SNUPN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SNUPN
Entrez Gene ID	10073
Full Name	snurportin 1
Synonyms	KPNBL,RNUT1,Snurportin1
General protein information	Preferred Names snurportin 1 Names snurportin-1 RNA U transporter 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q24.2
Summary	The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	607902

mRNA and Protein(s)

mRNA	Protein	Name
NM_005701.3	NP_005692.1	snurportin-1
NM_001042588.1	NP_001036053.1	snurportin-1
NM_005701.4	NP_005692.1	snurportin-1
NM_001042581.1	NP_001036046.1	snurportin-1

Pathways from BioSystems

Homologies

Homo sapiens (human)	SNUPN	NP_005692.1
Rattus norvegicus (Norway rat)	Snupn	NP_001004270.1
Gallus gallus (chicken)	SNUPN	NP_001074347.1
Xenopus tropicalis (tropical clawed frog)	snupn	NP_001165191.1
Mus musculus (house mouse)	Snupn	NP_848461.1
Pan troglodytes (chimpanzee)	SNUPN	XP_001137623.2
Bos taurus (cattle)	SNUPN	NP_001033635.1
Danio rerio (zebrafish)	snupn	NP_955988.1
	LOC712678	XP_001101744.2
Oryza sativa (rice)	Os01g0101300	NP_001041742.1
Canis lupus familiaris (dog)	SNUPN	XP_544780.2
Caenorhabditis elegans (roundworm)	F23F1.5	NP_493639.1
Arabidopsis thaliana (thale cress)	AT4G24880	NP_567711.1

Gene Ontology
Bibliography

Related articles in PubMed

Filtering genetic variants and placing informative priors based on putative biological function.
Friedrichs S, Malzahn D, Pugh EW, Almeida M, Liu XQ, Bailey JN
BMC genetics17 Suppl 28(2016 Feb)

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.
K?rl? K, Karaca S, Dehne HJ, Samwer M, Pan KT, Lenz C, Urlaub H, G?rlich D
eLife4(2015 Dec)

The interaction of CRM1 and the nuclear pore protein Tpr.
Zhao CL, Mahboobi SH, Moussavi-Baygi R, Mofrad MR
PloS one9(4)e93709(2014)

Structural determinants and mechanism of mammalian CRM1 allostery.
D?lker N, Blanchet CE, Vo? B, Haselbach D, Kappel C, Monecke T, Svergun DI, Stark H, Ficner R, Zachariae U, Grubm?ller H, Dickmanns A
Structure (London, England : 1993)21(8)1350-60(2013 Aug)

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.
G?ttler T, Madl T, Neumann P, Deichsel D, Corsini L, Monecke T, Ficner R, Sattler M, G?rlich D
Nature structural & molecular biology17(11)1367-76(2010 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that marker rs218966 in gene PHF14 and rs9836027 in MAP4 significantly associated with hypertension; additionally, rare variants in SNUPN significantly associated with systolic blood pressure.
Title: Filtering genetic variants and placing informative priors based on putative biological function.

analysis of interactions between CRM1 and the nuclear pore protein Tpr and snurportin
Title: The interaction of CRM1 and the nuclear pore protein Tpr.

the binding of dimethylated RNA-caps to snurportin 1
Title: Molecular determinants of snurportin 1 ligand affinity and structural response upon binding.

study presents the crystal structure of the SPN1.CRM1.RanGTP export complex at 2.5 angstrom resolution (where SPN1 is snurportin1 and RanGTP is guanosine 5' triphosphate-bound Ran
Title: Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP.

There is an interaction between the N- and C-terminal domains of SPN, suggesting an autoregulatory function similar to that of importin-alpha.
Title: Cross-talk between snurportin1 subdomains.

