CMTM7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CMTM7
Entrez Gene ID	112616
Full Name	CKLF like MARVEL transmembrane domain containing 7
Synonyms	CKLFSF7
General protein information	Preferred Names CKLF like MARVEL transmembrane domain containing 7 Names CKLF-like MARVEL transmembrane domain-containing protein 7 chemokine-like factor super family 7 chemokine-like factor super family member 7 variant 2 chemokine-like factor superfamily 7 chemokine-like factor superfamily member 7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p22.3
Summary	This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016].
Disorder MIM:	607890

mRNA and Protein(s)

mRNA	Protein	Name
NM_138410.3	NP_612419.1	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform a
XM_017005646.1	XP_016861135.1	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform X2
NM_181472.2	NP_852137.1	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform b
NM_181472.3	NP_852137.1	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform b
NM_138410.2	NP_612419.1	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform a
NM_138410.4	NP_612419.1	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform a
XM_011533319.2	XP_011531621.1	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Cmtm7	NP_598739.1
Danio rerio (zebrafish)	cmtm7	NP_001123586.1
Xenopus tropicalis (tropical clawed frog)	cmtm7	NP_001015861.1
Pan troglodytes (chimpanzee)	CMTM7	XP_003309731.1
	CMTM7	XP_001097925.1
Gallus gallus (chicken)	CMTM7	NP_001007895.1
Homo sapiens (human)	CMTM7	NP_612419.1
Canis lupus familiaris (dog)	CMTM7	XP_005634694.1
Bos taurus (cattle)	CMTM7	NP_001069428.1
Rattus norvegicus (Norway rat)	Cmtm7	NP_001102770.1

Gene Ontology
Bibliography

Related articles in PubMed

CMTM7 knockdown increases tumorigenicity of human non-small cell lung cancer cells and EGFR-AKT signaling by reducing Rab5 activation.
Liu B, Su Y, Li T, Yuan W, Mo X, Li H, He Q, Ma D, Han W
Oncotarget6(38)41092-107(2015 Dec)

A novel 3p22.3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth.
Li H, Li J, Su Y, Fan Y, Guo X, Li L, Su X, Rong R, Ying J, Mo X, Liu K, Zhang Z, Yang F, Jiang G, Wang J, Zhang Y, Ma D, Tao Q, Han W
Oncogene33(24)3109-18(2014 Jun)

Change of CMTM7 expression, a potential tumor suppressor, is associated with poor clinical outcome in human non-small cell lung cancer.
Liu Q, Su Y, Jiang GC, Zhou ZL, Liu BC, Bu L, Yang F, Qiao F, Wang J
Chinese medical journal126(16)3006-12(2013 Aug)

Identification of CMTM7 as a transmembrane linker of BLNK and the B-cell receptor.
Miyazaki A, Yogosawa S, Murakami A, Kitamura D
PloS one7(2)e31829(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings indicate the role of CMTM7 protein in the regulation of epidermal growth factor receptor (EGFR)-AKT proto-oncogene protein signaling in tumor cells, and as a molecule related to Rab5 GTP-binding protein activation.
Title: CMTM7 knockdown increases tumorigenicity of human non-small cell lung cancer cells and EGFR-AKT signaling by reducing Rab5 activation.

Loss of CMTM7 by promoter CpG methylation is associated with neoplasms.
Title: A novel 3p22.3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth.

The CMTM7 expression may be related to survival of patients with non-smallcell lung cancer and a unique prognostic factor. CMTM7 may play an important role in NSCLC development.
Title: Change of CMTM7 expression, a potential tumor suppressor, is associated with poor clinical outcome in human non-small cell lung cancer.

CMTM7 functions to link sIgM and BLNK in the plasma membrane.
Title: Identification of CMTM7 as a transmembrane linker of BLNK and the B-cell receptor.

Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.

