-induced angiogenic effects
Title: RANTES/CCL5-induced pro-angiogenic effects depend on CCR1, CCR5 and glycosaminoglycans.

Data show that among expressed chemokines and cytokines, only CCL2, CCL7 and interleukin (IL)-6 were expressed at higher levels following FcepsilonRI-CCR1 costimulation.
Title: Identification of genes and proteins specifically regulated by costimulation of mast cell Fc? Receptor I and chemokine receptor 1.

CCR1 mediates recruitment of both infiltrating macrophages and resident microglia to sites of central nervous system inflammation.
Title: Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE.

The following Ccr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04804	NM_020542.2 Latest version!	Rattus norvegicus C-C motif chemokine receptor 1 (Ccr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ccr1 ( NM_020542.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_065417.1 Rattus norvegicus C-C motif chemokine receptor 1 (Ccr1), mRNA.

Price & Availability↑

CloneID	ORa04804
Clone ID Related Accession (Same CDS sequence)	NM_020542.2
Accession Version	NM_020542.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1068bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-26
Organism	Rattus norvegicus(Norway rat)
Product	C-C chemokine receptor type 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC079207.1. On Aug 8, 2004 this sequence version replaced NM_020542.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC079207.1, CK598894.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689595 [ECO:0000348] ##Evidence-Data-END##

ATGGAGATTT CAAATATCAC AGAAACCTAC CCCACAACCA CAGAATATGA CTATGGGGAC 
TCTACTCCAT GCCAAAAAAC TGATGTAAGA GCCTTCGGGG CTGGACTCCT GCCCCCCCTG 
TACTCTTTCG TGTTTATCAT TGGAGTGGTA GGCAATATCC TGGTGATTCT GGTGCTCATG 
CAGCATAGGA GGCTTCAAAG CATGACCAGC ATATACCTGT TCAACCTGGC TGTCTCTGAT 
CTGGTCTTCC TTTTCACTTT ACCTTTCTGG ATTGACTACA AGCTGAAAGA CAACTGGGTT 
TTTGGTGATG CCATGTGTAA GCTTCTCTCT GGGTTTTATT ACCTGGGCTT ATACAGTGAG 
ATCTTCTTTA TCATCCTGCT GACAATTGAC AGGTACCTGG CCATTGTCCA TGCAGTGTTT 
TCCCTGAGGG CCCGAACTGT CACTTTTGGC ATCATCACCA GTATTATTAT TTGGGCCCTA 
GCCATCTTAG CTTCTATTCC TGCCTTATGC TTTTTCAAGG CCCAGTGGGA GTTCACTCAC 
CATACCTGTA GCCCTCATTT CCCCGATGAG AGCCTGAAGA CGTGGAAGAG GTTTCAGGCT 
CTAAAGCTAA ACCTCCTTGG ACTAATTTTA CCTCTGTTAG TCATGATAAT TTGCTACGCA 
GGGATCATCA GAATTCTGCT CAGACGACCC AATGAGAAGA AGGCCAAAGC CGTGCGTCTG 
ATATTTGCTA TTACGCTTCT ATTCTTCCTC CTCTGGACCC CCTACAATCT GACTGTATTT 
GTTTCTGCTT TCCAAGATGT TCTATTCACC AATCAGTGTG AGCAGAGCAA GCAGCTGGAC 
CTGGCCATAC AGGTGACTGA AGTGATTGCC TACACCCACT GTTGTGTCAA TCCAATCATT 
TATGTCTTTG TGGGTGAGCG GTTCCGGAAG TACCTTCGGC AGCTGTTTCA AAGGCATGTG 
GCTATACCGC TGGCAAAATG GCTGCCCTTC TTCTCTGTGG ACCAACTAGA AAGGACCAGT 
TCCTTAACTC CATCCACAGG AGAACATGAA CTTTCTGGGG GCTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065417.1
CDS	351..1418
Translation	MEISNITETYPTTTEYDYGDSTPCQKTDVRAFGAGLLPPLYSFVFIIGVVGNILVILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDNWVFGDAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFSLRARTVTFGIITSIIIWALAILASIPALCFFKAQWEFTHHTCSPHFPDESLKTWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPNEKKAKAVRLIFAITLLFFLLWTPYNLTVFVSAFQDVLFTNQCEQSKQLDLAIQVTEVIAYTHCCVNPIIYVFVGERFRKYLRQLFQRHVAIPLAKWLPFFSVDQLERTSSLTPSTGEHELSGGF

