COX20 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COX20
Entrez Gene ID	116228
Full Name	COX20, cytochrome c oxidase assembly factor
Synonyms	FAM36A
General protein information	Preferred Names COX20, cytochrome c oxidase assembly factor Names cytochrome c oxidase protein 20 homolog COX20 Cox2 chaperone homolog family with sequence similarity 36, member A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q44
Summary	This gene encodes a protein that plays a role in the assembly of cytochrome C oxidase, an important component of the respiratory pathway. It contains two transmembrane helices and localizes to the mitochondrial membrane. Mutations in this gene can cause mitochondrial complex IV deficiency, which results in ataxia and muscle hypotonia. There are multiple pseudogenes for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
Disorder MIM:	614698
Disorder Html:	Mitochondrial complex IV deficiency, 220110 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_198076.5	NP_932342.1	cytochrome c oxidase protein 20 homolog isoform 1
NM_001312874.1	NP_001299803.1	cytochrome c oxidase assembly protein COX20, mitochondrial isoform 4
NM_001312872.1	NP_001299801.1	cytochrome c oxidase assembly protein COX20, mitochondrial isoform 2
NM_001312873.1	NP_001299802.1	cytochrome c oxidase assembly protein COX20, mitochondrial isoform 3
NM_001312871.1	NP_001299800.1	cytochrome c oxidase assembly protein COX20, mitochondrial isoform 1
NM_198076.6	NP_932342.1	cytochrome c oxidase assembly protein COX20, mitochondrial isoform 1

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	LOC100497666	XP_002942240.1
Canis lupus familiaris (dog)	COX20	XP_537221.1
Rattus norvegicus (Norway rat)	Cox20	NP_001099446.1
Gallus gallus (chicken)	COX20	NP_001264593.1
	COX20	XP_001089471.1
Bos taurus (cattle)	COX20	NP_001035675.1
Pan troglodytes (chimpanzee)	COX20	XP_003949782.1
Danio rerio (zebrafish)	zgc:92598	NP_001002712.1
Homo sapiens (human)	COX20	NP_932342.1
Mus musculus (house mouse)	Cox20	NP_079787.1

Gene Ontology
Bibliography

Related articles in PubMed

The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis.
Lorenzi I, Oeljeklaus S, Aich A, Rons?r C, Callegari S, Dudek J, Warscheid B, Dennerlein S, Rehling P
Biochimica et biophysica acta1865(2)323-333(2018 Feb)

Human mitochondrial cytochrome
Bourens M, Barrientos A
The Journal of biological chemistry292(19)7774-7783(2017 05)

Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase.
Bourens M, Boulet A, Leary SC, Barrientos A
Human molecular genetics23(11)2901-13(2014 Jun)

Recessive dystonia-ataxia syndrome in a Turkish family caused by a COX20 (FAM36A) mutation.
Doss S, Lohmann K, Seibler P, Arns B, Klopstock T, Z?hlke C, Freimann K, Winkler S, Lohnau T, Drungowski M, N?rnberg P, Wiegers K, Lohmann E, Naz S, Kasten M, Bohner G, Ramirez A, Endres M, Klein C
Journal of neurology261(1)207-12(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase.
Title: Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase.

This study deministrated that phenotypic spectrum of mutation in COX20 to a recessively inherited, early-onset dystonia-ataxia syndrome that is characterized by reduced complex IV activity.
Title: Recessive dystonia-ataxia syndrome in a Turkish family caused by a COX20 (FAM36A) mutation.

The function of the human gene FAM36A/COX20 in complex IV assembly and role of the gene in complex IV deficiency.
Title: A mutation in the FAM36A gene, the human ortholog of COX20, impairs cytochrome c oxidase assembly and is associated with ataxia and muscle hypotonia.