The following CMTM7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CMTM7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06099	NM_138410.4 Latest version!	Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu07572	NM_181472.3 Latest version!	Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OHu74649	XM_011533319.2 Latest version!	Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OHu93768	XM_017005646.1 Latest version!	Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu07572	NM_181472.2	Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OHu06099	NM_138410.2	Homo sapiens CKLF-like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu06099	NM_138410.3	Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CMTM7 ( NM_138410.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_612419.1 Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06099
Clone ID Related Accession (Same CDS sequence)	NM_138410.3 , NM_138410.2 , NM_138410.4
Accession Version	NM_138410.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-25
Organism	Homo sapiens(human)
Product	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF479263.2 and CD366110.1. On Feb 23, 2016 this sequence version replaced NM_138410.2. Transcript Variant: This variant (1) encodes the longer isoform (a). ##Evidence-Data-START## Transcript exon combination :: AF479263.2, SRR1163658.546923.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGCACG GAGCCGGGCT CGTCCGCACC ACGTGCAGCA GCGGCAGCGC GCTCGGACCC 
GGGGCCGGCG CGGCCCAGCC CAGCGCGAGC CCCTTGGAGG GGCTGCTGGA CCTCAGCTAC 
CCCCGCACCC ACGCGGCCCT GCTGAAAGTG GCGCAAATGG TCACCCTGCT GATTGCCTTC 
ATCTGTGTGC GGAGCTCCCT GTGGACCAAC TACAGCGCCT ACAGCTACTT TGAAGTGGTC 
ACCATTTGCG ACTTGATAAT GATCCTCGCC TTTTACCTGG TCCACCTCTT CCGCTTCTAC 
CGCGTGCTCA CCTGTATCAG CTGGCCCCTG TCGGAACTTC TGCACTATTT AATCGGTACC 
CTGCTCCTCC TCATCGCCTC CATTGTGGCA GCTTCCAAGA GTTACAACCA GAGCGGACTG 
GTAGCCGGAG CGATCTTTGG TTTCATGGCC ACCTTCCTCT GCATGGCAAG CATATGGCTG 
TCCTATAAGA TCTCGTGTGT AACCCAGTCC ACAGATGCAG CCGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612419.1
CDS	237..764
Translation	MSHGAGLVRTTCSSGSALGPGAGAAQPSASPLEGLLDLSYPRTHAALLKVAQMVTLLIAFICVRSSLWTNYSAYSYFEVVTICDLIMILAFYLVHLFRFYRVLTCISWPLSELLHYLIGTLLLLIASIVAASKSYNQSGLVAGAIFGFMATFLCMASIWLSYKISCVTQSTDAAV

Target ORF information:

RefSeq Version	NM_138410.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138410.3

ORF Insert Sequence:

ATGTCGCACG GAGCCGGGCT CGTCCGCACC ACGTGCAGCA GCGGCAGCGC GCTCGGACCC 
GGGGCCGGCG CGGCCCAGCC CAGCGCGAGC CCCTTGGAGG GGCTGCTGGA CCTCAGCTAC 
CCCCGCACCC ACGCGGCCCT GCTGAAAGTG GCGCAAATGG TCACCCTGCT GATTGCCTTC 
ATCTGTGTGC GGAGCTCCCT GTGGACCAAC TACAGCGCCT ACAGCTACTT TGAAGTGGTC 
ACCATTTGCG ACTTGATAAT GATCCTCGCC TTTTACCTGG TCCACCTCTT CCGCTTCTAC 
CGCGTGCTCA CCTGTATCAG CTGGCCCCTG TCGGAACTTC TGCACTATTT AATCGGTACC 
CTGCTCCTCC TCATCGCCTC CATTGTGGCA GCTTCCAAGA GTTACAACCA GAGCGGACTG 
GTAGCCGGAG CGATCTTTGG TTTCATGGCC ACCTTCCTCT GCATGGCAAG CATATGGCTG 
TCCTATAAGA TCTCGTGTGT AACCCAGTCC ACAGATGCAG CCGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CMTM7 ( NM_138410.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_612419.1 Homo sapiens CKLF-like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06099
Clone ID Related Accession (Same CDS sequence)	NM_138410.3 , NM_138410.2 , NM_138410.4
Accession Version	NM_138410.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform a
Comment

