SLITRK1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLITRK1
Entrez Gene ID	114798
Full Name	SLIT and NTRK like family member 1
Synonyms	LRRC12,TTM
General protein information	Preferred Names SLIT and NTRK like family member 1 Names SLIT and NTRK-like protein 1 leucine-rich repeat-containing protein 12 slit and trk like gene 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q31.1
Summary	This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Disorder MIM:	609678
Disorder Html:	Tourette syndrome, 137580 (3); ?Trichotillomania, 613229 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_052910.2	NP_443142.1	SLIT and NTRK-like protein 1 precursor
NM_001281503.1	NP_001268432.1	SLIT and NTRK-like protein 1 precursor
NM_001281503.2	NP_001268432.1	SLIT and NTRK-like protein 1 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Slitrk1	NP_001100753.1
Danio rerio (zebrafish)	LOC558743	XP_005174686.1
Homo sapiens (human)	SLITRK1	NP_001268432.1
	SLITRK1	XP_001093240.1
Mus musculus (house mouse)	Slitrk1	NP_951020.1
Gallus gallus (chicken)	SLITRK1	XP_416993.2
Xenopus tropicalis (tropical clawed frog)	slitrk1	NP_001096395.1
Bos taurus (cattle)	SLITRK1	XP_003586770.1
Pan troglodytes (chimpanzee)	SLITRK1	XP_001143864.1
Canis lupus familiaris (dog)	SLITRK1	XP_005634067.1

Gene Ontology
Bibliography

Related articles in PubMed

Slitrk1 is localized to excitatory synapses and promotes their development.
Beaubien F, Raja R, Kennedy TE, Fournier AE, Cloutier JF
Scientific reports627343(2016 Jun)

Analysis of SLITRK1 in Japanese patients with Tourette syndrome using a next-generation sequencer.
Inai A, Tochigi M, Kuwabara H, Nishimura F, Kato K, Eriguchi Y, Shimada T, Furukawa M, Kawamura Y, Sasaki T, Kakiuchi C, Kasai K, Kano Y
Psychiatric genetics25(6)256-8(2015 Dec)

A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
Cai DC, Fonteijn H, Guadalupe T, Zwiers M, Wittfeld K, Teumer A, Hoogman M, Arias-V?squez A, Yang Y, Buitelaar J, Fern?ndez G, Brunner HG, van Bokhoven H, Franke B, Hegenscheid K, Homuth G, Fisher SE, Grabe HJ, Francks C, Hagoort P
Genes, brain, and behavior13(7)675-85(2014 Sep)

Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
Xie T, Deng L, Mei P, Zhou Y, Wang B, Zhang J, Lin J, Wei Y, Zhang X, Xu R
Neurobiology of aging35(7)1778.e9-1778.e23(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data provide partial support for the implication of SLITRK1 in the pathogenesis of Tourette syndrome.
Title: Analysis of SLITRK1 in Japanese patients with Tourette syndrome using a next-generation sequencer.

The study of chromosomal aberrations in Tourette syndrome etiology has implicated multiple genes, with SLITRK1 being the most prominent example.
Title: The genetic basis of Gilles de la Tourette Syndrome.

One of the few genes that has been linked to TS is the SLITRK1 (Slit and Trk-like 1) gene, where four variations have been suggested as possible disease-associated changes
Title: Sequence analysis of SLITRK1 for var321 in Danish patients with Tourette syndrome and review of the literature.

the N400I variant of SLITRK1 may have a role in obsessive-compulsive disorder
Title: Characterization of SLITRK1 variation in obsessive-compulsive disorder.

DM1 motoneuron/muscle cell cocultures showed alterations that are consistent with the known role of SLITRK genes in neurite outgrowth, neuritogenesis, and synaptogenesis; functional defects can be directly attributed to SLITRK misexpression.
Title: Mutant human embryonic stem cells reveal neurite and synapse formation defects in type 1 myotonic dystrophy.