The following SNUPN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SNUPN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05131	NM_001042581.1 Latest version!	Homo sapiens snurportin 1 (SNUPN), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu05131	NM_001042588.1 Latest version!	Homo sapiens snurportin 1 (SNUPN), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu05131	NM_005701.4 Latest version!	Homo sapiens snurportin 1 (SNUPN), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu05131	NM_005701.3	Homo sapiens snurportin 1 (SNUPN), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SNUPN ( NM_005701.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005692.1 Homo sapiens snurportin 1 (SNUPN), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu05131
Clone ID Related Accession (Same CDS sequence)	NM_005701.3 , NM_001042588.1 , NM_005701.4 , NM_001042581.1
Accession Version	NM_005701.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	snurportin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD244425.1, AC105020.18 and BC004203.2. On Jul 20, 2006 this sequence version replaced NM_005701.2. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC004203.2, SRR1803612.59600.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGAGT TGAGTCAGGC CCTGGCTAGT AGCTTTTCTG TGTCTCAAGA TCTGAACAGC 
ACAGCTGCCC CACACCCCCG CCTATCCCAG TACAAGTCCA AGTACAGTTC CTTGGAGCAG 
AGTGAGCGCC GCCGGAGGTT ACTGGAACTG CAGAAATCCA AGCGGCTGGA TTATGTGAAC 
CATGCCAGAA GACTGGCTGA AGATGACTGG ACAGGGATGG AGAGTGAGGA AGAAAATAAG 
AAAGATGATG AAGAAATGGA CATTGACACT GTCAAGAAGT TACCAAAACA CTATGCTAAT 
CAATTGATGC TTTCTGAGTG GTTAATTGAC GTTCCTTCAG ATTTGGGGCA GGAATGGATT 
GTGGTCGTGT GCCCTGTTGG AAAAAGAGCC CTTATCGTGG CCTCCAGGGG TTCTACCAGT 
GCCTACACCA AGAGTGGCTA CTGTGTCAAC AGGTTTTCTT CACTTCTGCC AGGAGGCAAC 
AGGCGAAACT CAACAGCAAA AGACTACACC ATTCTAGATT GCATTTACAA TGAGGTAAAC 
CAGACCTACT ACGTTCTGGA TGTGATGTGC TGGCGGGGAC ACCCTTTTTA TGATTGCCAG 
ACTGATTTCC GATTCTACTG GATGCATTCA AAGTTACCAG AAGAAGAAGG ACTGGGAGAG 
AAAACCAAGC TTAATCCTTT TAAATTTGTG GGGCTAAAGA ACTTCCCTTG CACTCCCGAA 
AGCCTGTGTG ATGTGCTATC TATGGATTTC CCTTTTGAGG TAGATGGACT TCTCTTCTAC 
CACAAACAGA CCCACTACAG CCCCGGAAGC ACTCCCTTGG TGGGCTGGCT GCGCCCCTAC 
ATGGTGTCAG ATGTCCTTGG TGTAGCTGTG CCGGCTGGCC CGCTGACCAC CAAGCCAGAC 
TATGCTGGGC ACCAGCTCCA GCAGATTATG GAGCACAAGA AGAGCCAGAA GGAAGGCATG 
AAGGAGAAAC TCACACACAA GGCCTCTGAG AATGGGCACT ATGAATTGGA GCACCTGTCT 
ACTCCCAAGT TGAAGGGTTC TTCCCATAGC CCAGACCACC CTGGATGCCT CATGGAGAAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005692.1
CDS	446..1528
Translation	MEELSQALASSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRRLLELQKSKRLDYVNHARRLAEDDWTGMESEEENKKDDEEMDIDTVKKLPKHYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNSTAKDYTILDCIYNEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTKLNPFKFVGLKNFPCTPESLCDVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPAGPLTTKPDYAGHQLQQIMEHKKSQKEGMKEKLTHKASENGHYELEHLSTPKLKGSSHSPDHPGCLMEN

Target ORF information:

RefSeq Version	NM_005701.3
Organism	Homo sapiens(human)
Definition	Homo sapiens snurportin 1 (SNUPN), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005701.3

ORF Insert Sequence:

ATGGAAGAGT TGAGTCAGGC CCTGGCTAGT AGCTTTTCTG TGTCTCAAGA TCTGAACAGC 
ACAGCTGCCC CACACCCCCG CCTATCCCAG TACAAGTCCA AGTACAGTTC CTTGGAGCAG 
AGTGAGCGCC GCCGGAGGTT ACTGGAACTG CAGAAATCCA AGCGGCTGGA TTATGTGAAC 
CATGCCAGAA GACTGGCTGA AGATGACTGG ACAGGGATGG AGAGTGAGGA AGAAAATAAG 
AAAGATGATG AAGAAATGGA CATTGACACT GTCAAGAAGT TACCAAAACA CTATGCTAAT 
CAATTGATGC TTTCTGAGTG GTTAATTGAC GTTCCTTCAG ATTTGGGGCA GGAATGGATT 
GTGGTCGTGT GCCCTGTTGG AAAAAGAGCC CTTATCGTGG CCTCCAGGGG TTCTACCAGT 
GCCTACACCA AGAGTGGCTA CTGTGTCAAC AGGTTTTCTT CACTTCTGCC AGGAGGCAAC 
AGGCGAAACT CAACAGCAAA AGACTACACC ATTCTAGATT GCATTTACAA TGAGGTAAAC 
CAGACCTACT ACGTTCTGGA TGTGATGTGC TGGCGGGGAC ACCCTTTTTA TGATTGCCAG 
ACTGATTTCC GATTCTACTG GATGCATTCA AAGTTACCAG AAGAAGAAGG ACTGGGAGAG 
AAAACCAAGC TTAATCCTTT TAAATTTGTG GGGCTAAAGA ACTTCCCTTG CACTCCCGAA 
AGCCTGTGTG ATGTGCTATC TATGGATTTC CCTTTTGAGG TAGATGGACT TCTCTTCTAC 
CACAAACAGA CCCACTACAG CCCCGGAAGC ACTCCCTTGG TGGGCTGGCT GCGCCCCTAC 
ATGGTGTCAG ATGTCCTTGG TGTAGCTGTG CCGGCTGGCC CGCTGACCAC CAAGCCAGAC 
TATGCTGGGC ACCAGCTCCA GCAGATTATG GAGCACAAGA AGAGCCAGAA GGAAGGCATG 
AAGGAGAAAC TCACACACAA GGCCTCTGAG AATGGGCACT ATGAATTGGA GCACCTGTCT 
ACTCCCAAGT TGAAGGGTTC TTCCCATAGC CCAGACCACC CTGGATGCCT CATGGAGAAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNUPN ( NM_001042588.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001036053.1 Homo sapiens snurportin 1 (SNUPN), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu05131
Clone ID Related Accession (Same CDS sequence)	NM_005701.3 , NM_001042588.1 , NM_005701.4 , NM_001042581.1
Accession Version	NM_001042588.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	snurportin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU945130.1 and BC004203.2. Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.141060.1, SRR1660805.275815.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGAGT TGAGTCAGGC CCTGGCTAGT AGCTTTTCTG TGTCTCAAGA TCTGAACAGC 
ACAGCTGCCC CACACCCCCG CCTATCCCAG TACAAGTCCA AGTACAGTTC CTTGGAGCAG 
AGTGAGCGCC GCCGGAGGTT ACTGGAACTG CAGAAATCCA AGCGGCTGGA TTATGTGAAC 
CATGCCAGAA GACTGGCTGA AGATGACTGG ACAGGGATGG AGAGTGAGGA AGAAAATAAG 
AAAGATGATG AAGAAATGGA CATTGACACT GTCAAGAAGT TACCAAAACA CTATGCTAAT 
CAATTGATGC TTTCTGAGTG GTTAATTGAC GTTCCTTCAG ATTTGGGGCA GGAATGGATT 
GTGGTCGTGT GCCCTGTTGG AAAAAGAGCC CTTATCGTGG CCTCCAGGGG TTCTACCAGT 
GCCTACACCA AGAGTGGCTA CTGTGTCAAC AGGTTTTCTT CACTTCTGCC AGGAGGCAAC 
AGGCGAAACT CAACAGCAAA AGACTACACC ATTCTAGATT GCATTTACAA TGAGGTAAAC 
CAGACCTACT ACGTTCTGGA TGTGATGTGC TGGCGGGGAC ACCCTTTTTA TGATTGCCAG 
ACTGATTTCC GATTCTACTG GATGCATTCA AAGTTACCAG AAGAAGAAGG ACTGGGAGAG 
AAAACCAAGC TTAATCCTTT TAAATTTGTG GGGCTAAAGA ACTTCCCTTG CACTCCCGAA 
AGCCTGTGTG ATGTGCTATC TATGGATTTC CCTTTTGAGG TAGATGGACT TCTCTTCTAC 
CACAAACAGA CCCACTACAG CCCCGGAAGC ACTCCCTTGG TGGGCTGGCT GCGCCCCTAC 
ATGGTGTCAG ATGTCCTTGG TGTAGCTGTG CCGGCTGGCC CGCTGACCAC CAAGCCAGAC 
TATGCTGGGC ACCAGCTCCA GCAGATTATG GAGCACAAGA AGAGCCAGAA GGAAGGCATG 
AAGGAGAAAC TCACACACAA GGCCTCTGAG AATGGGCACT ATGAATTGGA GCACCTGTCT 
ACTCCCAAGT TGAAGGGTTC TTCCCATAGC CCAGACCACC CTGGATGCCT CATGGAGAAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001036053.1
CDS	146..1228
Translation	MEELSQALASSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRRLLELQKSKRLDYVNHARRLAEDDWTGMESEEENKKDDEEMDIDTVKKLPKHYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNSTAKDYTILDCIYNEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTKLNPFKFVGLKNFPCTPESLCDVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPAGPLTTKPDYAGHQLQQIMEHKKSQKEGMKEKLTHKASENGHYELEHLSTPKLKGSSHSPDHPGCLMEN