ATGTCGCACG GAGCCGGGCT CGTCCGCACC ACGTGCAGCA GCGGCAGCGC GCTCGGACCC 
GGGGCCGGCG CGGCCCAGCC CAGCGCGAGC CCCTTGGAGG GGCTGCTGGA CCTCAGCTAC 
CCCCGCACCC ACGCGGCCCT GCTGAAAGTG GCGCAAATGG TCACCCTGCT GATTGCCTTC 
ATCTGTGTGC GGAGCTCCCT GTGGACCAAC TACAGCGCCT ACAGCTACTT TGAAGTGGTC 
ACCATTTGCG ACTTGATAAT GATCCTCGCC TTTTACCTGG TCCACCTCTT CCGCTTCTAC 
CGCGTGCTCA CCTGTATCAG CTGGCCCCTG TCGGAACTTC TGCACTATTT AATCGGTACC 
CTGCTCCTCC TCATCGCCTC CATTGTGGCA GCTTCCAAGA GTTACAACCA GAGCGGACTG 
GTAGCCGGAG CGATCTTTGG TTTCATGGCC ACCTTCCTCT GCATGGCAAG CATATGGCTG 
TCCTATAAGA TCTCGTGTGT AACCCAGTCC ACAGATGCAG CCGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612419.1
Translation	MSHGAGLVRTTCSSGSALGPGAGAAQPSASPLEGLLDLSYPRTHAALLKVAQMVTLLIAFICVRSSLWTNYSAYSYFEVVTICDLIMILAFYLVHLFRFYRVLTCISWPLSELLHYLIGTLLLLIASIVAASKSYNQSGLVAGAIFGFMATFLCMASIWLSYKISCVTQSTDAAV

Target ORF information:

RefSeq Version	NM_138410.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens CKLF-like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138410.2

ORF Insert Sequence:

ATGTCGCACG GAGCCGGGCT CGTCCGCACC ACGTGCAGCA GCGGCAGCGC GCTCGGACCC 
GGGGCCGGCG CGGCCCAGCC CAGCGCGAGC CCCTTGGAGG GGCTGCTGGA CCTCAGCTAC 
CCCCGCACCC ACGCGGCCCT GCTGAAAGTG GCGCAAATGG TCACCCTGCT GATTGCCTTC 
ATCTGTGTGC GGAGCTCCCT GTGGACCAAC TACAGCGCCT ACAGCTACTT TGAAGTGGTC 
ACCATTTGCG ACTTGATAAT GATCCTCGCC TTTTACCTGG TCCACCTCTT CCGCTTCTAC 
CGCGTGCTCA CCTGTATCAG CTGGCCCCTG TCGGAACTTC TGCACTATTT AATCGGTACC 
CTGCTCCTCC TCATCGCCTC CATTGTGGCA GCTTCCAAGA GTTACAACCA GAGCGGACTG 
GTAGCCGGAG CGATCTTTGG TTTCATGGCC ACCTTCCTCT GCATGGCAAG CATATGGCTG 
TCCTATAAGA TCTCGTGTGT AACCCAGTCC ACAGATGCAG CCGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CMTM7 ( NM_138410.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_612419.1 Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06099
Clone ID Related Accession (Same CDS sequence)	NM_138410.3 , NM_138410.2 , NM_138410.4
Accession Version	NM_138410.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF479263.2, CD366110.1 and AC098475.2. On May 17, 2019 this sequence version replaced NM_138410.3. Transcript Variant: This variant (1) encodes the longer isoform (a). ##Evidence-Data-START## Transcript exon combination :: BM764608.1, DRR138512.122023.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000334983.10/ ENSP00000335605.5 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCGCACG GAGCCGGGCT CGTCCGCACC ACGTGCAGCA GCGGCAGCGC GCTCGGACCC 
GGGGCCGGCG CGGCCCAGCC CAGCGCGAGC CCCTTGGAGG GGCTGCTGGA CCTCAGCTAC 
CCCCGCACCC ACGCGGCCCT GCTGAAAGTG GCGCAAATGG TCACCCTGCT GATTGCCTTC 
ATCTGTGTGC GGAGCTCCCT GTGGACCAAC TACAGCGCCT ACAGCTACTT TGAAGTGGTC 
ACCATTTGCG ACTTGATAAT GATCCTCGCC TTTTACCTGG TCCACCTCTT CCGCTTCTAC 
CGCGTGCTCA CCTGTATCAG CTGGCCCCTG TCGGAACTTC TGCACTATTT AATCGGTACC 
CTGCTCCTCC TCATCGCCTC CATTGTGGCA GCTTCCAAGA GTTACAACCA GAGCGGACTG 
GTAGCCGGAG CGATCTTTGG TTTCATGGCC ACCTTCCTCT GCATGGCAAG CATATGGCTG 
TCCTATAAGA TCTCGTGTGT AACCCAGTCC ACAGATGCAG CCGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612419.1
CDS	55..582
Translation	MSHGAGLVRTTCSSGSALGPGAGAAQPSASPLEGLLDLSYPRTHAALLKVAQMVTLLIAFICVRSSLWTNYSAYSYFEVVTICDLIMILAFYLVHLFRFYRVLTCISWPLSELLHYLIGTLLLLIASIVAASKSYNQSGLVAGAIFGFMATFLCMASIWLSYKISCVTQSTDAAV