These results suggest that HNRNPU, FAM36A, and NCRNA00201 are not major genes for microcephaly and corpus callosum abnormalities but are good candidates for intellectual disability (ID) and seizures.
Title: Molecular characterization of 1q44 microdeletion in 11 patients reveals three candidate genes for intellectual disability and seizures.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following COX20 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX20 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13129	NM_198076.6 Latest version!	Homo sapiens cytochrome c oxidase assembly factor COX20 (COX20), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu13129	NM_001312871.1 Latest version!	Homo sapiens cytochrome c oxidase assembly factor COX20 (COX20), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu74970	NM_001312872.1 Latest version!	Homo sapiens cytochrome c oxidase assembly factor COX20 (COX20), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu74971	NM_001312873.1 Latest version!	Homo sapiens cytochrome c oxidase assembly factor COX20 (COX20), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu74972	NM_001312874.1 Latest version!	Homo sapiens cytochrome c oxidase assembly factor COX20 (COX20), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu13129	NM_198076.5	Homo sapiens COX20, cytochrome c oxidase assembly factor (COX20), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COX20 ( NM_198076.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_932342.1 Homo sapiens COX20, cytochrome c oxidase assembly factor (COX20), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13129
Clone ID Related Accession (Same CDS sequence)	NM_198076.5 , NM_001312871.1 , NM_198076.6
Accession Version	NM_198076.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	cytochrome c oxidase protein 20 homolog isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA157561.1, AK125259.1, AK000866.1 and EL947693.1. On Aug 19, 2015 this sequence version replaced NM_198076.4. Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Variants 1 and 2 encode the same protein (isoform 1). ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 22356826; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCCC CGCCGGAGCC CGGTGAGCCC GAGGAGAGGA AGTCCCTTAA GCTCCTAGGA 
TTTTTAGATG TTGAAAATAC TCCCTGCGCC CGGCATTCAA TATTGTATGG TTCATTAGGA 
TCTGTTGTGG CTGGCTTTGG ACATTTTTTG TTCACTAGTA GAATTAGAAG ATCATGTGAT 
GTTGGAGTAG GAGGGTTTAT CTTGGTGACT TTGGGATGCT GGTTTCATTG TAGGTATAAT 
TATGCAAAGC AAAGAATCCA GGAAAGAATT GCCAGAGAAG AAATTAAAAA GAAGATATTA 
TATGAAGGTA CCCACCTCGA TCCTGAAAGA AAACACAACG GCAGCAGCAG CAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_932342.1
CDS	387..743
Translation	MAAPPEPGEPEERKSLKLLGFLDVENTPCARHSILYGSLGSVVAGFGHFLFTSRIRRSCDVGVGGFILVTLGCWFHCRYNYAKQRIQERIAREEIKKKILYEGTHLDPERKHNGSSSN

Target ORF information:

RefSeq Version	NM_198076.5
Organism	Homo sapiens(human)
Definition	Homo sapiens COX20, cytochrome c oxidase assembly factor (COX20), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198076.5

ORF Insert Sequence:

ATGGCCGCCC CGCCGGAGCC CGGTGAGCCC GAGGAGAGGA AGTCCCTTAA GCTCCTAGGA 
TTTTTAGATG TTGAAAATAC TCCCTGCGCC CGGCATTCAA TATTGTATGG TTCATTAGGA 
TCTGTTGTGG CTGGCTTTGG ACATTTTTTG TTCACTAGTA GAATTAGAAG ATCATGTGAT 
GTTGGAGTAG GAGGGTTTAT CTTGGTGACT TTGGGATGCT GGTTTCATTG TAGGTATAAT 
TATGCAAAGC AAAGAATCCA GGAAAGAATT GCCAGAGAAG AAATTAAAAA GAAGATATTA 
TATGAAGGTA CCCACCTCGA TCCTGAAAGA AAACACAACG GCAGCAGCAG CAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX20 ( NM_001312871.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001299800.1 Homo sapiens cytochrome c oxidase assembly factor COX20 (COX20), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13129
Clone ID Related Accession (Same CDS sequence)	NM_198076.5 , NM_001312871.1 , NM_198076.6
Accession Version	NM_001312871.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-15
Organism	Homo sapiens(human)
Product	cytochrome c oxidase assembly protein COX20, mitochondrial isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA164934.1, DA752002.1, AK000866.1 and EL947693.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1). ##Evidence-Data-START## Transcript exon combination :: DA164934.1, DA752002.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 22356826; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCCC CGCCGGAGCC CGGTGAGCCC GAGGAGAGGA AGTCCCTTAA GCTCCTAGGA 
TTTTTAGATG TTGAAAATAC TCCCTGCGCC CGGCATTCAA TATTGTATGG TTCATTAGGA 
TCTGTTGTGG CTGGCTTTGG ACATTTTTTG TTCACTAGTA GAATTAGAAG ATCATGTGAT 
GTTGGAGTAG GAGGGTTTAT CTTGGTGACT TTGGGATGCT GGTTTCATTG TAGGTATAAT 
TATGCAAAGC AAAGAATCCA GGAAAGAATT GCCAGAGAAG AAATTAAAAA GAAGATATTA 
TATGAAGGTA CCCACCTCGA TCCTGAAAGA AAACACAACG GCAGCAGCAG CAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001299800.1
CDS	268..624
Translation	MAAPPEPGEPEERKSLKLLGFLDVENTPCARHSILYGSLGSVVAGFGHFLFTSRIRRSCDVGVGGFILVTLGCWFHCRYNYAKQRIQERIAREEIKKKILYEGTHLDPERKHNGSSSN

