MLLT11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MLLT11
Entrez Gene ID	10962
Full Name	MLLT11, transcription factor 7 cofactor
Synonyms	AF1Q
General protein information	Preferred Names MLLT11, transcription factor 7 cofactor Names protein AF1q ALL1 fused gene from chromosome 1q myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008].
Disorder MIM:	604684

mRNA and Protein(s)

mRNA	Protein	Name
NM_006818.4	NP_006809.1	protein AF1q
NM_006818.3	NP_006809.1	protein AF1q

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MLLT11	XP_513785.1
	MLLT11	XP_001103655.1
Canis lupus familiaris (dog)	MLLT11	XP_003432297.1
Homo sapiens (human)	MLLT11	NP_006809.1
Bos taurus (cattle)	MLLT11	NP_001069637.1
Mus musculus (house mouse)	Mllt11	NP_064298.1
Rattus norvegicus (Norway rat)	Mllt11	NP_001013934.1

Gene Ontology
Bibliography

Related articles in PubMed

The Interaction of TXNIP and AFq1 Genes Increases the Susceptibility of Schizophrenia.
Su Y, Ding W, Xing M, Qi D, Li Z, Cui D
Molecular neurobiology54(6)4806-4812(2017 Aug)

AF1q Mediates Tumor Progression in Colorectal Cancer by Regulating AKT Signaling.
Hu J, Li G, Liu L, Wang Y, Li X, Gong J
International journal of molecular sciences18(5)(2017 May)

Involvement of AF1q/MLLT11 in the progression of ovarian cancer.
Tiberio P, Lozneanu L, Angeloni V, Cavadini E, Pinciroli P, Callari M, Carcangiu ML, Lorusso D, Raspagliesi F, Pala V, Daidone MG, Appierto V
Oncotarget8(14)23246-23264(2017 Apr)

Activation of Wnt signaling pathway by AF1q enriches stem-like population and enhance mammosphere formation of breast cells.
Tse CO, Kim S, Park J
Biochemical and biophysical research communications484(4)884-889(2017 03)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

AF1q was significantly lower in borderline ovarian tumors (i.e., tumors of low malignant potential without stromal invasion) than in invasive tumors, thus corroborating the association between high AF1q expression and increased migratory/invasive cell behavior and confirming its potential role in ovarian cancer progression.
Title: Involvement of AF1q/MLLT11 in the progression of ovarian cancer.

These results suggest that AF1q would have a role as an enhancer in generation of stem-like population through activation of Wnt signaling pathway.
Title: Activation of Wnt signaling pathway by AF1q enriches stem-like population and enhance mammosphere formation of breast cells.

Data show that MLLT11/AF1q-induced PDGFR signaling enhanced STAT3 activity through Src kinase activation.
Title: MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling.

Results demonstrate that AF1q gene transcription is regulated by REST through direct binding at -383 to -363 bp of AF1q promoter.
Title: RE1 silencing transcription factor (REST) negatively regulates ALL1-fused from chromosome 1q (AF1q) gene transcription.

Findings indicate that breast cancer cells with a hyperactive AF1q/TCF7/CD44 regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties.
Title: AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis.

The following MLLT11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MLLT11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16243	NM_006818.4 Latest version!	Homo sapiens MLLT11 transcription factor 7 cofactor (MLLT11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu16243	NM_006818.3	Homo sapiens MLLT11 transcription factor 7 cofactor (MLLT11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MLLT11 ( NM_006818.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006809.1 Homo sapiens MLLT11 transcription factor 7 cofactor (MLLT11), mRNA.

Price & Availability↑

CloneID	OHu16243
Clone ID Related Accession (Same CDS sequence)	NM_006818.4 , NM_006818.3
Accession Version	NM_006818.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 273bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Homo sapiens(human)
Product	protein AF1q
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL590133.32. On Jul 27, 2019 this sequence version replaced NM_006818.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.137394.1, BC022448.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGGACC CTGTGAGTAG CCAGTACAGT TCCTTTCTTT TCTGGAGGAT GCCCATCCCA 
GAACTGGATC TGTCGGAGCT GGAAGGCCTG GGTCTGTCAG ATACAGCCAC CTACAAGGTC 
AAAGACAGCA GCGTTGGCAA AATGATCGGG CAAGCAACTG CAGCAGACCA GGAGAAAAAC 
CCTGAAGGTG ATGGCCTCCT TGAGTACAGC ACCTTCAACT TCTGGAGAGC TCCCATTGCC 
AGCATCCACT CCTTCGAACT GGACTTGCTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006809.1
CDS	164..436
Translation	MRDPVSSQYSSFLFWRMPIPELDLSELEGLGLSDTATYKVKDSSVGKMIGQATAADQEKNPEGDGLLEYSTFNFWRAPIASIHSFELDLL