Target ORF information:

RefSeq Version	NM_138410.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138410.4

ORF Insert Sequence:

ATGTCGCACG GAGCCGGGCT CGTCCGCACC ACGTGCAGCA GCGGCAGCGC GCTCGGACCC 
GGGGCCGGCG CGGCCCAGCC CAGCGCGAGC CCCTTGGAGG GGCTGCTGGA CCTCAGCTAC 
CCCCGCACCC ACGCGGCCCT GCTGAAAGTG GCGCAAATGG TCACCCTGCT GATTGCCTTC 
ATCTGTGTGC GGAGCTCCCT GTGGACCAAC TACAGCGCCT ACAGCTACTT TGAAGTGGTC 
ACCATTTGCG ACTTGATAAT GATCCTCGCC TTTTACCTGG TCCACCTCTT CCGCTTCTAC 
CGCGTGCTCA CCTGTATCAG CTGGCCCCTG TCGGAACTTC TGCACTATTT AATCGGTACC 
CTGCTCCTCC TCATCGCCTC CATTGTGGCA GCTTCCAAGA GTTACAACCA GAGCGGACTG 
GTAGCCGGAG CGATCTTTGG TTTCATGGCC ACCTTCCTCT GCATGGCAAG CATATGGCTG 
TCCTATAAGA TCTCGTGTGT AACCCAGTCC ACAGATGCAG CCGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CMTM7 ( NM_181472.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_852137.1 Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07572
Clone ID Related Accession (Same CDS sequence)	NM_181472.2 , NM_181472.3
Accession Version	NM_181472.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF479263.2 and AK308878.1. On Feb 23, 2016 this sequence version replaced NM_181472.1. Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. ##Evidence-Data-START## Transcript exon combination :: AK308878.1, BX437916.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGCACG GAGCCGGGCT CGTCCGCACC ACGTGCAGCA GCGGCAGCGC GCTCGGACCC 
GGGGCCGGCG CGGCCCAGCC CAGCGCGAGC CCCTTGGAGG GGCTGCTGGA CCTCAGCTAC 
CCCCGCACCC ACGCGGCCCT GCTGAAAGTG GCGCAAATGG TCACCCTGCT GATTGCCTTC 
ATCTGTGTGC GGAGCTCCCT GTGGACCAAC TACAGCGCCT ACAGCTACTT TGAAGTGGTC 
ACCATTTGCG ACTTGATAAT GATCCTCGCC TTTTACCTGG TCCACCTCTT CCGCTTCTAC 
CGCGTGCTCA CCTGTATCAG CTGGCCCCTG TCGATCTTTG GTTTCATGGC CACCTTCCTC 
TGCATGGCAA GCATATGGCT GTCCTATAAG ATCTCGTGTG TAACCCAGTC CACAGATGCA 
GCCGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_852137.1
CDS	237..665
Translation	MSHGAGLVRTTCSSGSALGPGAGAAQPSASPLEGLLDLSYPRTHAALLKVAQMVTLLIAFICVRSSLWTNYSAYSYFEVVTICDLIMILAFYLVHLFRFYRVLTCISWPLSIFGFMATFLCMASIWLSYKISCVTQSTDAAV