Target ORF information:

RefSeq Version	NM_020542.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-C motif chemokine receptor 1 (Ccr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020542.2

ORF Insert Sequence:

ATGGAGATTT CAAATATCAC AGAAACCTAC CCCACAACCA CAGAATATGA CTATGGGGAC 
TCTACTCCAT GCCAAAAAAC TGATGTAAGA GCCTTCGGGG CTGGACTCCT GCCCCCCCTG 
TACTCTTTCG TGTTTATCAT TGGAGTGGTA GGCAATATCC TGGTGATTCT GGTGCTCATG 
CAGCATAGGA GGCTTCAAAG CATGACCAGC ATATACCTGT TCAACCTGGC TGTCTCTGAT 
CTGGTCTTCC TTTTCACTTT ACCTTTCTGG ATTGACTACA AGCTGAAAGA CAACTGGGTT 
TTTGGTGATG CCATGTGTAA GCTTCTCTCT GGGTTTTATT ACCTGGGCTT ATACAGTGAG 
ATCTTCTTTA TCATCCTGCT GACAATTGAC AGGTACCTGG CCATTGTCCA TGCAGTGTTT 
TCCCTGAGGG CCCGAACTGT CACTTTTGGC ATCATCACCA GTATTATTAT TTGGGCCCTA 
GCCATCTTAG CTTCTATTCC TGCCTTATGC TTTTTCAAGG CCCAGTGGGA GTTCACTCAC 
CATACCTGTA GCCCTCATTT CCCCGATGAG AGCCTGAAGA CGTGGAAGAG GTTTCAGGCT 
CTAAAGCTAA ACCTCCTTGG ACTAATTTTA CCTCTGTTAG TCATGATAAT TTGCTACGCA 
GGGATCATCA GAATTCTGCT CAGACGACCC AATGAGAAGA AGGCCAAAGC CGTGCGTCTG 
ATATTTGCTA TTACGCTTCT ATTCTTCCTC CTCTGGACCC CCTACAATCT GACTGTATTT 
GTTTCTGCTT TCCAAGATGT TCTATTCACC AATCAGTGTG AGCAGAGCAA GCAGCTGGAC 
CTGGCCATAC AGGTGACTGA AGTGATTGCC TACACCCACT GTTGTGTCAA TCCAATCATT 
TATGTCTTTG TGGGTGAGCG GTTCCGGAAG TACCTTCGGC AGCTGTTTCA AAGGCATGTG 
GCTATACCGC TGGCAAAATG GCTGCCCTTC TTCTCTGTGG ACCAACTAGA AAGGACCAGT 
TCCTTAACTC CATCCACAGG AGAACATGAA CTTTCTGGGG GCTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, ?-arrestin-mediated internalization.
The Journal of biological chemistry288(45)32194-210(2013 Nov)
Gilliland CT,Salanga CL,Kawamura T,Trejo J,Handel TM

RANTES/CCL5-induced pro-angiogenic effects depend on CCR1, CCR5 and glycosaminoglycans.
Angiogenesis15(4)727-44(2012 Dec)
Suffee N,Hlawaty H,Meddahi-Pelle A,Maillard L,Louedec L,Haddad O,Martin L,Laguillier C,Richard B,Oudar O,Letourneur D,Charnaux N,Sutton A

Identification of genes and proteins specifically regulated by costimulation of mast cell Fc? Receptor I and chemokine receptor 1.
Experimental and molecular pathology92(3)267-74(2012 Jun)
Aye CC,Toda M,Morohoshi K,Ono SJ

Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis.
PLoS pathogens8(8)e1002865(2012)
Lionakis MS,Fischer BG,Lim JK,Swamydas M,Wan W,Richard Lee CC,Cohen JI,Scheinberg P,Gao JL,Murphy PM

A novel role for CCL3 (MIP-1?) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function.
Leukemia25(7)1174-81(2011 Jul)
Vallet S,Pozzi S,Patel K,Vaghela N,Fulciniti MT,Veiby P,Hideshima T,Santo L,Cirstea D,Scadden DT,Anderson KC,Raje N

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Ccr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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