The following SLITRK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLITRK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20555	NM_001281503.2 Latest version!	Homo sapiens SLIT and NTRK like family member 1 (SLITRK1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu20555	NM_052910.2 Latest version!	Homo sapiens SLIT and NTRK like family member 1 (SLITRK1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu20555	NM_001281503.1	Homo sapiens SLIT and NTRK like family member 1 (SLITRK1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLITRK1 ( NM_052910.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_443142.1 Homo sapiens SLIT and NTRK like family member 1 (SLITRK1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20555
Clone ID Related Accession (Same CDS sequence)	NM_052910.2 , NM_001281503.1 , NM_001281503.2
Accession Version	NM_052910.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2091bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-08
Organism	Homo sapiens(human)
Product	SLIT and NTRK-like protein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB067497.1, DA240278.1, AA677641.1 and AI500170.1. This sequence is a reference standard in the RefSeqGene project. On Jul 30, 2013 this sequence version replaced NM_052910.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AB067497.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTTT GGATTCTGTT GCTGGAGACG TCTCTTTGTT TTGCCGCTGG AAACGTTACA 
GGGGACGTTT GCAAAGAGAA GATCTGTTCC TGCAATGAGA TAGAAGGGGA CCTACACGTA 
GACTGTGAAA AAAAGGGCTT CACAAGTCTG CAGCGTTTCA CTGCCCCGAC TTCCCAGTTT 
TACCATTTAT TTCTGCATGG CAATTCCCTC ACTCGACTTT TCCCTAATGA GTTCGCTAAC 
TTTTATAATG CGGTTAGTTT GCACATGGAA AACAATGGCT TGCATGAAAT CGTTCCGGGG 
GCTTTTCTGG GGCTGCAGCT GGTGAAAAGG CTGCACATCA ACAACAACAA GATCAAGTCT 
TTTCGAAAGC AGACTTTTCT GGGGCTGGAC GATCTGGAAT ATCTCCAGGC TGATTTTAAT 
TTATTACGAG ATATAGACCC GGGGGCCTTC CAGGACTTGA ACAAGCTGGA GGTGCTCATT 
TTAAATGACA ATCTCATCAG CACCCTACCT GCCAACGTGT TCCAGTATGT GCCCATCACC 
CACCTCGACC TCCGGGGTAA CAGGCTGAAA ACGCTGCCCT ATGAGGAGGT CTTGGAGCAA 
ATCCCTGGTA TTGCGGAGAT CCTGCTAGAG GATAACCCTT GGGACTGCAC CTGTGATCTG 
CTCTCCCTGA AAGAATGGCT GGAAAACATT CCCAAGAATG CCCTGATCGG CCGAGTGGTC 
TGCGAAGCCC CCACCAGACT GCAGGGTAAA GACCTCAATG AAACCACCGA ACAGGACTTG 
TGTCCTTTGA AAAACCGAGT GGATTCTAGT CTCCCGGCGC CCCCTGCCCA AGAAGAGACC 
TTTGCTCCTG GACCCCTGCC AACTCCTTTC AAGACAAATG GGCAAGAGGA TCATGCCACA 
CCAGGGTCTG CTCCAAACGG AGGTACAAAG ATCCCAGGCA ACTGGCAGAT CAAAATCAGA 
CCCACAGCAG CGATAGCGAC GGGTAGCTCC AGGAACAAAC CCTTAGCTAA CAGTTTACCC 
TGCCCTGGGG GCTGCAGCTG CGACCACATC CCAGGGTCGG GTTTAAAGAT GAACTGCAAC 
AACAGGAACG TGAGCAGCTT GGCTGATTTG AAGCCCAAGC TCTCTAACGT GCAGGAGCTT 
TTCCTACGAG ATAACAAGAT CCACAGCATC CGAAAATCGC ACTTTGTGGA TTACAAGAAC 
CTCATTCTGT TGGATCTGGG CAACAATAAC ATCGCTACTG TAGAGAACAA CACTTTCAAG 
AACCTTTTGG ACCTCAGGTG GCTATACATG GATAGCAATT ACCTGGACAC GCTGTCCCGG 
GAGAAATTCG CGGGGCTGCA AAACCTAGAG TACCTGAACG TGGAGTACAA CGCTATCCAG 
CTCATCCTCC CGGGCACTTT CAATGCCATG CCCAAACTGA GGATCCTCAT TCTCAACAAC 
AACCTGCTGA GGTCCCTGCC TGTGGACGTG TTCGCTGGGG TCTCGCTCTC TAAACTCAGC 
CTGCACAACA ATTACTTCAT GTACCTCCCG GTGGCAGGGG TGCTGGACCA GTTAACCTCC 
ATCATCCAGA TAGACCTCCA CGGAAACCCC TGGGAGTGCT CCTGCACAAT TGTGCCTTTC 
AAGCAGTGGG CAGAACGCTT GGGTTCCGAA GTGCTGATGA GCGACCTCAA GTGTGAGACG 
CCGGTGAACT TCTTTAGAAA GGATTTCATG CTCCTCTCCA ATGACGAGAT CTGCCCTCAG 
CTGTACGCTA GGATCTCGCC CACGTTAACT TCGCACAGTA AAAACAGCAC TGGGTTGGCG 
GAGACCGGGA CGCACTCCAA CTCCTACCTA GACACCAGCA GGGTGTCCAT CTCGGTGTTG 
GTCCCGGGAC TGCTGCTGGT GTTTGTCACC TCCGCCTTCA CCGTGGTGGG CATGCTCGTG 
TTTATCCTGA GGAACCGAAA GCGGTCCAAG AGACGAGATG CCAACTCCTC CGCGTCCGAG 
ATTAATTCCC TACAGACAGT CTGTGACTCT TCCTACTGGC ACAATGGGCC TTACAACGCA 
GATGGGGCCC ACAGAGTGTA TGACTGTGGC TCTCACTCGC TCTCAGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443142.1
CDS	887..2977
Translation	MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKTNGQEDHATPGSAPNGGTKIPGNWQIKIRPTAAIATGSSRNKPLANSLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICPQLYARISPTLTSHSKNSTGLAETGTHSNSYLDTSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQTVCDSSYWHNGPYNADGAHRVYDCGSHSLSD