Target ORF information:

RefSeq Version	NM_181472.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181472.2

ORF Insert Sequence:

ATGTCGCACG GAGCCGGGCT CGTCCGCACC ACGTGCAGCA GCGGCAGCGC GCTCGGACCC 
GGGGCCGGCG CGGCCCAGCC CAGCGCGAGC CCCTTGGAGG GGCTGCTGGA CCTCAGCTAC 
CCCCGCACCC ACGCGGCCCT GCTGAAAGTG GCGCAAATGG TCACCCTGCT GATTGCCTTC 
ATCTGTGTGC GGAGCTCCCT GTGGACCAAC TACAGCGCCT ACAGCTACTT TGAAGTGGTC 
ACCATTTGCG ACTTGATAAT GATCCTCGCC TTTTACCTGG TCCACCTCTT CCGCTTCTAC 
CGCGTGCTCA CCTGTATCAG CTGGCCCCTG TCGATCTTTG GTTTCATGGC CACCTTCCTC 
TGCATGGCAA GCATATGGCT GTCCTATAAG ATCTCGTGTG TAACCCAGTC CACAGATGCA 
GCCGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CMTM7 ( NM_181472.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_852137.1 Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07572
Clone ID Related Accession (Same CDS sequence)	NM_181472.2 , NM_181472.3
Accession Version	NM_181472.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF479263.2 and AK308878.1. On May 31, 2019 this sequence version replaced NM_181472.2. Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. ##Evidence-Data-START## Transcript exon combination :: AK308878.1, BX437916.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGCACG GAGCCGGGCT CGTCCGCACC ACGTGCAGCA GCGGCAGCGC GCTCGGACCC 
GGGGCCGGCG CGGCCCAGCC CAGCGCGAGC CCCTTGGAGG GGCTGCTGGA CCTCAGCTAC 
CCCCGCACCC ACGCGGCCCT GCTGAAAGTG GCGCAAATGG TCACCCTGCT GATTGCCTTC 
ATCTGTGTGC GGAGCTCCCT GTGGACCAAC TACAGCGCCT ACAGCTACTT TGAAGTGGTC 
ACCATTTGCG ACTTGATAAT GATCCTCGCC TTTTACCTGG TCCACCTCTT CCGCTTCTAC 
CGCGTGCTCA CCTGTATCAG CTGGCCCCTG TCGATCTTTG GTTTCATGGC CACCTTCCTC 
TGCATGGCAA GCATATGGCT GTCCTATAAG ATCTCGTGTG TAACCCAGTC CACAGATGCA 
GCCGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_852137.1
CDS	55..483
Translation	MSHGAGLVRTTCSSGSALGPGAGAAQPSASPLEGLLDLSYPRTHAALLKVAQMVTLLIAFICVRSSLWTNYSAYSYFEVVTICDLIMILAFYLVHLFRFYRVLTCISWPLSIFGFMATFLCMASIWLSYKISCVTQSTDAAV

Target ORF information:

RefSeq Version	NM_181472.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181472.3

ORF Insert Sequence:

ATGTCGCACG GAGCCGGGCT CGTCCGCACC ACGTGCAGCA GCGGCAGCGC GCTCGGACCC 
GGGGCCGGCG CGGCCCAGCC CAGCGCGAGC CCCTTGGAGG GGCTGCTGGA CCTCAGCTAC 
CCCCGCACCC ACGCGGCCCT GCTGAAAGTG GCGCAAATGG TCACCCTGCT GATTGCCTTC 
ATCTGTGTGC GGAGCTCCCT GTGGACCAAC TACAGCGCCT ACAGCTACTT TGAAGTGGTC 
ACCATTTGCG ACTTGATAAT GATCCTCGCC TTTTACCTGG TCCACCTCTT CCGCTTCTAC 
CGCGTGCTCA CCTGTATCAG CTGGCCCCTG TCGATCTTTG GTTTCATGGC CACCTTCCTC 
TGCATGGCAA GCATATGGCT GTCCTATAAG ATCTCGTGTG TAACCCAGTC CACAGATGCA 
GCCGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CMTM7 ( XM_011533319.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011531621.1 Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant X1, mRNA.

