ARL6IP5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ARL6IP5
Entrez Gene ID	10550
Full Name	ADP ribosylation factor like GTPase 6 interacting protein 5
Synonyms	DERP11,GTRAP3-18,HSPC127,JWA,PRAF3,Yip6b,addicsin,hp22,jmx
General protein information	Preferred Names ADP ribosylation factor like GTPase 6 interacting protein 5 Names PRA1 family protein 3 ADP-ribosylation factor GTPase 6 interacting protein 5 ADP-ribosylation factor-like 6 interacting protein 5 ADP-ribosylation factor-like protein 6-interacting protein 5 ADP-ribosylation-like factor 6 interacting protein 5 ARL-6-interacting protein 5 JM5 PRA1 domain family 3 aip-5 cytoskeleton-related vitamin A-responsive protein dermal papilla derived protein 11 glutamate transporter EAAC1-interacting protein glutamate transporter EEAC1-associated protein prenylated Rab acceptor protein 2 protein JWa putative MAPK activating protein PM27
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p14.1
Summary	Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008].
Disorder MIM:	605709

mRNA and Protein(s)

mRNA	Protein	Name
NM_006407.4	NP_006398.1	PRA1 family protein 3
NM_006407.3	NP_006398.1	PRA1 family protein 3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ARL6IP5	XP_533764.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005121	XP_314002.4
	ARL6IP5	XP_001087809.1
Rattus norvegicus (Norway rat)	Arl6ip5	NP_076462.1
Danio rerio (zebrafish)	arl6ip5b	NP_001002517.1
Pan troglodytes (chimpanzee)	ARL6IP5	XP_003950188.1
Mus musculus (house mouse)	Arl6ip5	NP_075368.1
Caenorhabditis elegans (roundworm)	praf-3	NP_001023104.1
Xenopus tropicalis (tropical clawed frog)	arl6ip5	NP_001120902.1
Homo sapiens (human)	ARL6IP5	NP_006398.1
Bos taurus (cattle)	ARL6IP5	NP_001014891.1
Gallus gallus (chicken)	ARL6IP5	NP_001012623.1
Drosophila melanogaster (fruit fly)	Jwa	NP_609901.4
Danio rerio (zebrafish)	arl6ip5a	NP_001006096.1

Gene Ontology
Bibliography

Related articles in PubMed

JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2.
Zhao X, Wang R, Xiong J, Yan D, Li A, Wang S, Xu J, Zhou J
Toxicology letters27732-40(2017 Aug)

JWA loss promotes cell migration and cytoskeletal rearrangement by affecting HER2 expression and identifies a high-risk subgroup of HER2-positive gastric carcinoma patients.
Qian J, Zhu W, Wang K, Ma L, Xu J, Xu T, R?e OD, Li A, Zhou J, Shu Y
Oncotarget7(24)36865-36884(2016 Jun)

EGCG regulates the cross-talk between JWA and topoisomerase II? in non-small-cell lung cancer (NSCLC) cells.
Li Y, Shen X, Wang X, Li A, Wang P, Jiang P, Zhou J, Feng Q
Scientific reports511009(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Protective effect of JWA against paraquat neurotoxicity involves regulation of the MEK/PI3K-Nrf2 axis.
Title: JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2.

our results demonstrate that JWA is a novel negative regulator of HER2 expression...in HER2-positive gastric cancer cells
Title: JWA loss promotes cell migration and cytoskeletal rearrangement by affecting HER2 expression and identifies a high-risk subgroup of HER2-positive gastric carcinoma patients.

JWA and topoisomerase II alpha regulate each other in tumor cells arrested in G2/M.
Title: EGCG regulates the cross-talk between JWA and topoisomerase II? in non-small-cell lung cancer (NSCLC) cells.

the JWA gene may regulate human breast cancer cells through the MAPK signaling pathway using different types of regulation.
Title: Effects of the JWA gene in the regulation of human breast cancer cells.

JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells.
Title: JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells.

The following ARL6IP5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ARL6IP5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24499	NM_006407.4 Latest version!	Homo sapiens ADP ribosylation factor like GTPase 6 interacting protein 5 (ARL6IP5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu24499	NM_006407.3	Homo sapiens ADP ribosylation factor like GTPase 6 interacting protein 5 (ARL6IP5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ARL6IP5 ( NM_006407.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006398.1 Homo sapiens ADP ribosylation factor like GTPase 6 interacting protein 5 (ARL6IP5), mRNA.

