Arl6ip5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Arl6ip5
Entrez Gene ID	66028
Full Name	ADP-ribosylation factor like GTPase 6 interacting protein 5
Synonyms	Gtrap3-18
General protein information	Preferred Names ADP-ribosylation factor like GTPase 6 interacting protein 5 Names PRA1 family protein 3 ADP-ribosylation factor-like 6 interacting protein 5 ADP-ribosylation factor-like protein 6-interacting protein 5 ADP-ribosylation-like factor 6 interacting protein 5 ARL-6-interacting protein 5 aip-5 glutamate transporter EAAC1-interacting protein prenylated Rab acceptor protein 2 protein JWa
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q34
Summary	modifies glutamate transporter EAAC1 function by lowering EAAC1 substrate affinity; regulates glutamate transport [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_023972.3	NP_076462.1	PRA1 family protein 3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ARL6IP5	XP_533764.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005121	XP_314002.4
	ARL6IP5	XP_001087809.1
Rattus norvegicus (Norway rat)	Arl6ip5	NP_076462.1
Danio rerio (zebrafish)	arl6ip5b	NP_001002517.1
Pan troglodytes (chimpanzee)	ARL6IP5	XP_003950188.1
Mus musculus (house mouse)	Arl6ip5	NP_075368.1
Caenorhabditis elegans (roundworm)	praf-3	NP_001023104.1
Xenopus tropicalis (tropical clawed frog)	arl6ip5	NP_001120902.1
Homo sapiens (human)	ARL6IP5	NP_006398.1
Bos taurus (cattle)	ARL6IP5	NP_001014891.1
Gallus gallus (chicken)	ARL6IP5	NP_001012623.1
Drosophila melanogaster (fruit fly)	Jwa	NP_609901.4
Danio rerio (zebrafish)	arl6ip5a	NP_001006096.1

Gene Ontology
Bibliography

Related articles in PubMed

JWA regulates chronic morphine dependence via the delta opioid receptor.
Wu Y, Chen R, Zhao X, Li A, Li G, Zhou J
Biochemical and biophysical research communications409(3)520-5(2011 Jun)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

Modulation of the neural glutamate transporter EAAC1 by the addicsin-interacting protein ARL6IP1.
Akiduki S, Ikemoto MJ
The Journal of biological chemistry283(46)31323-32(2008 Nov)

Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis.
Cao Z, Li C, Higginbotham JN, Franklin JL, Tabb DL, Graves-Deal R, Hill S, Cheek K, Jerome WG, Lapierre LA, Goldenring JR, Ham AJ, Coffey RJ
Molecular & cellular proteomics : MCP7(9)1651-67(2008 Sep)

JWA is required for arsenic trioxide induced apoptosis in HeLa and MCF-7 cells via reactive oxygen species and mitochondria linked signal pathway.
Zhou J, Ye J, Zhao X, Li A, Zhou J
Toxicology and applied pharmacology230(1)33-40(2008 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These observations suggest that JWA is directly involved in the regulation of chronic morphine dependence.
Title: JWA regulates chronic morphine dependence via the delta opioid receptor.

Results suggest a model where protein trafficking and neuronal differentiation are directly linked by the interaction of Rab1 and its regulator GTRAP3-18.
Title: GTRAP3-18 serves as a negative regulator of Rab1 in protein transport and neuronal differentiation.

The expression and distribution of the neuronal glutamate transporter, excitatory amino acid carrier-1 (EAAC1), are demonstrated in the dorsal root ganglion neurons and their central terminals.
Title: Evidence of neuronal excitatory amino acid carrier 1 expression in rat dorsal root ganglion neurons and their central terminals.

The following Arl6ip5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Arl6ip5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13724	NM_023972.3 Latest version!	Rattus norvegicus ADP-ribosylation factor like GTPase 6 interacting protein 5 (Arl6ip5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Arl6ip5 ( NM_023972.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_076462.1 Rattus norvegicus ADP-ribosylation factor like GTPase 6 interacting protein 5 (Arl6ip5), mRNA.