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CloneID	OHu74649
Clone ID Related Accession (Same CDS sequence)	XM_011533319.2
Accession Version	XM_011533319.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011533319.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGCACG GAGCCGGGCT CGTCCGCACC ACGTGCAGCA GCGGCAGCGC GCTCGGACCC 
GGGGCCGGCG CGGCCCAGCC CAGCGCGAGC CCCTTGGAGG GGCTGCTGGA CCTCAGCTAC 
CCCCGCACCC ACGCGGCCCT GCTGAAAGTG GCGCAAATGG TCACCCTGCT GATTGCCTTC 
ATCTGTGTGC GGAGCTCCCT GTGGACCAAC TACAGCGCCT ACAGCTACTT TGAAGTGGTC 
ACCATTTGCG ACTTGATAAT GATCCTCGCC TTTTACCTGG TCCACCTCTT CCGCTTCTAC 
CGCGTGCTCA CCTGTATCAG CTGGCCCCTG TCGGAACTTC TGCACTATTT AATCGGTACC 
CTGCTCCTCC TCATCGCCTC CATTGTGGCA GCTTCCAAGA GTTACAACCA GAGCGGACTG 
GTAGCCGGAG CGGATAATCA AAGTCCATTG GCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011531621.1
CDS	63..518
Translation	MSHGAGLVRTTCSSGSALGPGAGAAQPSASPLEGLLDLSYPRTHAALLKVAQMVTLLIAFICVRSSLWTNYSAYSYFEVVTICDLIMILAFYLVHLFRFYRVLTCISWPLSELLHYLIGTLLLLIASIVAASKSYNQSGLVAGADNQSPLA

Target ORF information:

RefSeq Version	XM_011533319.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011533319.2

ORF Insert Sequence:

ATGTCGCACG GAGCCGGGCT CGTCCGCACC ACGTGCAGCA GCGGCAGCGC GCTCGGACCC 
GGGGCCGGCG CGGCCCAGCC CAGCGCGAGC CCCTTGGAGG GGCTGCTGGA CCTCAGCTAC 
CCCCGCACCC ACGCGGCCCT GCTGAAAGTG GCGCAAATGG TCACCCTGCT GATTGCCTTC 
ATCTGTGTGC GGAGCTCCCT GTGGACCAAC TACAGCGCCT ACAGCTACTT TGAAGTGGTC 
ACCATTTGCG ACTTGATAAT GATCCTCGCC TTTTACCTGG TCCACCTCTT CCGCTTCTAC 
CGCGTGCTCA CCTGTATCAG CTGGCCCCTG TCGGAACTTC TGCACTATTT AATCGGTACC 
CTGCTCCTCC TCATCGCCTC CATTGTGGCA GCTTCCAAGA GTTACAACCA GAGCGGACTG 
GTAGCCGGAG CGGATAATCA AAGTCCATTG GCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CMTM7 ( XM_017005646.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016861135.1 Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu93768
Clone ID Related Accession (Same CDS sequence)	XM_017005646.1
Accession Version	XM_017005646.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGCACG GAGCCGGGCT CGTCCGCACC ACGTGCAGCA GCGGCAGCGC GCTCGGACCC 
GGGGCCGGCG CGGCCCAGCC CAGCGCGAGC CCCTTGGAGG GGCTGCTGGA CCTCAGCTAC 
CCCCGCACCC ACGCGGCCCT GCTGAAAGTG GCGCAAATGG TCACCCTGCT GATTGCCTTC 
ATCTGTGTGC GGAGCTCCCT GTGGACCAAC TACAGCGCCT ACAGCTACTT TGAAGTGGTC 
ACCATTTGCG ACTTGATAAT GATCCTCGCC TTTTACCTGG TCCACCTCTT CCGCTTCTAC 
CGCGTGCTCA CCTGTATCAG CTGGCCCCTG TCGGAACTTC TGCACTATTT AATCGGTACC 
CTGCTCCTCC TCATCGCCTC CATTGTGGCA GCTTCCAAGA GTTACAACCA GAGCGGACTG 
GTAGCCGGAG CGGTGAGGAT GTTTTGGGGA GCCTTTAGGA ATGAATTCTT ATTTAAAATG 
CTCATTTTCT TCCTGATGGG GGAAGAGAAG GGCTTGGTTT CTGGGGCATT CCCTTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016861135.1
CDS	83..622
Translation	MSHGAGLVRTTCSSGSALGPGAGAAQPSASPLEGLLDLSYPRTHAALLKVAQMVTLLIAFICVRSSLWTNYSAYSYFEVVTICDLIMILAFYLVHLFRFYRVLTCISWPLSELLHYLIGTLLLLIASIVAASKSYNQSGLVAGAVRMFWGAFRNEFLFKMLIFFLMGEEKGLVSGAFPS

