Slitrk1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slitrk1
Entrez Gene ID	76965
Full Name	SLIT and NTRK-like family, member 1
Synonyms	3200001I04Rik
General protein information	Preferred Names SLIT and NTRK-like family, member 1 Names SLIT and NTRK-like protein 1 slit and trk like gene 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 E3

mRNA and Protein(s)

mRNA	Protein	Name
NM_199065.2	NP_951020.1	SLIT and NTRK-like protein 1 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Slitrk1	NP_001100753.1
Danio rerio (zebrafish)	LOC558743	XP_005174686.1
Homo sapiens (human)	SLITRK1	NP_001268432.1
	SLITRK1	XP_001093240.1
Mus musculus (house mouse)	Slitrk1	NP_951020.1
Gallus gallus (chicken)	SLITRK1	XP_416993.2
Xenopus tropicalis (tropical clawed frog)	slitrk1	NP_001096395.1
Bos taurus (cattle)	SLITRK1	XP_003586770.1
Pan troglodytes (chimpanzee)	SLITRK1	XP_001143864.1
Canis lupus familiaris (dog)	SLITRK1	XP_005634067.1

Gene Ontology
Bibliography

Related articles in PubMed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstr?m E, Pachnis V, Marklund U
Gastroenterology(2017 Oct)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Slitrk1 is localized to excitatory synapses and promotes their development.
Beaubien F, Raja R, Kennedy TE, Fournier AE, Cloutier JF
Scientific reports627343(2016 Jun)

Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.
Um JW, Pramanik G, Ko JS, Song MY, Lee D, Kim H, Park KS, S?dhof TC, Tabuchi K, Ko J
Cell reports6(6)1096-1109(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results lead us to conclude that noradrenergic mechanisms are involved in the behavioral abnormalities of Slitrk1-deficient mice. Elevated anxiety due to Slitrk1 dysfunction may contribute to the pathogenesis of neuropsychiatric diseases
Title: Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities.

Data show that the expression of SLITRK1 is dynamic and specifically associated with the circuits most commonly implicated in TS and related disorders, suggesting that SLITRK1 contributes to the development of corticostriatal-thalamocortical circuits.
Title: Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome.

The following Slitrk1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slitrk1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58371	NM_199065.2 Latest version!	Mus musculus SLIT and NTRK-like family, member 1 (Slitrk1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slitrk1 ( NM_199065.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_951020.1 Mus musculus SLIT and NTRK-like family, member 1 (Slitrk1), mRNA.