Target ORF information:

RefSeq Version	NM_001042588.1
Organism	Homo sapiens(human)
Definition	Homo sapiens snurportin 1 (SNUPN), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001042588.1

ORF Insert Sequence:

ATGGAAGAGT TGAGTCAGGC CCTGGCTAGT AGCTTTTCTG TGTCTCAAGA TCTGAACAGC 
ACAGCTGCCC CACACCCCCG CCTATCCCAG TACAAGTCCA AGTACAGTTC CTTGGAGCAG 
AGTGAGCGCC GCCGGAGGTT ACTGGAACTG CAGAAATCCA AGCGGCTGGA TTATGTGAAC 
CATGCCAGAA GACTGGCTGA AGATGACTGG ACAGGGATGG AGAGTGAGGA AGAAAATAAG 
AAAGATGATG AAGAAATGGA CATTGACACT GTCAAGAAGT TACCAAAACA CTATGCTAAT 
CAATTGATGC TTTCTGAGTG GTTAATTGAC GTTCCTTCAG ATTTGGGGCA GGAATGGATT 
GTGGTCGTGT GCCCTGTTGG AAAAAGAGCC CTTATCGTGG CCTCCAGGGG TTCTACCAGT 
GCCTACACCA AGAGTGGCTA CTGTGTCAAC AGGTTTTCTT CACTTCTGCC AGGAGGCAAC 
AGGCGAAACT CAACAGCAAA AGACTACACC ATTCTAGATT GCATTTACAA TGAGGTAAAC 
CAGACCTACT ACGTTCTGGA TGTGATGTGC TGGCGGGGAC ACCCTTTTTA TGATTGCCAG 
ACTGATTTCC GATTCTACTG GATGCATTCA AAGTTACCAG AAGAAGAAGG ACTGGGAGAG 
AAAACCAAGC TTAATCCTTT TAAATTTGTG GGGCTAAAGA ACTTCCCTTG CACTCCCGAA 
AGCCTGTGTG ATGTGCTATC TATGGATTTC CCTTTTGAGG TAGATGGACT TCTCTTCTAC 
CACAAACAGA CCCACTACAG CCCCGGAAGC ACTCCCTTGG TGGGCTGGCT GCGCCCCTAC 
ATGGTGTCAG ATGTCCTTGG TGTAGCTGTG CCGGCTGGCC CGCTGACCAC CAAGCCAGAC 
TATGCTGGGC ACCAGCTCCA GCAGATTATG GAGCACAAGA AGAGCCAGAA GGAAGGCATG 
AAGGAGAAAC TCACACACAA GGCCTCTGAG AATGGGCACT ATGAATTGGA GCACCTGTCT 
ACTCCCAAGT TGAAGGGTTC TTCCCATAGC CCAGACCACC CTGGATGCCT CATGGAGAAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNUPN ( NM_005701.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005692.1 Homo sapiens snurportin 1 (SNUPN), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu05131
Clone ID Related Accession (Same CDS sequence)	NM_005701.3 , NM_001042588.1 , NM_005701.4 , NM_001042581.1
Accession Version	NM_005701.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	snurportin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC004203.2. On May 17, 2019 this sequence version replaced NM_005701.3. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.330177.1, SRR7346977.494009.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000308588.10/ ENSP00000309831.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAAGAGT TGAGTCAGGC CCTGGCTAGT AGCTTTTCTG TGTCTCAAGA TCTGAACAGC 
ACAGCTGCCC CACACCCCCG CCTATCCCAG TACAAGTCCA AGTACAGTTC CTTGGAGCAG 
AGTGAGCGCC GCCGGAGGTT ACTGGAACTG CAGAAATCCA AGCGGCTGGA TTATGTGAAC 
CATGCCAGAA GACTGGCTGA AGATGACTGG ACAGGGATGG AGAGTGAGGA AGAAAATAAG 
AAAGATGATG AAGAAATGGA CATTGACACT GTCAAGAAGT TACCAAAACA CTATGCTAAT 
CAATTGATGC TTTCTGAGTG GTTAATTGAC GTTCCTTCAG ATTTGGGGCA GGAATGGATT 
GTGGTCGTGT GCCCTGTTGG AAAAAGAGCC CTTATCGTGG CCTCCAGGGG TTCTACCAGT 
GCCTACACCA AGAGTGGCTA CTGTGTCAAC AGGTTTTCTT CACTTCTGCC AGGAGGCAAC 
AGGCGAAACT CAACAGCAAA AGACTACACC ATTCTAGATT GCATTTACAA TGAGGTAAAC 
CAGACCTACT ACGTTCTGGA TGTGATGTGC TGGCGGGGAC ACCCTTTTTA TGATTGCCAG 
ACTGATTTCC GATTCTACTG GATGCATTCA AAGTTACCAG AAGAAGAAGG ACTGGGAGAG 
AAAACCAAGC TTAATCCTTT TAAATTTGTG GGGCTAAAGA ACTTCCCTTG CACTCCCGAA 
AGCCTGTGTG ATGTGCTATC TATGGATTTC CCTTTTGAGG TAGATGGACT TCTCTTCTAC 
CACAAACAGA CCCACTACAG CCCCGGAAGC ACTCCCTTGG TGGGCTGGCT GCGCCCCTAC 
ATGGTGTCAG ATGTCCTTGG TGTAGCTGTG CCGGCTGGCC CGCTGACCAC CAAGCCAGAC 
TATGCTGGGC ACCAGCTCCA GCAGATTATG GAGCACAAGA AGAGCCAGAA GGAAGGCATG 
AAGGAGAAAC TCACACACAA GGCCTCTGAG AATGGGCACT ATGAATTGGA GCACCTGTCT 
ACTCCCAAGT TGAAGGGTTC TTCCCATAGC CCAGACCACC CTGGATGCCT CATGGAGAAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005692.1
CDS	66..1148
Translation	MEELSQALASSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRRLLELQKSKRLDYVNHARRLAEDDWTGMESEEENKKDDEEMDIDTVKKLPKHYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNSTAKDYTILDCIYNEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTKLNPFKFVGLKNFPCTPESLCDVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPAGPLTTKPDYAGHQLQQIMEHKKSQKEGMKEKLTHKASENGHYELEHLSTPKLKGSSHSPDHPGCLMEN