Target ORF information:

RefSeq Version	XM_017005646.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CKLF like MARVEL transmembrane domain containing 7 (CMTM7), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017005646.1

ORF Insert Sequence:

ATGTCGCACG GAGCCGGGCT CGTCCGCACC ACGTGCAGCA GCGGCAGCGC GCTCGGACCC 
GGGGCCGGCG CGGCCCAGCC CAGCGCGAGC CCCTTGGAGG GGCTGCTGGA CCTCAGCTAC 
CCCCGCACCC ACGCGGCCCT GCTGAAAGTG GCGCAAATGG TCACCCTGCT GATTGCCTTC 
ATCTGTGTGC GGAGCTCCCT GTGGACCAAC TACAGCGCCT ACAGCTACTT TGAAGTGGTC 
ACCATTTGCG ACTTGATAAT GATCCTCGCC TTTTACCTGG TCCACCTCTT CCGCTTCTAC 
CGCGTGCTCA CCTGTATCAG CTGGCCCCTG TCGGAACTTC TGCACTATTT AATCGGTACC 
CTGCTCCTCC TCATCGCCTC CATTGTGGCA GCTTCCAAGA GTTACAACCA GAGCGGACTG 
GTAGCCGGAG CGGTGAGGAT GTTTTGGGGA GCCTTTAGGA ATGAATTCTT ATTTAAAATG 
CTCATTTTCT TCCTGATGGG GGAAGAGAAG GGCTTGGTTT CTGGGGCATT CCCTTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CMTM7 knockdown increases tumorigenicity of human non-small cell lung cancer cells and EGFR-AKT signaling by reducing Rab5 activation.
Oncotarget6(38)41092-107(2015 Dec)
Liu B,Su Y,Li T,Yuan W,Mo X,Li H,He Q,Ma D,Han W

A novel 3p22.3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth.
Oncogene33(24)3109-18(2014 Jun)
Li H,Li J,Su Y,Fan Y,Guo X,Li L,Su X,Rong R,Ying J,Mo X,Liu K,Zhang Z,Yang F,Jiang G,Wang J,Zhang Y,Ma D,Tao Q,Han W

Change of CMTM7 expression, a potential tumor suppressor, is associated with poor clinical outcome in human non-small cell lung cancer.
Chinese medical journal126(16)3006-12(2013 Aug)
Liu Q,Su Y,Jiang GC,Zhou ZL,Liu BC,Bu L,Yang F,Qiao F,Wang J

Identification of CMTM7 as a transmembrane linker of BLNK and the B-cell receptor.
PloS one7(2)e31829(2012)
Miyazaki A,Yogosawa S,Murakami A,Kitamura D

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CMTM7 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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