Target ORF information:

RefSeq Version	NM_052910.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SLIT and NTRK like family member 1 (SLITRK1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052910.2

ORF Insert Sequence:

ATGCTGCTTT GGATTCTGTT GCTGGAGACG TCTCTTTGTT TTGCCGCTGG AAACGTTACA 
GGGGACGTTT GCAAAGAGAA GATCTGTTCC TGCAATGAGA TAGAAGGGGA CCTACACGTA 
GACTGTGAAA AAAAGGGCTT CACAAGTCTG CAGCGTTTCA CTGCCCCGAC TTCCCAGTTT 
TACCATTTAT TTCTGCATGG CAATTCCCTC ACTCGACTTT TCCCTAATGA GTTCGCTAAC 
TTTTATAATG CGGTTAGTTT GCACATGGAA AACAATGGCT TGCATGAAAT CGTTCCGGGG 
GCTTTTCTGG GGCTGCAGCT GGTGAAAAGG CTGCACATCA ACAACAACAA GATCAAGTCT 
TTTCGAAAGC AGACTTTTCT GGGGCTGGAC GATCTGGAAT ATCTCCAGGC TGATTTTAAT 
TTATTACGAG ATATAGACCC GGGGGCCTTC CAGGACTTGA ACAAGCTGGA GGTGCTCATT 
TTAAATGACA ATCTCATCAG CACCCTACCT GCCAACGTGT TCCAGTATGT GCCCATCACC 
CACCTCGACC TCCGGGGTAA CAGGCTGAAA ACGCTGCCCT ATGAGGAGGT CTTGGAGCAA 
ATCCCTGGTA TTGCGGAGAT CCTGCTAGAG GATAACCCTT GGGACTGCAC CTGTGATCTG 
CTCTCCCTGA AAGAATGGCT GGAAAACATT CCCAAGAATG CCCTGATCGG CCGAGTGGTC 
TGCGAAGCCC CCACCAGACT GCAGGGTAAA GACCTCAATG AAACCACCGA ACAGGACTTG 
TGTCCTTTGA AAAACCGAGT GGATTCTAGT CTCCCGGCGC CCCCTGCCCA AGAAGAGACC 
TTTGCTCCTG GACCCCTGCC AACTCCTTTC AAGACAAATG GGCAAGAGGA TCATGCCACA 
CCAGGGTCTG CTCCAAACGG AGGTACAAAG ATCCCAGGCA ACTGGCAGAT CAAAATCAGA 
CCCACAGCAG CGATAGCGAC GGGTAGCTCC AGGAACAAAC CCTTAGCTAA CAGTTTACCC 
TGCCCTGGGG GCTGCAGCTG CGACCACATC CCAGGGTCGG GTTTAAAGAT GAACTGCAAC 
AACAGGAACG TGAGCAGCTT GGCTGATTTG AAGCCCAAGC TCTCTAACGT GCAGGAGCTT 
TTCCTACGAG ATAACAAGAT CCACAGCATC CGAAAATCGC ACTTTGTGGA TTACAAGAAC 
CTCATTCTGT TGGATCTGGG CAACAATAAC ATCGCTACTG TAGAGAACAA CACTTTCAAG 
AACCTTTTGG ACCTCAGGTG GCTATACATG GATAGCAATT ACCTGGACAC GCTGTCCCGG 
GAGAAATTCG CGGGGCTGCA AAACCTAGAG TACCTGAACG TGGAGTACAA CGCTATCCAG 
CTCATCCTCC CGGGCACTTT CAATGCCATG CCCAAACTGA GGATCCTCAT TCTCAACAAC 
AACCTGCTGA GGTCCCTGCC TGTGGACGTG TTCGCTGGGG TCTCGCTCTC TAAACTCAGC 
CTGCACAACA ATTACTTCAT GTACCTCCCG GTGGCAGGGG TGCTGGACCA GTTAACCTCC 
ATCATCCAGA TAGACCTCCA CGGAAACCCC TGGGAGTGCT CCTGCACAAT TGTGCCTTTC 
AAGCAGTGGG CAGAACGCTT GGGTTCCGAA GTGCTGATGA GCGACCTCAA GTGTGAGACG 
CCGGTGAACT TCTTTAGAAA GGATTTCATG CTCCTCTCCA ATGACGAGAT CTGCCCTCAG 
CTGTACGCTA GGATCTCGCC CACGTTAACT TCGCACAGTA AAAACAGCAC TGGGTTGGCG 
GAGACCGGGA CGCACTCCAA CTCCTACCTA GACACCAGCA GGGTGTCCAT CTCGGTGTTG 
GTCCCGGGAC TGCTGCTGGT GTTTGTCACC TCCGCCTTCA CCGTGGTGGG CATGCTCGTG 
TTTATCCTGA GGAACCGAAA GCGGTCCAAG AGACGAGATG CCAACTCCTC CGCGTCCGAG 
ATTAATTCCC TACAGACAGT CTGTGACTCT TCCTACTGGC ACAATGGGCC TTACAACGCA 
GATGGGGCCC ACAGAGTGTA TGACTGTGGC TCTCACTCGC TCTCAGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLITRK1 ( NM_001281503.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001268432.1 Homo sapiens SLIT and NTRK like family member 1 (SLITRK1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20555
Clone ID Related Accession (Same CDS sequence)	NM_052910.2 , NM_001281503.1 , NM_001281503.2
