TRIM6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TRIM6
Entrez Gene ID	117854
Full Name	tripartite motif containing 6
Synonyms	RNF89
General protein information	Preferred Names tripartite motif containing 6 Names tripartite motif-containing protein 6 RING finger protein 89 RING-type E3 ubiquitin transferase TRIM6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Summary	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010].
Disorder MIM:	607564

mRNA and Protein(s)

mRNA	Protein	Name
NM_058166.4	NP_477514.1	tripartite motif-containing protein 6 isoform 2
NM_001198644.1	NP_001185573.1	tripartite motif-containing protein 6 isoform 3
NM_058166.5	NP_477514.1	tripartite motif-containing protein 6 isoform 2
NM_001003818.2	NP_001003818.1	tripartite motif-containing protein 6 isoform 1
NM_001003818.3	NP_001003818.1	tripartite motif-containing protein 6 isoform 1
NM_001198645.1	NP_001185574.1	tripartite motif-containing protein 6 isoform 3
NM_001198644.2	NP_001185573.1	tripartite motif-containing protein 6 isoform 3
NM_001198645.2	NP_001185574.1	tripartite motif-containing protein 6 isoform 3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TRIM6	NP_001192119.1
Rattus norvegicus (Norway rat)	Trim6	NP_001163932.1
Homo sapiens (human)	TRIM6	NP_001003818.1
Pan troglodytes (chimpanzee)	TRIM6	NP_001192105.1
Bos taurus (cattle)	TRIM6	NP_001192118.1
Mus musculus (house mouse)	Trim6	NP_001013637.1

Gene Ontology
Bibliography

Related articles in PubMed

The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication.
Bharaj P, Atkins C, Luthra P, Giraldo MI, Dawes BE, Miorin L, Johnson JR, Krogan NJ, Basler CF, Freiberg AN, Rajsbaum R
Journal of virology91(18)(2017 Sep)

The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKK? Kinase-Mediated Type-I IFN Antiviral Response.
Bharaj P, Wang YE, Dawes BE, Yun TE, Park A, Yen B, Basler CF, Freiberg AN, Lee B, Rajsbaum R
PLoS pathogens12(9)e1005880(2016 Sep)

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
Mandell MA, Jain A, Arko-Mensah J, Chauhan S, Kimura T, Dinkins C, Silvestri G, M?nch J, Kirchhoff F, Simonsen A, Wei Y, Levine B, Johansen T, Deretic V
Developmental cell30(4)394-409(2014 Aug)

Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKK? kinase-mediated antiviral response.
Rajsbaum R, Versteeg GA, Schmid S, Maestre AM, Belicha-Villanueva A, Mart?nez-Romero C, Patel JR, Morrison J, Pisanelli G, Miorin L, Laurent-Rolle M, Moulton HM, Stein DA, Fernandez-Sesma A, tenOever BR, Garc?a-Sastre A
Immunity40(6)880-95(2014 Jun)

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Lauc G, Huffman JE, Pu?i? M, Zgaga L, Adamczyk B, Mu?ini? A, Novokmet M, Pola?ek O, Gornik O, Kri?ti? J, Keser T, Vitart V, Scheijen B, Uh HW, Molokhia M, Patrick AL, McKeigue P, Kol?i? I, Luki? IK, Swann O, van Leeuwen FN, Ruhaak LR, Houwing-Duistermaat JJ, Slagboom PE, Beekman M, de Craen AJ, Deelder AM, Zeng Q, Wang W, Hastie ND, Gyllensten U, Wilson JF, Wuhrer M, Wright AF, Rudd PM, Hayward C, Aulchenko Y, Campbell H, Rudan I
PLoS genetics9(1)e1003225(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Intriguingly, the authors also found that TRIM6 enhances ebola virus polymerase activity in a minigenome assay and TRIM6 knockout cells have reduced replication of infectious ebola virus, suggesting that VP35 hijacks TRIM6 to promote ebola virus replication through ubiquitination.
Title: The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication.

Live NiV infection, but not a recombinant NiV lacking the M protein, reduced the levels of endogenous TRIM6 protein expression. To our knowledge, matrix proteins of paramyxoviruses have never been reported to be involved in innate immune antagonism. We report here a novel mechanism of viral innate immune evasion by targeting TRIM6, IKKepsilon and unanchored polyubiquitin chains.
Title: The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKK? Kinase-Mediated Type-I IFN Antiviral Response.

TRIM6 and the E2-ubiquitin conjugase UbE2K cooperated in the synthesis of unanchored K48-linked polyubiquitin chains, which activated IKKepsilon for subsequent STAT1 phosphorylation.
Title: Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKK? kinase-mediated antiviral response.

heterologous RING, B-box 2, and CC domains from related TRIM proteins can functionally substitute for TRIM5alpha(rh) domains.
Title: Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains.

The following TRIM6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TRIM6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03491	NM_001003818.3 Latest version!	Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu05695	NM_058166.5 Latest version!	Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu05768	NM_001198645.2 Latest version!	Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu05768	NM_001198644.2 Latest version!	Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu05695	NM_058166.4	Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu03491	NM_001003818.2	Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu05768	NM_001198644.1	Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu05768	NM_001198645.1	Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TRIM6 ( NM_001003818.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001003818.1 Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03491
Clone ID Related Accession (Same CDS sequence)	NM_001003818.2 , NM_001003818.3
Accession Version	NM_001003818.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1551bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	tripartite motif-containing protein 6 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK290172.1, BC047564.1, AK316178.1, AF220030.1 and AK023210.1. On Oct 30, 2010 this sequence version replaced NM_001003818.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290172.1, BC047564.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGCGGGT CAGAGAGGAT TCTACAGGCA GGAAACATCT TAGAAATCAG GGTTGGGCAG 
GCAGGAGCCA GGAGAGTAGC TACAATGACT TCACCAGTAC TGGTGGACAT ACGAGAAGAG 
GTGACCTGCC CTATCTGCCT GGAGCTCCTA ACAGAACCCC TGAGCATAGA CTGTGGCCAC 
AGCTTCTGCC AAGCCTGCAT CACACCAAAT GGCAGGGAAT CAGTGATTGG TCAAGAAGGG 
GAAAGAAGCT GCCCTGTGTG CCAGACCAGC TACCAGCCAG GGAACCTGCG GCCTAATCGG 
CATCTGGCCA ACATAGTGAG GCGGCTCAGA GAGGTAGTGT TGGGCCCTGG GAAGCAGCTG 
AAAGCAGTTC TTTGTGCAGA CCATGGAGAA AAACTGCAGC TCTTCTGTCA GGAGGATGGG 
AAGGTCATTT GCTGGCTTTG TGAGCGGTCT CAGGAGCACC GTGGTCACCA CACGTTCCTC 
GTGGAGGAGG TTGCCCAGGA GTACCAGGAG AAGTTTCAGG AGTCTCTAAA GAAGCTGAAG 
AACGAGGAGC AGGAAGCTGA GAAGCTAACA GCTTTTATCA GAGAGAAGAA AACATCCTGG 
AAGAATCAGA TGGAGCCTGA GAGATGCAGG ATCCAGACAG AGTTTAATCA GCTGCGAAAT 
ATCCTAGACA GAGTGGAGCA ACGGGAGCTG AAAAAGCTGG AACAGGAAGA GAAGAAGGGG 
CTACGAATTA TAGAAGAGGC TGAGAATGAT CTGGTCCACC AGACCCAGTC GCTGCGAGAG 
CTCATCTCGG ATCTGGAGCG TCGATGTCAG GGGTCAACAA TGGAGCTGCT GCAGGATGTG 
AGTGATGTCA CAGAAAGGAG TGAGTTCTGG ACCCTGAGGA AGCCAGAAGC TCTCCCTACA 
AAGCTGAGAA GTATGTTCCG AGCCCCAGAT CTGAAAAGGA TGCTGCGAGT GTGTAGAGAG 
CTGACAGATG TCCAAAGCTA CTGGGTTGAC GTGACCCTGA ATCCACACAC AGCTAATTTA 
AATCTTGTCC TGGCTAAAAA CCGGAGACAA GTGAGGTTTG TGGGAGCTAA AGTATCTGGA 
CCTTCCTGTC TGGAAAAGCA TTATGACTGT AGTGTCCTGG GCTCCCAGCA CTTCTCCTCT 
GGTAAGCATT ACTGGGAGGT AGATGTGGCC AAGAAGACTG CCTGGATCCT GGGGGTATGC 
AGCAATTCAC TGGGACCTAC ATTCTCTTTC AACCATTTTG CTCAAAATCA CAGTGCTTAC 
TCCAGGTATC AGCCTCAGAG TGGATACTGG GTGATTGGGT TACAGCATAA CCATGAATAT 
AGGGCCTATG AGGATTCTTC CCCTTCCCTG CTTCTCTCCA TGACAGTGCC CCCTCGCCGT 
GTTGGGGTTT TCTTAGATTA TGAGGCTGGT ACTGTCTCCT TTTATAATGT CACAAACCAT 
GGCTTCCCCA TCTACACTTT CTCTAAATAT TACTTTCCCA CTACTCTTTG TCCATATTTT 
AATCCTTGCA ACTGTGTAAT TCCTATGACC CTGCGTCGTC CAAGCTCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003818.1
CDS	264..1814
Translation	MCGSERILQAGNILEIRVGQAGARRVATMTSPVLVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQPGNLRPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCERSQEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSYWVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDCSVLGSQHFSSGKHYWEVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVIPMTLRRPSS

Target ORF information:

RefSeq Version	NM_001003818.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003818.2

ORF Insert Sequence:

ATGTGCGGGT CAGAGAGGAT TCTACAGGCA GGAAACATCT TAGAAATCAG GGTTGGGCAG 
GCAGGAGCCA GGAGAGTAGC TACAATGACT TCACCAGTAC TGGTGGACAT ACGAGAAGAG 
GTGACCTGCC CTATCTGCCT GGAGCTCCTA ACAGAACCCC TGAGCATAGA CTGTGGCCAC 
AGCTTCTGCC AAGCCTGCAT CACACCAAAT GGCAGGGAAT CAGTGATTGG TCAAGAAGGG 
GAAAGAAGCT GCCCTGTGTG CCAGACCAGC TACCAGCCAG GGAACCTGCG GCCTAATCGG 
CATCTGGCCA ACATAGTGAG GCGGCTCAGA GAGGTAGTGT TGGGCCCTGG GAAGCAGCTG 
AAAGCAGTTC TTTGTGCAGA CCATGGAGAA AAACTGCAGC TCTTCTGTCA GGAGGATGGG 
AAGGTCATTT GCTGGCTTTG TGAGCGGTCT CAGGAGCACC GTGGTCACCA CACGTTCCTC 
GTGGAGGAGG TTGCCCAGGA GTACCAGGAG AAGTTTCAGG AGTCTCTAAA GAAGCTGAAG 
AACGAGGAGC AGGAAGCTGA GAAGCTAACA GCTTTTATCA GAGAGAAGAA AACATCCTGG 
AAGAATCAGA TGGAGCCTGA GAGATGCAGG ATCCAGACAG AGTTTAATCA GCTGCGAAAT 
ATCCTAGACA GAGTGGAGCA ACGGGAGCTG AAAAAGCTGG AACAGGAAGA GAAGAAGGGG 
CTACGAATTA TAGAAGAGGC TGAGAATGAT CTGGTCCACC AGACCCAGTC GCTGCGAGAG 
CTCATCTCGG ATCTGGAGCG TCGATGTCAG GGGTCAACAA TGGAGCTGCT GCAGGATGTG 
AGTGATGTCA CAGAAAGGAG TGAGTTCTGG ACCCTGAGGA AGCCAGAAGC TCTCCCTACA 
AAGCTGAGAA GTATGTTCCG AGCCCCAGAT CTGAAAAGGA TGCTGCGAGT GTGTAGAGAG 
CTGACAGATG TCCAAAGCTA CTGGGTTGAC GTGACCCTGA ATCCACACAC AGCTAATTTA 
AATCTTGTCC TGGCTAAAAA CCGGAGACAA GTGAGGTTTG TGGGAGCTAA AGTATCTGGA 
CCTTCCTGTC TGGAAAAGCA TTATGACTGT AGTGTCCTGG GCTCCCAGCA CTTCTCCTCT 
GGTAAGCATT ACTGGGAGGT AGATGTGGCC AAGAAGACTG CCTGGATCCT GGGGGTATGC 
AGCAATTCAC TGGGACCTAC ATTCTCTTTC AACCATTTTG CTCAAAATCA CAGTGCTTAC 
TCCAGGTATC AGCCTCAGAG TGGATACTGG GTGATTGGGT TACAGCATAA CCATGAATAT 
AGGGCCTATG AGGATTCTTC CCCTTCCCTG CTTCTCTCCA TGACAGTGCC CCCTCGCCGT 
GTTGGGGTTT TCTTAGATTA TGAGGCTGGT ACTGTCTCCT TTTATAATGT CACAAACCAT 
GGCTTCCCCA TCTACACTTT CTCTAAATAT TACTTTCCCA CTACTCTTTG TCCATATTTT 
AATCCTTGCA ACTGTGTAAT TCCTATGACC CTGCGTCGTC CAAGCTCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRIM6 ( NM_001003818.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001003818.1 Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03491
Clone ID Related Accession (Same CDS sequence)	NM_001003818.2 , NM_001003818.3
Accession Version	NM_001003818.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1551bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	tripartite motif-containing protein 6 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK290172.1, BC047564.1, AK316178.1 and AF220030.1. On Nov 22, 2018 this sequence version replaced NM_001003818.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC047564.1, SRR1803611.47676.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380097.8/ ENSP00000369440.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGCGGGT CAGAGAGGAT TCTACAGGCA GGAAACATCT TAGAAATCAG GGTTGGGCAG 
GCAGGAGCCA GGAGAGTAGC TACAATGACT TCACCAGTAC TGGTGGACAT ACGAGAAGAG 
GTGACCTGCC CTATCTGCCT GGAGCTCCTA ACAGAACCCC TGAGCATAGA CTGTGGCCAC 
AGCTTCTGCC AAGCCTGCAT CACACCAAAT GGCAGGGAAT CAGTGATTGG TCAAGAAGGG 
GAAAGAAGCT GCCCTGTGTG CCAGACCAGC TACCAGCCAG GGAACCTGCG GCCTAATCGG 
CATCTGGCCA ACATAGTGAG GCGGCTCAGA GAGGTAGTGT TGGGCCCTGG GAAGCAGCTG 
AAAGCAGTTC TTTGTGCAGA CCATGGAGAA AAACTGCAGC TCTTCTGTCA GGAGGATGGG 
AAGGTCATTT GCTGGCTTTG TGAGCGGTCT CAGGAGCACC GTGGTCACCA CACGTTCCTC 
GTGGAGGAGG TTGCCCAGGA GTACCAGGAG AAGTTTCAGG AGTCTCTAAA GAAGCTGAAG 
AACGAGGAGC AGGAAGCTGA GAAGCTAACA GCTTTTATCA GAGAGAAGAA AACATCCTGG 
AAGAATCAGA TGGAGCCTGA GAGATGCAGG ATCCAGACAG AGTTTAATCA GCTGCGAAAT 
ATCCTAGACA GAGTGGAGCA ACGGGAGCTG AAAAAGCTGG AACAGGAAGA GAAGAAGGGG 
CTACGAATTA TAGAAGAGGC TGAGAATGAT CTGGTCCACC AGACCCAGTC GCTGCGAGAG 
CTCATCTCGG ATCTGGAGCG TCGATGTCAG GGGTCAACAA TGGAGCTGCT GCAGGATGTG 
AGTGATGTCA CAGAAAGGAG TGAGTTCTGG ACCCTGAGGA AGCCAGAAGC TCTCCCTACA 
AAGCTGAGAA GTATGTTCCG AGCCCCAGAT CTGAAAAGGA TGCTGCGAGT GTGTAGAGAG 
CTGACAGATG TCCAAAGCTA CTGGGTTGAC GTGACCCTGA ATCCACACAC AGCTAATTTA 
AATCTTGTCC TGGCTAAAAA CCGGAGACAA GTGAGGTTTG TGGGAGCTAA AGTATCTGGA 
CCTTCCTGTC TGGAAAAGCA TTATGACTGT AGTGTCCTGG GCTCCCAGCA CTTCTCCTCT 
GGTAAGCATT ACTGGGAGGT AGATGTGGCC AAGAAGACTG CCTGGATCCT GGGGGTATGC 
AGCAATTCAC TGGGACCTAC ATTCTCTTTC AACCATTTTG CTCAAAATCA CAGTGCTTAC 
TCCAGGTATC AGCCTCAGAG TGGATACTGG GTGATTGGGT TACAGCATAA CCATGAATAT 
AGGGCCTATG AGGATTCTTC CCCTTCCCTG CTTCTCTCCA TGACAGTGCC CCCTCGCCGT 
GTTGGGGTTT TCTTAGATTA TGAGGCTGGT ACTGTCTCCT TTTATAATGT CACAAACCAT 
GGCTTCCCCA TCTACACTTT CTCTAAATAT TACTTTCCCA CTACTCTTTG TCCATATTTT 
AATCCTTGCA ACTGTGTAAT TCCTATGACC CTGCGTCGTC CAAGCTCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003818.1
CDS	262..1812
Translation	MCGSERILQAGNILEIRVGQAGARRVATMTSPVLVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQPGNLRPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCERSQEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSYWVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDCSVLGSQHFSSGKHYWEVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVIPMTLRRPSS

Target ORF information:

RefSeq Version	NM_001003818.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003818.3

ORF Insert Sequence:

ATGTGCGGGT CAGAGAGGAT TCTACAGGCA GGAAACATCT TAGAAATCAG GGTTGGGCAG 
GCAGGAGCCA GGAGAGTAGC TACAATGACT TCACCAGTAC TGGTGGACAT ACGAGAAGAG 
GTGACCTGCC CTATCTGCCT GGAGCTCCTA ACAGAACCCC TGAGCATAGA CTGTGGCCAC 
AGCTTCTGCC AAGCCTGCAT CACACCAAAT GGCAGGGAAT CAGTGATTGG TCAAGAAGGG 
GAAAGAAGCT GCCCTGTGTG CCAGACCAGC TACCAGCCAG GGAACCTGCG GCCTAATCGG 
CATCTGGCCA ACATAGTGAG GCGGCTCAGA GAGGTAGTGT TGGGCCCTGG GAAGCAGCTG 
AAAGCAGTTC TTTGTGCAGA CCATGGAGAA AAACTGCAGC TCTTCTGTCA GGAGGATGGG 
AAGGTCATTT GCTGGCTTTG TGAGCGGTCT CAGGAGCACC GTGGTCACCA CACGTTCCTC 
GTGGAGGAGG TTGCCCAGGA GTACCAGGAG AAGTTTCAGG AGTCTCTAAA GAAGCTGAAG 
AACGAGGAGC AGGAAGCTGA GAAGCTAACA GCTTTTATCA GAGAGAAGAA AACATCCTGG 
AAGAATCAGA TGGAGCCTGA GAGATGCAGG ATCCAGACAG AGTTTAATCA GCTGCGAAAT 
ATCCTAGACA GAGTGGAGCA ACGGGAGCTG AAAAAGCTGG AACAGGAAGA GAAGAAGGGG 
CTACGAATTA TAGAAGAGGC TGAGAATGAT CTGGTCCACC AGACCCAGTC GCTGCGAGAG 
CTCATCTCGG ATCTGGAGCG TCGATGTCAG GGGTCAACAA TGGAGCTGCT GCAGGATGTG 
AGTGATGTCA CAGAAAGGAG TGAGTTCTGG ACCCTGAGGA AGCCAGAAGC TCTCCCTACA 
AAGCTGAGAA GTATGTTCCG AGCCCCAGAT CTGAAAAGGA TGCTGCGAGT GTGTAGAGAG 
CTGACAGATG TCCAAAGCTA CTGGGTTGAC GTGACCCTGA ATCCACACAC AGCTAATTTA 
AATCTTGTCC TGGCTAAAAA CCGGAGACAA GTGAGGTTTG TGGGAGCTAA AGTATCTGGA 
CCTTCCTGTC TGGAAAAGCA TTATGACTGT AGTGTCCTGG GCTCCCAGCA CTTCTCCTCT 
GGTAAGCATT ACTGGGAGGT AGATGTGGCC AAGAAGACTG CCTGGATCCT GGGGGTATGC 
AGCAATTCAC TGGGACCTAC ATTCTCTTTC AACCATTTTG CTCAAAATCA CAGTGCTTAC 
TCCAGGTATC AGCCTCAGAG TGGATACTGG GTGATTGGGT TACAGCATAA CCATGAATAT 
AGGGCCTATG AGGATTCTTC CCCTTCCCTG CTTCTCTCCA TGACAGTGCC CCCTCGCCGT 
GTTGGGGTTT TCTTAGATTA TGAGGCTGGT ACTGTCTCCT TTTATAATGT CACAAACCAT 
GGCTTCCCCA TCTACACTTT CTCTAAATAT TACTTTCCCA CTACTCTTTG TCCATATTTT 
AATCCTTGCA ACTGTGTAAT TCCTATGACC CTGCGTCGTC CAAGCTCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRIM6 ( NM_058166.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_477514.1 Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu05695
Clone ID Related Accession (Same CDS sequence)	NM_058166.4 , NM_058166.5
Accession Version	NM_058166.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1467bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	tripartite motif-containing protein 6 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB233046.1, AK027664.1, DC354457.1, AK290172.1, AF220030.1 and AK023210.1. On Oct 30, 2010 this sequence version replaced NM_058166.3. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream AUG start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF220030.1, SRR1803611.29479.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTTCAC CAGTACTGGT GGACATACGA GAAGAGGTGA CCTGCCCTAT CTGCCTGGAG 
CTCCTAACAG AACCCCTGAG CATAGACTGT GGCCACAGCT TCTGCCAAGC CTGCATCACA 
CCAAATGGCA GGGAATCAGT GATTGGTCAA GAAGGGGAAA GAAGCTGCCC TGTGTGCCAG 
ACCAGCTACC AGCCAGGGAA CCTGCGGCCT AATCGGCATC TGGCCAACAT AGTGAGGCGG 
CTCAGAGAGG TAGTGTTGGG CCCTGGGAAG CAGCTGAAAG CAGTTCTTTG TGCAGACCAT 
GGAGAAAAAC TGCAGCTCTT CTGTCAGGAG GATGGGAAGG TCATTTGCTG GCTTTGTGAG 
CGGTCTCAGG AGCACCGTGG TCACCACACG TTCCTCGTGG AGGAGGTTGC CCAGGAGTAC 
CAGGAGAAGT TTCAGGAGTC TCTAAAGAAG CTGAAGAACG AGGAGCAGGA AGCTGAGAAG 
CTAACAGCTT TTATCAGAGA GAAGAAAACA TCCTGGAAGA ATCAGATGGA GCCTGAGAGA 
TGCAGGATCC AGACAGAGTT TAATCAGCTG CGAAATATCC TAGACAGAGT GGAGCAACGG 
GAGCTGAAAA AGCTGGAACA GGAAGAGAAG AAGGGGCTAC GAATTATAGA AGAGGCTGAG 
AATGATCTGG TCCACCAGAC CCAGTCGCTG CGAGAGCTCA TCTCGGATCT GGAGCGTCGA 
TGTCAGGGGT CAACAATGGA GCTGCTGCAG GATGTGAGTG ATGTCACAGA AAGGAGTGAG 
TTCTGGACCC TGAGGAAGCC AGAAGCTCTC CCTACAAAGC TGAGAAGTAT GTTCCGAGCC 
CCAGATCTGA AAAGGATGCT GCGAGTGTGT AGAGAGCTGA CAGATGTCCA AAGCTACTGG 
GTTGACGTGA CCCTGAATCC ACACACAGCT AATTTAAATC TTGTCCTGGC TAAAAACCGG 
AGACAAGTGA GGTTTGTGGG AGCTAAAGTA TCTGGACCTT CCTGTCTGGA AAAGCATTAT 
GACTGTAGTG TCCTGGGCTC CCAGCACTTC TCCTCTGGTA AGCATTACTG GGAGGTAGAT 
GTGGCCAAGA AGACTGCCTG GATCCTGGGG GTATGCAGCA ATTCACTGGG ACCTACATTC 
TCTTTCAACC ATTTTGCTCA AAATCACAGT GCTTACTCCA GGTATCAGCC TCAGAGTGGA 
TACTGGGTGA TTGGGTTACA GCATAACCAT GAATATAGGG CCTATGAGGA TTCTTCCCCT 
TCCCTGCTTC TCTCCATGAC AGTGCCCCCT CGCCGTGTTG GGGTTTTCTT AGATTATGAG 
GCTGGTACTG TCTCCTTTTA TAATGTCACA AACCATGGCT TCCCCATCTA CACTTTCTCT 
AAATATTACT TTCCCACTAC TCTTTGTCCA TATTTTAATC CTTGCAACTG TGTAATTCCT 
ATGACCCTGC GTCGTCCAAG CTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_477514.1
CDS	149..1615
Translation	MTSPVLVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQPGNLRPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCERSQEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSYWVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDCSVLGSQHFSSGKHYWEVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVIPMTLRRPSS

Target ORF information:

RefSeq Version	NM_058166.4
Organism	Homo sapiens(human)
Definition	Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_058166.4

ORF Insert Sequence:

ATGACTTCAC CAGTACTGGT GGACATACGA GAAGAGGTGA CCTGCCCTAT CTGCCTGGAG 
CTCCTAACAG AACCCCTGAG CATAGACTGT GGCCACAGCT TCTGCCAAGC CTGCATCACA 
CCAAATGGCA GGGAATCAGT GATTGGTCAA GAAGGGGAAA GAAGCTGCCC TGTGTGCCAG 
ACCAGCTACC AGCCAGGGAA CCTGCGGCCT AATCGGCATC TGGCCAACAT AGTGAGGCGG 
CTCAGAGAGG TAGTGTTGGG CCCTGGGAAG CAGCTGAAAG CAGTTCTTTG TGCAGACCAT 
GGAGAAAAAC TGCAGCTCTT CTGTCAGGAG GATGGGAAGG TCATTTGCTG GCTTTGTGAG 
CGGTCTCAGG AGCACCGTGG TCACCACACG TTCCTCGTGG AGGAGGTTGC CCAGGAGTAC 
CAGGAGAAGT TTCAGGAGTC TCTAAAGAAG CTGAAGAACG AGGAGCAGGA AGCTGAGAAG 
CTAACAGCTT TTATCAGAGA GAAGAAAACA TCCTGGAAGA ATCAGATGGA GCCTGAGAGA 
TGCAGGATCC AGACAGAGTT TAATCAGCTG CGAAATATCC TAGACAGAGT GGAGCAACGG 
GAGCTGAAAA AGCTGGAACA GGAAGAGAAG AAGGGGCTAC GAATTATAGA AGAGGCTGAG 
AATGATCTGG TCCACCAGAC CCAGTCGCTG CGAGAGCTCA TCTCGGATCT GGAGCGTCGA 
TGTCAGGGGT CAACAATGGA GCTGCTGCAG GATGTGAGTG ATGTCACAGA AAGGAGTGAG 
TTCTGGACCC TGAGGAAGCC AGAAGCTCTC CCTACAAAGC TGAGAAGTAT GTTCCGAGCC 
CCAGATCTGA AAAGGATGCT GCGAGTGTGT AGAGAGCTGA CAGATGTCCA AAGCTACTGG 
GTTGACGTGA CCCTGAATCC ACACACAGCT AATTTAAATC TTGTCCTGGC TAAAAACCGG 
AGACAAGTGA GGTTTGTGGG AGCTAAAGTA TCTGGACCTT CCTGTCTGGA AAAGCATTAT 
GACTGTAGTG TCCTGGGCTC CCAGCACTTC TCCTCTGGTA AGCATTACTG GGAGGTAGAT 
GTGGCCAAGA AGACTGCCTG GATCCTGGGG GTATGCAGCA ATTCACTGGG ACCTACATTC 
TCTTTCAACC ATTTTGCTCA AAATCACAGT GCTTACTCCA GGTATCAGCC TCAGAGTGGA 
TACTGGGTGA TTGGGTTACA GCATAACCAT GAATATAGGG CCTATGAGGA TTCTTCCCCT 
TCCCTGCTTC TCTCCATGAC AGTGCCCCCT CGCCGTGTTG GGGTTTTCTT AGATTATGAG 
GCTGGTACTG TCTCCTTTTA TAATGTCACA AACCATGGCT TCCCCATCTA CACTTTCTCT 
AAATATTACT TTCCCACTAC TCTTTGTCCA TATTTTAATC CTTGCAACTG TGTAATTCCT 
ATGACCCTGC GTCGTCCAAG CTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRIM6 ( NM_058166.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_477514.1 Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu05695
Clone ID Related Accession (Same CDS sequence)	NM_058166.4 , NM_058166.5
Accession Version	NM_058166.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1467bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-31
Organism	Homo sapiens(human)
Product	tripartite motif-containing protein 6 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK027664.1, DC354457.1, AK290172.1 and AF220030.1. On Jun 1, 2019 this sequence version replaced NM_058166.4. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream AUG start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.29479.1, AF220030.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTTCAC CAGTACTGGT GGACATACGA GAAGAGGTGA CCTGCCCTAT CTGCCTGGAG 
CTCCTAACAG AACCCCTGAG CATAGACTGT GGCCACAGCT TCTGCCAAGC CTGCATCACA 
CCAAATGGCA GGGAATCAGT GATTGGTCAA GAAGGGGAAA GAAGCTGCCC TGTGTGCCAG 
ACCAGCTACC AGCCAGGGAA CCTGCGGCCT AATCGGCATC TGGCCAACAT AGTGAGGCGG 
CTCAGAGAGG TAGTGTTGGG CCCTGGGAAG CAGCTGAAAG CAGTTCTTTG TGCAGACCAT 
GGAGAAAAAC TGCAGCTCTT CTGTCAGGAG GATGGGAAGG TCATTTGCTG GCTTTGTGAG 
CGGTCTCAGG AGCACCGTGG TCACCACACG TTCCTCGTGG AGGAGGTTGC CCAGGAGTAC 
CAGGAGAAGT TTCAGGAGTC TCTAAAGAAG CTGAAGAACG AGGAGCAGGA AGCTGAGAAG 
CTAACAGCTT TTATCAGAGA GAAGAAAACA TCCTGGAAGA ATCAGATGGA GCCTGAGAGA 
TGCAGGATCC AGACAGAGTT TAATCAGCTG CGAAATATCC TAGACAGAGT GGAGCAACGG 
GAGCTGAAAA AGCTGGAACA GGAAGAGAAG AAGGGGCTAC GAATTATAGA AGAGGCTGAG 
AATGATCTGG TCCACCAGAC CCAGTCGCTG CGAGAGCTCA TCTCGGATCT GGAGCGTCGA 
TGTCAGGGGT CAACAATGGA GCTGCTGCAG GATGTGAGTG ATGTCACAGA AAGGAGTGAG 
TTCTGGACCC TGAGGAAGCC AGAAGCTCTC CCTACAAAGC TGAGAAGTAT GTTCCGAGCC 
CCAGATCTGA AAAGGATGCT GCGAGTGTGT AGAGAGCTGA CAGATGTCCA AAGCTACTGG 
GTTGACGTGA CCCTGAATCC ACACACAGCT AATTTAAATC TTGTCCTGGC TAAAAACCGG 
AGACAAGTGA GGTTTGTGGG AGCTAAAGTA TCTGGACCTT CCTGTCTGGA AAAGCATTAT 
GACTGTAGTG TCCTGGGCTC CCAGCACTTC TCCTCTGGTA AGCATTACTG GGAGGTAGAT 
GTGGCCAAGA AGACTGCCTG GATCCTGGGG GTATGCAGCA ATTCACTGGG ACCTACATTC 
TCTTTCAACC ATTTTGCTCA AAATCACAGT GCTTACTCCA GGTATCAGCC TCAGAGTGGA 
TACTGGGTGA TTGGGTTACA GCATAACCAT GAATATAGGG CCTATGAGGA TTCTTCCCCT 
TCCCTGCTTC TCTCCATGAC AGTGCCCCCT CGCCGTGTTG GGGTTTTCTT AGATTATGAG 
GCTGGTACTG TCTCCTTTTA TAATGTCACA AACCATGGCT TCCCCATCTA CACTTTCTCT 
AAATATTACT TTCCCACTAC TCTTTGTCCA TATTTTAATC CTTGCAACTG TGTAATTCCT 
ATGACCCTGC GTCGTCCAAG CTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_477514.1
CDS	139..1605
Translation	MTSPVLVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQPGNLRPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCERSQEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSYWVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDCSVLGSQHFSSGKHYWEVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVIPMTLRRPSS

Target ORF information:

RefSeq Version	NM_058166.5
Organism	Homo sapiens(human)
Definition	Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_058166.5

ORF Insert Sequence:

ATGACTTCAC CAGTACTGGT GGACATACGA GAAGAGGTGA CCTGCCCTAT CTGCCTGGAG 
CTCCTAACAG AACCCCTGAG CATAGACTGT GGCCACAGCT TCTGCCAAGC CTGCATCACA 
CCAAATGGCA GGGAATCAGT GATTGGTCAA GAAGGGGAAA GAAGCTGCCC TGTGTGCCAG 
ACCAGCTACC AGCCAGGGAA CCTGCGGCCT AATCGGCATC TGGCCAACAT AGTGAGGCGG 
CTCAGAGAGG TAGTGTTGGG CCCTGGGAAG CAGCTGAAAG CAGTTCTTTG TGCAGACCAT 
GGAGAAAAAC TGCAGCTCTT CTGTCAGGAG GATGGGAAGG TCATTTGCTG GCTTTGTGAG 
CGGTCTCAGG AGCACCGTGG TCACCACACG TTCCTCGTGG AGGAGGTTGC CCAGGAGTAC 
CAGGAGAAGT TTCAGGAGTC TCTAAAGAAG CTGAAGAACG AGGAGCAGGA AGCTGAGAAG 
CTAACAGCTT TTATCAGAGA GAAGAAAACA TCCTGGAAGA ATCAGATGGA GCCTGAGAGA 
TGCAGGATCC AGACAGAGTT TAATCAGCTG CGAAATATCC TAGACAGAGT GGAGCAACGG 
GAGCTGAAAA AGCTGGAACA GGAAGAGAAG AAGGGGCTAC GAATTATAGA AGAGGCTGAG 
AATGATCTGG TCCACCAGAC CCAGTCGCTG CGAGAGCTCA TCTCGGATCT GGAGCGTCGA 
TGTCAGGGGT CAACAATGGA GCTGCTGCAG GATGTGAGTG ATGTCACAGA AAGGAGTGAG 
TTCTGGACCC TGAGGAAGCC AGAAGCTCTC CCTACAAAGC TGAGAAGTAT GTTCCGAGCC 
CCAGATCTGA AAAGGATGCT GCGAGTGTGT AGAGAGCTGA CAGATGTCCA AAGCTACTGG 
GTTGACGTGA CCCTGAATCC ACACACAGCT AATTTAAATC TTGTCCTGGC TAAAAACCGG 
AGACAAGTGA GGTTTGTGGG AGCTAAAGTA TCTGGACCTT CCTGTCTGGA AAAGCATTAT 
GACTGTAGTG TCCTGGGCTC CCAGCACTTC TCCTCTGGTA AGCATTACTG GGAGGTAGAT 
GTGGCCAAGA AGACTGCCTG GATCCTGGGG GTATGCAGCA ATTCACTGGG ACCTACATTC 
TCTTTCAACC ATTTTGCTCA AAATCACAGT GCTTACTCCA GGTATCAGCC TCAGAGTGGA 
TACTGGGTGA TTGGGTTACA GCATAACCAT GAATATAGGG CCTATGAGGA TTCTTCCCCT 
TCCCTGCTTC TCTCCATGAC AGTGCCCCCT CGCCGTGTTG GGGTTTTCTT AGATTATGAG 
GCTGGTACTG TCTCCTTTTA TAATGTCACA AACCATGGCT TCCCCATCTA CACTTTCTCT 
AAATATTACT TTCCCACTAC TCTTTGTCCA TATTTTAATC CTTGCAACTG TGTAATTCCT 
ATGACCCTGC GTCGTCCAAG CTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRIM6 ( NM_001198644.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001185573.1 Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu05768
Clone ID Related Accession (Same CDS sequence)	NM_001198644.1 , NM_001198645.1 , NM_001198644.2 , NM_001198645.2
Accession Version	NM_001198644.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	tripartite motif-containing protein 6 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK290172.1, BC047564.1, DA401634.1, AK298301.1, AK316178.1, AK293295.1, AF220030.1 and AK023210.1. Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region, and uses a downstream AUG start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Both variants 3 and 4 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298301.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCTG AGAGATGCAG GATCCAGACA GAGTTTAATC AGCTGCGAAA TATCCTAGAC 
AGAGTGGAGC AACGGGAGCT GAAAAAGCTG GAACAGGAAG AGAAGAAGGG GCTACGAATT 
ATAGAAGAGG CTGAGAATGA TCTGGTCCAC CAGACCCAGT CGCTGCGAGA GCTCATCTCG 
GATCTGGAGC GTCGATGTCA GGGGTCAACA ATGGAGCTGC TGCAGGATGT GAGTGATGTC 
ACAGAAAGGA GTGAGTTCTG GACCCTGAGG AAGCCAGAAG CTCTCCCTAC AAAGCTGAGA 
AGTATGTTCC GAGCCCCAGA TCTGAAAAGG ATGCTGCGAG TGTGTAGAGA GCTGACAGAT 
GTCCAAAGCT ACTGGGTTGA CGTGACCCTG AATCCACACA CAGCTAATTT AAATCTTGTC 
CTGGCTAAAA ACCGGAGACA AGTGAGGTTT GTGGGAGCTA AAGTATCTGG ACCTTCCTGT 
CTGGAAAAGC ATTATGACTG TAGTGTCCTG GGCTCCCAGC ACTTCTCCTC TGGTAAGCAT 
TACTGGGAGG TAGATGTGGC CAAGAAGACT GCCTGGATCC TGGGGGTATG CAGCAATTCA 
CTGGGACCTA CATTCTCTTT CAACCATTTT GCTCAAAATC ACAGTGCTTA CTCCAGGTAT 
CAGCCTCAGA GTGGATACTG GGTGATTGGG TTACAGCATA ACCATGAATA TAGGGCCTAT 
GAGGATTCTT CCCCTTCCCT GCTTCTCTCC ATGACAGTGC CCCCTCGCCG TGTTGGGGTT 
TTCTTAGATT ATGAGGCTGG TACTGTCTCC TTTTATAATG TCACAAACCA TGGCTTCCCC 
ATCTACACTT TCTCTAAATA TTACTTTCCC ACTACTCTTT GTCCATATTT TAATCCTTGC 
AACTGTGTAA TTCCTATGAC CCTGCGTCGT CCAAGCTCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001185573.1
CDS	383..1324
Translation	MEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSYWVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDCSVLGSQHFSSGKHYWEVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVIPMTLRRPSS

Target ORF information:

RefSeq Version	NM_001198644.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001198644.1

ORF Insert Sequence:

ATGGAGCCTG AGAGATGCAG GATCCAGACA GAGTTTAATC AGCTGCGAAA TATCCTAGAC 
AGAGTGGAGC AACGGGAGCT GAAAAAGCTG GAACAGGAAG AGAAGAAGGG GCTACGAATT 
ATAGAAGAGG CTGAGAATGA TCTGGTCCAC CAGACCCAGT CGCTGCGAGA GCTCATCTCG 
GATCTGGAGC GTCGATGTCA GGGGTCAACA ATGGAGCTGC TGCAGGATGT GAGTGATGTC 
ACAGAAAGGA GTGAGTTCTG GACCCTGAGG AAGCCAGAAG CTCTCCCTAC AAAGCTGAGA 
AGTATGTTCC GAGCCCCAGA TCTGAAAAGG ATGCTGCGAG TGTGTAGAGA GCTGACAGAT 
GTCCAAAGCT ACTGGGTTGA CGTGACCCTG AATCCACACA CAGCTAATTT AAATCTTGTC 
CTGGCTAAAA ACCGGAGACA AGTGAGGTTT GTGGGAGCTA AAGTATCTGG ACCTTCCTGT 
CTGGAAAAGC ATTATGACTG TAGTGTCCTG GGCTCCCAGC ACTTCTCCTC TGGTAAGCAT 
TACTGGGAGG TAGATGTGGC CAAGAAGACT GCCTGGATCC TGGGGGTATG CAGCAATTCA 
CTGGGACCTA CATTCTCTTT CAACCATTTT GCTCAAAATC ACAGTGCTTA CTCCAGGTAT 
CAGCCTCAGA GTGGATACTG GGTGATTGGG TTACAGCATA ACCATGAATA TAGGGCCTAT 
GAGGATTCTT CCCCTTCCCT GCTTCTCTCC ATGACAGTGC CCCCTCGCCG TGTTGGGGTT 
TTCTTAGATT ATGAGGCTGG TACTGTCTCC TTTTATAATG TCACAAACCA TGGCTTCCCC 
ATCTACACTT TCTCTAAATA TTACTTTCCC ACTACTCTTT GTCCATATTT TAATCCTTGC 
AACTGTGTAA TTCCTATGAC CCTGCGTCGT CCAAGCTCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRIM6 ( NM_001198645.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001185574.1 Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu05768
Clone ID Related Accession (Same CDS sequence)	NM_001198644.1 , NM_001198645.1 , NM_001198644.2 , NM_001198645.2
Accession Version	NM_001198645.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	tripartite motif-containing protein 6 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK290172.1, BC047564.1, DA401634.1, AK293295.1, AF220030.1 and AK023210.1. Transcript Variant: This variant (4) lacks two alternate exons in the 5' coding region, and uses a downstream AUG start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Both variants 3 and 4 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK293295.1, DC300030.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCTG AGAGATGCAG GATCCAGACA GAGTTTAATC AGCTGCGAAA TATCCTAGAC 
AGAGTGGAGC AACGGGAGCT GAAAAAGCTG GAACAGGAAG AGAAGAAGGG GCTACGAATT 
ATAGAAGAGG CTGAGAATGA TCTGGTCCAC CAGACCCAGT CGCTGCGAGA GCTCATCTCG 
GATCTGGAGC GTCGATGTCA GGGGTCAACA ATGGAGCTGC TGCAGGATGT GAGTGATGTC 
ACAGAAAGGA GTGAGTTCTG GACCCTGAGG AAGCCAGAAG CTCTCCCTAC AAAGCTGAGA 
AGTATGTTCC GAGCCCCAGA TCTGAAAAGG ATGCTGCGAG TGTGTAGAGA GCTGACAGAT 
GTCCAAAGCT ACTGGGTTGA CGTGACCCTG AATCCACACA CAGCTAATTT AAATCTTGTC 
CTGGCTAAAA ACCGGAGACA AGTGAGGTTT GTGGGAGCTA AAGTATCTGG ACCTTCCTGT 
CTGGAAAAGC ATTATGACTG TAGTGTCCTG GGCTCCCAGC ACTTCTCCTC TGGTAAGCAT 
TACTGGGAGG TAGATGTGGC CAAGAAGACT GCCTGGATCC TGGGGGTATG CAGCAATTCA 
CTGGGACCTA CATTCTCTTT CAACCATTTT GCTCAAAATC ACAGTGCTTA CTCCAGGTAT 
CAGCCTCAGA GTGGATACTG GGTGATTGGG TTACAGCATA ACCATGAATA TAGGGCCTAT 
GAGGATTCTT CCCCTTCCCT GCTTCTCTCC ATGACAGTGC CCCCTCGCCG TGTTGGGGTT 
TTCTTAGATT ATGAGGCTGG TACTGTCTCC TTTTATAATG TCACAAACCA TGGCTTCCCC 
ATCTACACTT TCTCTAAATA TTACTTTCCC ACTACTCTTT GTCCATATTT TAATCCTTGC 
AACTGTGTAA TTCCTATGAC CCTGCGTCGT CCAAGCTCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001185574.1
CDS	287..1228
Translation	MEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSYWVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDCSVLGSQHFSSGKHYWEVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVIPMTLRRPSS

Target ORF information:

RefSeq Version	NM_001198645.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001198645.1

ORF Insert Sequence:

ATGGAGCCTG AGAGATGCAG GATCCAGACA GAGTTTAATC AGCTGCGAAA TATCCTAGAC 
AGAGTGGAGC AACGGGAGCT GAAAAAGCTG GAACAGGAAG AGAAGAAGGG GCTACGAATT 
ATAGAAGAGG CTGAGAATGA TCTGGTCCAC CAGACCCAGT CGCTGCGAGA GCTCATCTCG 
GATCTGGAGC GTCGATGTCA GGGGTCAACA ATGGAGCTGC TGCAGGATGT GAGTGATGTC 
ACAGAAAGGA GTGAGTTCTG GACCCTGAGG AAGCCAGAAG CTCTCCCTAC AAAGCTGAGA 
AGTATGTTCC GAGCCCCAGA TCTGAAAAGG ATGCTGCGAG TGTGTAGAGA GCTGACAGAT 
GTCCAAAGCT ACTGGGTTGA CGTGACCCTG AATCCACACA CAGCTAATTT AAATCTTGTC 
CTGGCTAAAA ACCGGAGACA AGTGAGGTTT GTGGGAGCTA AAGTATCTGG ACCTTCCTGT 
CTGGAAAAGC ATTATGACTG TAGTGTCCTG GGCTCCCAGC ACTTCTCCTC TGGTAAGCAT 
TACTGGGAGG TAGATGTGGC CAAGAAGACT GCCTGGATCC TGGGGGTATG CAGCAATTCA 
CTGGGACCTA CATTCTCTTT CAACCATTTT GCTCAAAATC ACAGTGCTTA CTCCAGGTAT 
CAGCCTCAGA GTGGATACTG GGTGATTGGG TTACAGCATA ACCATGAATA TAGGGCCTAT 
GAGGATTCTT CCCCTTCCCT GCTTCTCTCC ATGACAGTGC CCCCTCGCCG TGTTGGGGTT 
TTCTTAGATT ATGAGGCTGG TACTGTCTCC TTTTATAATG TCACAAACCA TGGCTTCCCC 
ATCTACACTT TCTCTAAATA TTACTTTCCC ACTACTCTTT GTCCATATTT TAATCCTTGC 
AACTGTGTAA TTCCTATGAC CCTGCGTCGT CCAAGCTCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRIM6 ( NM_001198644.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001185573.1 Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 3, mRNA.

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CloneID	OHu05768
Clone ID Related Accession (Same CDS sequence)	NM_001198644.1 , NM_001198645.1 , NM_001198644.2 , NM_001198645.2
Accession Version	NM_001198644.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-31
Organism	Homo sapiens(human)
Product	tripartite motif-containing protein 6 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK290172.1, BC047564.1, DA401634.1, AK298301.1, AK316178.1, AK293295.1 and AF220030.1. On Jun 1, 2019 this sequence version replaced NM_001198644.1. Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region, and uses a downstream AUG start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Both variants 3 and 4 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298301.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCTG AGAGATGCAG GATCCAGACA GAGTTTAATC AGCTGCGAAA TATCCTAGAC 
AGAGTGGAGC AACGGGAGCT GAAAAAGCTG GAACAGGAAG AGAAGAAGGG GCTACGAATT 
ATAGAAGAGG CTGAGAATGA TCTGGTCCAC CAGACCCAGT CGCTGCGAGA GCTCATCTCG 
GATCTGGAGC GTCGATGTCA GGGGTCAACA ATGGAGCTGC TGCAGGATGT GAGTGATGTC 
ACAGAAAGGA GTGAGTTCTG GACCCTGAGG AAGCCAGAAG CTCTCCCTAC AAAGCTGAGA 
AGTATGTTCC GAGCCCCAGA TCTGAAAAGG ATGCTGCGAG TGTGTAGAGA GCTGACAGAT 
GTCCAAAGCT ACTGGGTTGA CGTGACCCTG AATCCACACA CAGCTAATTT AAATCTTGTC 
CTGGCTAAAA ACCGGAGACA AGTGAGGTTT GTGGGAGCTA AAGTATCTGG ACCTTCCTGT 
CTGGAAAAGC ATTATGACTG TAGTGTCCTG GGCTCCCAGC ACTTCTCCTC TGGTAAGCAT 
TACTGGGAGG TAGATGTGGC CAAGAAGACT GCCTGGATCC TGGGGGTATG CAGCAATTCA 
CTGGGACCTA CATTCTCTTT CAACCATTTT GCTCAAAATC ACAGTGCTTA CTCCAGGTAT 
CAGCCTCAGA GTGGATACTG GGTGATTGGG TTACAGCATA ACCATGAATA TAGGGCCTAT 
GAGGATTCTT CCCCTTCCCT GCTTCTCTCC ATGACAGTGC CCCCTCGCCG TGTTGGGGTT 
TTCTTAGATT ATGAGGCTGG TACTGTCTCC TTTTATAATG TCACAAACCA TGGCTTCCCC 
ATCTACACTT TCTCTAAATA TTACTTTCCC ACTACTCTTT GTCCATATTT TAATCCTTGC 
AACTGTGTAA TTCCTATGAC CCTGCGTCGT CCAAGCTCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001185573.1
CDS	381..1322
Translation	MEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSYWVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDCSVLGSQHFSSGKHYWEVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVIPMTLRRPSS

Target ORF information:

RefSeq Version	NM_001198644.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001198644.2

ORF Insert Sequence:

ATGGAGCCTG AGAGATGCAG GATCCAGACA GAGTTTAATC AGCTGCGAAA TATCCTAGAC 
AGAGTGGAGC AACGGGAGCT GAAAAAGCTG GAACAGGAAG AGAAGAAGGG GCTACGAATT 
ATAGAAGAGG CTGAGAATGA TCTGGTCCAC CAGACCCAGT CGCTGCGAGA GCTCATCTCG 
GATCTGGAGC GTCGATGTCA GGGGTCAACA ATGGAGCTGC TGCAGGATGT GAGTGATGTC 
ACAGAAAGGA GTGAGTTCTG GACCCTGAGG AAGCCAGAAG CTCTCCCTAC AAAGCTGAGA 
AGTATGTTCC GAGCCCCAGA TCTGAAAAGG ATGCTGCGAG TGTGTAGAGA GCTGACAGAT 
GTCCAAAGCT ACTGGGTTGA CGTGACCCTG AATCCACACA CAGCTAATTT AAATCTTGTC 
CTGGCTAAAA ACCGGAGACA AGTGAGGTTT GTGGGAGCTA AAGTATCTGG ACCTTCCTGT 
CTGGAAAAGC ATTATGACTG TAGTGTCCTG GGCTCCCAGC ACTTCTCCTC TGGTAAGCAT 
TACTGGGAGG TAGATGTGGC CAAGAAGACT GCCTGGATCC TGGGGGTATG CAGCAATTCA 
CTGGGACCTA CATTCTCTTT CAACCATTTT GCTCAAAATC ACAGTGCTTA CTCCAGGTAT 
CAGCCTCAGA GTGGATACTG GGTGATTGGG TTACAGCATA ACCATGAATA TAGGGCCTAT 
GAGGATTCTT CCCCTTCCCT GCTTCTCTCC ATGACAGTGC CCCCTCGCCG TGTTGGGGTT 
TTCTTAGATT ATGAGGCTGG TACTGTCTCC TTTTATAATG TCACAAACCA TGGCTTCCCC 
ATCTACACTT TCTCTAAATA TTACTTTCCC ACTACTCTTT GTCCATATTT TAATCCTTGC 
AACTGTGTAA TTCCTATGAC CCTGCGTCGT CCAAGCTCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRIM6 ( NM_001198645.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001185574.1 Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu05768
Clone ID Related Accession (Same CDS sequence)	NM_001198644.1 , NM_001198645.1 , NM_001198644.2 , NM_001198645.2
Accession Version	NM_001198645.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	tripartite motif-containing protein 6 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK290172.1, BC047564.1, DA401634.1, AK293295.1 and AF220030.1. On May 31, 2019 this sequence version replaced NM_001198645.1. Transcript Variant: This variant (4) lacks two alternate exons in the 5' coding region, and uses a downstream AUG start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Both variants 3 and 4 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK293295.1, DC300030.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCTG AGAGATGCAG GATCCAGACA GAGTTTAATC AGCTGCGAAA TATCCTAGAC 
AGAGTGGAGC AACGGGAGCT GAAAAAGCTG GAACAGGAAG AGAAGAAGGG GCTACGAATT 
ATAGAAGAGG CTGAGAATGA TCTGGTCCAC CAGACCCAGT CGCTGCGAGA GCTCATCTCG 
GATCTGGAGC GTCGATGTCA GGGGTCAACA ATGGAGCTGC TGCAGGATGT GAGTGATGTC 
ACAGAAAGGA GTGAGTTCTG GACCCTGAGG AAGCCAGAAG CTCTCCCTAC AAAGCTGAGA 
AGTATGTTCC GAGCCCCAGA TCTGAAAAGG ATGCTGCGAG TGTGTAGAGA GCTGACAGAT 
GTCCAAAGCT ACTGGGTTGA CGTGACCCTG AATCCACACA CAGCTAATTT AAATCTTGTC 
CTGGCTAAAA ACCGGAGACA AGTGAGGTTT GTGGGAGCTA AAGTATCTGG ACCTTCCTGT 
CTGGAAAAGC ATTATGACTG TAGTGTCCTG GGCTCCCAGC ACTTCTCCTC TGGTAAGCAT 
TACTGGGAGG TAGATGTGGC CAAGAAGACT GCCTGGATCC TGGGGGTATG CAGCAATTCA 
CTGGGACCTA CATTCTCTTT CAACCATTTT GCTCAAAATC ACAGTGCTTA CTCCAGGTAT 
CAGCCTCAGA GTGGATACTG GGTGATTGGG TTACAGCATA ACCATGAATA TAGGGCCTAT 
GAGGATTCTT CCCCTTCCCT GCTTCTCTCC ATGACAGTGC CCCCTCGCCG TGTTGGGGTT 
TTCTTAGATT ATGAGGCTGG TACTGTCTCC TTTTATAATG TCACAAACCA TGGCTTCCCC 
ATCTACACTT TCTCTAAATA TTACTTTCCC ACTACTCTTT GTCCATATTT TAATCCTTGC 
AACTGTGTAA TTCCTATGAC CCTGCGTCGT CCAAGCTCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001185574.1
CDS	285..1226
Translation	MEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSYWVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDCSVLGSQHFSSGKHYWEVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVIPMTLRRPSS

Target ORF information:

RefSeq Version	NM_001198645.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tripartite motif containing 6 (TRIM6), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001198645.2

ORF Insert Sequence:

ATGGAGCCTG AGAGATGCAG GATCCAGACA GAGTTTAATC AGCTGCGAAA TATCCTAGAC 
AGAGTGGAGC AACGGGAGCT GAAAAAGCTG GAACAGGAAG AGAAGAAGGG GCTACGAATT 
ATAGAAGAGG CTGAGAATGA TCTGGTCCAC CAGACCCAGT CGCTGCGAGA GCTCATCTCG 
GATCTGGAGC GTCGATGTCA GGGGTCAACA ATGGAGCTGC TGCAGGATGT GAGTGATGTC 
ACAGAAAGGA GTGAGTTCTG GACCCTGAGG AAGCCAGAAG CTCTCCCTAC AAAGCTGAGA 
AGTATGTTCC GAGCCCCAGA TCTGAAAAGG ATGCTGCGAG TGTGTAGAGA GCTGACAGAT 
GTCCAAAGCT ACTGGGTTGA CGTGACCCTG AATCCACACA CAGCTAATTT AAATCTTGTC 
CTGGCTAAAA ACCGGAGACA AGTGAGGTTT GTGGGAGCTA AAGTATCTGG ACCTTCCTGT 
CTGGAAAAGC ATTATGACTG TAGTGTCCTG GGCTCCCAGC ACTTCTCCTC TGGTAAGCAT 
TACTGGGAGG TAGATGTGGC CAAGAAGACT GCCTGGATCC TGGGGGTATG CAGCAATTCA 
CTGGGACCTA CATTCTCTTT CAACCATTTT GCTCAAAATC ACAGTGCTTA CTCCAGGTAT 
CAGCCTCAGA GTGGATACTG GGTGATTGGG TTACAGCATA ACCATGAATA TAGGGCCTAT 
GAGGATTCTT CCCCTTCCCT GCTTCTCTCC ATGACAGTGC CCCCTCGCCG TGTTGGGGTT 
TTCTTAGATT ATGAGGCTGG TACTGTCTCC TTTTATAATG TCACAAACCA TGGCTTCCCC 
ATCTACACTT TCTCTAAATA TTACTTTCCC ACTACTCTTT GTCCATATTT TAATCCTTGC 
AACTGTGTAA TTCCTATGAC CCTGCGTCGT CCAAGCTCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication.
Journal of virology91(18)(2017 Sep)
Bharaj P,Atkins C,Luthra P,Giraldo MI,Dawes BE,Miorin L,Johnson JR,Krogan NJ,Basler CF,Freiberg AN,Rajsbaum R

The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKK? Kinase-Mediated Type-I IFN Antiviral Response.
PLoS pathogens12(9)e1005880(2016 Sep)
Bharaj P,Wang YE,Dawes BE,Yun TE,Park A,Yen B,Basler CF,Freiberg AN,Lee B,Rajsbaum R

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
Developmental cell30(4)394-409(2014 Aug)
Mandell MA,Jain A,Arko-Mensah J,Chauhan S,Kimura T,Dinkins C,Silvestri G,M?nch J,Kirchhoff F,Simonsen A,Wei Y,Levine B,Johansen T,Deretic V

Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKK? kinase-mediated antiviral response.
Immunity40(6)880-95(2014 Jun)
Rajsbaum R,Versteeg GA,Schmid S,Maestre AM,Belicha-Villanueva A,Mart?nez-Romero C,Patel JR,Morrison J,Pisanelli G,Miorin L,Laurent-Rolle M,Moulton HM,Stein DA,Fernandez-Sesma A,tenOever BR,Garc?a-Sastre A

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
PLoS genetics9(1)e1003225(2013)
Lauc G,Huffman JE,Pu?i? M,Zgaga L,Adamczyk B,Mu?ini? A,Novokmet M,Pola?ek O,Gornik O,Kri?ti? J,Keser T,Vitart V,Scheijen B,Uh HW,Molokhia M,Patrick AL,McKeigue P,Kol?i? I,Luki? IK,Swann O,van Leeuwen FN,Ruhaak LR,Houwing-Duistermaat JJ,Slagboom PE,Beekman M,de Craen AJ,Deelder AM,Zeng Q,Wang W,Hastie ND,Gyllensten U,Wilson JF,Wuhrer M,Wright AF,Rudd PM,Hayward C,Aulchenko Y,Campbell H,Rudan I

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TRIM6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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