Price & Availability↑

CloneID	OMu58371
Clone ID Related Accession (Same CDS sequence)	NM_199065.2
Accession Version	NM_199065.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2091bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	SLIT and NTRK-like protein 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CO430912.1, AK173296.1 and BE956915.1. On May 24, 2007 this sequence version replaced NM_199065.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGCTGCTTT GGATTCTGTT GCTGGAGACG TCTCTTTGTT TTGCCGCTGG AAACGTTACA 
GGGGACGTTT GTAAAGAGAA GATCTGTTCT TGCAATGAGA TAGAAGGGGA CTTACACGTA 
GACTGTGAAA AAAAGGGCTT CACAAGTCTG CAGCGCTTCA CCGCCCCGAC TTCCCAGTTT 
TACCATTTAT TTCTGCATGG CAATTCCCTC ACTCGACTTT TCCCTAATGA GTTCGCTAAC 
TTTTATAATG CGGTTAGTTT GCATATGGAA AACAATGGCT TGCATGAGAT CGTTCCGGGG 
GCATTTCTGG GGCTGCAGCT GGTGAAACGG CTGCACATCA ACAACAACAA GATCAAGTCT 
TTTCGAAAGC AGACTTTTTT GGGGCTGGAC GATCTGGAAT ACCTCCAGGC TGATTTTAAT 
TTATTACGGG ATATAGACCC GGGGGCCTTC CAGGACTTGA ACAAGTTGGA AGTCCTCATT 
TTAAACGACA ATCTCATCAG CACCCTACCT GCTAATGTAT TCCAGTATGT GCCCATCACC 
CACCTCGACC TCCGTGGAAA CAGGCTGAAA ACACTGCCCT ATGAGGAGGT CTTGGAGCAG 
ATCCCTGGCA TTGCCGAGAT CCTGCTAGAG GATAACCCTT GGGACTGCAC CTGTGATCTG 
CTCTCCCTGA AGGAATGGCT AGAGAACATT CCCAAAAACG CCCTAATCGG TCGAGTGGTC 
TGCGAAGCCC CCACCAGGCT CCAGGGTAAA GACCTCAATG AAACCACGGA ACAGGACCTG 
TGTCCTTTAA AAAACAGAGT GGATTCTAGT CTCCCGGCTC CCCCTGCCCA GGAAGAAACC 
TTCGCTCCTG GCCCCCTGCC AACTCCTTTC AAGACAAATG GGCAGGATGA GCATGCTACC 
CCAGGGGCTG TTCCAAATGG AGGTACAAAG ATCCCGGGCA ACTGGCAGCT CAAAATCAAA 
CCCACGCCAC CGATAGCAAC TGGGAGCGCC AGAAACAAAC CCCCAGTGCA TGGCTTGCCC 
TGCCCCGGGG GCTGCAGCTG TGACCACATC CCAGGCTCAG GCTTAAAGAT GAACTGTAAC 
AACCGGAACG TGAGCAGCTT GGCTGATTTG AAGCCTAAGC TTTCCAACGT GCAGGAGCTT 
TTCCTTCGAG ATAACAAGAT CCATAGCATC CGAAAATCAC ACTTTGTGGA TTACAAGAAC 
CTCATTCTGT TGGATCTGGG CAACAACAAC ATCGCAAACA TAGAGAACAA CACTTTCAAG 
AACCTTTTGG ACCTCAGGTG GCTCTACATG GATAGTAACT ACCTGGACAC TCTGTCCCGG 
GAGAAATTTG CTGGGCTGCA GAACCTGGAG TATCTGAATG TGGAGTACAA CGCGATTCAG 
CTCATTCTCC CTGGTACTTT CAATGCCATG CCGAAACTGA GGATTCTTAT TCTCAACAAC 
AACTTGCTGA GGTCCCTACC GGTGGACGTC TTTGCTGGGG TCTCCCTGTC TAAGCTCAGT 
CTGCACAATA ATTACTTCAT GTACCTCCCT GTGGCAGGGG TGCTGGACCA GTTAACCTCC 
ATCATCCAGA TAGACCTGCA TGGCAACCCC TGGGAGTGCT CCTGCACCAT TGTGCCTTTC 
AAGCAATGGG CAGAACGTCT GGGCTCCGAG GTGCTGATGA GCGACCTCAA GTGTGAGACA 
CCGGTGAACT TCTTTAGGAA GGATTTCATG CTGCTCTCCA ATGAGGAGAT CTGCCCCCAG 
CTGTATGCGA GGATCTCGCC CACGTTAACT TCGCACAGTA AAAACAGCAC TGGGTTGGCG 
GAGACCGGGA CACACTCCAA CTCCTACCTA GACACCAGCA GGGTGTCCAT CTCCGTGTTG 
GTCCCGGGAC TGCTGCTGGT GTTCGTCACC TCCGCCTTCA CCGTGGTGGG CATGCTCGTG 
TTTATCCTGA GGAACCGAAA GCGGTCCAAG AGAAGGGATG CCAATTCCTC TGCGTCCGAA 
ATTAATTCCC TACAGACAGT CTGTGACTCT TCCTACTGGC ACAATGGGCC TTACAATGCA 
GATGGGTCCC ATAGGGTGTA TGACTGTGGC TCTCACTCAC TTTCAGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_951020.1
CDS	963..3053
Translation	MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKTNGQDEHATPGAVPNGGTKIPGNWQLKIKPTPPIATGSARNKPPVHGLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIANIENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNEEICPQLYARISPTLTSHSKNSTGLAETGTHSNSYLDTSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQTVCDSSYWHNGPYNADGSHRVYDCGSHSLSD

Target ORF information:

RefSeq Version	NM_199065.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus SLIT and NTRK-like family, member 1 (Slitrk1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199065.2

ORF Insert Sequence:

ATGCTGCTTT GGATTCTGTT GCTGGAGACG TCTCTTTGTT TTGCCGCTGG AAACGTTACA 
GGGGACGTTT GTAAAGAGAA GATCTGTTCT TGCAATGAGA TAGAAGGGGA CTTACACGTA 
GACTGTGAAA AAAAGGGCTT CACAAGTCTG CAGCGCTTCA CCGCCCCGAC TTCCCAGTTT 
TACCATTTAT TTCTGCATGG CAATTCCCTC ACTCGACTTT TCCCTAATGA GTTCGCTAAC 
TTTTATAATG CGGTTAGTTT GCATATGGAA AACAATGGCT TGCATGAGAT CGTTCCGGGG 
GCATTTCTGG GGCTGCAGCT GGTGAAACGG CTGCACATCA ACAACAACAA GATCAAGTCT 
TTTCGAAAGC AGACTTTTTT GGGGCTGGAC GATCTGGAAT ACCTCCAGGC TGATTTTAAT 
TTATTACGGG ATATAGACCC GGGGGCCTTC CAGGACTTGA ACAAGTTGGA AGTCCTCATT 
TTAAACGACA ATCTCATCAG CACCCTACCT GCTAATGTAT TCCAGTATGT GCCCATCACC 
CACCTCGACC TCCGTGGAAA CAGGCTGAAA ACACTGCCCT ATGAGGAGGT CTTGGAGCAG 
ATCCCTGGCA TTGCCGAGAT CCTGCTAGAG GATAACCCTT GGGACTGCAC CTGTGATCTG 
CTCTCCCTGA AGGAATGGCT AGAGAACATT CCCAAAAACG CCCTAATCGG TCGAGTGGTC 
TGCGAAGCCC CCACCAGGCT CCAGGGTAAA GACCTCAATG AAACCACGGA ACAGGACCTG 
TGTCCTTTAA AAAACAGAGT GGATTCTAGT CTCCCGGCTC CCCCTGCCCA GGAAGAAACC 
TTCGCTCCTG GCCCCCTGCC AACTCCTTTC AAGACAAATG GGCAGGATGA GCATGCTACC 
CCAGGGGCTG TTCCAAATGG AGGTACAAAG ATCCCGGGCA ACTGGCAGCT CAAAATCAAA 
CCCACGCCAC CGATAGCAAC TGGGAGCGCC AGAAACAAAC CCCCAGTGCA TGGCTTGCCC 
TGCCCCGGGG GCTGCAGCTG TGACCACATC CCAGGCTCAG GCTTAAAGAT GAACTGTAAC 
AACCGGAACG TGAGCAGCTT GGCTGATTTG AAGCCTAAGC TTTCCAACGT GCAGGAGCTT 
TTCCTTCGAG ATAACAAGAT CCATAGCATC CGAAAATCAC ACTTTGTGGA TTACAAGAAC 
CTCATTCTGT TGGATCTGGG CAACAACAAC ATCGCAAACA TAGAGAACAA CACTTTCAAG 
AACCTTTTGG ACCTCAGGTG GCTCTACATG GATAGTAACT ACCTGGACAC TCTGTCCCGG 
GAGAAATTTG CTGGGCTGCA GAACCTGGAG TATCTGAATG TGGAGTACAA CGCGATTCAG 
CTCATTCTCC CTGGTACTTT CAATGCCATG CCGAAACTGA GGATTCTTAT TCTCAACAAC 
AACTTGCTGA GGTCCCTACC GGTGGACGTC TTTGCTGGGG TCTCCCTGTC TAAGCTCAGT 
CTGCACAATA ATTACTTCAT GTACCTCCCT GTGGCAGGGG TGCTGGACCA GTTAACCTCC 
ATCATCCAGA TAGACCTGCA TGGCAACCCC TGGGAGTGCT CCTGCACCAT TGTGCCTTTC 
AAGCAATGGG CAGAACGTCT GGGCTCCGAG GTGCTGATGA GCGACCTCAA GTGTGAGACA 
CCGGTGAACT TCTTTAGGAA GGATTTCATG CTGCTCTCCA ATGAGGAGAT CTGCCCCCAG 
CTGTATGCGA GGATCTCGCC CACGTTAACT TCGCACAGTA AAAACAGCAC TGGGTTGGCG 
GAGACCGGGA CACACTCCAA CTCCTACCTA GACACCAGCA GGGTGTCCAT CTCCGTGTTG 
GTCCCGGGAC TGCTGCTGGT GTTCGTCACC TCCGCCTTCA CCGTGGTGGG CATGCTCGTG 
TTTATCCTGA GGAACCGAAA GCGGTCCAAG AGAAGGGATG CCAATTCCTC TGCGTCCGAA 
ATTAATTCCC TACAGACAGT CTGTGACTCT TCCTACTGGC ACAATGGGCC TTACAATGCA 
GATGGGTCCC ATAGGGTGTA TGACTGTGGC TCTCACTCAC TTTCAGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Gastroenterology(2017 Oct)
Memic F,Knoflach V,Morarach K,Sadler R,Laranjeira C,Hjerling-Leffler J,Sundstr?m E,Pachnis V,Marklund U

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Slitrk1 is localized to excitatory synapses and promotes their development.
Scientific reports627343(2016 Jun)
Beaubien F,Raja R,Kennedy TE,Fournier AE,Cloutier JF

Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.
Cell reports6(6)1096-1109(2014 Mar)
Um JW,Pramanik G,Ko JS,Song MY,Lee D,Kim H,Park KS,S?dhof TC,Tabuchi K,Ko J

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Slitrk1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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