Accession Version	NM_001281503.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2091bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	SLIT and NTRK-like protein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY157227.1, DC334447.1, AB067497.1 and AI500170.1. Transcript Variant: This variant (2) lacks an internal segment compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.133080.1, SRR1660807.27083.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTTT GGATTCTGTT GCTGGAGACG TCTCTTTGTT TTGCCGCTGG AAACGTTACA 
GGGGACGTTT GCAAAGAGAA GATCTGTTCC TGCAATGAGA TAGAAGGGGA CCTACACGTA 
GACTGTGAAA AAAAGGGCTT CACAAGTCTG CAGCGTTTCA CTGCCCCGAC TTCCCAGTTT 
TACCATTTAT TTCTGCATGG CAATTCCCTC ACTCGACTTT TCCCTAATGA GTTCGCTAAC 
TTTTATAATG CGGTTAGTTT GCACATGGAA AACAATGGCT TGCATGAAAT CGTTCCGGGG 
GCTTTTCTGG GGCTGCAGCT GGTGAAAAGG CTGCACATCA ACAACAACAA GATCAAGTCT 
TTTCGAAAGC AGACTTTTCT GGGGCTGGAC GATCTGGAAT ATCTCCAGGC TGATTTTAAT 
TTATTACGAG ATATAGACCC GGGGGCCTTC CAGGACTTGA ACAAGCTGGA GGTGCTCATT 
TTAAATGACA ATCTCATCAG CACCCTACCT GCCAACGTGT TCCAGTATGT GCCCATCACC 
CACCTCGACC TCCGGGGTAA CAGGCTGAAA ACGCTGCCCT ATGAGGAGGT CTTGGAGCAA 
ATCCCTGGTA TTGCGGAGAT CCTGCTAGAG GATAACCCTT GGGACTGCAC CTGTGATCTG 
CTCTCCCTGA AAGAATGGCT GGAAAACATT CCCAAGAATG CCCTGATCGG CCGAGTGGTC 
TGCGAAGCCC CCACCAGACT GCAGGGTAAA GACCTCAATG AAACCACCGA ACAGGACTTG 
TGTCCTTTGA AAAACCGAGT GGATTCTAGT CTCCCGGCGC CCCCTGCCCA AGAAGAGACC 
TTTGCTCCTG GACCCCTGCC AACTCCTTTC AAGACAAATG GGCAAGAGGA TCATGCCACA 
CCAGGGTCTG CTCCAAACGG AGGTACAAAG ATCCCAGGCA ACTGGCAGAT CAAAATCAGA 
CCCACAGCAG CGATAGCGAC GGGTAGCTCC AGGAACAAAC CCTTAGCTAA CAGTTTACCC 
TGCCCTGGGG GCTGCAGCTG CGACCACATC CCAGGGTCGG GTTTAAAGAT GAACTGCAAC 
AACAGGAACG TGAGCAGCTT GGCTGATTTG AAGCCCAAGC TCTCTAACGT GCAGGAGCTT 
TTCCTACGAG ATAACAAGAT CCACAGCATC CGAAAATCGC ACTTTGTGGA TTACAAGAAC 
CTCATTCTGT TGGATCTGGG CAACAATAAC ATCGCTACTG TAGAGAACAA CACTTTCAAG 
AACCTTTTGG ACCTCAGGTG GCTATACATG GATAGCAATT ACCTGGACAC GCTGTCCCGG 
GAGAAATTCG CGGGGCTGCA AAACCTAGAG TACCTGAACG TGGAGTACAA CGCTATCCAG 
CTCATCCTCC CGGGCACTTT CAATGCCATG CCCAAACTGA GGATCCTCAT TCTCAACAAC 
AACCTGCTGA GGTCCCTGCC TGTGGACGTG TTCGCTGGGG TCTCGCTCTC TAAACTCAGC 
CTGCACAACA ATTACTTCAT GTACCTCCCG GTGGCAGGGG TGCTGGACCA GTTAACCTCC 
ATCATCCAGA TAGACCTCCA CGGAAACCCC TGGGAGTGCT CCTGCACAAT TGTGCCTTTC 
AAGCAGTGGG CAGAACGCTT GGGTTCCGAA GTGCTGATGA GCGACCTCAA GTGTGAGACG 
CCGGTGAACT TCTTTAGAAA GGATTTCATG CTCCTCTCCA ATGACGAGAT CTGCCCTCAG 
CTGTACGCTA GGATCTCGCC CACGTTAACT TCGCACAGTA AAAACAGCAC TGGGTTGGCG 
GAGACCGGGA CGCACTCCAA CTCCTACCTA GACACCAGCA GGGTGTCCAT CTCGGTGTTG 
GTCCCGGGAC TGCTGCTGGT GTTTGTCACC TCCGCCTTCA CCGTGGTGGG CATGCTCGTG 
TTTATCCTGA GGAACCGAAA GCGGTCCAAG AGACGAGATG CCAACTCCTC CGCGTCCGAG 
ATTAATTCCC TACAGACAGT CTGTGACTCT TCCTACTGGC ACAATGGGCC TTACAACGCA 
GATGGGGCCC ACAGAGTGTA TGACTGTGGC TCTCACTCGC TCTCAGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001268432.1
CDS	444..2534
Translation	MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKTNGQEDHATPGSAPNGGTKIPGNWQIKIRPTAAIATGSSRNKPLANSLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICPQLYARISPTLTSHSKNSTGLAETGTHSNSYLDTSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQTVCDSSYWHNGPYNADGAHRVYDCGSHSLSD

