Gene Symbol | IRAK3 |
Entrez Gene ID | 11213 |
Full Name | interleukin 1 receptor associated kinase 3 |
Synonyms | ASRT5,IRAKM |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]. |
Disorder MIM: | |
Disorder Html: | {Asthma susceptibility 5}, 611064 (3) |