Price & Availability↑

CloneID	ORa13724
Clone ID Related Accession (Same CDS sequence)	NM_023972.3
Accession Version	NM_023972.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-23
Organism	Rattus norvegicus(Norway rat)
Product	PRA1 family protein 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF240182.1. On Jun 10, 2007 this sequence version replaced NM_023972.2. ##Evidence-Data-START## Transcript exon combination :: AF240182.1, BC061548.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGACGTGA ACCTTGCCCC GCTCCGTGCC TGGGATGATT TCTTCCCGGG CTCTGATCGT 
TTCGCACGGC CGGACTTCAG GGATATATCC AAATGGAACA ACCGTGTAGT GAGCAATCTG 
CTCTATTACC AGACCAACTA CCTGGTGGTG GCTGCCATGA TGATTTCAGT CGTTGGGTTT 
CTGAGCCCCT TCAACATGAT CCTTGGAGGA ATCATTGTGG TGCTGGTGTT CACGGGGTTT 
GTGTGGGCAG CACACAATAA AGACATCCTC CGCCGGATGA AGAAGCAGTA CCCAACGGCC 
TTTGTCATGG TGGTCATGCT AGCCAGCTAC TTCCTCATAT CCATGTTTGG GGGTGTCATG 
GTCTTTGTGT TTGGCATCAC GTTTCCCTTA TTGTTGATGT TCATCCATGC ATCCCTGAGA 
CTTCGAAACC TCAAGAACAA ACTGGAAAAT AAAATGGAGG GAATAGGCTT GAAGAAAACG 
CCGATGGGCA TCATCCTGGA TGCCTTGGAA CAGCAGGAAG ACAGCATCAA TAAATTTGCT 
GACTACATCA GCAAAGCCAG GGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076462.1
CDS	1..567
Translation	MDVNLAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISVVGFLSPFNMILGGIIVVLVFTGFVWAAHNKDILRRMKKQYPTAFVMVVMLASYFLISMFGGVMVFVFGITFPLLLMFIHASLRLRNLKNKLENKMEGIGLKKTPMGIILDALEQQEDSINKFADYISKARE

Target ORF information:

RefSeq Version	NM_023972.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ADP-ribosylation factor like GTPase 6 interacting protein 5 (Arl6ip5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023972.3

ORF Insert Sequence:

ATGGACGTGA ACCTTGCCCC GCTCCGTGCC TGGGATGATT TCTTCCCGGG CTCTGATCGT 
TTCGCACGGC CGGACTTCAG GGATATATCC AAATGGAACA ACCGTGTAGT GAGCAATCTG 
CTCTATTACC AGACCAACTA CCTGGTGGTG GCTGCCATGA TGATTTCAGT CGTTGGGTTT 
CTGAGCCCCT TCAACATGAT CCTTGGAGGA ATCATTGTGG TGCTGGTGTT CACGGGGTTT 
GTGTGGGCAG CACACAATAA AGACATCCTC CGCCGGATGA AGAAGCAGTA CCCAACGGCC 
TTTGTCATGG TGGTCATGCT AGCCAGCTAC TTCCTCATAT CCATGTTTGG GGGTGTCATG 
GTCTTTGTGT TTGGCATCAC GTTTCCCTTA TTGTTGATGT TCATCCATGC ATCCCTGAGA 
CTTCGAAACC TCAAGAACAA ACTGGAAAAT AAAATGGAGG GAATAGGCTT GAAGAAAACG 
CCGATGGGCA TCATCCTGGA TGCCTTGGAA CAGCAGGAAG ACAGCATCAA TAAATTTGCT 
GACTACATCA GCAAAGCCAG GGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

JWA regulates chronic morphine dependence via the delta opioid receptor.
Biochemical and biophysical research communications409(3)520-5(2011 Jun)
Wu Y,Chen R,Zhao X,Li A,Li G,Zhou J

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

Modulation of the neural glutamate transporter EAAC1 by the addicsin-interacting protein ARL6IP1.
The Journal of biological chemistry283(46)31323-32(2008 Nov)
Akiduki S,Ikemoto MJ

Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis.
Molecular & cellular proteomics : MCP7(9)1651-67(2008 Sep)
Cao Z,Li C,Higginbotham JN,Franklin JL,Tabb DL,Graves-Deal R,Hill S,Cheek K,Jerome WG,Lapierre LA,Goldenring JR,Ham AJ,Coffey RJ

JWA is required for arsenic trioxide induced apoptosis in HeLa and MCF-7 cells via reactive oxygen species and mitochondria linked signal pathway.
Toxicology and applied pharmacology230(1)33-40(2008 Jul)
Zhou J,Ye J,Zhao X,Li A,Zhou J