Target ORF information:

RefSeq Version	NM_001281503.1
Organism	Homo sapiens(human)
Definition	Homo sapiens SLIT and NTRK like family member 1 (SLITRK1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001281503.1

ORF Insert Sequence:

ATGCTGCTTT GGATTCTGTT GCTGGAGACG TCTCTTTGTT TTGCCGCTGG AAACGTTACA 
GGGGACGTTT GCAAAGAGAA GATCTGTTCC TGCAATGAGA TAGAAGGGGA CCTACACGTA 
GACTGTGAAA AAAAGGGCTT CACAAGTCTG CAGCGTTTCA CTGCCCCGAC TTCCCAGTTT 
TACCATTTAT TTCTGCATGG CAATTCCCTC ACTCGACTTT TCCCTAATGA GTTCGCTAAC 
TTTTATAATG CGGTTAGTTT GCACATGGAA AACAATGGCT TGCATGAAAT CGTTCCGGGG 
GCTTTTCTGG GGCTGCAGCT GGTGAAAAGG CTGCACATCA ACAACAACAA GATCAAGTCT 
TTTCGAAAGC AGACTTTTCT GGGGCTGGAC GATCTGGAAT ATCTCCAGGC TGATTTTAAT 
TTATTACGAG ATATAGACCC GGGGGCCTTC CAGGACTTGA ACAAGCTGGA GGTGCTCATT 
TTAAATGACA ATCTCATCAG CACCCTACCT GCCAACGTGT TCCAGTATGT GCCCATCACC 
CACCTCGACC TCCGGGGTAA CAGGCTGAAA ACGCTGCCCT ATGAGGAGGT CTTGGAGCAA 
ATCCCTGGTA TTGCGGAGAT CCTGCTAGAG GATAACCCTT GGGACTGCAC CTGTGATCTG 
CTCTCCCTGA AAGAATGGCT GGAAAACATT CCCAAGAATG CCCTGATCGG CCGAGTGGTC 
TGCGAAGCCC CCACCAGACT GCAGGGTAAA GACCTCAATG AAACCACCGA ACAGGACTTG 
TGTCCTTTGA AAAACCGAGT GGATTCTAGT CTCCCGGCGC CCCCTGCCCA AGAAGAGACC 
TTTGCTCCTG GACCCCTGCC AACTCCTTTC AAGACAAATG GGCAAGAGGA TCATGCCACA 
CCAGGGTCTG CTCCAAACGG AGGTACAAAG ATCCCAGGCA ACTGGCAGAT CAAAATCAGA 
CCCACAGCAG CGATAGCGAC GGGTAGCTCC AGGAACAAAC CCTTAGCTAA CAGTTTACCC 
TGCCCTGGGG GCTGCAGCTG CGACCACATC CCAGGGTCGG GTTTAAAGAT GAACTGCAAC 
AACAGGAACG TGAGCAGCTT GGCTGATTTG AAGCCCAAGC TCTCTAACGT GCAGGAGCTT 
TTCCTACGAG ATAACAAGAT CCACAGCATC CGAAAATCGC ACTTTGTGGA TTACAAGAAC 
CTCATTCTGT TGGATCTGGG CAACAATAAC ATCGCTACTG TAGAGAACAA CACTTTCAAG 
AACCTTTTGG ACCTCAGGTG GCTATACATG GATAGCAATT ACCTGGACAC GCTGTCCCGG 
GAGAAATTCG CGGGGCTGCA AAACCTAGAG TACCTGAACG TGGAGTACAA CGCTATCCAG 
CTCATCCTCC CGGGCACTTT CAATGCCATG CCCAAACTGA GGATCCTCAT TCTCAACAAC 
AACCTGCTGA GGTCCCTGCC TGTGGACGTG TTCGCTGGGG TCTCGCTCTC TAAACTCAGC 
CTGCACAACA ATTACTTCAT GTACCTCCCG GTGGCAGGGG TGCTGGACCA GTTAACCTCC 
ATCATCCAGA TAGACCTCCA CGGAAACCCC TGGGAGTGCT CCTGCACAAT TGTGCCTTTC 
AAGCAGTGGG CAGAACGCTT GGGTTCCGAA GTGCTGATGA GCGACCTCAA GTGTGAGACG 
CCGGTGAACT TCTTTAGAAA GGATTTCATG CTCCTCTCCA ATGACGAGAT CTGCCCTCAG 
CTGTACGCTA GGATCTCGCC CACGTTAACT TCGCACAGTA AAAACAGCAC TGGGTTGGCG 
GAGACCGGGA CGCACTCCAA CTCCTACCTA GACACCAGCA GGGTGTCCAT CTCGGTGTTG 
GTCCCGGGAC TGCTGCTGGT GTTTGTCACC TCCGCCTTCA CCGTGGTGGG CATGCTCGTG 
TTTATCCTGA GGAACCGAAA GCGGTCCAAG AGACGAGATG CCAACTCCTC CGCGTCCGAG 
ATTAATTCCC TACAGACAGT CTGTGACTCT TCCTACTGGC ACAATGGGCC TTACAACGCA 
GATGGGGCCC ACAGAGTGTA TGACTGTGGC TCTCACTCGC TCTCAGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLITRK1 ( NM_001281503.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001268432.1 Homo sapiens SLIT and NTRK like family member 1 (SLITRK1), transcript variant 2, mRNA.