Target ORF information:

RefSeq Version	NM_005701.4
Organism	Homo sapiens(human)
Definition	Homo sapiens snurportin 1 (SNUPN), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005701.4

ORF Insert Sequence:

ATGGAAGAGT TGAGTCAGGC CCTGGCTAGT AGCTTTTCTG TGTCTCAAGA TCTGAACAGC 
ACAGCTGCCC CACACCCCCG CCTATCCCAG TACAAGTCCA AGTACAGTTC CTTGGAGCAG 
AGTGAGCGCC GCCGGAGGTT ACTGGAACTG CAGAAATCCA AGCGGCTGGA TTATGTGAAC 
CATGCCAGAA GACTGGCTGA AGATGACTGG ACAGGGATGG AGAGTGAGGA AGAAAATAAG 
AAAGATGATG AAGAAATGGA CATTGACACT GTCAAGAAGT TACCAAAACA CTATGCTAAT 
CAATTGATGC TTTCTGAGTG GTTAATTGAC GTTCCTTCAG ATTTGGGGCA GGAATGGATT 
GTGGTCGTGT GCCCTGTTGG AAAAAGAGCC CTTATCGTGG CCTCCAGGGG TTCTACCAGT 
GCCTACACCA AGAGTGGCTA CTGTGTCAAC AGGTTTTCTT CACTTCTGCC AGGAGGCAAC 
AGGCGAAACT CAACAGCAAA AGACTACACC ATTCTAGATT GCATTTACAA TGAGGTAAAC 
CAGACCTACT ACGTTCTGGA TGTGATGTGC TGGCGGGGAC ACCCTTTTTA TGATTGCCAG 
ACTGATTTCC GATTCTACTG GATGCATTCA AAGTTACCAG AAGAAGAAGG ACTGGGAGAG 
AAAACCAAGC TTAATCCTTT TAAATTTGTG GGGCTAAAGA ACTTCCCTTG CACTCCCGAA 
AGCCTGTGTG ATGTGCTATC TATGGATTTC CCTTTTGAGG TAGATGGACT TCTCTTCTAC 
CACAAACAGA CCCACTACAG CCCCGGAAGC ACTCCCTTGG TGGGCTGGCT GCGCCCCTAC 
ATGGTGTCAG ATGTCCTTGG TGTAGCTGTG CCGGCTGGCC CGCTGACCAC CAAGCCAGAC 
TATGCTGGGC ACCAGCTCCA GCAGATTATG GAGCACAAGA AGAGCCAGAA GGAAGGCATG 
AAGGAGAAAC TCACACACAA GGCCTCTGAG AATGGGCACT ATGAATTGGA GCACCTGTCT 
ACTCCCAAGT TGAAGGGTTC TTCCCATAGC CCAGACCACC CTGGATGCCT CATGGAGAAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNUPN ( NM_001042581.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001036046.1 Homo sapiens snurportin 1 (SNUPN), transcript variant 2, mRNA.