Target ORF information:

RefSeq Version	NM_001312871.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase assembly factor COX20 (COX20), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001312871.1

ORF Insert Sequence:

ATGGCCGCCC CGCCGGAGCC CGGTGAGCCC GAGGAGAGGA AGTCCCTTAA GCTCCTAGGA 
TTTTTAGATG TTGAAAATAC TCCCTGCGCC CGGCATTCAA TATTGTATGG TTCATTAGGA 
TCTGTTGTGG CTGGCTTTGG ACATTTTTTG TTCACTAGTA GAATTAGAAG ATCATGTGAT 
GTTGGAGTAG GAGGGTTTAT CTTGGTGACT TTGGGATGCT GGTTTCATTG TAGGTATAAT 
TATGCAAAGC AAAGAATCCA GGAAAGAATT GCCAGAGAAG AAATTAAAAA GAAGATATTA 
TATGAAGGTA CCCACCTCGA TCCTGAAAGA AAACACAACG GCAGCAGCAG CAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX20 ( NM_198076.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_932342.1 Homo sapiens cytochrome c oxidase assembly factor COX20 (COX20), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13129
Clone ID Related Accession (Same CDS sequence)	NM_198076.5 , NM_001312871.1 , NM_198076.6
Accession Version	NM_198076.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-15
Organism	Homo sapiens(human)
Product	cytochrome c oxidase assembly protein COX20, mitochondrial isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK125259.1, AK000866.1 and EL947693.1. On Nov 22, 2018 this sequence version replaced NM_198076.5. Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Variants 1 and 2 encode the same protein (isoform 1). ##Evidence-Data-START## Transcript exon combination :: SRR3476690.226321.1, SRR1803614.58235.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 22356826; reported by MitoCarta MANE Ensembl match :: ENST00000411948.7/ ENSP00000406327.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGCCC CGCCGGAGCC CGGTGAGCCC GAGGAGAGGA AGTCCCTTAA GCTCCTAGGA 
TTTTTAGATG TTGAAAATAC TCCCTGCGCC CGGCATTCAA TATTGTATGG TTCATTAGGA 
TCTGTTGTGG CTGGCTTTGG ACATTTTTTG TTCACTAGTA GAATTAGAAG ATCATGTGAT 
GTTGGAGTAG GAGGGTTTAT CTTGGTGACT TTGGGATGCT GGTTTCATTG TAGGTATAAT 
TATGCAAAGC AAAGAATCCA GGAAAGAATT GCCAGAGAAG AAATTAAAAA GAAGATATTA 
TATGAAGGTA CCCACCTCGA TCCTGAAAGA AAACACAACG GCAGCAGCAG CAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_932342.1
CDS	58..414
Translation	MAAPPEPGEPEERKSLKLLGFLDVENTPCARHSILYGSLGSVVAGFGHFLFTSRIRRSCDVGVGGFILVTLGCWFHCRYNYAKQRIQERIAREEIKKKILYEGTHLDPERKHNGSSSN

Target ORF information:

RefSeq Version	NM_198076.6
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase assembly factor COX20 (COX20), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198076.6

ORF Insert Sequence:

ATGGCCGCCC CGCCGGAGCC CGGTGAGCCC GAGGAGAGGA AGTCCCTTAA GCTCCTAGGA 
TTTTTAGATG TTGAAAATAC TCCCTGCGCC CGGCATTCAA TATTGTATGG TTCATTAGGA 
TCTGTTGTGG CTGGCTTTGG ACATTTTTTG TTCACTAGTA GAATTAGAAG ATCATGTGAT 
GTTGGAGTAG GAGGGTTTAT CTTGGTGACT TTGGGATGCT GGTTTCATTG TAGGTATAAT 
TATGCAAAGC AAAGAATCCA GGAAAGAATT GCCAGAGAAG AAATTAAAAA GAAGATATTA 
TATGAAGGTA CCCACCTCGA TCCTGAAAGA AAACACAACG GCAGCAGCAG CAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX20 ( NM_001312872.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001299801.1 Homo sapiens cytochrome c oxidase assembly factor COX20 (COX20), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu74970
Clone ID Related Accession (Same CDS sequence)	NM_001312872.1
Accession Version	NM_001312872.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-15
Organism	Homo sapiens(human)
Product	cytochrome c oxidase assembly protein COX20, mitochondrial isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA157561.1, BQ189361.1, AK000866.1 and EL947693.1. Transcript Variant: This variant (3) has a shorter 5' UTR and contains an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is longer than isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.380880.1, CK299501.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 22356826; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCCC CGCCGGAGCC CGGTGAGCCC GAGGAGAGGA AGGCATCTTG TACGTCGTTA 
CATTTATCAT ATTGGAAGTC CCTTAAGCTC CTAGGATTTT TAGATGTTGA AAATACTCCC 
TGCGCCCGGC ATTCAATATT GTATGGTTCA TTAGGATCTG TTGTGGCTGG CTTTGGACAT 
TTTTTGTTCA CTAGTAGAAT TAGAAGATCA TGTGATGTTG GAGTAGGAGG GTTTATCTTG 
GTGACTTTGG GATGCTGGTT TCATTGTAGG TATAATTATG CAAAGCAAAG AATCCAGGAA 
AGAATTGCCA GAGAAGAAAT TAAAAAGAAG ATATTATATG AAGGTACCCA CCTCGATCCT 
GAAAGAAAAC ACAACGGCAG CAGCAGCAAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001299801.1
CDS	240..632
Translation	MAAPPEPGEPEERKASCTSLHLSYWKSLKLLGFLDVENTPCARHSILYGSLGSVVAGFGHFLFTSRIRRSCDVGVGGFILVTLGCWFHCRYNYAKQRIQERIAREEIKKKILYEGTHLDPERKHNGSSSN

Target ORF information:

RefSeq Version	NM_001312872.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase assembly factor COX20 (COX20), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001312872.1

ORF Insert Sequence:

ATGGCCGCCC CGCCGGAGCC CGGTGAGCCC GAGGAGAGGA AGGCATCTTG TACGTCGTTA 
CATTTATCAT ATTGGAAGTC CCTTAAGCTC CTAGGATTTT TAGATGTTGA AAATACTCCC 
TGCGCCCGGC ATTCAATATT GTATGGTTCA TTAGGATCTG TTGTGGCTGG CTTTGGACAT 
TTTTTGTTCA CTAGTAGAAT TAGAAGATCA TGTGATGTTG GAGTAGGAGG GTTTATCTTG 
GTGACTTTGG GATGCTGGTT TCATTGTAGG TATAATTATG CAAAGCAAAG AATCCAGGAA 
AGAATTGCCA GAGAAGAAAT TAAAAAGAAG ATATTATATG AAGGTACCCA CCTCGATCCT 
GAAAGAAAAC ACAACGGCAG CAGCAGCAAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX20 ( NM_001312873.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001299802.1 Homo sapiens cytochrome c oxidase assembly factor COX20 (COX20), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu74971
Clone ID Related Accession (Same CDS sequence)	NM_001312873.1
Accession Version	NM_001312873.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 222bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-15
Organism	Homo sapiens(human)
Product	cytochrome c oxidase assembly protein COX20, mitochondrial isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX323046.3. Transcript Variant: This variant (4) has a shorter 5' UTR, lacks an exon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.218373.1, SRR1660809.218226.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 22356826; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCCC CGCCGGAGCC CGGTAGAATT AGAAGATCAT GTGATGTTGG AGTAGGAGGG 
TTTATCTTGG TGACTTTGGG ATGCTGGTTT CATTGTAGGT ATAATTATGC AAAGCAAAGA 
ATCCAGGAAA GAATTGCCAG AGAAGAAATT AAAAAGAAGA TATTATATGA AGGTACCCAC 
CTCGATCCTG AAAGAAAACA CAACGGCAGC AGCAGCAATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001299802.1
CDS	240..461
Translation	MAAPPEPGRIRRSCDVGVGGFILVTLGCWFHCRYNYAKQRIQERIAREEIKKKILYEGTHLDPERKHNGSSSN

