KLLN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KLLN
Entrez Gene ID	100144748
Full Name	killin, p53 regulated DNA replication inhibitor
Synonyms	CWS4,KILLIN
General protein information	Preferred Names killin, p53 regulated DNA replication inhibitor Names killin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q23.31
Summary	The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012].
Disorder MIM:	612105
Disorder Html:	Cowden syndrome 4, 615107 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001126049.1	NP_001119521.1	killin

Pathways from BioSystems

Homologies

	LOC100426503	XP_002805787.1
Pan troglodytes (chimpanzee)	KLLN	XP_003312729.1
Homo sapiens (human)	KLLN	NP_001119521.1

Gene Ontology
Bibliography

Related articles in PubMed

Circulating levels of PTEN and KLLN in papillary thyroid carcinoma: can they be considered as novel diagnostic biomarkers?
Razavi SA, Modarressi MH, Yaghmaei P, Tavangar SM, Hedayati M
Endocrine57(3)428-435(2017 Sep)

Upregulated microRNA-224 promotes ovarian cancer cell proliferation by targeting KLLN.
Hu K, Liang M
In vitro cellular & developmental biology. Animal53(2)149-156(2017 Feb)

Cancer-predisposition gene KLLN maintains pericentric H3K9 trimethylation protecting genomic stability.
Nizialek EA, Sankunny M, Niazi F, Eng C
Nucleic acids research44(8)3586-94(2016 05)

KLLN epigenotype-phenotype associations in Cowden syndrome.
Nizialek EA, Mester JL, Dhiman VK, Smiraglia DJ, Eng C
European journal of human genetics : EJHG23(11)1538-43(2015 Nov)

Cell cycle specific distribution of killin: evidence for negative regulation of both DNA and RNA synthesis.
Qiao M, Luo D, Kuang Y, Feng H, Luo G, Liang P
Cell cycle (Georgetown, Tex.)14(12)1823-9(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

overexpression of microRNA-224 enhanced the proliferation abilities of HO8910 and knockdown of microRNA-224 suppressed the proliferation abilities of HO8910PM by KLLN-cyclin A pathway.
Title: Upregulated microRNA-224 promotes ovarian cancer cell proliferation by targeting KLLN.

The results suggest a critical role for KLLN as a potential regulator of pericentric heterochromatin formation, genomic stability and gene expression.
Title: Cancer-predisposition gene KLLN maintains pericentric H3K9 trimethylation protecting genomic stability.

Germline promoter hypermethylation of KLLN is associated with particular malignant and benign Cowden syndrome features, which is dependent on the PTEN mutation status.
Title: KLLN epigenotype-phenotype associations in Cowden syndrome.

Killin has a role in competitively inhibiting the formation of DNA replication forks during S-phase, as well as potentially negatively regulate RNA synthesis during other cell cycle phases
Title: Cell cycle specific distribution of killin: evidence for negative regulation of both DNA and RNA synthesis.

Nuclear KLLN expression associates with improved relapse-free survival for prostate carcinoma
Title: Nuclear KLLN expression associates with improved relapse-free survival for prostate carcinoma.

The following KLLN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KLLN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu18226	NM_001126049.1 Latest version!	Homo sapiens killin, p53 regulated DNA replication inhibitor (KLLN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KLLN ( NM_001126049.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001119521.1 Homo sapiens killin, p53 regulated DNA replication inhibitor (KLLN), mRNA.