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CloneID	OHu05131
Clone ID Related Accession (Same CDS sequence)	NM_005701.3 , NM_001042588.1 , NM_005701.4 , NM_001042581.1
Accession Version	NM_001042581.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Homo sapiens(human)
Product	snurportin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD244425.1 and BC004203.2. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.56280.1, SRR5189667.396541.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGAGT TGAGTCAGGC CCTGGCTAGT AGCTTTTCTG TGTCTCAAGA TCTGAACAGC 
ACAGCTGCCC CACACCCCCG CCTATCCCAG TACAAGTCCA AGTACAGTTC CTTGGAGCAG 
AGTGAGCGCC GCCGGAGGTT ACTGGAACTG CAGAAATCCA AGCGGCTGGA TTATGTGAAC 
CATGCCAGAA GACTGGCTGA AGATGACTGG ACAGGGATGG AGAGTGAGGA AGAAAATAAG 
AAAGATGATG AAGAAATGGA CATTGACACT GTCAAGAAGT TACCAAAACA CTATGCTAAT 
CAATTGATGC TTTCTGAGTG GTTAATTGAC GTTCCTTCAG ATTTGGGGCA GGAATGGATT 
GTGGTCGTGT GCCCTGTTGG AAAAAGAGCC CTTATCGTGG CCTCCAGGGG TTCTACCAGT 
GCCTACACCA AGAGTGGCTA CTGTGTCAAC AGGTTTTCTT CACTTCTGCC AGGAGGCAAC 
AGGCGAAACT CAACAGCAAA AGACTACACC ATTCTAGATT GCATTTACAA TGAGGTAAAC 
CAGACCTACT ACGTTCTGGA TGTGATGTGC TGGCGGGGAC ACCCTTTTTA TGATTGCCAG 
ACTGATTTCC GATTCTACTG GATGCATTCA AAGTTACCAG AAGAAGAAGG ACTGGGAGAG 
AAAACCAAGC TTAATCCTTT TAAATTTGTG GGGCTAAAGA ACTTCCCTTG CACTCCCGAA 
AGCCTGTGTG ATGTGCTATC TATGGATTTC CCTTTTGAGG TAGATGGACT TCTCTTCTAC 
CACAAACAGA CCCACTACAG CCCCGGAAGC ACTCCCTTGG TGGGCTGGCT GCGCCCCTAC 
ATGGTGTCAG ATGTCCTTGG TGTAGCTGTG CCGGCTGGCC CGCTGACCAC CAAGCCAGAC 
TATGCTGGGC ACCAGCTCCA GCAGATTATG GAGCACAAGA AGAGCCAGAA GGAAGGCATG 
AAGGAGAAAC TCACACACAA GGCCTCTGAG AATGGGCACT ATGAATTGGA GCACCTGTCT 
ACTCCCAAGT TGAAGGGTTC TTCCCATAGC CCAGACCACC CTGGATGCCT CATGGAGAAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001036046.1
CDS	341..1423
Translation	MEELSQALASSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRRLLELQKSKRLDYVNHARRLAEDDWTGMESEEENKKDDEEMDIDTVKKLPKHYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNSTAKDYTILDCIYNEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTKLNPFKFVGLKNFPCTPESLCDVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPAGPLTTKPDYAGHQLQQIMEHKKSQKEGMKEKLTHKASENGHYELEHLSTPKLKGSSHSPDHPGCLMEN