Target ORF information:

RefSeq Version	NM_006818.4
Organism	Homo sapiens(human)
Definition	Homo sapiens MLLT11 transcription factor 7 cofactor (MLLT11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006818.4

ORF Insert Sequence:

ATGAGGGACC CTGTGAGTAG CCAGTACAGT TCCTTTCTTT TCTGGAGGAT GCCCATCCCA 
GAACTGGATC TGTCGGAGCT GGAAGGCCTG GGTCTGTCAG ATACAGCCAC CTACAAGGTC 
AAAGACAGCA GCGTTGGCAA AATGATCGGG CAAGCAACTG CAGCAGACCA GGAGAAAAAC 
CCTGAAGGTG ATGGCCTCCT TGAGTACAGC ACCTTCAACT TCTGGAGAGC TCCCATTGCC 
AGCATCCACT CCTTCGAACT GGACTTGCTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MLLT11 ( NM_006818.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006809.1 Homo sapiens MLLT11 transcription factor 7 cofactor (MLLT11), mRNA.

Price & Availability↑

CloneID	OHu16243
Clone ID Related Accession (Same CDS sequence)	NM_006818.4 , NM_006818.3
Accession Version	NM_006818.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 273bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	protein AF1q
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC022448.1 and BC006471.2. On Nov 16, 2004 this sequence version replaced NM_006818.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.266213.1, BC022448.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGGACC CTGTGAGTAG CCAGTACAGT TCCTTTCTTT TCTGGAGGAT GCCCATCCCA 
GAACTGGATC TGTCGGAGCT GGAAGGCCTG GGTCTGTCAG ATACAGCCAC CTACAAGGTC 
AAAGACAGCA GCGTTGGCAA AATGATCGGG CAAGCAACTG CAGCAGACCA GGAGAAAAAC 
CCTGAAGGTG ATGGCCTCCT TGAGTACAGC ACCTTCAACT TCTGGAGAGC TCCCATTGCC 
AGCATCCACT CCTTCGAACT GGACTTGCTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006809.1
CDS	886..1158
Translation	MRDPVSSQYSSFLFWRMPIPELDLSELEGLGLSDTATYKVKDSSVGKMIGQATAADQEKNPEGDGLLEYSTFNFWRAPIASIHSFELDLL

Target ORF information:

RefSeq Version	NM_006818.3
Organism	Homo sapiens(human)
Definition	Homo sapiens MLLT11 transcription factor 7 cofactor (MLLT11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006818.3

ORF Insert Sequence:

ATGAGGGACC CTGTGAGTAG CCAGTACAGT TCCTTTCTTT TCTGGAGGAT GCCCATCCCA 
GAACTGGATC TGTCGGAGCT GGAAGGCCTG GGTCTGTCAG ATACAGCCAC CTACAAGGTC 
AAAGACAGCA GCGTTGGCAA AATGATCGGG CAAGCAACTG CAGCAGACCA GGAGAAAAAC 
CCTGAAGGTG ATGGCCTCCT TGAGTACAGC ACCTTCAACT TCTGGAGAGC TCCCATTGCC 
AGCATCCACT CCTTCGAACT GGACTTGCTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Interaction of TXNIP and AFq1 Genes Increases the Susceptibility of Schizophrenia.
Molecular neurobiology54(6)4806-4812(2017 Aug)
Su Y,Ding W,Xing M,Qi D,Li Z,Cui D

AF1q Mediates Tumor Progression in Colorectal Cancer by Regulating AKT Signaling.
International journal of molecular sciences18(5)(2017 May)
Hu J,Li G,Liu L,Wang Y,Li X,Gong J

Involvement of AF1q/MLLT11 in the progression of ovarian cancer.
Oncotarget8(14)23246-23264(2017 Apr)
Tiberio P,Lozneanu L,Angeloni V,Cavadini E,Pinciroli P,Callari M,Carcangiu ML,Lorusso D,Raspagliesi F,Pala V,Daidone MG,Appierto V

Activation of Wnt signaling pathway by AF1q enriches stem-like population and enhance mammosphere formation of breast cells.
Biochemical and biophysical research communications484(4)884-889(2017 03)
Tse CO,Kim S,Park J

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MLLT11 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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