Price & Availability↑

CloneID	OHu24499
Clone ID Related Accession (Same CDS sequence)	NM_006407.4 , NM_006407.3
Accession Version	NM_006407.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	PRA1 family protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092060.2, BG483337.1, AF125530.1, AF070523.1 and BU149630.1. On Nov 22, 2018 this sequence version replaced NM_006407.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA554914.1, AF070523.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000273258.4/ ENSP00000273258.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACGTTA ATATCGCCCC ACTCCGCGCC TGGGACGATT TCTTCCCGGG TTCCGATCGC 
TTTGCCCGGC CGGACTTCAG GGACATTTCC AAATGGAACA ACCGCGTAGT GAGCAACCTG 
CTCTATTACC AGACCAACTA CCTGGTGGTG GCTGCCATGA TGATTTCCAT TGTGGGGTTT 
CTGAGTCCCT TCAACATGAT CCTGGGAGGA ATCGTGGTGG TGCTGGTGTT CACAGGGTTT 
GTGTGGGCAG CCCACAATAA AGACGTCCTT CGCCGGATGA AGAAGCGCTA CCCCACGACG 
TTCGTTATGG TGGTCATGTT GGCGAGCTAT TTCCTTATCT CCATGTTTGG AGGAGTCATG 
GTCTTTGTGT TTGGCATTAC TTTTCCTTTG CTGTTGATGT TTATCCATGC ATCGTTGAGA 
CTTCGGAACC TCAAGAACAA ACTGGAGAAT AAAATGGAAG GAATAGGTTT GAAGAGGACA 
CCGATGGGCA TTGTCCTGGA TGCCCTAGAA CAGCAGGAAG AAGGCATCAA CAGACTCACT 
GACTATATCA GCAAAGTGAA GGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006398.1
CDS	112..678
Translation	MDVNIAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISIVGFLSPFNMILGGIVVVLVFTGFVWAAHNKDVLRRMKKRYPTTFVMVVMLASYFLISMFGGVMVFVFGITFPLLLMFIHASLRLRNLKNKLENKMEGIGLKRTPMGIVLDALEQQEEGINRLTDYISKVKE

Target ORF information:

RefSeq Version	NM_006407.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ADP ribosylation factor like GTPase 6 interacting protein 5 (ARL6IP5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006407.4

ORF Insert Sequence:

ATGGACGTTA ATATCGCCCC ACTCCGCGCC TGGGACGATT TCTTCCCGGG TTCCGATCGC 
TTTGCCCGGC CGGACTTCAG GGACATTTCC AAATGGAACA ACCGCGTAGT GAGCAACCTG 
CTCTATTACC AGACCAACTA CCTGGTGGTG GCTGCCATGA TGATTTCCAT TGTGGGGTTT 
CTGAGTCCCT TCAACATGAT CCTGGGAGGA ATCGTGGTGG TGCTGGTGTT CACAGGGTTT 
GTGTGGGCAG CCCACAATAA AGACGTCCTT CGCCGGATGA AGAAGCGCTA CCCCACGACG 
TTCGTTATGG TGGTCATGTT GGCGAGCTAT TTCCTTATCT CCATGTTTGG AGGAGTCATG 
GTCTTTGTGT TTGGCATTAC TTTTCCTTTG CTGTTGATGT TTATCCATGC ATCGTTGAGA 
CTTCGGAACC TCAAGAACAA ACTGGAGAAT AAAATGGAAG GAATAGGTTT GAAGAGGACA 
CCGATGGGCA TTGTCCTGGA TGCCCTAGAA CAGCAGGAAG AAGGCATCAA CAGACTCACT 
GACTATATCA GCAAAGTGAA GGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARL6IP5 ( NM_006407.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006398.1 Homo sapiens ADP ribosylation factor like GTPase 6 interacting protein 5 (ARL6IP5), mRNA.