Target ORF information:

RefSeq Version	NM_001042581.1
Organism	Homo sapiens(human)
Definition	Homo sapiens snurportin 1 (SNUPN), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001042581.1

ORF Insert Sequence:

ATGGAAGAGT TGAGTCAGGC CCTGGCTAGT AGCTTTTCTG TGTCTCAAGA TCTGAACAGC 
ACAGCTGCCC CACACCCCCG CCTATCCCAG TACAAGTCCA AGTACAGTTC CTTGGAGCAG 
AGTGAGCGCC GCCGGAGGTT ACTGGAACTG CAGAAATCCA AGCGGCTGGA TTATGTGAAC 
CATGCCAGAA GACTGGCTGA AGATGACTGG ACAGGGATGG AGAGTGAGGA AGAAAATAAG 
AAAGATGATG AAGAAATGGA CATTGACACT GTCAAGAAGT TACCAAAACA CTATGCTAAT 
CAATTGATGC TTTCTGAGTG GTTAATTGAC GTTCCTTCAG ATTTGGGGCA GGAATGGATT 
GTGGTCGTGT GCCCTGTTGG AAAAAGAGCC CTTATCGTGG CCTCCAGGGG TTCTACCAGT 
GCCTACACCA AGAGTGGCTA CTGTGTCAAC AGGTTTTCTT CACTTCTGCC AGGAGGCAAC 
AGGCGAAACT CAACAGCAAA AGACTACACC ATTCTAGATT GCATTTACAA TGAGGTAAAC 
CAGACCTACT ACGTTCTGGA TGTGATGTGC TGGCGGGGAC ACCCTTTTTA TGATTGCCAG 
ACTGATTTCC GATTCTACTG GATGCATTCA AAGTTACCAG AAGAAGAAGG ACTGGGAGAG 
AAAACCAAGC TTAATCCTTT TAAATTTGTG GGGCTAAAGA ACTTCCCTTG CACTCCCGAA 
AGCCTGTGTG ATGTGCTATC TATGGATTTC CCTTTTGAGG TAGATGGACT TCTCTTCTAC 
CACAAACAGA CCCACTACAG CCCCGGAAGC ACTCCCTTGG TGGGCTGGCT GCGCCCCTAC 
ATGGTGTCAG ATGTCCTTGG TGTAGCTGTG CCGGCTGGCC CGCTGACCAC CAAGCCAGAC 
TATGCTGGGC ACCAGCTCCA GCAGATTATG GAGCACAAGA AGAGCCAGAA GGAAGGCATG 
AAGGAGAAAC TCACACACAA GGCCTCTGAG AATGGGCACT ATGAATTGGA GCACCTGTCT 
ACTCCCAAGT TGAAGGGTTC TTCCCATAGC CCAGACCACC CTGGATGCCT CATGGAGAAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Filtering genetic variants and placing informative priors based on putative biological function.
BMC genetics17 Suppl 28(2016 Feb)
Friedrichs S,Malzahn D,Pugh EW,Almeida M,Liu XQ,Bailey JN

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.
eLife4(2015 Dec)
K?rl? K,Karaca S,Dehne HJ,Samwer M,Pan KT,Lenz C,Urlaub H,G?rlich D

The interaction of CRM1 and the nuclear pore protein Tpr.
PloS one9(4)e93709(2014)
Zhao CL,Mahboobi SH,Moussavi-Baygi R,Mofrad MR

Structural determinants and mechanism of mammalian CRM1 allostery.
Structure (London, England : 1993)21(8)1350-60(2013 Aug)
D?lker N,Blanchet CE,Vo? B,Haselbach D,Kappel C,Monecke T,Svergun DI,Stark H,Ficner R,Zachariae U,Grubm?ller H,Dickmanns A

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.
Nature structural & molecular biology17(11)1367-76(2010 Nov)
G?ttler T,Madl T,Neumann P,Deichsel D,Corsini L,Monecke T,Ficner R,Sattler M,G?rlich D

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SNUPN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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