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CloneID	OHu20555
Clone ID Related Accession (Same CDS sequence)	NM_052910.2 , NM_001281503.1 , NM_001281503.2
Accession Version	NM_001281503.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2091bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-01
Organism	Homo sapiens(human)
Product	SLIT and NTRK-like protein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL355481.12, HY157227.1, DC334447.1, AB067497.1 and AI500170.1. On Jun 2, 2019 this sequence version replaced NM_001281503.1. Transcript Variant: This variant (2) lacks an internal segment compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.133080.1, SRR1660809.112857.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTTT GGATTCTGTT GCTGGAGACG TCTCTTTGTT TTGCCGCTGG AAACGTTACA 
GGGGACGTTT GCAAAGAGAA GATCTGTTCC TGCAATGAGA TAGAAGGGGA CCTACACGTA 
GACTGTGAAA AAAAGGGCTT CACAAGTCTG CAGCGTTTCA CTGCCCCGAC TTCCCAGTTT 
TACCATTTAT TTCTGCATGG CAATTCCCTC ACTCGACTTT TCCCTAATGA GTTCGCTAAC 
TTTTATAATG CGGTTAGTTT GCACATGGAA AACAATGGCT TGCATGAAAT CGTTCCGGGG 
GCTTTTCTGG GGCTGCAGCT GGTGAAAAGG CTGCACATCA ACAACAACAA GATCAAGTCT 
TTTCGAAAGC AGACTTTTCT GGGGCTGGAC GATCTGGAAT ATCTCCAGGC TGATTTTAAT 
TTATTACGAG ATATAGACCC GGGGGCCTTC CAGGACTTGA ACAAGCTGGA GGTGCTCATT 
TTAAATGACA ATCTCATCAG CACCCTACCT GCCAACGTGT TCCAGTATGT GCCCATCACC 
CACCTCGACC TCCGGGGTAA CAGGCTGAAA ACGCTGCCCT ATGAGGAGGT CTTGGAGCAA 
ATCCCTGGTA TTGCGGAGAT CCTGCTAGAG GATAACCCTT GGGACTGCAC CTGTGATCTG 
CTCTCCCTGA AAGAATGGCT GGAAAACATT CCCAAGAATG CCCTGATCGG CCGAGTGGTC 
TGCGAAGCCC CCACCAGACT GCAGGGTAAA GACCTCAATG AAACCACCGA ACAGGACTTG 
TGTCCTTTGA AAAACCGAGT GGATTCTAGT CTCCCGGCGC CCCCTGCCCA AGAAGAGACC 
TTTGCTCCTG GACCCCTGCC AACTCCTTTC AAGACAAATG GGCAAGAGGA TCATGCCACA 
CCAGGGTCTG CTCCAAACGG AGGTACAAAG ATCCCAGGCA ACTGGCAGAT CAAAATCAGA 
CCCACAGCAG CGATAGCGAC GGGTAGCTCC AGGAACAAAC CCTTAGCTAA CAGTTTACCC 
TGCCCTGGGG GCTGCAGCTG CGACCACATC CCAGGGTCGG GTTTAAAGAT GAACTGCAAC 
AACAGGAACG TGAGCAGCTT GGCTGATTTG AAGCCCAAGC TCTCTAACGT GCAGGAGCTT 
TTCCTACGAG ATAACAAGAT CCACAGCATC CGAAAATCGC ACTTTGTGGA TTACAAGAAC 
CTCATTCTGT TGGATCTGGG CAACAATAAC ATCGCTACTG TAGAGAACAA CACTTTCAAG 
AACCTTTTGG ACCTCAGGTG GCTATACATG GATAGCAATT ACCTGGACAC GCTGTCCCGG 
GAGAAATTCG CGGGGCTGCA AAACCTAGAG TACCTGAACG TGGAGTACAA CGCTATCCAG 
CTCATCCTCC CGGGCACTTT CAATGCCATG CCCAAACTGA GGATCCTCAT TCTCAACAAC 
AACCTGCTGA GGTCCCTGCC TGTGGACGTG TTCGCTGGGG TCTCGCTCTC TAAACTCAGC 
CTGCACAACA ATTACTTCAT GTACCTCCCG GTGGCAGGGG TGCTGGACCA GTTAACCTCC 
ATCATCCAGA TAGACCTCCA CGGAAACCCC TGGGAGTGCT CCTGCACAAT TGTGCCTTTC 
AAGCAGTGGG CAGAACGCTT GGGTTCCGAA GTGCTGATGA GCGACCTCAA GTGTGAGACG 
CCGGTGAACT TCTTTAGAAA GGATTTCATG CTCCTCTCCA ATGACGAGAT CTGCCCTCAG 
CTGTACGCTA GGATCTCGCC CACGTTAACT TCGCACAGTA AAAACAGCAC TGGGTTGGCG 
GAGACCGGGA CGCACTCCAA CTCCTACCTA GACACCAGCA GGGTGTCCAT CTCGGTGTTG 
GTCCCGGGAC TGCTGCTGGT GTTTGTCACC TCCGCCTTCA CCGTGGTGGG CATGCTCGTG 
TTTATCCTGA GGAACCGAAA GCGGTCCAAG AGACGAGATG CCAACTCCTC CGCGTCCGAG 
ATTAATTCCC TACAGACAGT CTGTGACTCT TCCTACTGGC ACAATGGGCC TTACAACGCA 
GATGGGGCCC ACAGAGTGTA TGACTGTGGC TCTCACTCGC TCTCAGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001268432.1
CDS	525..2615
Translation	MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKTNGQEDHATPGSAPNGGTKIPGNWQIKIRPTAAIATGSSRNKPLANSLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICPQLYARISPTLTSHSKNSTGLAETGTHSNSYLDTSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQTVCDSSYWHNGPYNADGAHRVYDCGSHSLSD

