MRLN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRLN
Entrez Gene ID	100507027
Full Name	myoregulin
Synonyms	LINC00948,Linc-RAM,M1,MLN,MUSER1
General protein information	Preferred Names myoregulin Names myoregulin long intergenic non-protein coding RNA 948 muscle enriched RNA 1 muscle specific 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q21.2
Summary	This gene encodes a small peptide that shares structural similarity to the small peptides sarcolipin and phospholamban, which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs). This protein is thought to have a similar function to these peptides, regulating Ca(2+) reuptake in the sarcoplasmic reticulum by inhibiting the Ca(2+) pump activity of SERCAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2015].
Disorder MIM:	616246

mRNA and Protein(s)

mRNA	Protein	Name
NM_001304732.1	NP_001291661.1	myoregulin
NM_001304731.2	NP_001291660.1	myoregulin
NM_001304731.1	NP_001291660.1	myoregulin
NM_001304732.2	NP_001291661.1	myoregulin

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD.
Yu X, Zhang Y, Li T, Ma Z, Jia H, Chen Q, Zhao Y, Zhai L, Zhong R, Li C, Zou X, Meng J, Chen AK, Puri PL, Chen M, Zhu D
Nature communications814016(2017 Jan)

A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.
Anderson DM, Anderson KM, Chang CL, Makarewich CA, Nelson BR, McAnally JR, Kasaragod P, Shelton JM, Liou J, Bassel-Duby R, Olson EN
Cell160(4)595-606(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The human and mouse MLN genes consist of three exons that span 16.5 and 15.0 kb, respectively, with the ORF located in exon 3; findings identify MLN as an important regulator of skeletal muscle physiology.
Title: A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.

The following MRLN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRLN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu81121	NM_001304731.2 Latest version!	Homo sapiens myoregulin (MRLN), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu81121	NM_001304732.2 Latest version!	Homo sapiens myoregulin (MRLN), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu81121	NM_001304731.1	Homo sapiens myoregulin (MRLN), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu81121	NM_001304732.1	Homo sapiens myoregulin (MRLN), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRLN ( NM_001304732.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291661.1 Homo sapiens myoregulin (MRLN), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu81121
Clone ID Related Accession (Same CDS sequence)	NM_001304732.1 , NM_001304731.2 , NM_001304731.1 , NM_001304732.2
Accession Version	NM_001304732.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 141bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	myoregulin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB019391.1, BM021470.1 and BG210823.1. On Feb 6, 2015 this sequence version replaced NR_038200.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: BM021470.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2158800 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA 
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291661.1
CDS	339..479
Translation	MTGKNWILISTTTPKSLEDEIVGRLLKILFVIFVDLISIIYVVITS

Target ORF information:

RefSeq Version	NM_001304732.1
Organism	Homo sapiens(human)
Definition	Homo sapiens myoregulin (MRLN), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304732.1

ORF Insert Sequence:

1
61
121

ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA 
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRLN ( NM_001304731.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291660.1 Homo sapiens myoregulin (MRLN), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu81121
Clone ID Related Accession (Same CDS sequence)	NM_001304732.1 , NM_001304731.2 , NM_001304731.1 , NM_001304732.2
Accession Version	NM_001304731.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 141bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	myoregulin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC022027.7, AB019391.1 and BG210823.1. On May 17, 2019 this sequence version replaced NM_001304731.1. Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AB019391.1, W69924.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000414264.6/ ENSP00000488748.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA 
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291660.1
CDS	227..367
Translation	MTGKNWILISTTTPKSLEDEIVGRLLKILFVIFVDLISIIYVVITS

Target ORF information:

RefSeq Version	NM_001304731.2
Organism	Homo sapiens(human)
Definition	Homo sapiens myoregulin (MRLN), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304731.2

ORF Insert Sequence:

1
61
121

ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA 
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRLN ( NM_001304731.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291660.1 Homo sapiens myoregulin (MRLN), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu81121
Clone ID Related Accession (Same CDS sequence)	NM_001304732.1 , NM_001304731.2 , NM_001304731.1 , NM_001304732.2
Accession Version	NM_001304731.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 141bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	myoregulin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB019391.1 and BG210823.1. On Feb 6, 2015 this sequence version replaced NR_038199.1. Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AB019391.1, AF086308.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA 
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291660.1
CDS	217..357
Translation	MTGKNWILISTTTPKSLEDEIVGRLLKILFVIFVDLISIIYVVITS

Target ORF information:

RefSeq Version	NM_001304731.1
Organism	Homo sapiens(human)
Definition	Homo sapiens myoregulin (MRLN), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304731.1

ORF Insert Sequence:

1
61
121

ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA 
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRLN ( NM_001304732.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291661.1 Homo sapiens myoregulin (MRLN), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu81121
Clone ID Related Accession (Same CDS sequence)	NM_001304732.1 , NM_001304731.2 , NM_001304731.1 , NM_001304732.2
Accession Version	NM_001304732.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 141bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-09
Organism	Homo sapiens(human)
Product	myoregulin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC022027.7, AB019391.1, BM021470.1 and BG210823.1. On May 31, 2019 this sequence version replaced NM_001304732.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: BM021470.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2158800 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA 
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291661.1
CDS	349..489
Translation	MTGKNWILISTTTPKSLEDEIVGRLLKILFVIFVDLISIIYVVITS

Target ORF information:

RefSeq Version	NM_001304732.2
Organism	Homo sapiens(human)
Definition	Homo sapiens myoregulin (MRLN), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304732.2

ORF Insert Sequence:

1
61
121

ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA 
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD.
Nature communications814016(2017 Jan)
Yu X,Zhang Y,Li T,Ma Z,Jia H,Chen Q,Zhao Y,Zhai L,Zhong R,Li C,Zou X,Meng J,Chen AK,Puri PL,Chen M,Zhu D

A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.
Cell160(4)595-606(2015 Feb)
Anderson DM,Anderson KM,Chang CL,Makarewich CA,Nelson BR,McAnally JR,Kasaragod P,Shelton JM,Liou J,Bassel-Duby R,Olson EN

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MRLN cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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