Price & Availability↑

CloneID	OHu18226
Clone ID Related Accession (Same CDS sequence)	NM_001126049.1
Accession Version	NM_001126049.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	killin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EU552092.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: EU552092.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGATCGCC CGGGGCCAGG CTCCGCGCGC CCCGGCCGGA CCGTGCACGT TTGGGGTTAC 
CGGGTTGAGT GGAAAGTACG GAACGGTAGG AAGCTGCAGC CCAGCGAGTG GGCGGGGCGA 
GGAGACCTAG GAGGGTTCAA AAGGAGGTGG AAGGATACAC GGGCCACAGT CGGAACTACT 
TTCCGAAGGA GGTCACGTGT GTCCCTAGTT GGGGAACTTT CCAAATTCCC ACTCCCCAGT 
GATAGCTCCG GAGGCAAGTC GTCTTCTTCC TTTGCTCGGG GTGCTCTTGC CTGGTGCAGG 
CAGCGGAACC CCAACCCTTC CTGCGCCGCG GCGGAAACAG GGGCTCGGAC CAGCCTCCCG 
AAGGAGCGCT GTCGGGGCTG GCGCTTGGGG AACTGGTTAC ACAAGCACCC ACATCCAAAC 
ACGTGCCCCC GCCTCCCCGC CTGCTGGCTG CCGCCGATTC TTACAGAACG CGGGGAGAGA 
GTCCCCAAAC TGGTGCCACT CCTCGCCTGC TACCCTAAGA GCAAGCCAAA GGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001119521.1
CDS	951..1487
Translation	MDRPGPGSARPGRTVHVWGYRVEWKVRNGRKLQPSEWAGRGDLGGFKRRWKDTRATVGTTFRRRSRVSLVGELSKFPLPSDSSGGKSSSSFARGALAWCRQRNPNPSCAAAETGARTSLPKERCRGWRLGNWLHKHPHPNTCPRLPACWLPPILTERGERVPKLVPLLACYPKSKPKD

Target ORF information:

RefSeq Version	NM_001126049.1
Organism	Homo sapiens(human)
Definition	Homo sapiens killin, p53 regulated DNA replication inhibitor (KLLN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001126049.1

ORF Insert Sequence:

ATGGATCGCC CGGGGCCAGG CTCCGCGCGC CCCGGCCGGA CCGTGCACGT TTGGGGTTAC 
CGGGTTGAGT GGAAAGTACG GAACGGTAGG AAGCTGCAGC CCAGCGAGTG GGCGGGGCGA 
GGAGACCTAG GAGGGTTCAA AAGGAGGTGG AAGGATACAC GGGCCACAGT CGGAACTACT 
TTCCGAAGGA GGTCACGTGT GTCCCTAGTT GGGGAACTTT CCAAATTCCC ACTCCCCAGT 
GATAGCTCCG GAGGCAAGTC GTCTTCTTCC TTTGCTCGGG GTGCTCTTGC CTGGTGCAGG 
CAGCGGAACC CCAACCCTTC CTGCGCCGCG GCGGAAACAG GGGCTCGGAC CAGCCTCCCG 
AAGGAGCGCT GTCGGGGCTG GCGCTTGGGG AACTGGTTAC ACAAGCACCC ACATCCAAAC 
ACGTGCCCCC GCCTCCCCGC CTGCTGGCTG CCGCCGATTC TTACAGAACG CGGGGAGAGA 
GTCCCCAAAC TGGTGCCACT CCTCGCCTGC TACCCTAAGA GCAAGCCAAA GGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Circulating levels of PTEN and KLLN in papillary thyroid carcinoma: can they be considered as novel diagnostic biomarkers?
Endocrine57(3)428-435(2017 Sep)
Razavi SA,Modarressi MH,Yaghmaei P,Tavangar SM,Hedayati M

Upregulated microRNA-224 promotes ovarian cancer cell proliferation by targeting KLLN.
In vitro cellular & developmental biology. Animal53(2)149-156(2017 Feb)
Hu K,Liang M

Cancer-predisposition gene KLLN maintains pericentric H3K9 trimethylation protecting genomic stability.
Nucleic acids research44(8)3586-94(2016 05)
Nizialek EA,Sankunny M,Niazi F,Eng C

KLLN epigenotype-phenotype associations in Cowden syndrome.
European journal of human genetics : EJHG23(11)1538-43(2015 Nov)
Nizialek EA,Mester JL,Dhiman VK,Smiraglia DJ,Eng C

Cell cycle specific distribution of killin: evidence for negative regulation of both DNA and RNA synthesis.
Cell cycle (Georgetown, Tex.)14(12)1823-9(2015)
Qiao M,Luo D,Kuang Y,Feng H,Luo G,Liang P

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KLLN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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