Target ORF information:

RefSeq Version	NM_001281503.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SLIT and NTRK like family member 1 (SLITRK1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001281503.2

ORF Insert Sequence:

ATGCTGCTTT GGATTCTGTT GCTGGAGACG TCTCTTTGTT TTGCCGCTGG AAACGTTACA 
GGGGACGTTT GCAAAGAGAA GATCTGTTCC TGCAATGAGA TAGAAGGGGA CCTACACGTA 
GACTGTGAAA AAAAGGGCTT CACAAGTCTG CAGCGTTTCA CTGCCCCGAC TTCCCAGTTT 
TACCATTTAT TTCTGCATGG CAATTCCCTC ACTCGACTTT TCCCTAATGA GTTCGCTAAC 
TTTTATAATG CGGTTAGTTT GCACATGGAA AACAATGGCT TGCATGAAAT CGTTCCGGGG 
GCTTTTCTGG GGCTGCAGCT GGTGAAAAGG CTGCACATCA ACAACAACAA GATCAAGTCT 
TTTCGAAAGC AGACTTTTCT GGGGCTGGAC GATCTGGAAT ATCTCCAGGC TGATTTTAAT 
TTATTACGAG ATATAGACCC GGGGGCCTTC CAGGACTTGA ACAAGCTGGA GGTGCTCATT 
TTAAATGACA ATCTCATCAG CACCCTACCT GCCAACGTGT TCCAGTATGT GCCCATCACC 
CACCTCGACC TCCGGGGTAA CAGGCTGAAA ACGCTGCCCT ATGAGGAGGT CTTGGAGCAA 
ATCCCTGGTA TTGCGGAGAT CCTGCTAGAG GATAACCCTT GGGACTGCAC CTGTGATCTG 
CTCTCCCTGA AAGAATGGCT GGAAAACATT CCCAAGAATG CCCTGATCGG CCGAGTGGTC 
TGCGAAGCCC CCACCAGACT GCAGGGTAAA GACCTCAATG AAACCACCGA ACAGGACTTG 
TGTCCTTTGA AAAACCGAGT GGATTCTAGT CTCCCGGCGC CCCCTGCCCA AGAAGAGACC 
TTTGCTCCTG GACCCCTGCC AACTCCTTTC AAGACAAATG GGCAAGAGGA TCATGCCACA 
CCAGGGTCTG CTCCAAACGG AGGTACAAAG ATCCCAGGCA ACTGGCAGAT CAAAATCAGA 
CCCACAGCAG CGATAGCGAC GGGTAGCTCC AGGAACAAAC CCTTAGCTAA CAGTTTACCC 
TGCCCTGGGG GCTGCAGCTG CGACCACATC CCAGGGTCGG GTTTAAAGAT GAACTGCAAC 
AACAGGAACG TGAGCAGCTT GGCTGATTTG AAGCCCAAGC TCTCTAACGT GCAGGAGCTT 
TTCCTACGAG ATAACAAGAT CCACAGCATC CGAAAATCGC ACTTTGTGGA TTACAAGAAC 
CTCATTCTGT TGGATCTGGG CAACAATAAC ATCGCTACTG TAGAGAACAA CACTTTCAAG 
AACCTTTTGG ACCTCAGGTG GCTATACATG GATAGCAATT ACCTGGACAC GCTGTCCCGG 
GAGAAATTCG CGGGGCTGCA AAACCTAGAG TACCTGAACG TGGAGTACAA CGCTATCCAG 
CTCATCCTCC CGGGCACTTT CAATGCCATG CCCAAACTGA GGATCCTCAT TCTCAACAAC 