Target ORF information:

RefSeq Version	NM_001312873.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase assembly factor COX20 (COX20), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001312873.1

ORF Insert Sequence:

ATGGCCGCCC CGCCGGAGCC CGGTAGAATT AGAAGATCAT GTGATGTTGG AGTAGGAGGG 
TTTATCTTGG TGACTTTGGG ATGCTGGTTT CATTGTAGGT ATAATTATGC AAAGCAAAGA 
ATCCAGGAAA GAATTGCCAG AGAAGAAATT AAAAAGAAGA TATTATATGA AGGTACCCAC 
CTCGATCCTG AAAGAAAACA CAACGGCAGC AGCAGCAATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX20 ( NM_001312874.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001299803.1 Homo sapiens cytochrome c oxidase assembly factor COX20 (COX20), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu74972
Clone ID Related Accession (Same CDS sequence)	NM_001312874.1
Accession Version	NM_001312874.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 186bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-15
Organism	Homo sapiens(human)
Product	cytochrome c oxidase assembly protein COX20, mitochondrial isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA157561.1, AK130498.1, AK000866.1 and EL947693.1. Transcript Variant: This variant (5) has a shorter 5' UTR and uses an alternate splice site, which results in a frameshift, compared to variant 1. The encoded isoform (4) has a shorter, distinct C-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.46850.1, AK130498.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 22356826; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCCC CGCCGGAGCC CGGTGAGCCC GAGGAGAGGA AGTCCCTTAA GCTCCTAGGA 
TTTTTAGATG TTGAAAATAC TCCCTGCGCC CGGCATTCAA TATTGTATGG TTCATTAGGA 
TCTGTTGTGG CTGGCTTTGG ACATTTTTTG TTCACTAAAT TAGAAGATCA TGTGATGTTG 
GAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001299803.1
CDS	240..425
Translation	MAAPPEPGEPEERKSLKLLGFLDVENTPCARHSILYGSLGSVVAGFGHFLFTKLEDHVMLE

Target ORF information:

RefSeq Version	NM_001312874.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase assembly factor COX20 (COX20), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001312874.1

ORF Insert Sequence:

ATGGCCGCCC CGCCGGAGCC CGGTGAGCCC GAGGAGAGGA AGTCCCTTAA GCTCCTAGGA 
TTTTTAGATG TTGAAAATAC TCCCTGCGCC CGGCATTCAA TATTGTATGG TTCATTAGGA 
TCTGTTGTGG CTGGCTTTGG ACATTTTTTG TTCACTAAAT TAGAAGATCA TGTGATGTTG 
GAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis.
Biochimica et biophysica acta1865(2)323-333(2018 Feb)
Lorenzi I,Oeljeklaus S,Aich A,Rons?r C,Callegari S,Dudek J,Warscheid B,Dennerlein S,Rehling P

Human mitochondrial cytochrome
The Journal of biological chemistry292(19)7774-7783(2017 05)
Bourens M,Barrientos A

Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase.
Human molecular genetics23(11)2901-13(2014 Jun)
Bourens M,Boulet A,Leary SC,Barrientos A

Recessive dystonia-ataxia syndrome in a Turkish family caused by a COX20 (FAM36A) mutation.
Journal of neurology261(1)207-12(2014 Jan)
Doss S,Lohmann K,Seibler P,Arns B,Klopstock T,Z?hlke C,Freimann K,Winkler S,Lohnau T,Drungowski M,N?rnberg P,Wiegers K,Lohmann E,Naz S,Kasten M,Bohner G,Ramirez A,Endres M,Klein C

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COX20 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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ORF Insert Sequence:

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ORF Insert Sequence:

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