Price & Availability↑

CloneID	OHu24499
Clone ID Related Accession (Same CDS sequence)	NM_006407.4 , NM_006407.3
Accession Version	NM_006407.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	PRA1 family protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG483337.1, AF125530.1, AF070523.1 and BU149630.1. On Sep 8, 2004 this sequence version replaced NM_006407.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.301492.1, AF070523.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGTTA ATATCGCCCC ACTCCGCGCC TGGGACGATT TCTTCCCGGG TTCCGATCGC 
TTTGCCCGGC CGGACTTCAG GGACATTTCC AAATGGAACA ACCGCGTAGT GAGCAACCTG 
CTCTATTACC AGACCAACTA CCTGGTGGTG GCTGCCATGA TGATTTCCAT TGTGGGGTTT 
CTGAGTCCCT TCAACATGAT CCTGGGAGGA ATCGTGGTGG TGCTGGTGTT CACAGGGTTT 
GTGTGGGCAG CCCACAATAA AGACGTCCTT CGCCGGATGA AGAAGCGCTA CCCCACGACG 
TTCGTTATGG TGGTCATGTT GGCGAGCTAT TTCCTTATCT CCATGTTTGG AGGAGTCATG 
GTCTTTGTGT TTGGCATTAC TTTTCCTTTG CTGTTGATGT TTATCCATGC ATCGTTGAGA 
CTTCGGAACC TCAAGAACAA ACTGGAGAAT AAAATGGAAG GAATAGGTTT GAAGAGGACA 
CCGATGGGCA TTGTCCTGGA TGCCCTAGAA CAGCAGGAAG AAGGCATCAA CAGACTCACT 
GACTATATCA GCAAAGTGAA GGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006398.1
CDS	110..676
Translation	MDVNIAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISIVGFLSPFNMILGGIVVVLVFTGFVWAAHNKDVLRRMKKRYPTTFVMVVMLASYFLISMFGGVMVFVFGITFPLLLMFIHASLRLRNLKNKLENKMEGIGLKRTPMGIVLDALEQQEEGINRLTDYISKVKE

Target ORF information:

RefSeq Version	NM_006407.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ADP ribosylation factor like GTPase 6 interacting protein 5 (ARL6IP5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006407.3

ORF Insert Sequence:

ATGGACGTTA ATATCGCCCC ACTCCGCGCC TGGGACGATT TCTTCCCGGG TTCCGATCGC 
TTTGCCCGGC CGGACTTCAG GGACATTTCC AAATGGAACA ACCGCGTAGT GAGCAACCTG 
CTCTATTACC AGACCAACTA CCTGGTGGTG GCTGCCATGA TGATTTCCAT TGTGGGGTTT 
CTGAGTCCCT TCAACATGAT CCTGGGAGGA ATCGTGGTGG TGCTGGTGTT CACAGGGTTT 
GTGTGGGCAG CCCACAATAA AGACGTCCTT CGCCGGATGA AGAAGCGCTA CCCCACGACG 
TTCGTTATGG TGGTCATGTT GGCGAGCTAT TTCCTTATCT CCATGTTTGG AGGAGTCATG 
GTCTTTGTGT TTGGCATTAC TTTTCCTTTG CTGTTGATGT TTATCCATGC ATCGTTGAGA 
CTTCGGAACC TCAAGAACAA ACTGGAGAAT AAAATGGAAG GAATAGGTTT GAAGAGGACA 
CCGATGGGCA TTGTCCTGGA TGCCCTAGAA CAGCAGGAAG AAGGCATCAA CAGACTCACT 
GACTATATCA GCAAAGTGAA GGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2.
Toxicology letters27732-40(2017 Aug)
Zhao X,Wang R,Xiong J,Yan D,Li A,Wang S,Xu J,Zhou J

JWA loss promotes cell migration and cytoskeletal rearrangement by affecting HER2 expression and identifies a high-risk subgroup of HER2-positive gastric carcinoma patients.
Oncotarget7(24)36865-36884(2016 Jun)
Qian J,Zhu W,Wang K,Ma L,Xu J,Xu T,R?e OD,Li A,Zhou J,Shu Y

EGCG regulates the cross-talk between JWA and topoisomerase II? in non-small-cell lung cancer (NSCLC) cells.
Scientific reports511009(2015 Jun)
Li Y,Shen X,Wang X,Li A,Wang P,Jiang P,Zhou J,Feng Q

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ARL6IP5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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