AACCTGCTGA GGTCCCTGCC TGTGGACGTG TTCGCTGGGG TCTCGCTCTC TAAACTCAGC 
CTGCACAACA ATTACTTCAT GTACCTCCCG GTGGCAGGGG TGCTGGACCA GTTAACCTCC 
ATCATCCAGA TAGACCTCCA CGGAAACCCC TGGGAGTGCT CCTGCACAAT TGTGCCTTTC 
AAGCAGTGGG CAGAACGCTT GGGTTCCGAA GTGCTGATGA GCGACCTCAA GTGTGAGACG 
CCGGTGAACT TCTTTAGAAA GGATTTCATG CTCCTCTCCA ATGACGAGAT CTGCCCTCAG 
CTGTACGCTA GGATCTCGCC CACGTTAACT TCGCACAGTA AAAACAGCAC TGGGTTGGCG 
GAGACCGGGA CGCACTCCAA CTCCTACCTA GACACCAGCA GGGTGTCCAT CTCGGTGTTG 
GTCCCGGGAC TGCTGCTGGT GTTTGTCACC TCCGCCTTCA CCGTGGTGGG CATGCTCGTG 
TTTATCCTGA GGAACCGAAA GCGGTCCAAG AGACGAGATG CCAACTCCTC CGCGTCCGAG 
ATTAATTCCC TACAGACAGT CTGTGACTCT TCCTACTGGC ACAATGGGCC TTACAACGCA 
GATGGGGCCC ACAGAGTGTA TGACTGTGGC TCTCACTCGC TCTCAGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Slitrk1 is localized to excitatory synapses and promotes their development.
Scientific reports627343(2016 Jun)
Beaubien F,Raja R,Kennedy TE,Fournier AE,Cloutier JF

Analysis of SLITRK1 in Japanese patients with Tourette syndrome using a next-generation sequencer.
Psychiatric genetics25(6)256-8(2015 Dec)
Inai A,Tochigi M,Kuwabara H,Nishimura F,Kato K,Eriguchi Y,Shimada T,Furukawa M,Kawamura Y,Sasaki T,Kakiuchi C,Kasai K,Kano Y

A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
Genes, brain, and behavior13(7)675-85(2014 Sep)
Cai DC,Fonteijn H,Guadalupe T,Zwiers M,Wittfeld K,Teumer A,Hoogman M,Arias-V?squez A,Yang Y,Buitelaar J,Fern?ndez G,Brunner HG,van Bokhoven H,Franke B,Hegenscheid K,Homuth G,Fisher SE,Grabe HJ,Francks C,Hagoort P

Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
Neurobiology of aging35(7)1778.e9-1778.e23(2014 Jul)
Xie T,Deng L,Mei P,Zhou Y,Wang B,Zhang J,Lin J,Wei Y,Zhang X,Xu R

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SLITRK1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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